Glucovans an yi nufin masu ciwon sukari. Mafi yawanci ana amfani dashi yayin rashin ingancin sauran hanyoyin magani, abubuwan cin abinci da kuma motsa jiki.
Sunan kasa da kasa mai zaman kansa
Metformin + Glibenclamide.
ATX
A10BD02.
Glucovans magani ne ga masu ciwon sukari.
Saki siffofin da abun da ke ciki
Ana amfani da miyagun ƙwayoyi a tsarin kwamfutar hannu.
Babban abubuwa masu aiki:
- 500 mg metformin hydrochloride;
- glibenclamide a cikin adadin 2.5-5 MG, dangane da irin sakin.
Componentsarin aka gyara:
- magnesium stearate;
- povidone;
- croscarmellose sodium;
- MCC;
- povidone K-30;
- tsarkakakken ruwa;
- baƙin ƙarfe baƙin ƙarfe;
- macrogol;
- baƙin ƙarfe baƙin ƙarfe;
- Opadry 31F22700 ko Opadry PY-L-24808.
Magungunan Glucovans suna samuwa a cikin nau'ikan allunan, inda manyan kayan abinci masu aiki sune metformin hydrochloride da glibenclamide.
Aikin magunguna
Magungunan sun kasance hade ne da wasu magunguna biyu na baka. Metformin hydrochloride wani biguanide ne. Abun yana taimakawa rage yawan abubuwan glucose na plasma. Ba ya kunna samar da insulin sabili da haka baya tayar da haɓakar ƙwanƙwasa jini. Metformin nan da nan yana da matakai daban-daban guda uku na aikin harhada magunguna:
- yana rage haɓakar kwayar hepatic ta hanyar hana glycogenolysis da gluconeogenesis;
- yana ƙara ji daɗin adadin masu karɓar zuwa kashi na insulin, yin amfani / amfani da glucose ta ƙwayoyin tsoka;
- yana hana shan glucose daga narkewa.
Glibenclamide yana ɗayan abubuwan da aka samo asali na sulfonylurea.
Matakan glucose suna raguwa saboda kunnawar insulin ta hanyar sel wadanda aka keɓance a cikin hanji.
Abubuwan da aka tambaya suna da hanyoyin aiwatar da aiki daban-daban, amma suna haɗu da juna dangane da ayyukan hypoglycemic da kuma inganta ayyukan hormone.
Pharmacokinetics
Lokacin da kake kulawa da baka, glibenclamide yana da kashi 95% daga hanji. An lura da mafi girman abubuwan da ke cikin plasma bayan sa'o'i 4-4.5. An raba shi gaba daya a cikin hanta. Rabin rayuwar shine awa 4-12.
Tare da gudanar da maganin baka na miyagun ƙwayoyi Glucovans, abu mai aiki - glipenclamide - yana tunawa da kashi 95% daga cikin hanji kuma ya rushe gaba daya a cikin hanta.
Ana amfani da Metformin daga narkewa. Matsakaicin matakinsa a cikin tsiron ya samu cikin awa 2-2.5.
Kusan kashi 30% na kwayoyin ɗin cikin hanji yana fitar dashi ta hanyar da ba ta canzawa. Ba shi da ƙarfi ga metabolism, kodan ya keɓe shi. Rabin rayuwar kusan 7 hours ne. A cikin marasa lafiya da ke fama da gazawar koda, wannan lokacin ya karu zuwa awa 9-12.
Alamu don amfani
Type 2 ciwon sukari a cikin manya:
- a cikin rashi ingantaccen kuzari daga motsa jiki, hanyoyin rage cin abinci da monotherapy;
- a cikin haƙuri tare da sarrafawa da barga glycemia.
Ciwon sukari na Type II shine babbar alama ta shan Glucovans, gami da ga marasa lafiya da ke ɗauke da ƙwayar cutar glycemia.
Contraindications
Ba za a iya amfani da miyagun ƙwayoyi a cikin waɗannan lambobin masu zuwa ba:
- ciki da shayarwa;
- rashin haƙuri ɗaya;
- nau'in ciwon sukari ketoacidosis;
- porphyria;
- m siffofin cututtukan zuciya;
- gazawar hanta;
- gazawar renal tare da CC har zuwa 60 ml / min;
- kamuwa da cutar sankara / precoma;
- haɗuwa tare da miconazole;
- wani nau'in cuta mai sa maye da maye wanda tsokanar giya ta lalace;
- lactic acidosis;
- nau'in ciwon sukari na 1;
- hanyoyin shiga (tilas);
- cututtuka na kullum / m tare da hypoxia na nama (gami da raunin numfashi / rauni).
Tare da kulawa
Ba a son amfani da maganin ga tsofaffi waɗanda ke yin aiki na zahiri. Wannan yana da alaƙa da haɗarin lactic acidosis a cikin mambobin wannan rukuni.
Magungunan sun ƙunshi lactose, saboda haka an umurce shi da taka tsantsan ga mutanen da ke da nau'ikan cututtukan cututtukan ƙwayoyin cuta waɗanda ke da alaƙa da cututtukan GGM, rashin lactase ko rashin kula da galactose.
