Magungunan magungunan cikin gida Glimepiride (INN) daga kamfanin pharmacological Company Pharmstandard yadda ya kamata yana rage yawan cutar a cikin marasa lafiya tare da kamuwa da cutar sankara mai nau'in ciwon sukari na 2.
Musamman, wakilin antidiabetic yana taimakawa tare da rashin iyawar maganin abinci, motsa jiki da asarar nauyi. Kamar kowane magani, glimepiride yana da wasu halaye na kayan aikin magani wanda duka likitan da mai haƙuri ya kamata ya sani game da su.
Sunan Latin na wannan kayan aiki shine Glimepiride. Babban kayan maganin shine rukuni na sulfonylureas. Maƙerin kuma yana ƙara ƙaramin adadin ƙarin abubuwa a cikin samfur ɗin: sukari madara (lactose), celclose microcrystalline, sulfate sodium lauryl, sitaci pregelatinized sitaci, magnesium stearate da wasu dyes.
Pharmstandard yana samar da wakilin maganin cututtukan ƙwayar cuta a cikin kwamfutar hannu (kwamfutar hannu 1 ya ƙunshi 1, 2, 3 ko 4 mg na glimepiride).
Ana ɗaukar maganin a baka, a wanke da ruwa kaɗan. Bayan shiga cikin jikin mutum, an isa mafi girman abun ciki mai aiki a cikin kimanin awa 2.5. Cin abinci a zahiri baya tasiri shaƙar glimepiride.
Babban kaddarorin abubuwan da ke aiki an bayyana su kamar haka:
- Imarfafa samar da hormone mai saurin sukari daga ƙwayoyin beta na tsibirin na Langerhans.
- Kyakkyawan amsawa game da ƙwayoyin beta zuwa haɓakar jiki na glucose. Ya kamata a lura cewa adadin insulin da aka samar yana da ƙima fiye da ƙarƙashin rinjayar magungunan gargajiya - abubuwan da suka samo asali na sulfonylurea.
- Hibaryewar ɓoyewar glucose ta hanta da rage yawan narkewar ƙwayar sukari da hanta.
- Susara yawan mai saurin ƙwaƙƙwaran ƙwayoyin tsoratarwa na tso adi da ƙwayar tsoka zuwa sakamakon insulin.
- Glimeperid yana haɓaka abun ciki na alpha-tocopherol, aikin glutathione peroxidase, catalase, da superoxide dismutase. Wannan yana haifar da raguwa ga haɓakar damuwa na oxidative, wanda koyaushe yana tare da ciwon sukari na 2.
- Zaɓin inhibition na cyclooxygenase, kazalika da raguwa a cikin juyawar thromboxane A2 daga arachidonic acid. Wannan tsari yana da tasirin antithrombotic.
- Normalization na lipid matakan da rage a cikin maida hankali ne malondialdehyde a cikin jini jini. Wadannan hanyoyin guda biyu suna haifar da tasirin anti-atherogenic na miyagun ƙwayoyi.
Kashi uku na metabolites na glimepiride ke hanjin ciki, sai kashi biyu bisa uku na kodan ya kece.
A cikin marasa lafiya waɗanda ke fama da cututtukan koda, bayyanar glimepiride yana ƙaruwa kuma haɗuwa da ƙimar matsakaicinta a cikin ƙwayar jini yana raguwa.
Umarnin don amfani da allunan
Takardar sayen magani daga kwararrun masu magani shine babban yanayin da zaka iya sayan magungunan na Glimepiride. Lokacin sayen magani, al'ada ce don kulawa da bayanin da aka ayyana a cikin umarnin da aka haɗe.
Sashin magunguna da tsawon lokacin kulawa ana daukar su ne ta hanyar endocrinologist, gwargwadon matakin glycemia na mai haƙuri da kuma lafiyar sa gaba ɗaya. Lokacin ɗaukar Glimepiride, umarnin don amfani ya ƙunshi bayanin cewa yana da mahimmanci a sha 1 MG sau ɗaya a rana. Samun ingantaccen aikin magunguna, ana iya ɗaukar wannan matakan don kula da matakan sukari na yau da kullun.
Idan mafi ƙasƙanci sashi (1 MG) ba shi da tasiri, likitoci a hankali suna ba da 2 mg, 3 MG ko 4 MG na miyagun ƙwayoyi kowace rana. A cikin halayen da ba a san su ba, ana iya ƙara yawan zuwa 3 MG sau biyu a rana a ƙarƙashin tsananin kulawar likita.
Allunan dole ne a kwashe su gaba daya, ba a tauna shi kuma an wanke shi da ruwa. Idan kun tsallake maganin, ba za ku iya ninka biyu ba.
Hada glimepiride tare da insulin, kashi na maganin a cikin tambaya ba ya buƙatar canzawa. An wajabta maganin insulin tare da ƙaramin kashi, a hankali yana ƙara shi. Haɗin magunguna guda biyu yana buƙatar kulawa ta musamman daga likita.
Lokacin canza tsarin kulawa, alal misali, sakamakon canzawa daga wani wakilin antidiabetic zuwa glimepiride, suna farawa da ƙananan allurai (1 mg).
