Nau'in 2 na ciwon sukari mellitus cuta ce ta rayuwa wanda ke haifar sakamakon rikicewar hulɗa da insulin tare da sel.
Mutanen da ke da irin wannan malaise ba koyaushe suna iya ɗaukar matakan sukari daidai ta tsarin abinci da kuma matakai na musamman. Likitoci suna tsara Vildagliptin, wanda yake ragewa kuma yana riƙe glucose tsakanin iyakoki masu karɓa.
Bayani na gaba ɗaya, abun da ya shafi da kuma sakin saki
Vildagliptin wakili ne na sabon aji na kwayoyi waɗanda ake amfani da su sosai wajen maganin cututtukan type 2. Yana tayar da tsibiran da ke motsa jiki kuma yana hana ayyukan dipeptidyl peptidase-4. Yana da tasirin hypoglycemic.
Ana iya tsara magungunan azaman azaman jiyya, kuma a hade tare da wasu magunguna. An haɗe shi tare da ƙayyadaddun sulfonylurea, tare da thiazolidinedione, tare da metformin da insulin.
Vildagliptin sunan duniya ne don sashi mai aiki. An gabatar da kwayoyi biyu tare da wannan abu akan kasuwar magunguna, sunayen kasuwancin su ne Vildagliptin da Galvus. Na farko ya ƙunshi kawai Vildagliptin, na biyu - haɗuwa da Vildagliptin da Metformin.
Siffar saki: Allunan tare da sashi na 50 MG, shiryawa - guda 28.
Magunguna da magunguna
Vildagliptin wani abu ne wanda ke hanzarta hana dipeptidyl peptidase tare da karuwa sosai a cikin GLP da HIP. Kwayoyin Hormones sun shiga cikin hanji a cikin awanni 24 kuma suna ƙaruwa saboda karɓar abinci. Abun yana haɓaka tsinkaye akan sel na betta don glucose. Wannan yana tabbatar da daidaituwa na aiki da sinadarin-insulin-insulin na insulin.
Tare da karuwa a cikin GLP, akwai karuwa a tsinkaye na sel alpha zuwa sukari, wanda ke tabbatar da daidaituwar tsarin glucose mai dogaro da insulin. Akwai raguwa a yawan yawan lemun tsami a cikin jini yayin aikin jiyya. Tare da raguwa a cikin glucagon, raguwa a cikin juriya na insulin yana faruwa.
Abubuwan da ke aiki suna ɗaukar hanzari, suna ƙaruwa da matakin hormones a cikin jini bayan sa'o'i 2. An lura da ƙarancin furotin - ba fiye da 10%. An rarraba Vildagliptin daidai tsakanin sel jini da jini. Matsakaicin sakamako yana faruwa bayan 6 hours. Magungunan sun fi dacewa a kan komai a ciki, tare da abinci, ƙwayar sha yana ragewa zuwa kaɗan - by 19%.
Baiyi aiki ba kuma baya jinkirta kewa, ba gurbi bane. An samo shi a cikin jini na jini bayan sa'o'i 2. Rabin rayuwar daga jikin shine 3 hours, ba tare da la'akari da sashi ba. Biotransformation shine babbar hanyar wuce gona da iri. 15% na miyagun ƙwayoyi an keɓe su a cikin feces, 85% - daga kodan (ba a canzawa 22.9%). Mafi girman abin tunawa abu ya kasance ne bayan minti 120.
Manuniya da contraindications
Babban nuni ga alƙawarin shine ciwon sukari na 2. An tsara Vildagliptin a matsayin babban jiyya, maganin rikice-rikice-ɓangarori guda biyu (tare da halartar ƙarin magani), magani na ɓangarori uku (tare da halartar magunguna biyu).
A farkon lamari, ana gudanar da jiyya tare da motsa jiki da abinci da aka zaɓa musamman. Idan monotherapy ba shi da tasiri, ana amfani da hadadden tare da haɗuwa da magungunan masu zuwa: Kalaman sulfonylurea, thiazolidinedione, metformin, insulin.
