Magungunan gungun rukuni ne na cututtukan jini. Ana ɗaukar ta baki. Babban aikin shine tasiri kan ayyukan samar da insulin. Koyaya, wannan baya nufin ana iya amfani dashi don yanayin cututtukan da suka dogara da insulin ba. Yankin ƙwayar yana yin faɗaɗa saboda tasirin cutar farji. Yana da contraindications da yawa, ƙuntatawa na dangi akan amfani. Don kawar da mummunan halayen da ƙara haɓaka, ya kamata a sha maganin a wani lokaci.
Sunan kasa da kasa mai zaman kansa
Glimepiride.
Babban aikin glimepiride shine tasirin sakamako na samar da insulin.
ATX
A10BB12.
Saki siffofin da abun da ke ciki
Ana ba da magani a cikin nau'ikan daban-daban, yana bambanta a cikin sashi na abu mai aiki: 2, 3 da 4 MG. Zaku iya siyan sa cikin ingantaccen tsari. Allunan suna dauke da kayan aiki mai aiki iri guda. Abun da ya haɗa ya haɗa da wasu abubuwa:
- lactose;
- microcrystalline cellulose;
- pregelatinized sitaci;
- sodium lauryl sulfate;
- magnesium stearate.
Bugu da ƙari, ƙwayar na iya ƙunsar dyes. Koyaya, basu cikin kowane nau'in glimepiride, amma suna ƙunshe cikin allunan tare da sigogin babban kashi na 3 MG. Ana bayar da maganin a cikin fakiti 30.
Aikin magunguna
Magungunan suna wakiltar wakilai na hypoglycemic na kungiyar sulfonamides. An danganta shi da kwayoyi na ƙarni na uku. Ka'idar aiki ta dogara ne akan tsarin aiwatar da sakin insulin. Ana samun wannan sakamako ta hanyar ƙarfafa wasu ƙwayoyin ɓangaren ɓangaren endocrine na pancreas. Suna yin ayyuka da yawa: kunna sakin insulin, a lokaci guda suna ba da gudummawa ga raguwar glucose jini.
Magungunan suna da sakamako mai dogaro. Don haka, tare da rage adadin glimepiride, yawan sakin insulin yana raguwa. Koyaya, tare da waɗannan bayanan farko, miyagun ƙwayoyi suna riƙe daidai matakin glucose na plasma kamar yadda wasu samfuran analogues suke a cikin manyan allurai. Ana samun wannan sakamakon saboda ƙaruwa mai mahimmanci zuwa insulin.
A miyagun ƙwayoyi ne roba. Saboda iyawar daidaita yanayin mai haƙuri lokacin da tasirin insulin bai wadatar ba, ana amfani dashi don rashin lafiyar insulin-insulin-da-mellitus na rashin insulin da nau'in II na sukari mellitus. Hanyar kunnawa na samarda insulin shine yazayar. Ya dogara ne akan isar da glucose a cikin kwayoyin beta na pancreas, wanda ke haifar da karuwa a cikin ayyukan samar da AFT. Kwayoyin enzyme suna toshe tashoshin alli na alli na ATP.
Ana amfani da Glimepiride don mellitus-non-insulin-dogara da ciwon sukari mellitus da nau'in ciwon sukari na II.
Wannan yana haifar da rikicewar tsarin sakin potassium daga tantanin halitta. Sannan depolarization daga cikin sel membrane yana haɓaka. A wannan matakin, tasirin alli mai dogaro mai budewa, wanda ke haifar da karuwar adadin kalsiya a cikin kwayoyin cytoplasm na sel. A matakin karshe, motsin insulin zuwa cikin membranes yana hanzarta, sakamakon haka, abubuwan da suke dauke da kwayoyin insulin wadanda suke hade da membrane tantanin halitta.
Amfanin magani shine ƙarancin tasiri akan kunnawar sakin insulin, ta haka ne zai iya rage haɗarin cutar hawan jini. Sauran kaddarorin: rage kiba a cikin yawan narkewar insulin ta hanta, a rage raguwar samar da glucose a cikin kyallen wannan kwayoyin. Ari ga haka, an lura da hana kwayoyi masu yawa na abubuwan da suka haifar da haifar da cutuwar jini. Wannan yana samar da tasirin antithrombotic.
