Simgal magani ne wanda ya kasance rukunin rukunin rage kiba, wato, ragewan cholesterol. Akwai shi a cikin nau'i na allunan ruwan hoda mai launi, convex a garesu, kuma a cikin membrane fim. Babban sinadarin Simgal shine simvastatin, daga ciki za'a iya fahimtar cewa maganin yana cikin rukunin magungunan da ake kira statins. Yawan sashi na magani ya sha bamban - 10, 20 da 40 milligram.
Baya ga simvastatin, Simgal kuma ya ƙunshi irin waɗannan ƙarin abubuwa kamar ascorbic acid (bitamin C), butyl hydroxyanisole, sitaci sitaci, citric acid monohydrate, magnesium stearate, microcrystalline cellulose da lactose monohydrate.
Harsashi da kansa ya ƙunshi ruwan hoda na opadra, wanda, bi da bi, ya ƙunshi polyvinyl barasa, dioxide titanium, talc mai ladabi, lecithin, jan oxide, ruwan rawaya mai launin shuɗi da kuma indigo carmine based varnish.
Kayan yau da kullun na pharmacodynamics Simgala
Pharmacodynamics shine tasirin da maganin yake da shi ga jikin mutum. Simgal, ta yanayin halittar sa, anticholesterolemic - yana rage maida hankali kan "mummunan" cholesterol, wanda aka sanya kai tsaye akan bangon arteries kuma yana samar da filayen kwalliyar cholesterol. Kamar yadda kuka sani, atherosclerosis yana farawa a cikin samari, sabili da haka ya zama dole don sarrafa matakan cholesterol a wannan lokacin.
Simgal shine mai hana enzyme wanda ake kira HMG-CoA reductase. Idan an yi bayani dalla-dalla, zai hana aikin wannan enzyme gwargwadon iko. HMG-CoA reductase yana da alhakin canzawar HMG-CoA (hydroxymethylglutaryl-coenzyme A) zuwa mevalonate (mevalonic acid). Wannan amsawar ita ce farkon da madogara ta haɗi a cikin samuwar cholesterol. Madadin haka, HMG-CoA an canza zuwa acetyl-CoA (acetyl coenzyme A), wanda ke shiga cikin wasu, babu ƙananan matakai masu mahimmanci a jikinmu.
Ana samun Simgal ne ta wucin gadi ta amfani da naman gwari Aspergillus na musamman (a cikin Latin, sunan gaskiya shine Aspergillusterreus). Aspergillus an fermented a kan matsakaici na musamman na gina jiki, sakamakon abin da aka haifar samfuran amsawa. Daga waɗannan samfuran amsawa ne cewa an samu ƙwayar cuta ta zahiri.
An san cewa a cikin jikin mutum akwai nau'ikan lipids (fats). Wannan shine cholesterol wanda ke hade da ƙananan, mai ƙanƙanƙasa da babban lipoproteins mai yawa, triglycerides da chylomicrons. Mafi haɗari shine cholesterol da ke haɗuwa da ƙarancin lipoproteins mai yawa, ana kiran shi "mara kyau", yayin da ake danganta shi da manyan lipoproteins mai yawa, akasin haka, ana ɗauka "mai kyau". Simgal yana taimaka wa ƙananan ƙwayoyin triglycerides, haka kuma ƙwayar cholesterol da ke haɗuwa da ƙarancin lipoproteins mai ƙarancin girma. Bugu da ƙari, yana ƙara haɗuwa da ƙwayar cholesterol hade da babban lipoproteins mai yawa.
Sakamakon farko ya zama sananne makonni biyu bayan fara amfani da Simgal, ana lura da mafi girman tasirin bayan kusan wata guda.
Don kiyaye sakamako da aka cimma, dole ne a sha maganin har abada, tunda idan aka soke magani ba da gangan ba, matakin ƙwaƙwalwar jiki zai dawo cikin adon farko.
Ka'idodin Magunguna
Pharmacokinetics sune waɗancan canje-canje waɗanda ke faruwa a cikin jiki tare da miyagun ƙwayoyi. Simgal yana da kyau sosai a cikin karamin hanji.
Matsakaicin ƙwayar maganin ana lura dashi bayan sa'a daya da rabi zuwa awa biyu bayan amfani dashi, koyaya, bayan awa 12 daga maida hankali, kashi 10% kawai ya rage.
