Atoris wakili ne wanda ya danganta da jikin mutum. Abunda yake aiki shine atorvastatin. Tsarin aikinsa shine ikon takamaiman enzyme wanda ya ƙunshi haɗuwar tasirin cholesterol.
Ta hanyar hana samar da sinadarin cholesterol, haɓakar hankalin masu karɓar ƙwayoyi zuwa atherogenic lipids a hepatocytes da sauran ƙwayoyin suna ƙaruwa. Wadannan Tsarin karɓar karɓa suna da ikon ɗaure kwayoyin LDL kuma suyi amfani dasu daga ƙwayar plasma, wanda, a ƙarshe, yana haifar da raguwa a cikin tarin ƙwayoyin atherogenic na lipoproteins a cikin jini. Tasirin hypolipPs na abu shine saboda tasirinsa akan endothelium na jiragen ruwa da abubuwa masu fasali.
A ƙarƙashin tasirin atorvastatin, vasodilation na faruwa. Kwayoyin Atorvastatin suna rage matakin cikakken cholesterol, gungun atherogenic na lipoproteins, TG da sauran abubuwan atherogenic. Hakanan yana taimakawa wajen haɓaka matakin antiatherogenic lipoproteins. Tasirin warkewa yana ci gaba bayan makonni 2-3 daga farkon amfanin Atoris. Bayan wata daya, ana lura da mafi girman tasirin.
Atoris kai tsaye ya haɗa da atorvastatin da sauran abubuwan taimako.
Hanyar aiwatar da magani da alamomi don amfani
Mafi yawa daga cikin magungunan suna sha ta hanyar narkewa. Saboda babban aiki na rayuwa yayin aikin hanta, bioavailability na miyagun ƙwayoyi bai wuce 12% ba.
Atorvastatin baya ketare shinge na jijiyoyin jini. Ana amfani da fili ne musamman a cikin abun da ke ciki na bile). Kusan rabin abin da aka zubar dashi da feces, kusan kashi biyu - tare da fitsari.
Alamu don alƙawarin Atoris sune yanayin hauhawar jini. Don rage ƙwayar ƙwayar ƙwayar jini, ƙwayoyin atherogenic lipoproteins da triglycerides.
Waɗannan halaye masu zuwa alamu ne ga nadin Atoris:
- Primary hyperlipidemia: gami da polygenic hypercholesterolemia, familial hypercholesterolemia da kuma bambance-bambancen hade. Atoris ci yana samar da karuwa a cikin ƙwayoyin lilaproteins na ƙwayoyin anti-atherogenic a cikin jini kuma suna rage girman matakin rabo na atherogenic zuwa antiatherogenic. Ana amfani dashi lokacin da ba zai yiwu a gyara matakan lipid ba ta hanyar abinci da sauran hanyoyin da ba magani ba na maganin.
- Don rigakafin cututtukan zuciya.
- A hadarin mummunan bala'i da jijiyoyin jini a cikin marasa lafiya da keɓaɓɓen hanya na cututtukan zuciya, amma waɗanda suke cikin hadarin. Riskungiyar haɗarin ta haɗa da mutanen da shekarunsu suka fi shekaru 55, masu shan sigari waɗanda ke fama da hauhawar jini, mellitus na sukari, tare da ƙananan matakan lipoproteins mai yawa, tare da tsinkayar ƙwayar cuta.
- A hadarin da ke tattare da mummunar cuta na zuciya da jijiyoyin jini a cikin marasa lafiya da ke fama da cututtukan zuciya don rage hadarin mutuwa, matsananciyar cutar sankara, mummunan hadarin cerebrovascular, asibiti na sakandare a asibiti sakamakon rashin angina da kuma farfadowa.
Nau'in saki na Atoris - Allunan. Ana samun magungunan masu zuwa na maganin - allunan dauke da kwayar 10 mg, 20 mg, 30 mg da 40 mg.
Umarnin don amfani da miyagun ƙwayoyi
Kafin farawa tare da Atoris, mara lafiya ya kamata ya fara dacewa da rage rage kiba don rage matakan rage kiba .. Hakanan yakamata a bi tsarin abincin yayin magani.
Magungunan an yi shi ne don gudanar da maganin baka, ba tare da la'akari da abinci ba. Zai fi dacewa a sha maganin da yamma. Likita ya saita kashi na maganin kuma yana iya bambanta daga milig 10 zuwa 80 a kashi daya na tsawon awanni 24. Zaɓin zaɓi ne yayin yin la’akari da matakin farko na cholesterol, makasudin magani da kuma halayen tasirin miyagun ƙwayoyi akan mutum.
Yana yiwuwa a yi amfani da atorvastatin a wani nau'in sakewa. Pewarewar amfanin Atoris shine buƙatar kiyaye ainihin lokacin gudanarwa yau da kullun. Sakamakon warkewa yana faruwa ne bayan makonni 2 daga farkon farfaɗo, kuma ana samun mafi girman wata guda bayan farawar jiyya. A wannan batun, sashi na miyagun ƙwayoyi ba ya canzawa sama da wata daya bayan fara maganin.