Harkokin canji daga insulin faris zuwa shan Glimepiride yana yiwuwa, lokacin da mai haƙuri ya riƙe aikin asirin ƙwayoyin beta na pancreatic a cikin nau'in 2 na ciwon sukari. A karkashin kulawar likita, marasa lafiya suna daukar 1 mg na miyagun ƙwayoyi sau ɗaya a rana.
Lokacin sayen wakilin maganin cututtukan ƙwayar cuta, ya kamata ka kula da lokacin ƙarewarsa. Don glimepiride, shekaru 2 ne.
Contraindications da m halayen
Kamar kowane magani, magungunan Glimepiride contraindications da mummunan tasirin na iya zama dalilin da yasa aka haramta amfani da shi ga wasu rukunin marasa lafiya.
Tunda abun da ke ciki na allunan sun hada da abubuwanda ke haifar da rashin lafiyan jijiyoyi, daya daga cikin manyan abubuwan da ke haifar da wannan maganin na hypoglycemic shine rashin kwanciyar hankali ga wadannan abubuwan.
Ari ga haka, an hana karɓar kuɗi lokacin da:
- mai ciwon sukari mai ciwon sukari;
- insulin dogara da ciwon sukari;
- coma mai ciwon sukari, precoma;
- koda ko lalatawar hanta;
- dauke da yaro;
- nono.
Masu haɓaka wannan magani sun gudanar da karatun asibiti da kuma bayan-tallace na kasuwanci da yawa. A sakamakon haka, sun sami damar yin amfani da jerin tasirin sakamako masu illa, sun haɗa da:
- Halin da fata (itching, kurji, urticaria).
- Rashin lafiyar Gastrointestinal (zawo, amai, tashin zuciya, ciwon ciki).
- Liverarancin aikin hanta (hepatitis, haɓaka enzymes hanta, jaundice, gazawar hanta da cholestasis).
- Ragewa cikin sauri na matakin sukari (hypoglycemia).
- Hypersensitivity dauki (saukar karfin jini, gajeriyar numfashi, rawar jiki).
- Rage yawan taro a cikin jini.
- Rage ƙarancin gani na gani (yawanci yakan faru ne a farkon makon farko na jiyya).
- Rushewar tsarin hematopoietic (haɓakar agranulocytosis, leukopenia, hemolytic anemia a cikin ciwon sukari mellitus, thrombocytopenia, pancytopenia).
Idan yanayin yawan zubar jini ya hauhawa, to jinin haila yana faruwa, zai kasance ne daga awanni 12 zuwa 72. Sakamakon shan magani mai yawa, mai haƙuri yana da alamu masu zuwa:
- jin zafi a gefen dama;
- yawan tashin zuciya da amai;
- tashin hankali;
- ƙanƙantar tsoka na son rai (rawar jiki);
- ƙaruwar barci;
- tarko da rashin daidaituwa;
- rashin ci gaba
Alamar da ke sama a mafi yawan lokuta ana haifar da su ta hanyar shan ƙwayoyi a cikin narkewa. A matsayin magani, laushi na ciki ko amai ya zama dole. Don yin wannan, ɗauki carbon mai kunnawa ko wasu adsorbents, kazalika da kayan maye. Zai yiwu akwai lokuta na asibiti na haƙuri da haƙuri glucose.
Yin hulɗa tare da wasu kwayoyi
Ga masu ciwon sukari da yawa, tambayar ta taso game da ko za a iya ɗaukar Glimepiride tare da wasu magunguna banda injections na insulin. Ba shi da sauƙi a ba da amsa. Akwai jerin ƙwayoyi masu yawa waɗanda zasu iya samun tasiri daban-daban akan tasirin glimepiride. Don haka, wasu suna ƙaruwa da tasirin hypoglycemic, yayin da wasu, akasin haka, rage shi.
A wannan batun, likitoci suna ba da shawarar sosai cewa marasa lafiya su ba da rahoton duk canje-canje a yanayin lafiyar su, da kuma duk wasu cututtukan haɗin gwiwa tare da ciwon sukari.
Tebur yana nuna manyan magunguna da abubuwan da ke shafar glimepiride. Yin amfani da su a lokaci ɗaya ba a ke so ba, amma a wasu halaye ana iya tsara shi ƙarƙashin ƙararrun kwararrun masu ba da magani.
Magunguna waɗanda zasu iya inganta tasirin hypoglycemic sune:
- allurar insulin;
- Fenfluramine;
- Fibrates;
- kayan coumarin;
- Disopyramids;
- Allopurinol;
- Chloramphenicol;
- Cyclophosphamide;
- Feniramidol;
- Fluoxetine;
- Guanethidine;
- MAO inhibitors, PASK;
- Phenylbutazone;
- Sulfonamides;
- ACE masu hanawa;
- anabolics;
- Proben kashe kansa;
- Isophosphamides;
- Miconazole;
- Pentoxifylline;
- Azapropazone;
- Tetracycline;
- quinolones.
Magunguna waɗanda ke rage tasirin sukari lokacin da aka haɗu da glimepiride:
- Acetazolamide.