Bugu da kari, an sanya magani a hankali don karancin adrenal, cututtuka na febrile da cututtukan thyroid.
Yadda ake ɗaukar Glucovans
Allurar likita ta ƙaddara da daban-daban. Matsakaicin farko - 1 kwamfutar hannu 1 lokaci a rana. Adadin miyagun ƙwayoyi na iya ƙaruwa ta 0.5 g na metformin da 5 MG na glibenclamide kowace rana a cikin sati biyu har sai an daidaita haɗarin glucose a cikin jini.
Matsakaicin adadin shine allunan 6 na magani na 2.5 + 500 MG ko allunan 4 (5 + 500 MG).
Ya kamata a sha magungunan yayin cin abinci. A lokaci guda, abinci ya kamata ya ƙunshi yawancin carbohydrates kamar yadda zai yiwu.
Shan maganin don ciwon sukari
Masu ciwon sukari da suke amfani da miyagun ƙwayoyi a cikin tambaya yakamata su tabbatar da sarrafa glucose na jini da daidaita sashi na insulin.
Sakamakon Gefen Glucovans
Gastrointestinal fili
Rashin ci, rashin jin ciki, amai / tashin zuciya. Wannan cutar mafi yawanci ana lura dashi ne a farkon farawa kuma ya tafi cikin kwanaki 3-4.
Hematopoietic gabobin
A cikin mafi yawan lokuta, thromocytopenia, leukopenia, pancytopenia, marrow aplasia, hemolytic nau'i na anemia. Wadannan halayen marasa kyau sun ɓace bayan dakatar da amfani da miyagun ƙwayoyi.
Tsarin juyayi na tsakiya
Daga gefen tsarin juyayi na tsakiya, za a iya lura da karancin ciki, damuwa, ciwon kai da dandano na karfe a cikin motsi na baka.
A wani bangare na gabobi
A cikin kwanakin farko na shan maganin, raunin gani na iya faruwa saboda raguwa a cikin taro na glucose a cikin jini.
Daga gefen metabolism
Sakamakon sakamako na yau da kullun shine hypoglycemia. Lokacin da ake bincikar cutar megaloblastic anemia, haɗarin haɗarin etiology dole ne a la'akari.
Mafi yawan tasirin sakamako na shan Glucovans shine hypoglycemia.
Cutar Al'aura
A cikin mafi yawan lokuta, anaphylaxis. Za'a iya lura da halayen rashin haƙuri na ƙwayoyin sulfonamide.
Tasiri kan ikon sarrafa abubuwan inji
Dole ne a sanar da mai haƙuri game da yiwuwar haɓakar haɓakar hypoglycemia kuma cewa lokacin tuki, yana aiki tare da kayan aiki masu rikitarwa kuma a cikin yanayi inda ake buƙatar ƙara yawan kulawa, yakamata a hankali.
Umarni na musamman
Yi amfani da tsufa
Kowane mutum a cikin wannan rukuni, an ba da allurai gwargwadon aikin ƙodan.
Adadin farko ya zama bai wuce 1 kwamfutar hannu na 2.5 + 500 MG ba. A wannan yanayin, ya kamata a ba wa mara lafiya kulawa tare da kula da kodan.
Adanar Glucovans ga yara
Ba da shawarar amfani da shi ba a cikin marasa lafiya na ƙananan shekaru.
Yi amfani da lokacin daukar ciki da lactation
A miyagun ƙwayoyi ne wanda ba a ke so don amfani da lokacin gestation. Lokacin da ake shirin yin juna biyu, dole ne a soke magungunan kuma a fara samar da insulin.
Lokacin da ake shirin yin juna biyu, dole ne a soke maganin Glukvans.
Aikace-aikacen aiki mara kyau
Ba da shawarar don amfani a cikin mutanen da ke fama da gazawar rashin lafiya ba.
Amfani don aikin hanta mai rauni
Ga mutanen da ke fama da ciwon hanta, an wajabta maganin tare da tsananin taka tsantsan.
Yawan Glucovans
Lokacin da aka ɗauka cikin babban allurai, hypoglycemia na iya faruwa. Jinkirta tsawon lokaci zai iya haifar da laitososis na lactic, ƙoshin numfashi da sauran bayyananniyar bayyanuwa.
Matsakaici / m alamu na hypoglycemia yayin riƙe ƙwarewar haƙuri za a iya gyara tare da sukari. A irin waɗannan halayen, mai haƙuri yana buƙatar kashi da kuma daidaita abinci mai gina jiki.
Bayyanar cututtukan cututtukan ƙwayar cuta a cikin masu ciwon sukari sun haɗa da samar da gaggawa na kulawa da lafiya.
Idan akwai rikitarwa mai rikitarwa idan aka sami ƙarin yawan ƙwayar cutar Glucovans, likita na gaggawa ya zama dole.
Ba a kawar da maganin lokacin aikin dialysis.
Yin hulɗa tare da wasu kwayoyi
Abubuwan haɗin gwiwa
Lokacin haɗuwa da miyagun ƙwayoyi da ake tambaya tare da miconazole, akwai haɗarin hauhawar jini, wanda zai haifar da coma.