Daga cikin abubuwan da ke faruwa sune:
- rashin haƙuri;
- rashi mai aiki;
- ciki
- karancin lactase;
- aikin lalata hanta;
- mutane kasa da shekara 18;
- bugun zuciya;
- lokacin lactation;
- rashin galactose.
Umarnin don amfani
Allunan ana daukar su a baki ba tare da an ambaci abinci ba. Dokar ta ƙaddara ta likita ne ya ƙaddara, la'akari da yanayin mai haƙuri da haƙuri da magani.
Yawan shawarar da aka bada shawarar shine 50-100 mg. A cikin nau'in ciwon sukari mai tsanani 2, an sanya magani a 100 MG kowace rana. A haɗe tare da wasu magunguna (dangane da illolin motsa jiki), abincin yau da kullun shine 50 MG (kwamfutar hannu 1). Tare da isasshen sakamako a lokacin jiyya hadaddun, kashi yana ƙaruwa zuwa 100 MG.
Babu cikakken bayani game da amfani da miyagun ƙwayoyi yayin daukar ciki da lactation. Sabili da haka, wannan rukuni ba a ke so shan magungunan da aka gabatar ba. Tare da matsanancin hankali ya kamata a ɗauka a cikin marasa lafiya da cutar hanta / koda.
Ba a ba da shawarar mutane underan shekaru 18 da yin amfani da miyagun ƙwayoyi ba. Ba zai dace ku fitar da motoci yayin shan maganin ba.
Tare da yin amfani da vildagliptin, ana iya ƙaruwa a cikin ƙididdigar hanta. A yayin jiyya na dogon lokaci, ana ba da shawarar yin nazarin ƙirar biochemical don lura da yanayin da kuma yiwuwar daidaitawar magani.
Tare da karuwa a aminotransferases, ya zama dole a sake gwada jini. Idan alamun suka karu fiye da sau 3, an dakatar da maganin.
Side effects da yawan abin sama da ya kamata
Daga cikin abubuwanda zasu iya faruwa ana lura da su:
- asthenia;
- rawar jiki, farin ciki, rauni, ciwon kai;
- tashin zuciya, amai, bayyanuwar reflux esophagitis, flatulence;
- guguwar mahaifa;
- maganin ciwon huhu
- karin nauyi;
- hepatitis;
- pruritus, urticaria;
- sauran halayen rashin lafiyan halayen.
Magungunan suna da haƙuri da haƙuri, maganin da aka yarda da shi a kowace rana yana zuwa 200 MG kowace rana. Lokacin amfani da fiye da 400 ml, mai zuwa na iya faruwa: zazzabi, kumburi, ƙarancin ƙarshen, tashin zuciya, suma. Idan bayyanar cututtuka ta faru, ya zama dole a kurkura ciki kuma a nemi taimakon likita.
Hakanan yana yiwuwa a kara furotin C-mai amsawa, myoglobin, creatine phosphokinase. Sau da yawa ana lura da angioedema yayin haɗuwa da ACE inhibitors. Tare da janyewar miyagun ƙwayoyi, sakamako masu illa suna ɓacewa.
Hadin gwiwar Magunguna da Analogs
Yuwuwar ma'amala da vildagliptin tare da wasu kwayoyi ta ƙasa. Babu wani sakamako game da magunguna waɗanda ake amfani da su sau da yawa a cikin lura da ciwon sukari na 2 (Metformin, Pioglitazone da sauransu) da magunguna masu kunkuntar magunguna (Amlodipine, Simvastatin).
Magunguna na iya samun sunan kasuwanci ko suna iri ɗaya tare da kayan aiki. A cikin kantin magunguna zaka iya samun Vildagliptin, Galvus. Dangane da maganin contraindications, likitan ya tsara irin waɗannan magunguna waɗanda ke nuna tasirin warkewa iri ɗaya.
