Ana kiranta ciwon sukari mellitus "annoba" na karni na XXI. Sabili da haka, shan magani shine ɗayan mahimman batutuwan don magance cutar. Shirye-shiryen umarnin Pioglitazone suna da cikakkun bayanai game da amfaninsu.
Manyan magunguna don ciwon sukari da ke dauke da wannan sinadarin sune Aktos, Pioglar, Diab-norm, Diaglitazone. Pioglitazone kanta farin lu'ulu'u ne, wanda ba shi da wari.
Yana kusan narkewa a cikin ruwa, amma yana narkewa sosai a cikin dimethylformamide. Amma game da ethanol na anhydrous, acetone da acetonitrile, abu a cikinsu yana narkewa kadan.
Pioglitazone wani ɓangare ne na ajin thiazolidinediones (glitazones); an nuna amfani da shi don rage sukarin jini. Tunda nau'in na biyu na ciwon sukari ana nuna shi ta hanyar ƙetarewar hankalin ƙwayoyin jikin mutum zuwa insulin, glitazones yana kunna masu karɓar raƙuman da ke cikin nuclei. A sakamakon haka, ƙwayoyin jijiyoyin jiki suna fara amsawa ga insulin na hormone.
Yawancin marasa lafiya suna tambayar wannan tambaya, shin zai yiwu a sha magani wanda ya ƙunshi pioglitazone a cikin nau'in cutar ta farko? Glitazones magunguna ne na musamman ga masu ciwon sukari na biyu. Ana amfani dasu azaman babban magani, kuma ƙari tare da metformin, sulfonamide ko insulin. Marasa lafiya suna fara shan ƙwayar magani idan motsa jiki da abinci mai kyau ba su da tasirin da ake so - sukarin jini na al'ada.
Glitazones a kwatancen da sauran magunguna masu rage sukari sun fi dacewa kawar da jure insulin. Suna rage yawan kitse a cikin jinin mutum da sake fasalin adipose nama daga rami na ciki zuwa yankin subcutaneous. Bugu da ƙari, abubuwa suna rage ƙananan triglycerides.
Umarnin don amfani da miyagun ƙwayoyi
Shan magungunan an nuna shi ne kawai bayan tattaunawa da likitan da ke halartar, wanda ya ba da daidai gwargwado, la'akari da halaye na mutum na haƙuri. Game da amfani da sinadaran Pioglitazone, dole ne a yi nazarin umarnin don maganin sosai don gujewa duk wani rikitarwa.
Ana nuna magungunan don amfani idan matakin farko yana daga 15 zuwa 30 MG, kuma mafi girman (kowace rana) shine 45 MG. Idan kun haɗu da abu tare da sauran magunguna, kashi ya kamata ya zama ba fiye da 30 MG. Ana nuna Pioglitazone don amfani sau ɗaya a rana.
Yayin jiyya, dole ne ku ci gaba da bin abinci da motsa jiki. Yana da matukar muhimmanci a duba matakin haemoglobin a cikin jini.
An nuna Pioglitazone tare da kulawa ta musamman ga marasa lafiya waɗanda ke da kumburi, hanta tana ɗauke da adadin enzymes. Tare da haɓakar hypoglycemia yayin haɗuwa da ƙwayar cuta yana buƙatar raguwa a cikin adadin insulin ko sulfonamides. Idan mai haƙuri yana da jaundice, za a iya yin amfani da mummunan sakamako akan jiki, don haka ya kamata a dakatar da jiyya. Marasa lafiya waɗanda ke da yanayin haihuwar jinin haila a cikin lokacin haila suna cikin haɗarin daukar ciki, don haka ya kamata a yi amfani da maganin hana haihuwa.
Contraindications da sakamako masu illa
Kafin yin amfani da magunguna dangane da Pioglitazone, kuna buƙatar tuntuɓi likita. Wannan abu yana da contraindications da yawa: rashin haƙuri ga Pioglitazone, nau'in 1 ciwon sukari mellitus, mai ciwon sukari ketoacidosis (rashi mai narkewar ƙwayar metabolism a sakamakon ƙarancin insulin), da kuma cututtukan hanta a babban matakin.
Matsayi na ALT (alanine aminotransferase) sau 2.5 ne sama da na al'ada, wanda zai iya nuna ci gaban cututtukan da yawa masu rauni, shekaru har zuwa shekaru 18 (ba a tantance tasirin abu a cikin marasa lafiya na wannan nau'in shekarun ba), lokacin cinikin ciki da shayarwa.
Idan an yi amfani da Pioglitazone da kyau ko don kowane dalili, mai haƙuri na iya fuskantar halayen masu illa kamar haka:
- hypoglycemia - raguwa mai sauri a cikin glucose na jini;
- kumburi, da haɗuwa tare da insulin yana ƙara haɗarin kumburi har zuwa 15.3%;
- anaemia - low haemoglobin a cikin jinin mutum;
- raguwa a matakin bilirubin;
- raguwa cikin alanine aminotransferase (ALT) - enzyme hypogenic;
- ragewan aspartate aminotransferase (AST) - wani enzyme wanda ke da alhakin ƙirar amino acid;
- raguwa a cikin alkaline phosphatase (ALP) - enzyme wanda ke rushe phosphates daga sunadarai, alkaloids, da sauransu.;
- ragewar gamma glutamyl transferase.
