Ba zai zama mai wuce gona da iri ba a faɗi cewa tare da haɓakar insulin analogues wani sabon zamani ya fara a rayuwar masu ciwon sukari. Saboda ƙirar su ta musamman, suna ba da izinin sarrafa glycemia fiye da yadda yake a da. Insulin Levemir yana ɗaya daga cikin wakilan magungunan zamani, analog na hormone na basal. Ya bayyana ne kwanan nan: a Turai a cikin 2004, a Rasha bayan shekaru biyu.
Levemir yana da dukkanin sifofin insulin tsayi mai tsayi: yana aiki a ko'ina, ba tare da kololuwa na tsawon awanni 24 ba, yana haifar da raguwar hauhawar jini a cikin dare, baya bayar da tasirin gudummawar nauyi ga marasa lafiya, wanda gaskiya ne ga masu ciwon sukari na 2. Tasirin sa yafi dacewa da ƙarancin dogaro akan halayen mutum fiye da na NPH-insulin, don haka ɗin yafi sauƙin zaba. A wata kalma, ya dace a bincika wannan magani.
Bruef umarnin
Levemir shine mahaifin kamfanin Danish mai suna Novo Nordisk, wanda aka san shi da sababbin hanyoyin magance cututtukan ciwon sukari. Magungunan sun sami nasarar wuce karatu da yawa, ciki har da yara da matasa, yayin daukar ciki. Duk sun tabbatar ba kawai lafiyar Levemir ba, har ma da ingantaccen tasiri fiye da insulins da aka yi amfani da su a baya. Gudanar da sukari daidai yake da nasara a cikin nau'in 1 na ciwon sukari kuma a cikin yanayi tare da ƙaramar buƙatar hormone: nau'in 2 a farkon maganin insulin da ciwon sukari na gestational.
Brief bayani game da miyagun ƙwayoyi daga umarnin don amfani:
Ciwon sukari da hauhawar jini zai zama abin da ya wuce
- Normalization na sukari -95%
- Cirewa kan jijiyoyin mara wuya - 70%
- Cire zuciyar mai karfin zuciya -90%
- Rabu da cutar hawan jini - 92%
- Increasearuwar kuzarin rana, inganta bacci da dare -97%
| Bayanin | Maganin mara launi tare da maida hankali akan U100, wanda aka kunsa a cikin gilashin gilashin (Levemir Penfill) ko alkalami waɗanda basu buƙatar cikawa (Levemir Flexpen). |
| Abun ciki | Sunan kasa da kasa wanda ba na mallakar sa ba ne don kayan mai aiki a Levemir (INN) shine insulin detemir. Baya ga shi, ƙwayar ta ƙunshi tsofaffi. Dukkanin abubuwan haɗin an gwada su don yawan guba da ƙwayar carcinogenicity. |
| Pharmacodynamics | Yana ba ku damar yin tawakkali cikin sakin insulin basal. Yana da bambanci kaɗan, wannan shine, tasirin yana bambanta kaɗan ba kawai a cikin haƙuri ɗaya ɗaya na masu ciwon sukari ba a cikin kwanaki daban-daban, har ma a wasu marasa lafiya. Yin amfani da insulin Levemir yana rage haɗarin haɓakar hypoglycemia, inganta haɓakar su. Wannan magani a halin yanzu shine insulin "matsakaici-tsaka-tsaki", yana dacewa da nauyin jikin mutum, yana haɓaka bayyanar da ji na cikakke. |
| Siffofin tsotsa | Levemir yana iya zama takaddun insulin hadaddun kwayoyin halitta - hexamers, ya ɗaura ƙuraje a cikin allurar, don haka sakinsa daga ƙwayar subcutaneous yayi jinkiri da kuma jituwa. Magungunan ba shi da cikakkiyar halayyar Protafan da Humulin NPH. Dangane da masana'anta, aikin Levemir ya fi sauƙi fiye da na babban mai fafatawa daga rukuni na insulin - Lantus. Dangane da lokacin aiki, Levemir ya wuce magungunan Tresiba na zamani mafi tsada, kuma Novo Nordisk ya inganta. |
| Alamu | Duk nau'ikan cututtukan cututtukan cututtukan da ke buƙatar maganin insulin don sakamako mai kyau. Levemir yana aiki daidai a kan yara, matasa da tsofaffi marasa lafiya, ana iya amfani dashi don keta hakkin hanta da kodan. Tare da nau'in ciwon sukari na 2, ana amfani da amfani dashi tare da haɗin gwiwa tare da wakilai na hypoglycemic. |
| Contraindications | Bai kamata a yi amfani da Levemir ba:
Ana amfani da miyagun ƙwayoyi ne kawai a ƙarƙashin ƙasa, an haramta gudanar da jijiyoyin jini. Ba a gudanar da karatun yara a ƙarƙashin shekaru biyu ba, saboda haka an ambaci wannan rukuni na marasa lafiya a cikin contraindications. Duk da haka, an sanya wannan insulin don yara ƙanana. |
