Saboda yawan kuɗin Amaril, ana amfani da analogues sau da yawa don daidaita glucose na jini a cikin masu ciwon sukari tare da nau'in cutar mai zaman kanta. Wannan magani yana da kyau don riƙe glycemia tare da abinci na musamman da wasanni.
Koyaya, ba kowa bane zai iya wadatar da wannan wakili na hypoglycemic. Sabili da haka, a wannan labarin, za a ba da sanarwar aikin magunguna na Amaril kuma za a ba da sunayen manyan analogues ɗin da aka samar a Rasha.
Aikin magani na magani
Amaryl magani ne na baki wanda ke taimakawa rage yawan sukari na jini ta hanyar kwantar da fitarwa da kuma aiki na insulin na kwayar halitta ta takamaiman sel da ke cikin kwayar ta pancreatic.
Babban hanyar inganta motsawar kwayar ita ce, Amaril yana kara yawan amsawar kwayar beta zuwa karuwa a cikin tattarawar glucose a cikin jinin mutum.
A cikin ƙananan allurai, wannan magani yana ba da gudummawa ga ƙaramin ƙaruwa a cikin sakin insulin. Amaryl yana da damar ƙara ƙarfin ji na ƙwayoyin sel waɗanda ke dogara da insulin zuwa insulin.
Kasancewa mai mahimmancin maganin sulfonylurea, Amaril yana da ikon yin tasiri kan ayyukan samar da insulin. An tabbatar da wannan ta hanyar gaskiyar cewa kwayar aiki mai aiki tana hulɗa tare da tashoshin ATP na sel. Amaryl yana ɗaure su don sunadarai akan saman membrane tantanin halitta. Wannan mallakin magungunan yana ba da damar haɓaka hankalin ƙwayoyin sel zuwa insulin.
Yawancin ƙwayar glucose ana tunawa da mafi yawan ƙwayoyin tsoka na jikin mutum.
Bugu da ƙari, yin amfani da miyagun ƙwayoyi yana hana sakin glucose ta sel ƙwayoyin hanta. Wannan tsari yana faruwa ne saboda haɓaka abubuwan da ke cikin fructose-2,6-biophosphate, wanda ke ba da gudummawa ga hana gluconeogenesis.
Kunnawar kwayar insulin yana faruwa ne saboda gaskiyar cewa kwayar mai aiki tana inganta haɓakar ions potassium zuwa sel, kuma yawan anarin potassium a cikin sel yana haifar da haɓakar haɓakar hormone.
Lokacin amfani da maganin haɗin gwiwa a hade tare da metformin, marasa lafiya suna da haɓakawa a cikin sarrafawa na rayuwa na matakan sukari a cikin jiki.
Gudanar da aikin haɗi tare da allurar insulin. Ana amfani da wannan hanyar sarrafawa a lokuta inda ba a sami ingantaccen matakin sarrafawa ba lokacin shan magani ɗaya. Lokacin aiwatar da wannan nau'in maganin ƙwayar cuta don ciwon sukari mellitus, ana buƙatar daidaita sashin insulin.
Yawan insulin da ake amfani da shi a wannan nau'in maganin yana raguwa sosai.
Pharmacokinetics na miyagun ƙwayoyi
Tare da kashi ɗaya na miyagun ƙwayoyi a kashi ɗaya na yau da kullum na 4 MG, ana lura da matsakaiciyar ƙwaƙwalwa bayan awa 2.5 kuma ya kai 309 ng / ml. A bioavailability na miyagun ƙwayoyi ne 100%. Cin abinci ba shi da wani takamaiman sakamako a tsarin sha, in banda raguwar hanzari a cikin saurin aiwatarwa.
Abubuwan da ke aiki na miyagun ƙwayoyi suna nunawa ta ikon iya shiga cikin abun da ke cikin madara mai nono kuma ta hanyar shinge na jini. Wanne ya iyakance yiwuwar amfani da maganin yayin daukar ciki da shayarwa.
Ana aiwatar da metabolism na abu mai aiki a cikin kyallen hanta. Babban isoenzyme wanda ya shiga metabolism shine CYP2C9. A kan aiwatar da metabolism na babban aiki mai karfi, an samar da metabolites guda biyu, wanda daga baya aka fesa cikin feces da fitsari.
Cutar da ƙwayar cuta ana yin ta ne ta hanyar ƙwayar kodan a cikin adadin 58% kuma kusan 35% tare da taimakon hanji. Abubuwan da ke amfani da maganin a cikin fitsari ba a gano su ba.
Dangane da sakamakon binciken, an gano cewa magunguna ba su dogara da jinsi na haƙuri da rukunin shekarunsa ba.
