Metglib magani ne da aka haɗu da shi tare da sakamako na hypoglycemic, an tsara shi don sarrafa nau'in ciwon sukari na 2. Potentialarfin maganin antidiabetic na miyagun ƙwayoyi na zaɓin farko ya tabbata ta nau'ikan magunguna biyu na asali tare da kayan aiki mai dacewa, wanda ke ba da iko mai iko na metabolism na insulin da glucagon. Maganin magani kuma ya dace da masu ciwon sukari waɗanda ke haɗar da shan Allunan tare da insulin: suna rage kashi da adadin injections na hormone.
Tabbas, yin amfani da shi bai zama barata ba a kowane yanayi (kamar kowane magani na hypoglycemic), amma Metglib ya cika cikakke da ƙa'idodi na zamani da dacewa da inganci.
Abun da magani
Kyakkyawan tunani da aka gwada da kuma kwantar da hankali a cikin ƙwayoyin cuta wanda ya kasance abubuwa biyu masu aiki - metformin (400-500 mg) da glibenclamide (2.5 MG) yana ba da damar fahimta kawai kuma mafi cikakken bayanin furotin na glycemic, amma kuma yana ba da damar rage girman abubuwan da ake amfani da su.
Lokacin da aka yi amfani da kowane magungunan gargajiya a cikin maganin monotherapy, maganin su ya sha bamban. Baya ga kayan aikin na yau da kullun, akwai kuma masu filfa a cikin nau'in cellulose, sitaci, gelatin, glycerin, talc da sauran abubuwan ƙari. Ana samar da allunan karfi na Metglib Force a cikin sashi na 5 glibenclamide da 500 mg metformin.
Ana iya gano hadadden magani ta waɗannan sharuɗɗa masu zuwa: Allunan kwalaji a cikin kwandon kariya na terracotta ko fararen launi tare da layin rabawa, an tattara su cikin ƙwayoyin kwano na 10 - 90. An saka blisters tare da umarnin a cikin kwali. A farashin Metglib mai araha: 240-360 rubles. don shiryawa.
Magungunan Magungunan Magunguna
Nau'in farko na tsari wanda mafi yawan masu ciwon sukari masu cutar 2 suna da masaniya shine metformin, magani ne kawai na irinsa a cikin rukunin biguanide wanda ke rage juriya daga masu karɓar sel zuwa lalacewa na insulin. Normalization na hankali yana da mahimmanci fiye da rudarwa game da samarwarsa, tunda idan akwai nau'in ciwon sukari na 2, cells-sel suna samar da ƙari mai yawa.
Baya ga haɓakar aikin insulin na gaba, ɓangaren shima yana da sauran ayyuka:
- Tarewa da kwantar da hankali na glucose a cikin bangon hanji, motsawar amfani dashi ta hanyar kyallen takarda;
- Haramcin gluconeogenesis;
- Kariya daga β-sel daga kangararru lokacin tsufa da kuma necrosis;
- Yin rigakafin kowane nau'in acidosis da mummunan cututtuka;
- Starfafa microcirculation na ƙwayoyin halittar ruwa, aikin endothelial da metabolism na lipid;
- Rage ƙarancin jinin haila, tare da hana damuwa damuwa, inganta haɓakar ƙwayoyin tsoka.
Wani mahimmin yanayi don daidaitaccen bayanin martaba na lipid a cikin nau'in ciwon sukari na 2 shine kula da nauyin jikin mutum. Metformin yana taimaka wa masu cutar sikila masu kiba. Wata cutar rashin hankali na kara damar kamuwa da cutar kansa ta hanyar 40%. Biagunide yana hana canje-canje masu muni. Ko da mutanen da ke da lafiya fiye da shekaru 40, WHO ta ba da shawarar yin amfani da Metformin a cikin mafi ƙarancin maganin don hana tsufa da al'amuran zuciya.
Sinadari na biyu, glibenclamide, wakili ne na sabon ƙarni na magungunan sulfonylurea.
An hada magungunan a cikin jerin magunguna masu mahimmanci tare da duka cututtukan cututtukan cututtukan fata da kuma cututtukan cututtukan fata.
Ta hanyar motsawar koda, fili yana haɓaka samar da insulin nasa. Dangane da β-sel waɗanda ke da alhakin ci gaban nau'in ciwon sukari na 2, glibenclamide yana tsaka tsaki kuma har ma yana kula da ayyukan su ta hanyar ƙarfafa masu karɓar ƙwayoyin insulin na ƙwaƙwalwar ƙwayar cuta.