Ya kamata tare da aidin ya kamata a gudanar da iv 48 hours kafin shan maganin, ba tare da la'akari da abincin ba.
Ba da shawarar haɗuwa ba
Phenylbutazone yana ƙaruwa da sakamako na hypoglycemic na sulfonylurea. Yana da kyau a bayar da fifiko ga wasu magungunan anti-inflammatory waɗanda ke da tasirin sakamako marasa ƙarfi.
Haɗin glibenclamide, barasa da bosentan yana ƙara haɗarin sakamako na hepatotoxic. Yana da kyau kar a hada waɗannan abubuwa masu aiki.
Haɗuwa yana buƙatar taka tsantsan
Babban magunguna na chlorpromazine da danazol suna kara yawan ƙwayar cuta, suna rage haɓakar insulin. Lokacin haɗuwa da miyagun ƙwayoyi tare da allunan da ke cikin tambaya, ya kamata a faɗakar da mai haƙuri game da buƙatar sarrafa ƙwayar ƙwayar plasma na glucose.
Tetracosactide da glucocorticosteroids suna tsokani ƙara yawan plasma na glucose kuma suna iya haifar da ketosis. Tare da wannan haɗin, mai haƙuri ya kamata ya kula da matakin glucose a cikin jini. Diuretics da kayan coumarin na iya samun sakamako iri ɗaya.
Tare da haɗuwa da miyagun ƙwayoyi Glucovans tare da glucocorticosteroids, mai haƙuri ya kamata ya kula da matakin glucose a cikin jini.
Amfani da magunguna masu haɗari tare da fluconazole da ACE inhibitors yana ƙara rabin rayuwar glibenclamide tare da haɗarin alamun hypoglycemic.
Amfani da barasa
A cikin lokacin amfani da miyagun ƙwayoyi, ya kamata a guji amfani da wakilin ethanol da ke da giya.
Analogs
- Glybophor;
- Glibomet;
- Duotrol;
- Douglimax;
- Amaryl;
- Dibizide M;
- Avandamet;
- Vokanamet.
Magunguna kan bar sharuɗan
Zan iya siye ba tare da takardar sayan magani ba
Ba za a iya samun sa ba tare da takardar sayan likita ba.
Nawa
Farashin a cikin kantin magunguna na Rasha yana farawa daga 270 rubles. kowace fakitin 30 Allunan na 2.5 + 500 MG.
Amaril yana ɗayan analogues na miyagun ƙwayoyi Glucovans.
Yanayin ajiya na miyagun ƙwayoyi
Umarnin ya ce ya zama dole don adana miyagun ƙwayoyi a ƙarƙashin yanayin zafi tsakanin + 15 ° ... 26 ° C. Ka nisanci dabbobi da yara.
Ranar karewa
Har zuwa shekaru 3.
Mai masana'anta
Kamfanin Norway da Faransawa Merck Sante.
Bayanin Glucovans
Likitoci
Alevtina Stepanova (therapist), dan shekara 43, St. Petersburg
Amintaccen magani mai inganci. Wannan shine mafi kyawun zaɓi idan monotherapy tare da wasu kwayoyi, aikin jiki da abinci ba su ba da tasirin da ake so.
Valery Torov (Likita), dan shekara 35, Ufa
Ana lura da mummunan halayen lokacin shan wannan magani, amma suna da yanayin ɗan gajeren lokaci kuma suna wucewa da kansu a cikin kwanakin farko bayan farkon far. Ina son tasiri da farashi mai araha a magani.
Ana bada maganin Glucovans ne kawai ta hanyar takardar sayan magani, yakamata a adana magungunan a zazzabi na + 15 ° C zuwa + 26 ° C.
Marasa lafiya
Lyudmila Korovina, mai shekara 44, Vologda
Na fara shan kwamfutar hannu guda 1 na magani kowace safiya. Haɗarin sukari a cikin ƙwayar magani ya rage daga 12 zuwa 8. Ba da daɗewa ba alamu suna da cikakkiyar lafiya. Kafin wannan, ba ganye ko magunguna ba. Na yi mamakin cewa har ma da irin wannan karamin matakin farko "yana aiki" yana bada tabbataccen kuzari. Yanzu kuma ina son yin gwaje-gwaje daga cututtukan fata, sannan lafiyata zata zama kamar ƙuruciyata.
Valentina Sverdlova, 39 years old, Moscow
Maigidana ya kasance yana amfani da Bagomet, amma, ya ɓace daga kantin magunguna a yankinmu, kuma babu sauran lokaci ko ƙoƙari don zuwa cibiyar da maraice bayan aiki. Yanayin matar aure ta fara lalacewa. Suga ya kasance koyaushe yana ƙaruwa, kumburi ya fara ɓarna, har ma leɓen ya zama shuɗi. Likita ya ba da shawarar amfani da wannan magani. A cikin kwanakin farko na matar, matar ta kasance mai tsananin haske, amma nan da nan rashin jin daɗi ya ɓace, kuma sukari ya ragu zuwa takwas.