Analogues na miyagun ƙwayoyi sun hada da:
- Onglisa (ingantaccen sinadari saxagliptin);
- Januvia (abu - sitagliptin);
- Trazenta (bangaren - linagliptin).
Kudin Vildagliptin ya tashi daga 760 zuwa 880 rubles, ya danganta da gefen kantin magani.
Ya kamata miyagun ƙwayoyi su kasance a zazzabi na akalla digiri 25 a cikin wuri bushe.
Ra'ayoyin masana da marasa lafiya
Ra'ayoyin masana da ra'ayoyin masu haƙuri game da magunguna galibi tabbatacce ne.
Gabanin tushen shan magunguna a cikin marasa lafiya da ke dauke da ciwon sukari na 2, an lura da sakamako mai zuwa:
- raguwa cikin sauri cikin glucose;
- gyara mai nuna yarda;
- sauƙi na amfani;
- weightarfin jikin mutum yayin aikin monotherapy ya kasance iri ɗaya ne;
- far yana haɗuwa da tasirin antihypertensive;
- sakamako masu illa suna faruwa a lokuta marasa galihu;
- rashin yanayin hypoglycemic yayin shan magani;
- normalization na lipid metabolism;
- kyakkyawan matakin tsaro;
- ingantaccen metabolism;
- ya dace da yawancin marasa lafiya da ke fama da ciwon sukari na 2.
Vildagliptin yayin gudanar da bincike ya tabbatar da inganci da kyakkyawan bayanin haƙuri. Dangane da hoton asibiti da alamu nazarce-nazarce, babu wasu maganganu na cututtukan cututtukan jini da aka lura yayin aikin magani.
Ana daukar Vildagliptin a matsayin magani mai narkewar ƙwayar cuta, wanda aka wajabta don masu ciwon sukari na 2. An sanya shi a cikin Rijistar Magunguna (RLS). An tsara shi azaman maganin hana ƙwaƙwalwar ƙwaƙwalwa kuma a haɗe tare da sauran jamiái. Ya danganta da yanayin cutar, tasirin magani, ana iya haɓaka magungunan tare da magungunan Metmorphine, abubuwan da ake amfani da su na sulfonylurea, insulin. Likitocin da ke halartar za su gabatar da daidai gwargwado kuma za su lura da yanayin mai haƙuri. Sau da yawa marasa lafiya da ke dauke da ciwon sukari na 2 suna da cututtukan da suka dace. Wannan yana rikitar da zaɓi game da zaɓin mafi kyawun aikin glucose. A irin waɗannan halayen, insulin shine mafi kyawun hanyar halitta don rage matakan sukari. Yawan cinsa mai yawa na iya haifar da hauhawar jini, hauhawar nauyi. Bayan binciken, an gano cewa amfani da Vildagliptin tare da insulin na iya samun sakamako mai kyau. Hadarin kamuwa da cututtukan zuciya, an rage kiba, an inganta kiba da narkewar ƙwayoyi ba tare da samun nauyi ba.
Frolova N. M., endocrinologist, likita na mafi girman rukuni
Na kasance ina shan Vildagliptin fiye da shekara guda, likita ya umurce ni da haɗin kai tare da Metformin. Na damu matuka cewa yayin dogon jiyya zan ƙara samun nauyi. Amma ta warke da nauyin kilogram 5 kacal a cikin 85. Daga cikin illolin sakamako, na lokaci-lokaci na samun maƙarƙashiya da tashin zuciya. Gabaɗaya, jiyya yana ba da sakamako da ake so kuma yana wucewa ba tare da wani tasiri mara amfani ba.
Olga, mai shekara 44, Saratov
Abubuwan bidiyo daga Dr. Malysheva game da samfuran da za a iya amfani dasu azaman ƙari ga kwayoyi don ciwon sukari:
Vildagliptin magani ne mai tasiri wanda ke rage matakan glucose kuma yana inganta aikin jijiyoyin jiki. Zai taimaka wa marasa lafiya waɗanda ba sa iya daidaita matakan sukari ta hanyar motsa jiki da abinci na musamman.