Bugu da ƙari, shirye-shiryen haɗuwa waɗanda ke ƙunshe da abubuwan sulfonamide, metformin, insulin, suna haifar da hypoglycemia.
Hakanan, lokacin amfani dashi, sakamakon rage tasirin maganin hana haifuwa na iya amfani da karfi.
Nazarin, fa'idodi da rashin amfani
Nazarin marasa lafiya da yawa waɗanda suka yi amfani da Aktos, Pioglar da sauran kwayoyi, galibi tabbatacce ne. Daga cikin fa'idodin, yana yiwuwa a bayyanar da tasiri na rage ƙarfin juriya ga insulin a tsakanin dukkanin magunguna masu rage sukari da aka sha da baki.
Amma akwai wasu ɓarna na glitazones, waɗanda aka bayyana a cikin masu zuwa: suna ƙasa da kwayoyi waɗanda ke ɗauke da metformin da sulfonylurea, haemoglobin yana raguwa da 0,5-1.5%, lokacin amfani, ana lura da matsakaicin nauyin kilogram 1-3 saboda yawan ƙwayar mai. da kuma riƙewar ruwa a jiki.
Sabili da haka, kafin shan glitazones, kuna buƙatar tuntuɓi likita kuma karanta sake dubawar marasa lafiya waɗanda suka riga sun cinye su.
Mai haƙuri da shan kayan Pioglitazone, farashin abin da ya dogara da magani, dole ne ya ƙayyade wane magani don amfani. Matsakaicin farashin kwalayen Pioglar (guda 30 na MG 30 kowannensu) shine 1083 rubles, Actos (guda 28 na 30 MG kowannensu) shine 3000 rubles. A tsari, mutum na tsakiyar aji zai iya siyan waɗannan magungunan. Babban farashin su saboda gaskiyar cewa waɗannan magunguna ne da aka shigo da su, an samar da Pioglar a Indiya, Actos - a Ireland.
Ba a yin amfani da magunguna a Rasha. Wadannan sun hada da:
- Diab norms;
- Astrozone;
- Diaglitazone.
Lokacin amfani, za a samar da sakamako na hypoglycemic. Diaglitazone, wanda farashinsa yakai kimanin 295 rubles, na iya zama babban madadin magunguna masu tsada. Astrozone da Diab-norm suna da kusan iri ɗaya contraindications da sakamako masu illa.
Diagnitazone na iya rage tasirin amfani da maganin hana haihuwa, wanda dole ne a lasafta shi.
Pioglitazone analogues
Saboda rashin jituwa da sakamako na mutum, ƙila a haramta amfani da Pioglitazone. Sabili da haka, likita ya tsara wasu magunguna waɗanda ke ɗauke da rosiglitazone.
Hakanan an haɗa wannan sinadarin a cikin rukunin thiazolidinediones (glitazones). Lokacin amfani da shi, za a yi aiki da tasiri iri ɗaya kamar daga pioglitazone, wato, ƙarfafa ƙwayoyin sel da masu karɓa don kawar da juriya na insulin.
Babban magungunan da ke dauke da rosiglitazone sune:
- Avandiya
- Roglit.
Kafin amfani dasu, kuna buƙatar tuntuɓi likita kuma karanta umarnin don amfani.
Shirye-shiryen Biguanide suna rage juriya ga insulin. Metformin, wanda shine ɗayan samfurin, yana rage samar da glucose ta hanta. Yi amfani da waɗannan kwayoyi tare da taka tsantsan, tunda biguanides yana cutar da aikin zuciya a cikin tsofaffi, mummunan tasiri akan aikin kodan da haɓakawa saboda lactic acidosis kuma za'a iya yin aiki. Shirye-shirye tare da metformin mai aiki mai aiki sun hada da Bagomet, Glucofage, Metformin-BMS, NovoFormin, Siofor da sauransu.
Hakanan yana rage Acarbose sukari na jini. Hanyar aikinta an yi niyya ne don hana enzymes waɗanda ke taimakawa wajen samar da carbohydrates a cikin tsarin narkewa. Hypoglycemia yana yiwuwa tare da ƙarin amfani da wasu kwayoyi da insulin. Don hana faruwar sakamako masu illa da ke tattare da ƙoshin abinci, ya fi kyau fara farawa tare da ƙananan allurai.
A cikin lura da ciwon sukari na 2, ana iya amfani da magungunan da ke ɗauke da pioglitazone ko analogues, ko Diaglitazone ko Metformin. Tunda wadannan kwayoyi suna da yawan gaske kuma yana haifar da illa, ana bada shawarar yin amfani da su ne bayan tattaunawa ga masu ciwon suga. kuma tare da likita. Bidiyo a cikin wannan labarin ya taƙaita tattaunawa game da