| Umarni na musamman | Rushewar Levemir ko kuma maimaitawa na rashin isasshen ƙwayar cuta yana haifar da mummunan cutar hyperglycemia da ketoacidosis. Wannan yana da haɗari musamman tare da ciwon sukari na 1. Wucewa da kashi, tsallake abinci, abubuwan da ba a sansu ba suna cike da rashin kuzari. Tare da watsi da ilimin insulin da kuma yawan maye gurbin abubuwan da ke faruwa a cikin girma da ƙananan glucose, rikicewar ciwon sukari ya haɓaka cikin hanzari. Bukatar Levemire yana ƙaruwa yayin wasanni, yayin rashin lafiya, musamman tare da zazzabi mai zafi, lokacin daukar ciki, farawa da rabi na biyu. Ana buƙatar daidaita yanayin ƙarfi don kumburi mai kumburi da ƙari na kullum. |
| Sashi | Jagororin suna ba da shawarar cewa don nau'in 1 na ciwon sukari, ƙididdigar adadin mutum na kowane mai haƙuri. Tare da nau'in cuta ta 2, zaɓin sashi yana farawa da raka'a 10 na Levemir kowace rana ko raka'a 0.1-0.2 a kowace kilogram, idan nauyin ya bambanta da matsakaici. A aikace, wannan adadin na iya wuce gona da iri idan mara lafiya ya bi tsarin abincin karas ko kuma ya kasance mai motsa jiki a cikin wasanni. Sabili da haka, wajibi ne don lissafin kashi na tsawon insulin bisa ga algorithms na musamman, yin la'akari da glycemia a cikin fewan kwanaki. |
| Adanawa | Levemir, kamar sauran insulins, yana buƙatar kariya daga haske, daskarewa da zafi mai zafi. Tsarin lalacewa mai yiwuwa ba zai bambanta ta kowace hanya daga sabo, sabili da haka ya kamata a biya kulawa ta musamman ga yanayin ajiya. Karancin da aka buda na tsawon makonni 6 a zazzabi a daki. Ana adana kwalaban ɓoye a cikin firiji, rayuwar rayuwar su daga ranar da aka ƙera shine watanni 30. |
| Farashi | Kayan katako 5 na 3 ml (duka raka'a 1500) na Levemir Penfill farashin daga 2800 rubles. Farashin Levemir Flexpen ya yi dan kadan. |
Game da abubuwan rashin amfani da Levemir
Levemir yana da ka'idodin aiki, alamomi da contraindications masu kama da sauran analogues na insulin. Babban bambanci shine tsawon lokacin aiki, sashi, jadawalin allurar da aka ba da shawara ga rukunoni daban-daban na masu fama da cutar sankara.
Menene aikin insulin levemir
Levemir yana da dogon insulin. Tasirinsa ya fi na magungunan gargajiya - cakuda insulin mutane da protamine. A cikin kashi kusan raka'a 0.3. a kowace kilogram, maganin yana aiki a cikin sa'o'i 24. Karami da ake buƙata sashi, da gajarta lokacin aiki. A cikin marasa lafiya da ke fama da cutar sankara, ta hanyar rage cin abinci mai ƙarancin carb, aikin zai iya ƙare bayan sa'o'i 14.
Ba za a iya amfani da insulin mai tsayi ba don gyaran glycemia yayin rana ko lokacin bacci. Idan ana samun karuwar sukari da maraice, yana da mahimmanci don yin allura mai mahimmanci na gajeren insulin, kuma bayan shi, gabatar da dogon hormone a cikin kashi ɗaya. Ba za ku iya haɗu da samfuran insulin na dura yanayi iri ɗaya a cikin sirinji iri ɗaya ba.
Sakin Fom
Insulin Levemir a cikin murfin
Levemir Flexpen da Penfill sun bambanta da nau'i kawai, magungunan da ke cikinsu daidai ne. Penfill - Waɗannan ƙananan katukan ne da za a iya saka su cikin alkalannin sirinji ko nau'in insulin daga gare su tare da ingantaccen sirinji na insulin. Levemir Flexpen shine alkalami mai cike da aka cika wanda aka yi amfani dashi har zuwa lokacin da aka warware matsalar. Ba za a iya cika su ba. Alkalami yana ba ka damar shiga insulin a cikin rukunin 1 naúrar. Suna buƙatar rarrabe bututun NovoFayn. Dogaro da kauri daga kasusuwa na nama, musamman bakin ciki (0.25 mm diamita) tsayi 6 mm ko bakin ciki (0.3 mm) 8 mm aka zaɓi. Farashin fakitin allura 100 kusan 700 rubles.