Maganin cakuda yana da amfani a kowane matakai na ci gaban cutar, saboda yana samar da sakamako mai tasiri:
- Pancreatic - yana ƙaruwa da ƙwaƙwalwar ƙwayoyin niyya, yana kare β-sel daga glucose mai ƙarfi, yana motsa mahaɗar insulin;
- Karin-pancreatic - metabolite kai tsaye yana aiki tare da tsoka da mai shimfiɗa mai, yana hana glucogenesis, kuma yana ba da damar glucose da kyau.
Imalarancin mafi kyawun kayan masarufi suna ba ka damar daidaita sashi don ƙarami, ƙara amincin ƙwayoyi, rage haɗarin sakamako masu illa da rikicewar aiki.
Pharmacokinetics na miyagun ƙwayoyi
Metformin a cikin tsarin narkewa yana kasancewa cikakke, an rarraba shi tare da babban gudu a cikin jiki, baya shiga cikin kariyar sunadarai. Its bioavailability kusan 50-60%.
Ba a gano metabolites metabolites ba a cikin jiki; ba canzawa, ana cire shi ta hanjin kodan da hanjinsa. Rabin rayuwar shine kimanin awanni 10, ana lura da matsakaicin matakin jini bayan sa'o'i 1-2 bayan kulawar maganin.
Glybenclamide daga ƙwayar gastrointestinal yana tunawa kuma ya rarraba ta hanyar kashi 84%, ganuwar maida hankali daidai yake da na metformin. Hanyoyin kariya na jini suna ɗaure wa magunguna da kashi 97%.
Canza glibenclamide zuwa inert metabolites yana faruwa a cikin hanta. Kusan rabin samfuran lalata suna kodan, sauran kuma bike ne. Rayuwa rabin rayuwa yana tare da metformin.
Alamu
An wajabta ƙarfin Metglib da Metglib Force don ciwon sukari na 2, idan gyarar salon rayuwa da magani na baya tare da metformin ko ƙwallon rukuni na monopreparations ba su bada izinin sarrafa glycemia gabaɗaya. An bada shawara don maye gurbin jiyya tare da maganin metformin da kwayoyi na sulfonylurea tare da hadaddun ƙwayoyi kuma a cikin yanayin tsayayyar iko na alamun glycemic don rage yawan magunguna da kuma nauyin a jikin mutum. Kwayoyi da masu ciwon sukari da ke dogaro da masu fama da cututtukan type 2 suma sun dace.
Contraindications
Haɗin haɗin yana ƙara yawan contraindications, kodayake a gaba ɗaya an gwada abubuwan da keɓaɓɓiyar tsari don aminci da tasiri a lokaci. Kar a rubata Metglib:
- Marasa lafiya tare da rashin kwanciyar hankali ga kowane bangare na tsarin;
- Mutanen da ke dauke da kwayar cutar motsa jiki da nau'in 1st na ciwon sukari;
- Shafar cutar siga ko masu fama da cutar siga;
- Marasa lafiya tare da tarihin raunin aikin koda da hanta;
- Idan a cikin binciken ƙididdigar halittarine ta haɓaka zuwa 110 mmol / l a cikin mata kuma 135 mmol / l a cikin maza;
- Tare da hypoxia na asali iri-iri;
- Marasa lafiya waɗanda aka gano tare da lactic da ketoacidosis;
- Masu ciwon sukari da cututtukan jini wanda ke haifar da rikicewar rayuwa;
- Dan lokaci - a lokacin mummunan rauni, kamuwa da cuta, ƙonewa mai yawa, gangrene;
- A lokacin ra'ayin mazan jiya;
- Tare da leukopenia, porphyria;
- Idan mai haƙuri ya kasance a kan abincin da ke fama da yunwa, yawan adadin kuzari wanda bai wuce 100 kcal / rana ba.
- Tare da maye giya (guda ɗaya ko na kullum).
Ga yara, masu juna biyu da masu shayarwa, babu wani tabbataccen tushe dangane da inganci da amincin magani, don haka Metglib shima ya haɗu a wannan rukuni na marasa lafiya.
Sashi da gudanarwa
Lokacin zabar wani kashi, likita ya mayar da hankali ga sakamakon gwaje-gwaje, matakin cutar, rikice-rikice masu alaƙa, shekarun masu ciwon sukari da amsawar jiki ga abubuwan da ke cikin miyagun ƙwayoyi.
Don garfin Metglib, bisa ga umarnin don amfani, kashi na farko na yau da kullun na iya zama 2.5 / 500 MG ko 5/500 MG sau ɗaya. Idan ɗaya daga cikin abubuwan Metglib ko wasu analogues na sulfonylurea da aka yi amfani dashi azaman magani na farko, to lokacin da ake maye gurbin magunguna tare da nau'in haɗin, ana jagorantar su ta hanyar abubuwan da suka gabata na allunan.