Wani dukiya shine damar Glimepiride don nuna tasirin anti-atherogenic. Wannan yana nufin cewa godiya gareshi an hana ci gaban cututtukan cututtukan zuciya. An samu wannan sakamakon ne ta hanyar inganta abubuwan da ke cikin jiki. Bugu da ƙari, an lura da rage girman matakin ƙananan aldehyde.
Saboda wannan, yawan rage kiba mai rage kiba. Magunguna a cikin tambaya suna da hannu a cikin sauran hanyoyin nazarin halittu, musamman, yana kawar da alamun bayyanar damuwa na oxidative wanda ke rakiyar marasa lafiya tare da ciwon sukari mellitus.
Pharmacokinetics
Magungunan suna aiki da sauri. Bayan mintina 120, an sami babban aikin glimepiride. Sakamakon sakamako yana kiyaye tsawon kwana 1. Bayan wannan, maida hankali akan abu mai aiki ya fara raguwa. Cutar da tsarin halittu masu aiki da kwayar halitta wanda ke damunshi a sati biyu.
Amfanin samfurin yana da sauri kuma cikakke sha. Magungunan da ake tambaya shine 100% na bioav samuwa. Lokacin da ya shiga hanta, aiwatar da hadawan abu da iskar shaka abu zai bunkasa. A wannan yanayin, ana fitar da metabolite mai aiki, wanda yake da ƙarancin ƙarfi fiye da glimepiride dangane da tsananin bayyanar jiki. Tsarin na rayuwa ya ci gaba. Sakamakon haka, an saki fili mai aiki.
Cire rabin rayuwa yana yin awa 5-8. Tsawon lokacinta ya dogara da yanayin jikin mutum da kasancewar wasu cututtuka. An nuna bangaren mai aiki a cikin wani tsari da aka gyara. Haka kuma, mafi yawancin abu ana cire shi daga jiki yayin urination, sauran adadin yayin lalata.
Rabin rayuwar glimepiride daga jiki shine 5-8 hours.
Alamu don amfani
A miyagun ƙwayoyi yana da kunkuntar yankin amfani. Don haka, an wajabta shi don nau'in ciwon sukari na II. Idan tasirin warkewa bashi da ƙarfi sosai, suna canzawa daga monotherapy zuwa magani mai wahala. A wannan yanayin, ana iya bada shawarar ƙarin ɗaukar insulin ko Metformin (250 mg).
Contraindications
An haramta amfani da kayan aiki a cikin irin waɗannan lokuta:
- acidosis na rayuwa, tare da rauni mai narkewa a cikin jiki;
- coma mai ciwon sukari, precoma;
- nau'in ciwon sukari na 1;
- pathologies wanda abinci ya daina sha ko wannan tsari ya cika da matsaloli;
- mutum mara kyau dauki ga aka gyara a cikin abun da ke ciki na wannan miyagun ƙwayoyi da sauran jamiái daga rukuni na sulfonamides da sulfonylurea Kalam;
- babban haɗarin hauhawar jini;
- mummunan aiki ga lactose, rashi lactase, ciwo na glucose-galactose malabsorption syndrome.
Tare da kulawa
Ya kamata a kula da yanayin mai haƙuri yayin kulawa tare da miyagun ƙwayoyi a lokuta idan akwai bukatar gaggawa na kula da insulin:
- ƙone tare da babban lalacewar abu na waje;
- tsananin tiyata;
- rauni da yawa;
- cututtukan da haɗarin malabsorption abinci yana ƙaruwa, alal misali, hanawar hanji ko paresis na ciki.
Yadda ake shan glimepiride
Allunan an yi su ne don maganin baka. Ba za a iya cutar da su ba, amma ana bada shawarar haɗiye shi da ruwa. Ana ɗaukar miyagun ƙwayoyi a kan komai a ciki, kafin abinci.
Tare da ciwon sukari
A mafi yawan lokuta, a farkon matakin, ana wajabta 1 mg na abu sau 1 a rana. Sannan, tare da hutu na makonni 1-2, wannan adadin yana ƙaruwa da farko zuwa 2 MG, sannan zuwa 3 MG. A mataki na ƙarshe, an wajabta 4 mg. Matsakaicin adadin maganin yau da kullun shine 6 MG.
Allunan ba za su iya ɗanɗana ba, amma ana bada shawarar haɗiye shi da ruwa.