Levemir Flexpen ya dace da marasa lafiya tare da salon rayuwa mai aiki da kuma rashin lokaci. Idan buƙatar insulin tayi karami, mataki na ɗaya 1 bazai ba ku damar yin daidai da lambar da ake so ba. Ga irin waɗannan mutane, ana bada shawarar Levemir Penfill a hade tare da ƙarin madaidaicin sirinji, misali, NovoPen Echo.
Daidai sashi
Ana ɗaukar kashi na Levemir daidai idan ba kawai sukari mai azumi ba, amma haemoglobin da ke glycated yana cikin yawan al'ada. Idan biyan diyya ga ciwon sukari bai isa ba, zaku iya canza adadin insulin tsawon kwana 3. Don ƙayyade gyaran da yakamata, mai ƙira ya ba da shawarar ɗaukar matsakaicin sukari a kan komai a ciki, kwanakin 3 na ƙarshe suna cikin lissafin
| Glycemia, mmol / l | Canjin yanayin | Valueimar gyara, raka'a |
| < 3,1 | Ragewa | 4 |
| 3,1-4 | 2 | |
| 4,1-6,5 | Babu canzawa | 0 |
| 6,6-8 | .Ara | 2 |
| 8,1-9 | 4 | |
| 9,1-10 | 6 | |
| > 10 | 10 |
Labari mai alaƙa: dokoki don ƙididdige yawan insulin don allura
Jadawalin allura
- Tare da nau'in ciwon sukari na 1 Koyarwar ta ba da shawarar gudanar da insulin na tsawon lokaci biyu: bayan farkawa da kuma kafin lokacin bacci. Irin wannan makirci yana ba da mafi kyawun diyya ga masu ciwon sukari fiye da guda. Ana lasafta allurai dabam. Don insulin safe - akan sukari mai azumi yau da kullun, don maraice - dangane da dabi'un darensa.
- Tare da nau'in ciwon sukari na 2 da guda biyu da na biyu mulki mai yiwuwa ne. Nazarin sun nuna cewa a farkon farawar insulin, allura guda ɗaya a rana ya isa don cimma maƙasudin matakin sukari. Gudanarwa na kashi ɗaya ba ya buƙatar karuwa a cikin ƙididdigar kashi. Tare da tsawan ciwon sukari mellitus, tsawon insulin ya fi hankali don gudanar da sau biyu a rana.
Yi amfani da yara
Don ba da izinin yin amfani da Levemir a cikin rukunin jama'a daban-daban, ana buƙatar ɗakunan karatu da suka haɗa da masu sa kai. Ga yara 'yan kasa da shekaru 2, wannan yana da alaƙa da matsaloli masu yawa, sabili da haka, a cikin umarnin don amfani, akwai iyakokin shekaru. Halin iri ɗaya ya kasance tare da sauran ruɗani na yau. Duk da wannan, ana amfani da Levemir cikin nasara a cikin jarirai har zuwa shekara guda. Yin jiyya tare da su yana da nasara kamar yadda yake a cikin manyan yara. A cewar iyaye, babu wani mummunan sakamako.
Sauyawa zuwa Levemir tare da insulin NPH ya zama dole idan:
- azumi sukari ne m,
- ana ganin jinin haila da daddare ko a maraice,
- yaro ya wuce kima.
Kwatanta Levemir da NPH-insulin
Ba kamar Levemir ba, duk insulin tare da protamine (Protafan, Humulin NPH da analogues) suna da tasirin sakamako mafi girma, wanda ke kara haɗarin hauhawar jini, tsalle-tsalle na sukari yana faruwa a cikin kullun.
Proven Levemir Amfanin:
- Yana da tasiri sosai wanda ake iya faɗi.
- Yana rage yiwuwar hauhawar jini: mai tsanani da kashi 69%, cikin dare a kashi 46%.
- Yana haifar da ƙarancin nauyi tare da ciwon sukari na 2: a cikin makonni 26, nauyin a cikin marasa lafiya akan Levemir yana ƙaruwa da kilogram 1.2, kuma a cikin masu ciwon sukari akan NPH-insulin ta 2.8 kg.
- Yana daidaita jin motsi, wanda ke haifar da raguwar ci a cikin marasa lafiya tare da kiba. Masu ciwon sukari a Levemir suna cinye matsakaita kimanin 160 kcal / rana.