Dosing titration ya kamata a hankali: bayan makonni 2, zaku iya kimanta tasirin maganin warkewa na farko da daidaita shi zuwa 5/500 mg. Tare da tazara tsakanin rabin wata, idan ya cancanta, za a iya ƙara yawan ƙa'idodin zuwa allunan 4 a matakin 5/500 MG ko allunan 6 tare da kashi 2.5 / 500 MG. Don Metglib tare da sashi na 2.5 / 500 MG, matsakaicin kashi shine 2 MG na miyagun ƙwayoyi.
An shirya jigilar magunguna ta dace a cikin tebur.
| Nau'in makoma | Yawan kwayoyin | Fasali na liyafar |
| MG 2,5 / 500 da 5/500 mg | 1 pc 2-4 inji mai kwakwalwa. | da safe tare da karin kumallo; safe da maraice, tare da abinci |
| 2.5 / 500 MG | 3,5,6 inji mai kwakwalwa | 3 rubles kowace rana, tare da karin kumallo, abincin rana, abincin dare |
| 5/500 mg | 3 inji mai kwakwalwa | 3 rubles kowace rana, tare da karin kumallo, abincin rana, abincin dare |
| 2.5 / 400 MG | daga guda biyu. | safe da maraice, a lokaci guda |
Ga tsofaffi masu cutar marasa ƙwaƙwalwa tare da iyakancin ƙwayar ƙwayar koda, ana ƙaddamar da matakin farko na Multiglib Force kamar kullum 2.5 / 500 MG. A wannan yanayin, dole ne a kula da yanayin kodan kodayaushe, tunda tarawar metformin yayin kawar da ita bai cika haɗari ba, amma mummunan rikicewa - lactic acidosis. Tare da matsanancin ƙoƙari na jiki da isasshen abinci mai gina jiki, iyakance iri ɗaya ne.
Abubuwan da ba a so, yawan abin sama da ya kamata
Abubuwan da ke haifar da sakamako ba dalili ba ne na ƙi magani: bayan jiki ya daidaita, alamu da yawa suna tafi da kansu, cutar da cutar sankarar cuta ba ta da yawa ba ta fi haɗari daga Metglib ba. Babban abu shine a yi lissafin daidai gwargwado: tare da haɗari ko yawan shaye-shaye, mai ciwon sukari ya fara cin abincin kyar, ya rasa ƙarfi, ya sami damuwa, hannayensa suna rawar jiki. Fatar ta yi fatwa da laushi, bugun bugun zuciya yana da sauri, wanda aka azabtar ya kusan kusan suma. Don samun hypoglycemia shine mafi kusantar tsofaffi da raunana da cutar da abinci mai ɗorewa na masu ciwon sukari.
Game da yawan abin sama da ya kamata, ana lura da masu zuwa:
- Ciwon ciki
- Migraines
- Rashin cutar dyspeptic;
- Daban-daban nau'in halayen rashin lafiyan mutum.
An kawar da rashin jin daɗi na ɗan lokaci ta hanyar maganin cututtukan, m alamun bayyanar cututtuka na buƙatar maye gurbin analogues na Metglib - Diabeton, Dimaril, Gluconorm, Bagomet Plus, Glukovans, Glibenclamide a hade tare da Metformin, Glucofast (a cikin shawarar likita).
Masu ciwon sukari Game da Metglieb
A wuraren tattaunawar da suka dace a kan Metglib, ra'ayoyin masu ciwon sukari da likitoci sun cakuda, saboda yawancin marasa lafiya suna cikin wahalar magani, kuma yana musu wahala kimanta tasirin magani na mutum. Informationarin bayani yana da alaƙa da tsarin magani: waɗanda aka zaɓa sashinsu daidai ba su korafin illar sakamako ba. Amma gwadawa kan ƙwarewar wani ciwon sukari bashi da ma'ana har ma da haɗari.
Takaita dukkan ra'ayoyin, zamu iya yanke hukuncin cewa Metglib don monotherapy na nau'in ciwon sukari na 2 shine mafi kyawun kayan aiki: babban aminci da ingantaccen bayanin martaba, farashi mai araha, sakamako mai kyau a kan nauyin mai haƙuri, rigakafin cututtukan zuciya da matsalolin oncological suna sanya miyagun ƙwayoyi a cikin kewayon girmamawa na kwayoyi na farko.