Dangane da wannan ka'ida, wajibi ne a yi aiki idan an shirya ɗaukar miyagun ƙwayoyi a cikin tambaya a lokaci ɗaya tare da Metformin. Kuna iya canja wurin mai haƙuri daga Metformin zuwa insulin. A wannan yanayin, ci gaba da layin jiyya tare da kashi inda aka katse magani. Wannan adadin yakamata a gyara. Yawan insulin kuma yana karuwa a hankali. Fara farawa tare da mafi ƙarancin adadin.
Lokacin da ya zama dole don canja wurin mai haƙuri daga ɗayan maganin hypoglycemic zuwa ƙwayar da ke cikin tambaya, ƙaramin allurai na glimepiride suma ana wajabta su da farko. Adadin da aka bada shawarar aikin abu shine 1 MG. Sannan an kara shi zuwa matakin da ake bukata.
Sakamakon sakamako na gliperimide
Magungunan za su iya ba da gudummawa ga ci gaban hanyoyin aiwatar da cututtukan cuta, wanda ya kamata a yi la’akari da shi lokacin nadawa.
A wani bangare na bangaren hangen nesa
Rashin gani na gani (aikin sake juyawa).
Gastrointestinal fili
Nausea, vomiting a kan tushen wannan yanayin pathological, sako-sako da bakin ciki, jin zafi a cikin epigastric yankin, rauni hanta aiki, wanda aka bayyana ta hanyar jaundice, hepatitis, canje-canje a cikin manyan alamomin aikin hanta a yayin nazarin dakin gwaje-gwaje.
Hematopoietic gabobin
Yawancin cututtukan da ke tasowa sakamakon canje-canje a cikin abubuwan da ke cikin jini, kamar leukopenia, da sauransu.
Daga gefen metabolism
Hypoglycemic halayen. Mafi yawancin lokuta, suna haɓakawa bayan ƙarshen hanya saboda canjin abinci. Wasu lokuta dalilin shine cin zarafin sashi na magani yayin jiyya.
Cutar Al'aura
Mafi sau da yawa, urticaria yana tasowa, amma alamun gamsuwa na iya faruwa: raunin jiki, dyspnea, shock anaphylactic.
Tasiri kan ikon sarrafa abubuwan inji
Ba'a ba da shawarar shiga cikin ayyukan da ake buƙatar babban matakin kulawa ba. Wannan ya faru ne saboda gaskiyar cewa a farkon matakin maganin ko lokacin da ake sauya sheka daga wani ƙwayar cuta zuwa wani, alamomin masu zuwa na iya bayyana: asarar hankali, raguwa a cikin adadin halayen psychomotor.
Bayan amfani da miyagun ƙwayoyi, girgiza anaphylactic na iya haɓaka.
Umarni na musamman
An bada shawara don shan ƙwayoyi a lokacin da aka ba shi. Saboda wannan, ana samun daidaito na yanayin haƙuri a cikin sauri. Idan ka rasa alƙawari, haramun ne akan shawararku don haɓaka adadin maganin. Tuntuɓi likita.
Idan alamun hypoglycemia ya faru lokacin amfani da kwamfutar hannu tare da maida hankali na 1 mg na glimepiride, to, matakan glucose na iya zama bisa al'ada ta hanyar abinci na musamman.
Yayinda kake karɓar maganin a cikin tambaya, buƙatarsa yana raguwa. Wannan ya faru ne sakamakon hauhawar hankali a hankali na hankali na insulin.
Ya kamata a ɗauka a cikin zuciya cewa a cikin marasa lafiya waɗanda ke da cututtukan cututtukan cututtuka na tsarin endocrine, haɗarin haɓakar ƙarancin adrenocortical yana ƙaruwa.
Ganin cewa ingantaccen sakamako na glimepiride an kiyaye shi tsawon makonni, ana iya buƙatar hutu lokacin juyawa daga ɗayan cututtukan jini zuwa wani.
Yayin shan Glimepiride, ya zama dole a gudanar da gwaje-gwaje a kai a kai don kimanta yawaitar glucose a cikin jini, da gemoclobin glycated.
Yayin shan maganin a cikin tambaya, wajibi ne don gudanar da gwaje-gwaje a kai a kai. A wannan yanayin, an kiyasta yawan haɗuwar glucose a cikin jini, da gemoclobin glycated.
Yi amfani da tsufa
Abubuwan da ke cikin magungunan magani ba su canzawa a cikin marasa lafiya na wannan rukunin. Sabili da haka, daidaitawa kashi ba lallai ba ne.
Aiki yara
Ba a sanya shi ba.
