Gwaje-gwaje na dakin gwaje-gwaje don ganewar asali, ciki har da ciwon sukari, suna taka muhimmiyar rawa. Ba koyaushe alamun bayyanar cutar ba ne da kuma matakin glycemia na jini yana nuna ainihin tsarin aiwatar da cuta a cikin jiki, wanda ke haifar da kurakuran ganewar asali a cikin kafa nau'in ciwon sukari.
Proinsulin wani nau'i ne mara aiki na kwayar sunadaran insulin wanda aka hade ta β-sel tsibirin dake cikin hanjin mutum. Bayan sharewa daga cikin proinsulin, shafin gina jiki (wanda kuma aka sani da suna "C-peptide"), ana samun kwayoyin insulin, wanda yake daidaita dukkan metabolism a jikin dan Adam, musamman ma catabolism na glucose da sauran sugars.
An adana wannan abu a cikin sel na tsibirin na Langerhans, inda aka canza shi zuwa insulin hormone mai aiki. Koyaya, kusan 15% na abu har yanzu yana shiga cikin jinin canzawa. Ta hanyar auna wannan adadin, a cikin yanayin C-peptide, mutum zai iya ƙayyade aikin ƙwayoyin β-sel da ƙarfin su na samar da insulin. Proinsulin yana da karancin aikin catabolic kuma ya fi tsayi a jikin mutum fiye da insulin. Amma, duk da wannan, babban allurai na proinsulin (wanda aka lura yayin ayyukan oncological a cikin farji (insulinoma, da dai sauransu)) na iya haifar da tsokar jini a cikin mutane.
Ana shirin yin gwajin proinsulin
Don ƙayyade matakin proinsulin a cikin mutane, an tattara jini mai ƙwayoyin cuta. A baya can, mai haƙuri yana buƙatar bin shawarwari masu ba da rikitarwa, waɗanda galibi suna kama da shiri don nazarin ƙirar ƙwayar cuta don tantance matakin glucose:
- Ana yin gudummawar jini da safe kafin abincin rana, a kan komai a ciki. An ba shi izinin ɗaukar ɗan ƙaramin ruwa mai karantawa, ba tare da ƙarin ƙari ba.
- Rana kafin nazarin, ya zama dole don ware abubuwan sha, shan sigari, matsanancin motsa jiki, da gudanar da magunguna, idan zai yiwu, musamman wasu magunguna masu rage sukari (glibenclamide, ciwon sukari, amaryl, da sauransu).
Alamu don nazarin dakin gwaje-gwaje
Ana yin bincike don proinsulin bisa ga alamun likitanci, don fayyace irin wannan gaskiyar:
- Bayanin abubuwan da ke haifar da yanayin kwantar da hankalin mutum.
- Bayyanar insulinomas.
- Eterayyade matakin aikin aikin reat-sel.
- Eterayyade nau'in asibiti na cututtukan ƙwayar cutar sankara (na 1 ko 2).
Fassarar sakamakon sakamako na proinsulin
A yadda aka saba, akan komai a ciki, kwayar cutar ta proinsulin a cikin mutum ba ta wuce 7 pm / L (ƙananan ɓacewa na sakamakon yana yiwuwa, a cikin dakunan gwaje-gwaje daban-daban tsakanin 0.5-1 pmol / L, wanda kuskuren kayan aikin bincike ya bayyana).
An lura da raguwa mai mahimmanci a cikin taro na jini na proinsulin jini kawai idan akwai nau'in ciwon sukari na 1 na mellitus. Increasearin haɓakar da ke ƙasan al'ada na hali ne na nau'in ciwon sukari na 2 na ciki, ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa, ƙwaƙwalwar endocrine na glandar thyroid, hanta da kodan.