- Corticosteroids.
- Diazoxide.
- Diuretics.
- Sympathomimetics.
- Kayan gado
- Progestogens.
- Phenytoin.
- Kwayoyin cutar ta thyroid.
- Estrogens.
- Phenothiazine.
- Glucagon.
- Rifampicin.
- Barbiturates
- Acid na Nicotinic
- Adrenaline.
- Abubuwan Coumarin.
Hakanan ya zama dole a yi hankali da abubuwa kamar su barasa da kuma maganin hana karuwa na histamine H2 (Clonidine da Reserpine).
Abubuwan Coumarin na iya haɓaka da rage glycemia a cikin marasa lafiya.
Kudin, sake dubawa da kuma alamun maganin
Kuna iya siyan wannan magani duka a cikin kantin magani na yau da kullun da kuma shafin yanar gizon masana'antun, bayan ganin hoto na kunshin musamman a gaba.
Zai yuwu a karɓi glimepiride akan sharuɗɗan preferenatory.
Don Glimepiride, farashin ya bambanta dangane da sashi na adadin da adadin allunan a cikin kunshin.
Da ke ƙasa akwai bayani game da tsadar maganin (Pharmstandard, Russia):
- Glimepiride 1 MG - daga 100 zuwa 145 rubles;
- Glimepiride 2 MG - daga 115 zuwa 240 rubles;
- Glimepiride 3 MG - daga 160 zuwa 275 rubles;
- Glimepepiride 4 MG - daga 210 zuwa 330 rubles.
Kamar yadda kake gani, farashin ya yarda sosai ga kowane mara lafiya, ba tare da la’akari da matakin samun kudin shiga ba. A yanar gizo zaka iya samun bita daban-daban game da magani. A matsayinka na mai mulkin, masu ciwon sukari sun gamsu da aikin wannan magani, kuma banda, kana buƙatar sha shi sau ɗaya kawai a rana.
Sakamakon sakamako masu illa ko maganin contraindications, likita na iya ba da wasu masu maye gurbin. Daga cikinsu, magunguna masu amfani da juna (waɗanda ke da nau'ikan aiki guda ɗaya) da magungunan analog (waɗanda ke ɗauke da abubuwa daban-daban, amma suna da irin tasirin warkewa) an rarrabe su.
Shahararrun samfuran dauke da kayan aiki guda ɗaya sune:
- Kwayoyin hana daukar ciki Glimepiride Teva - wani ingantaccen magani wanda ke rage glucose jini. Babban masana'antun sune Isra'ila da Hungary. A cikin Glimepiride Teva, umarnin ya ƙunshi kusan umarnin guda ɗaya da suka danganci amfani da shi. Koyaya, sigogin sun sha bamban da magungunan gida. Matsakaicin farashin 1 fakitin Glimepiride Teva 3 MG No. 30 shine 250 rubles.
- Glimepiride Canon wani magani ne wanda aka dogara da shi a cikin yaƙar cutar glycemia da alamomin kamuwa da cuta. Kamfanin samar da maganin Glimepiride Canon kuma ana faruwa ne a Rasha ta kamfanin samar da magunguna na Canonfarm Production. Glimepiride Canon ba shi da bambance-bambance na musamman, umarnin suna nuna iri ɗaya mai haɗari da haɗarin cutar. Matsakaicin farashin Glimepiride Canon (4 mg No. 30) shine 260 rubles. Magungunan Glimepirid Canon yana da adadi mai yawa kuma yana iya zama da amfani yayin da maganin bai dace da mai haƙuri ba.
- Altar sanannen magani ne tsakanin marassa lafiya. Glimepiride, wanda shine ɗayan magungunan Altar, yana ƙarfafa sakin insulin ta hanyar ƙwayoyin beta. Altar yana da fasalin aikace-aikace iri ɗaya. Wanda ya ƙera samfurin Altar shine Berlin-Chemie. Farashin 1 fakitin Altar yana kan matsakaita 250.
Akwai magunguna da yawa waɗanda suke da irin tasirin warkewa, misali:
- Metformin sanannen wakili ne na hypoglycemic. Babban bangaren suna iri ɗaya (metformin), a hankali yana rage matakan glucose kuma kusan ba zai taɓa haifar da hauhawar jini ba. Koyaya, Metformin yana da dogon jerin contraindications da sakamako masu illa. Matsakaicin farashin maganin Metformin (500 mg No. 60) shine 130 rubles. Tun da wannan kayan ɓangare ne na adadin ƙwayoyi masu yawa, zaku iya samun samfuran daban-daban - Metformin Richter, Canon, Teva, BMS.
- Sauran magungunan hypoglycemic - Siofor 1000, Vertex, Diabeton MV, Amaril, da dai sauransu.
Don haka, idan saboda wasu dalilai glimepiride bai dace ba, analogues na iya maye gurbin shi. Koyaya, wannan kayan aiki yana da tasiri a cikin haɓakar haɓakar hyperglycemia.
Ana ba da bayanai game da mafi kyawun magungunan rage sukari a cikin bidiyon a cikin wannan labarin.