Idan mara lafiya ya kasa aiki da kodan da kuma tsarin hana motsa jiki, mai haƙuri yana da haɓakar karɓar glimepiride da raguwa a cikin matsakaiciyar ƙwaƙwalwarsa a cikin ƙwayar jini, wanda ya haifar da ƙarin hanzarta kawar da ƙwayoyi saboda ƙananan ɗaukar nauyin kwayar mai aiki zuwa sunadarai
Janar halaye na miyagun ƙwayoyi
Ana daukar Amaryl ƙarni na uku na tsarin sulfonylurea. Kasashen da suka samar da maganin sune Jamus da Italiya. An sanya maganin a cikin nau'in kwamfutar hannu a 1, 2, 3 ko 4 MG. 1 kwamfutar hannu na Amaril ya ƙunshi babban bangaren - glimepiride da sauran magabata.
Sakamakon glimepiride an yi shi ne da nufin rage yawan glucose na jini ta hanyar ƙarfafa samar da insulin ta hanyar ƙwayoyin beta. Bugu da ƙari, abu mai aiki yana da tasirin insulinomimetic kuma yana ƙara haɓaka hankalin masu karɓar sel zuwa hormone na rage sukari.
Lokacin da mai haƙuri yayi magana da Amaryl, mafi girman taro na glimepiride an kai shi bayan sa'o'i 2.5. Ana iya shan maganin ba tare da la'akari da lokacin cin abinci ba. Koyaya, cin ɗan kaɗan yana shafar ayyukan glimepiride. Ainihin, wannan bangaren yana kwance ta hanjin ciki da kodan.
Kwararrun masu ba da magani sun ba da allunan Amaril ga mai haƙuri da nau'in ciwon sukari na 2 a matsayin maganin monotherapy ko kuma idan aka haɗu da wakilai na hypoglycemic.
Koyaya, shan maganin ba ya hana ci gaba da kiyayewa ga tsarin abincin da ya dace wanda ya ware fitsari da sauƙin narkewa mai narkewa, da salon rayuwa.
Umarnin don amfani da miyagun ƙwayoyi
Ba za ku iya sayan magani ba tare da takardar sayan likita. Kafin amfani da maganin, dole ne ku ziyarci likita ku tambaye shi duk tambayoyinku. Shine wanda zai iya tantance yadda yakamata a bayar da magani kuma zai iya tsara tsarin aikin tiyata dangane da matakin glucose na mai haƙuri.
Ana ɗaukar allunan Amaryl a baki ba tare da tauna ba, kuma an wanke su da isasshen ruwa. Idan mara lafiya ya manta da shan maganin, sai an ninka yawan maganin. A lokacin jiyya, ya kamata a bincika matakin sukari a kai a kai, kazalika da ƙwayar glycosylated haemoglobin.
Da farko, mara lafiya yana ɗaukar kashi ɗaya na 1 MG kowace rana. A hankali, a lokaci-lokaci na mako daya zuwa biyu, sashi na miyagun ƙwayoyi na iya ƙaruwa ta 1 MG. Misali, 1 mg, sannan 2 mg, 3 mg, da sauransu har zuwa 8 mg a rana.
Masu ciwon sukari waɗanda ke da kyautar glycemic control suna ɗaukar kashi ɗaya na yau da kullun zuwa 4 MG.
Sau da yawa, ana shan miyagun ƙwayoyi sau ɗaya kafin cin abincin safe ko, idan akwai tsallake amfani da allunan, kafin babban abincin. A wannan yanayin, kwararren yakamata ya yi la’akari da salon rayuwar masu ciwon sukari, lokacin cin abinci da aikinsa na zahiri. Wataƙila za a buƙaci daidaitawar magunguna lokacin da:
- rage nauyi;
- canza a cikin yanayin rayuwa na yau da kullun (abinci mai gina jiki, kaya, lokacin cin abinci);
- sauran dalilai.
Tabbatar tuntuɓar likita kuma fara tare da mafi ƙarancin (1 mg) na Amaril idan mai haƙuri yana buƙatar:
- sauya wani magani na rage sukari tare da Amaril;
- haɗin glimepiride da metformin;
- haɗuwa shine glimepiride da insulin.
Ba ya da kyau a sha magunguna ga marasa lafiya da ke fama da tabin hankali, har da na koda da / ko gazawar hanta.
Contraindications da mummunan halayen
Amaril glimepiride yana cikin magani, har da ƙarin abubuwan haɗin, koyaushe ba zai tasiri jikin mai cutar siga ba.
Kazalika da sauran hanyoyi, ƙwayar ta ƙunshi contraindications.
Haramun ne a sha kwayoyin cutar ga marasa lafiya a cikin halaye masu zuwa:
- nau'in ciwon sukari da ke dogaro da kansa;
- lokacin haila da shayarwa;
- ketoacidosis na masu ciwon sukari (metabolism na rashin abinci mai narkewa), yanayin ciwon suga da na coma;
- marasa lafiya a kasa da shekara 18;
- rashin galactose, rashi lactase;
- ci gaban glucose-galactose malabsorption;
- cin zarafin hanta da kodan, musamman marasa lafiya da ke fama da cutar sankara;
- mutum rashin jituwa ga abinda ke ciki na miyagun ƙwayoyi, abubuwan da ke haifar da maganin sulfonylurea, jami'ai na sulfonamide.