- Secreara yawan ɓoyewar GLP-1. Tare da nau'in ciwon sukari na 2, wannan yana haifar da karuwar mahaɗan insulin nasu.
- Yana da tasiri mai kyau akan metabolism-salt metabolism, wanda ke rage haɗarin hauhawar jini.
Onlyayan ɓarkewar Levemir kawai idan aka kwatanta da shirye-shiryen NPH shine babban farashi. A cikin 'yan shekarun nan, an haɗa shi cikin jerin mahimman magunguna, don haka marasa lafiya masu ciwon sukari na iya samun shi kyauta.
Analogs
Levemir sabon insulin ne, saboda haka bashi da ilimin tsutsotsi masu saukin tsada. Mafi kusanci a cikin kaddarorin da tsawon lokacin aiki shine kwayoyi daga ƙungiyar dogon insulin analogues - Lantus da Tujeo. Canzawa zuwa wani insulin yana buƙatar sake dawowa da ƙimar ƙwaƙwalwa kuma babu makawa yana haifar da lalacewa ta ɗan lokaci a cikin biyan bashin mellitus, sabili da haka, dole ne a canza magunguna kawai saboda dalilai na likita, alal misali, tare da rashin haƙuri na mutum.
Levemir ko Lantus - wanda yafi kyau
Maƙerin ya bayyana fa'idodin Levemir idan aka kwatanta da babban mai fafatawarsa - Lantus, wanda ya ba da farin ciki a cikin umarnin:
- aikin insulin ya fi dindindin;
- miyagun ƙwayoyi yana ba da ƙarancin nauyi.
Dangane da sake dubawa, waɗannan bambance-bambance kusan ba za a iya yin su ba, don haka marasa lafiya sun fi son magani, takardar sayan magani wanda zai fi sauƙi a wannan yankin.
Babban bambanci mai mahimmanci yana da mahimmanci ga marasa lafiya waɗanda ke narke insulin: Levemir ya haɗu da kyau tare da gishiri, kuma Lantus yana ɗan ɓoye kaddarorinsa lokacin dil.
Ciki da Levemir
Levemir baya tasiri kan ci gaban tayinSaboda haka, ana iya amfani da shi ta hanyar mata masu juna biyu, ciki har da waɗanda ke da ciwon sukari. Yawan maganin a lokacin daukar ciki yana buƙatar daidaitawa akai-akai, kuma ya kamata a zaɓi tare tare da likita.
Tare da nau'in ciwon sukari na 1, marasa lafiya a lokacin haihuwar yaro suna kasancewa kan wannan tsawon insulin ɗin da suka karɓa a farkon, kawai sashi zai canza. Sauyawa daga magungunan NPH zuwa Levemir ko Lantus ba lallai bane idan sukari ya zama al'ada.
Tare da ciwon sukari na gestational, a wasu lokuta yana yiwuwa a cimma daidaitaccen ƙwayar cuta ba tare da insulin ba, musamman game da abinci da ilimin jiki. Idan sukari yana yawan haɓaka, ana buƙatar maganin insulin don hana fetopathy a cikin tayin da ketoacidosis a cikin uwa.
Nasiha
Mafi yawan nazarin masu haƙuri game da Levemir suna da kyau. Baya ga haɓaka sarrafa glycemic, marasa lafiya suna lura da sauƙin amfani, kyakkyawan haƙuri, kyakkyawan ingancin kwalabe da alƙalami, allurai na bakin ciki waɗanda ke ba ku damar yin allurar marasa ciwo. Yawancin masu ciwon sukari suna da'awar cewa hypoglycemia a kan wannan insulin ba shi da m kuma mara ƙarfi.
Nazarin ra'ayoyi mara wuya ne. Sun fito ne daga iyayen jarirai masu ciwon sukari da kuma mata masu ciwon suga. Wadannan marasa lafiya suna buƙatar rage allurai na insulin, don haka Levemir Flexpen ba shi da matsala a gare su. Idan babu wani madadin, kuma kawai irin wannan magani za'a iya samu, masu ciwon sukari dole su fasa katuwar katako daga alƙawarin da za'a iya jefa shi kuma a sake haɗa su cikin wani ko kuma yin allura tare da sirinji.
Aikin Levemir yana da ban mamaki Ya fi damuwa makonni 6 bayan buɗewa. Marasa lafiya marasa ƙarancin insulin na dogon lokaci ba su da lokacin da za su kashe raka'a 300 na miyagun ƙwayoyi, don haka dole ne a zubar da ragowar.