A hankali sosai, maganin yana hulda da sunadaran plasma (kusan kashi 95%). Babban canjin Simgal yana cikin hanta. A can, yana ɗaukar ruwa hydrolysis (yana haɗawa da ƙwayoyin ruwa), yana haifar da samuwar beta-hydroxymetabolites, da kuma wasu sauran ƙwayoyin a cikin tsari mara aiki. Metabolites mai aiki ne wanda ke da babban tasiri na Simgal.
Rabin rayuwar miyagun ƙwayoyi (lokacin lokacin da yawan ƙwayoyi a cikin jini ya ragu daidai sau biyu) shine kimanin sa'o'i biyu.
An kawar da ita (i.e. kawar da ita) tare da feces, kuma wani karamin sashi yana cirewa da kodan a cikin yanayin rashin aiki.
Manuniya da contraindications don amfani da miyagun ƙwayoyi
Ya kamata a yi amfani da Simgal kawai kamar yadda likitanka ya umarta.
A yayin aiwatar da amfani da magani, shawarwarin likita da umarnin yin amfani da shi ya kamata a kiyaye su sosai.
Yawancin lokaci ana yin shi gwargwadon gwaje-gwaje na dakin gwaje-gwaje, a yayin da kwayar cutar cholesterol ta wuce al'ada (2.8 - 5.2 mmol / l).
An nuna Simgal a cikin halayen masu zuwa:
- Game da hypercholesterolemia na farko na nau'in na biyu, a cikin yanayin lokacin da rage cin abinci tare da karamin adadin cholesterol a hade tare da motsa jiki na yau da kullun da asarar nauyi ba shi da inganci, wanda yana da mahimmanci musamman ga marasa lafiya waɗanda suka fi dacewa haɓaka atherosclerosis na cututtukan jijiyoyin zuciya.
- Tare da hypercholesterolemia hade da hypertriglyceridemia, waɗanda ba amenable zuwa far tare da abinci da motsa jiki.
A cikin cututtukan zuciya na zuciya (CHD), an wajabta magungunan don hana haɓakar infassation myocardial (necrosis na ƙwayar zuciya); rage haɗarin yiwuwar mutuwa kwatsam; rage jinkirin yaduwar cututtukan atherosclerosis; rage haɗarin rikice-rikice yayin maniyyu daban-daban na farfadowa (sake dawowa da gudanawar jinin al'ada cikin tasoshin);
A cikin cututtukan cerebrovascular, an wajabta magani don shanyewar jiki ko rikicewar jijiyoyin bugun gini na hanji (cututtukan cututtukan mahaifa).
Yardajewa:
- Biliary pancreatitis da sauran cututtukan hanta a cikin babban matakan.
- Excessarancin ƙima na alamun gwajin hanta ba tare da cikakken dalili ba.
- Lokacin daukar ciki da lactation.
- Orarancin.
- Tarihin halayen rashin lafiyan halayen simvastatin ko wasu ɓangarorin miyagun ƙwayoyi, ko ga wasu magunguna na ƙungiyar ƙwararrun magunguna na ƙwayoyin cuta (rashin lafiyan lactose, rashi lactase, rashin haƙuri ga sauran HMG-CoA reductase inhibitors).
Tare da taka tsantsan, Simgal ya kamata a wajabta shi a cikin irin waɗannan halayen:
- cutarwa na barasa;
- marasa lafiya waɗanda ba su daɗewa ba lokacin juyawa na kwayoyin, saboda abin da aka tilasta musu ɗaukar immunosuppressants na dogon lokaci;
- koyaushe saukar karfin jini (hypotension);
- mummunan cututtuka, musamman rikitarwa;
- na rayuwa da rashin daidaituwa na hormonal;
- rashin daidaituwa na ruwa da ma'aunin lantarki;
- kwanan nan mummunan ayyukan da suka faru ko raunin rauni;
- myasthenia gravis - rauni na tsoka;
Ana buƙatar kulawa ta musamman lokacin da ake rubuta magunguna ga marasa lafiya da keɓaɓɓu.