Umarni da aka haɗe sun ce a farkon makonni na far, Amaryl ya kamata a ɗauka tare da taka tsantsan don guje wa ci gaban yanayin rashin lafiyar. Kari akan haka, idan akwai batun keta haddin abinci da kwayoyi daga narkewar abinci, rashi na glucose-6-phosphate dehydrogenase, cututtukan cutuka kuma a gaban hadarin haɓaka halin haɓaka na jini, ana amfani da Amaril a hankali.
Tare da yin amfani da allunan da ba su dace ba (misali, tsallake tsallakewa), mummunan halayen na iya haɓaka:
- Yanayin tashin hankali, alamomin su sune ciwon kai da tsananin damuwa, rashin kula, damuwa, rikici, rikicewa, nutsuwa, rawar jiki, tashin hankali da hangen nesa.
- Adrenergic counterregulation a matsayin mayar da martani ga saurin raguwar glucose, wanda aka nuna ta hanyar damuwa, damuwa, tachycardia, tashin hankali na zuciya da bayyanar gumi mai sanyi.
- Rashin narkewa - ƙarancin tashin zuciya, amai, flatulence, ciwon ciki, zawo, haɓaka hepatitis, haɓaka aikin hanta enzymes, jaundice ko cholestasis.
- Take hakkin tsarin hematopoietic - leukopenia, thrombocytopenia, granulocytopenia da wasu cututtukan.
- Allergy, wanda aka nuna ta fitsari na fata, ƙaiƙayi, amya, wani lokacin firgitar tashin hankali da rashin lafiyar amai da gudawa.
Sauran halayen suna yiwuwa - ɗaukar hoto da hyponatremia.
Kudin, sake dubawa da kuma analogues
Farashin magungunan Amaryl kai tsaye ya dogara da nau'in sakinsa. Tunda an shigo da maganin ne, ashe, farashinsa yayi yawa. Farashin farashi na allunan Amaryl sune kamar haka.
- 1 MG 30 Allunan - 370 rubles;
- 2 mg 30 Allunan - 775 rubles;
- 3 MG 30 Allunan - 1098 rubles;
- 4 MG 30 Allunan - 1540 rubles;
Amma ga ra'ayin masu ciwon sukari game da tasiri na miyagun ƙwayoyi, suna da inganci. Tare da tsawan amfani da miyagun ƙwayoyi, matakan glucose sun koma al'ada. Kodayake lissafin yana ƙunshe da sakamako masu illa da yawa, yawan abubuwan da suka fara samu kaɗan ne. Koyaya, akwai kuma sake dubawa marasa kyau waɗanda ke da alaƙa da hauhawar farashin maganin. Da yawa daga cikinsu dole ne su nemi maye gurbin Amaril.
A zahiri, wannan magani yana da maganganu da yawa da kuma analogues wanda aka samar a cikin Federationungiyar Rasha, misali:
- Glimepiride magani ne wanda ke dauke da sinadaran aiki guda iri iri, abubuwan da ke haifar da illa. Bambanci yana cikin ƙarin abubuwa kawai. Matsakaicin farashin maganin (2 mg No. 30) shine 189 rubles.
- Diagninide magani ne mai rage sukari, a cikin tsarin sa yayi daidai da magungunan da aka shigo da NovoNorm. Abubuwan da ke aiki shine repaglinide. Novonorm (Diagninide) yana da kusan iri ɗaya iri ɗaya da halayen da ba su dace ba. Don fahimtar mafi bambanci tsakanin waɗannan analogues guda biyu, yana da mahimmanci a gwada farashin: farashin Diaglinide (1 mg No. 30) shine 209 rubles, kuma NovoNorm (1 mg No. 30) shine 158 rubles.
- Glidiab magani ne na Rasha, wanda shima analog ne na sananniyar sananniyar ciwon sukari mellitus Diabeton. Matsakaicin farashin gilashin Glidiab (80 MG No. 60) shine 130 rubles, kuma farashin maganin Ciwon sukari (30 mg No. 60) shine 290 rubles.
Amaryl magani ne mai sauƙin sukari, amma yana da tsada. Sabili da haka, ana iya maye gurbin shi da rahusa, duka gida (Diclinid, Glidiab), da kuma magungunan shigo da (NovoNorm, Diabeton). Abun da ke ciki ya ƙunshi ko dai glimepiride, ko wasu abubuwa waɗanda ke taimakawa rage yawan glucose. Sanin game da alamun analogues, likita da mai haƙuri zasu iya yanke shawara wane magani ne mafi kyawun ɗauka. Bidiyo a cikin wannan labarin yana ci gaba da taken Amaril don ciwon sukari.