A farkon farawa kuma kamar yadda maganin ya canza, ya kamata a sanya ido a kan matakan rage kayan rage kiba a cikin jini. Dangane da canje-canje a bayanin martaba na lipid, gyara kashi ya zama dole.
A cikin hypercholesterolemia na farko da cakuda hyperlipidemia, ana fara amfani da farji tare da mafi ƙarancin warkewa, wanda za'a iya ƙaruwa bayan wata daya na maganin, la'akari da amsar haƙuri ga magani.
Tare da hypercholesterolemia na gado, allurai sun dace da nosology na baya. An zaɓi kashi na farko yayin yin la'akari da halaye na mutum na haƙuri, tare da yin la'akari da tsananin cutar. Ga mafi yawan marasa lafiya, matsakaicin warkewa yana da tasiri.
Yana yiwuwa a yi amfani da Atoris a hade tare da sauran hanyoyin maganin (misali, Tare da plasmapheresis) ko azaman maganin monotherapy.
Sakamakon sakamako na shan Atoris
Sakamakon magani mara kyau da halayen m a wasu halaye suna da 'yanci daga kashi da tsawon lokacin far.
Duk da wannan, sakamako na gefe yana da mafi ma'ana a cikin marasa lafiya da ke da jiyya na dogon lokaci a iyakar adadin magunguna.
Babban mawuyacin halayen sun hada da:
- Ciwon kai na yau da kullun, amai, har zuwa ƙwayar migraine. Rarraban bacci daban-daban, har zuwa ci gaban marowaci. Gajiya, rauni, zazzabin gaba ɗaya.
- Asthenia, ƙwaƙwalwar ƙwaƙwalwa. Paresthesia, neuropathy na gefe, olfaction da dandano mai ban sha'awa.
- Rashin hankali da rashin hankalin mutum. Rashin damuwa.
- Dry idanu. Cutar ciki na ciki a karkashin conjunctiva, glaucoma.
- Tachycardia, hauhawar jijiyoyin jini (hawan jini), rudani, damuwa a bayan jijiyar.
- Phlebitis, vasculitis. Lymphadenopathy, raguwa a cikin ƙididdigar platelet.
- Cututtukan cututtukan mahaifa, rhinitis; magungunan ƙwayar cuta na ƙwayar cuta daga ƙwayar cuta, ƙwayar hanci.
- Rashin hankali daga ƙwayar gastrointestinal: tashin zuciya, amai, jin ƙonewa a bayan sternum, damuwa mai narkewa, bloating, asarar kayan jiki, haɓaka ko rage yawan ci, asarar nauyi, bushewar bushewa, tsayayye belching, canje-canje mai kumburi a cikin ƙwayar bakin; esophagus; mucous membrane na harshe, ciki, karamin hanji. Wataƙila ƙari na miki na duodenal, zub da jini, zazzabi na jini da tenesmus. Alamar farin jini. Varfafa tsokoki na ƙafa, canje-canje mai kumburi a cikin jakar haɗin gwiwa, rauni na tsoka, raunin tsoka da ƙananan baya.
- Magana ga cututtukan ƙwayar cuta. Take hakkin aikin urinary, da kuma asarar ƙwayoyin jan jini a cikin fitsari.
- Ruwan ciki, na jini. ICD.
- Kumburi na epididymis, lalatawar jima'i a cikin maza. Karin gumi. Eczematous rashes, seborrhea, itching na fata. Rashin rikicewar ƙwayar cuta: tuntuɓar dermatitis; urticaria; Harshen Quincke na edema, girgiza ƙwayar anaphylactic yana yiwuwa.
- Tsarin jijiyar jijiya. Hypersensitivity to UV haskoki, Stevens-Johnson ciwo, Lyell
- Sugararancin sukari na jini (hypoglycemia).
- Kwari.
Rashin rikice-rikice sun haɗa da gynecomastia; wuce gona da iri na gurbataccen narkewar metabolism; zazzabi, rashin daidaituwa na asali da kuma aski.
Iyaka da sakamako masu illa
A cikin aikin geriatric, ba da shawarar canza sigar farko na miyagun ƙwayoyi ba. A cikin mutanen da ke fama da mummunar cutar hanta, ya zama dole don amfani da maganin tare da taka tsantsan (tunda an rage yawan metabolism da amfani da atorvastatin).
A wannan yanayin, ana bada shawara don kulawa da bayanan dakin gwaje-gwaje a kai tsaye na bayanan tsoffin lipid da aikin hanta. Tare da haɓakar ƙoshin enzymes hanta, ana bada shawarar yawan maganin da aka yi amfani dashi don ragewa ko ƙi rashin lafiya.
A cikin marasa lafiya da cututtukan zuciya, da na sauran wakilan ƙungiyar masu haɗarin haɗarin cutar zuciya, makasudin maganin shine rage matakan LDL da ƙasa da 3 mmol / L da jimlar cholesterol na ƙasa da 5 mmol / L.