Umarnin don amfani da miyagun ƙwayoyi
Amfani da miyagun ƙwayoyi ya kamata ya fara ne kawai bayan cikakken nazarin umarnin sa (bayani). Kafin yin amfani da shi, ya zama dole a tsara abincin da aka kafa daban-daban ga mai haƙuri, wanda zai taimaka rage matakin "mummunan" cholesterol da sauri. Wannan abincin zai buƙaci a bi shi duk lokacin warkewa.
Daidaitaccen tsari game da shan Simgal shine sau daya a rana a lokacin bacci, saboda cikin dare ne ake samar da mafi yawan sinadarin cholesterol, kuma magani a wannan lokacin zai zama mafi inganci. Zai fi kyau a sha shi kafin ko bayan abincin dare, amma ba a lokacin ba, saboda wannan yana iya ɗan hana metabolism na ƙwayoyi.
A cikin jiyya da aka yi niyya don rage darajar hypercholesterolemia, ana ba da shawarar Sigmal a cikin sashi na 10 MG zuwa 80 MG sau ɗaya a dare kafin lokacin bacci. Fara a zahiri da 10 MG. Matsakaicin izini na yau da kullun shine 80 MG. Yana da kyau a daidaita sashi a cikin makonni hudun farko daga farkon jiyya. Yawancin marasa lafiya suna iya ɗaukar allurai har zuwa 20 MG.
Tare da irin wannan ganewar asali kamar hyzycholesterolemia na homozygous, yana da hankali sosai don sanya magani a cikin kashi 40 MG kowace rana da dare ko 80 MG ya kasu kashi uku - 20 MG a safiya da yamma, da kuma 40 MG da dare.
Ga marasa lafiya da ke fama da cututtukan zuciya ko kuma hadarin kamuwa da shi, sashi na 20 zuwa 40 MG kowace rana ya fi kyau.
Idan marasa lafiya suka karɓi a lokaci guda Verapamil ko Amiodarone (magunguna don hawan jini da arrhythmias), to jimlar maganin yau da kullun na Simgal bai kamata ya wuce 20 mg ba.
Sakamakon sakamako na Simgal
Yin amfani da Simgal na iya tayar da bayyanar wasu sakamako masu illa a jiki.
Duk abubuwanda suka haifar da takaicin amfani da miyagun ƙwayoyi an bayyana su dalla-dalla tare da umarnin yin amfani da maganin.
Sakamakon sakamako na gaba na miyagun ƙwayoyi daga tsarin kwayoyin halitta ya zama sananne:
- Tsarin narkewa: jin zafi a ciki, tashin zuciya, amai, raunin garkuwar jiki, hanyoyin kumburi a cikin farji da hanta, haɓakar iskar gas mai yawa, karuwar abubuwan samfurori na samfuran hanta, creatine phosphokinase da alkaline phosphatase;
- Tsarin tsakiya da na jijiyoyi: jijiya, ciwon kai, hargitsi na bacci, farin ciki, raunin hankali, matsalar jijiya, hangen nesa, raguwar ɗanɗano;
- Tsarin Musculoskeletal: pathologies na ƙwayar tsoka, cramps, jin zafi, jin rauni, narkewar ƙwayoyin tsoka (rhabdomyolysis);
- Tsarin Urinary: gazawar cutar koda;
- Tsarin jini: raguwa a cikin platelet, sel jini da matakan haemoglobin;
- Bayyanar cututtuka na ƙwayar cuta: zazzabi, karuwa a cikin yawan ƙwayar ƙwayar ƙwayar jini, eosinophils, urticaria, redness na fata, kumburi, halayen rheumatic;
- Abubuwan da suka shafi fata: yawan tashin hankali zuwa haske, fatar fata, ƙaiƙayi, ƙyamar kansa, dermatomyositis;
- Sauran: saurin numfashi da bugun zuciya, rage libido.
Za'a iya siyan magungunan a kowane kantin magani ba tare da takardar sayan likita ba. Mafi ƙarancin farashi daga masana'antun cikin gida ba su wuce 200 rubles ba. Hakanan zaka iya yin umurni da miyagun ƙwayoyi a yanar gizo tare da bayarwa zuwa kantin magani da ake so ko gida. Akwai wasu analogues (canzawa) na Simgal: Lovastatin, Rosuvastatin, Torvakard, Akorta. Nazarin haƙuri game da Simgal galibi tabbatacce ne.
Masana za su yi magana game da mutummutumai a cikin bidiyo a cikin wannan labarin.