Yi amfani da lokacin daukar ciki da lactation
An haramta amfani da miyagun ƙwayoyi don amfani. A matakin shirin daukar ciki ko lokacin shayarwa, an canza mace zuwa insulin.
Aikace-aikacen aiki mara kyau
Ba a sanya shi ba.
Amfani don aikin hanta mai rauni
Ba'a ba da shawarar yin amfani da miyagun ƙwayoyi ba saboda aiki na jikin wannan aikin aiwatar da maganin ƙwayar cuta.
Yawan ruwan sama na Glimepiride
Idan adadin ƙwayar ya karu, sannu sannu sannu-sannu yana haɓaka jini. Wannan yanayin pathological an kiyaye shi tsawon sa'o'i 12-72. Bayyanar cututtuka: tashin zuciya, tashin hankali, hauhawar jini, ciwon kirji, tashin zuciya, rauni gaba daya, tashin zuciya, amai, amai, yawan ci, da ciwon kai. Adsorbents, laxatives taimaka kawar da alamun.
Idan an dauki manyan allurai na miyagun ƙwayoyi, lavage na ciki tare da dextrose ana bada shawara. Ana yin irin wannan jan a asibiti. Haka kuma, yana da mahimmanci don sarrafa matakin glucose a cikin jini.
Yin hulɗa tare da wasu kwayoyi
Kara tsanani na glimepiride lura yayin da ake ji insulinosoderzhaschih jamiái, hypoglycemic kwayoyi, ACE hanawa, anabolic steroids, coumarin Kalam, allopurinol, chloramphenicol, cyclophosphamide, disopyramide, Feniramidola, fenfluramine, fluoxetine, Dizopiramidona, kwayoyi na ifosfamide, guanethidine, Miconazole, Pentoxifylline, phenylbutazone, wajen rukuni na salicylates, quinolones, tetracyclines, sulfonamides.
An lura da haɓakar ƙoshin glimepiride tare da amfani da insulin a cikin lokaci guda, da magungunan hypoglycemic, magungunan coumarin.
Sauran kwayoyi, akasin haka, suna rage tasirin glimepiride. Wadannan sun hada da: Acetazolamide, barbiturates, corticosteroids, diuretics, Epinephrine, Diazoxide, nicotinic acid, sympathomimetics, laxatives, Glucagon, estrogen- da progesterone-dauke da kwayoyi, Rifampicin, Phenytoin, hormones wadanda aka tsara don maganin cututtukan thyroid.
Amfani da barasa
Ba'a ba da shawarar yin amfani da abin sha mai giya ba tare da glimepiride, saboda yana da wuya a faɗi abin da sakamako zai haifar. Alkahol zai iya haɓakawa da raunana sakamakon wakili a cikin tambaya.
Analogs
Madadin glimepiride da aka wajabta:
- Glibenclamide;
- Glianov;
- Amaryl;
- Ciwon sukari, da sauransu.
Magunguna kan bar sharuɗan
Magunguna magani ne.
Zan iya siye ba tare da takardar sayan magani ba
Babu irin wannan damar.
Farashi
Farashin ya bambanta da sashi na glimepiride kuma shine 190-350 rubles.
Yanayin ajiya na miyagun ƙwayoyi
Yara bai kamata su sami damar zuwa maganin ba. Zazzabi na cikin gida da za'a karba - har zuwa + 25 ° С.
Ranar karewa
Za'a iya amfani da maganin a cikin shekaru 2 daga ranar da aka sake shi.
Mai masana'anta
"Pharmstandard - Leksredstva", Rasha
Nasiha
Alice, ɗan shekara 42, Kirov
Kwayoyin masu ciwon sukari sun fi son allura, saboda ya fi dacewa, ba kwa buƙatar samun allura. Kuma ba kowa bane zai iya jure wa nau'in jini. Sabili da haka, na tambayi likita don karɓar maganin a cikin tsari mai ƙarfi. An yi kokarin kawar da alamun cutar. Ba a sami sakamako masu illa ba.
Elena, 46 years old, St. Petersburg
Idan akwai aiki na hanta mai rauni, babu wani magani da aka wajabta. Saboda wannan dalili, Na canza shi. Yana da shekaru 45, an gano rashin lafiyar hepatic. Amma ina son aikin Glimepiride, yana da sauri yana samar da sakamako mai warkewa, sakamakon da aka samu ana kiyaye shi na dogon lokaci.