Abubuwan da suka saba wa nadin Atoris sun hada da halaye masu zuwa:
- mummunan cutar hanta, gami da cututtukan hepatitis;
- gazawar tantanin halitta;
- canjin cirrhotic a cikin ƙwayar hanta;
- haɓaka ayyukan hanta enzymes na etiology da ba a sani ba.
- karin tsoka cuta;
- ciki da lactation;
- rashin daidaituwa na galactose;
- babban hadarin daukar ciki;
- m pancreatitis;
- shekarun yara;
- mutum rashin haƙuri.
Ba a ba da shawarar yin amfani da magani ba lokacin daukar ciki da kuma lactation. An ba da izinin amfani da kayan aikin ta hanyar mata masu haihuwar haihuwa kawai a cikin yanayin ƙarancin yiwuwar daukar ciki da kuma cikakkiyar ilimin mace game da tasirin cutar ƙwayar cuta.
Matan da suka isa haihuwa a lokacin shan Atoris an bada shawarar su kare kansu daga daukar ciki. Game da batun tsara haihuwa, dakatar da shan miyagun ƙwayoyi 4 makonni kafin ranar haihuwar da aka shirya.
An contraindicated don amfani da miyagun ƙwayoyi a cikin ilimin yara.
Umarni na musamman don amfani da Atoris
Kafin fara Atoris, mai haƙuri ya kamata ya fara dacewa da abincin gargajiya wanda aka fi sani da shi. Irin wannan abincin zai ninka tasiri na miyagun ƙwayoyi. Lokacin ɗaukar Atoris, haɓaka ayyukan aikin enzymes hanta yana yiwuwa. Irin wannan karuwa a cikin transaminases na kan lokaci ne, amma yana buƙatar saka idanu akai-akai na alamun aikin hepatocyte.
An dakatar da warkewar cutar idan akwai ƙarin ƙaruwa sau uku a cikin matakan hanta na hanta enzymes. Atorvastatin kuma na iya tayar da haɓaka a cikin ayyukan creatine phosphokinase da aminotransferase. Game da ciwo ko rashin jin daɗi, ya kamata ku tuntuɓi likitanka nan da nan.
Lokacin ɗaukar Atoris, nau'ikan myopathies daban-daban na iya haɓaka, har zuwa rhabdomyolysis, ƙarancin lalacewa na koda.
Babban haɗarin rhabdomyolysis a cikin marasa lafiya tare da yin amfani da haɗin haɗuwa da ke gaba tare da statins:
- Fibrates.
- Ayyukan Nicotinic acid da ire-irensa.
- Antimetabolites.
- Magungunan ƙwayoyin cuta, ƙungiyar macrolides.
- Magungunan antimycotic (azoles).
- Wasu magunguna an haɗa su da maganin antiretroviral.
A farkon alamun asibiti na haɓakar ciwon sanƙara, da ƙimar halittar phosphokinase ya kamata a ƙaddara kai tsaye.
Tare da ƙaruwa sama da goma na karuwar aikin enzyme, ana dakatar da magani nan da nan.
Magani a aikace
Atoris, umarninsa don amfani, farashi mai girma, sake dubawa mara kyau na yau da kullun yana sa mutane su nemi analogues na miyagun ƙwayoyi.
Umarni game da amfani da hadaddun tsari ba mai yawa bane ga duk rukunin magunguna masu rage rage kiba. Wannan ya faru ne sakamakon yawan kudaden da aka kashe na wadannan kudade. Amma wannan jagorar ya ƙunshi cikakkiyar bayanin magunguna da magunguna na magunguna, rikice-rikice da yiwuwar rikice-rikice. Sakamakon sakaci da karanta umarnin zai iya zama mai muni.
Ya kamata likita ya ba da maganin Atoris. A kowane hali ya kamata ku kanku ku sami magani. Wannan shi ne da farko saboda gaskiyar cewa kayan aiki bai dace da abubuwa masu yawa ba. Babu daidaituwa tare da irin waɗannan kwayoyi kamar cyclosporine, fluconazole, spirolactone, da sauransu.
Hakanan yakamata a amince da shawarar sauya wannan magani tare da takwaransa na cikin gida tare da mai halartar likitan. Bambanci, rashin alheri, na iya zama muhimmi.
Tunda maganin yana shafan cholesterol, yakamata a kula dashi akai-akai don dacewa da mafi ƙarancin warkewar cutar.
Hakanan, bisa ga halayyar, barasa bai dace da abu mai aiki ba - atorvastatin. Wannan haɗuwa ba ta da lafiya ga jiki.
Shahararrun analogues na Atoris a cikin rukunin magunguna sune Rosuvastatin da Simvastatin.
Kudin Atoris ya bambanta da ranar bayarwa da wurin siyarwa. Kuna iya siyan samfurin a kowane kantin magani a Rasha. Farashin miyagun ƙwayoyi a Rasha ya bambanta daga 357 zuwa 1026 rubles. A aikace, kayan aiki suna da duka ra'ayoyi masu kyau da marasa kyau na kwararrun likitoci.
Ana ba da bayani game da gumaka a cikin bidiyon a cikin wannan labarin.
