Ana amfani da magunguna daban-daban dangane da nau'in ciwon suga.
Don nau'in 1, an wajabta insulins, kuma don nau'in 2, galibi shirye-shiryen kwamfutar hannu.
Magungunan sukari na rage sukari sun hada da Glucovans.
Babban bayani game da miyagun ƙwayoyi
Tsarin tsari na Metformin
Glucovans (glucovance) - wani hadadden magani wanda ke da tasirin hypoglycemic. Its fasalin - biyu aiki fili aka gyara daban-daban pharmacological kungiyoyin na metformin da glibenclamide. Wannan haɗin yana haɓaka sakamako.
Glibenclamide wakili ne na 2 na ƙarni na abubuwan samo asali na sulfonylurea. Gane shi a matsayin magani mafi inganci a cikin wannan rukunin.
Ana daukar Metformin magani ne na farko, wanda ake amfani dashi lokacin rashin tasirin maganin abinci. Abun, idan aka kwatanta da glibenclamide, yana da ƙananan haɗarin hypoglycemia. Haɗin haɗakar abubuwan biyu yana ba ku damar cimma sakamako mai gamsarwa da haɓaka tasiri na jiyya.
Ayyukan miyagun ƙwayoyi ya kasance ne saboda abubuwa masu aiki guda 2 - glibenclamide / metformin. A matsayin kari, magnesium stearate, povidone K30, MCC, croscarmellose sodium ana amfani dasu.
Akwai shi a cikin kwamfutar hannu a cikin allunan guda biyu: 2.5 mg (glibenclamide) +500 mg (metformin) da 5 mg (glibenclamide) +500 mg (metformin).
Aikin magunguna
Tsarin Glibenclamide
Glibenclamide - yana toshe tashoshi na potassium kuma yana karfafa sel. Sakamakon haka, ƙwayar hormone ke ƙaruwa, yana shiga cikin jini da ruwa mai shiga tsakani.
Nessarfafawar motsawar ƙwayar hormone yana dogara ne akan sashi da aka dauka. Yana rage sukari a cikin duk masu cutar da masu ciwon sukari da kuma mutane masu lafiya.
Metformin - yana hana samuwar glucose a cikin hanta, yana kara yawan jiyo jijiyoyin jikin mutum zuwa ga hormone, yana hana sha sinadarin glucose a cikin jini.
Ba kamar glibenclamide ba, ba zai taɓar da ƙwayar insulin ba. Bugu da ƙari, yana da tasiri mai kyau a cikin bayanin martaba na lipid - total cholesterol, LDL, triglycerides. Ba ya rage matakin sukari na farko a cikin mutane masu lafiya.
Pharmacokinetics
Glibenclamide yana cikin ƙwazo sosai ba tare da la'akari da yawan abincin ba. Bayan sa'o'i 2.5, ana kaiwa kololuwa a cikin jini, bayan awanni 8 a hankali ya ragu. Rabin rayuwar shine awowi 10, kuma duka kawar shine kwanaki 2-3. Kusan gaba daya metabolized a cikin hanta. Abinda yake cikin fitsari da bile. Haɗa kai ga furotin plasma bai wuce 98% ba.
Bayan gudanar da baki, metformin ya kusan zama cikakke. Cin abinci yana rinjayar sha na metformin. Bayan awa 2.5, abu mafi girma na abun ya kai gareshi; yana da karanci cikin jini fiye da yadda yake cikin jini. Ba'a taɓa metabolized ba kuma ya bar canzawa. Rayuwa rabin jiki shine tsawon awa 6.2 Ana fitar dashi musamman da fitsari. Sadarwa tare da sunadarai ba shi da mahimmanci.
A bioavailability na miyagun ƙwayoyi iri ɗaya ne kamar yadda yake tare da keɓancewar kowane nau'in kayan aiki mai aiki.
Manuniya da contraindications
Daga cikin abubuwan da ke nuna shan Glucovans Allunan:
- Nau'in nau'in ciwon sukari na 2 a cikin rashin ingancin aikin maganin, motsa jiki;
- Nau'in nau'in ciwon sukari na 2 a cikin rashin sakamako yayin monotherapy tare da Metformin da Glibenclamide;
- lokacin maye gurbin jiyya a cikin marasa lafiya tare da matakin sarrafawa na glycemia.
Contraindications don amfani sune:
- Nau'in nau'in ciwon sukari na 1;
- rashin ƙarfi ga sulfonylureas, metformin;
- hypersensitivity zuwa wasu bangarorin na miyagun ƙwayoyi;
- ƙarancin koda;
- ciki / lactation;
- mai ciwon sukari mai ciwon sukari;
- hanyoyin tiyata;
- lactic acidosis;
- barasa maye;
- abincin hypocaloric;
- shekarun yara;
- bugun zuciya;
- gazawar numfashi;
- mummunan cututtukan cututtuka;
- bugun zuciya;
- porphyria;
- lalataccen aikin na koda.
Umarnin don amfani
An saita sashi ne ta hanyar likita, la'akari da matakin glycemia da halayen mutum na jiki. Matsakaici, daidaitaccen tsarin kulawa na iya zama ya zo daidai da wajabta. Farkon maganin jiyya ɗaya ne kowace rana. Don hana hypoglycemia, bai kamata ya wuce kashi da aka kafa na baya na metformin da glibenclamide dabam. Ana yin haɓaka, idan ya cancanta, ana yin kowane mako 2 ko fiye.
A cikin yanayin canjawa daga magani zuwa Glucovans, an umara maganin yin la'akari da abubuwan da suka gabata na kowane sashin aiki mai aiki. Matsakaicin yau da kullun shine raka'a 4 na 5 + 500 MG ko raka'a 6 na 2.5 + 500 MG.
Allunan ana amfani dasu a hade tare da abinci. Don hana ƙaramin matakin glucose a cikin jini, sanya abinci ya zama mai ƙyasi a cikin carbohydrates duk lokacin da ka sha magani.
Bidiyo daga Dr. Malysheva:
Musamman marasa lafiya
Ba a sanya magani ba lokacin tsarawa da lokacin daukar ciki. A irin waɗannan halayen, ana tura mai haƙuri zuwa insulin. Lokacin da kake shirin yin juna biyu, dole ne ka sanar da likitanka. Saboda ƙarancin bayanan bincike, tare da lactation, Glucovans ba a amfani da su.
Ba a ba da magani ga tsofaffi marasa lafiya (> 60 shekara) ba magani. Hakanan ba a ba da shawarar mutanen da suke aiki da ƙwaƙƙwaran aiki don shan magani ba. An danganta wannan da haɗarin haɗari na lactic acidosis. Tare da megoblastic anemia, yakamata a haifa a hankali cewa ƙwayar za ta rage shan ƙwayar B 12.
Umarni na musamman
Yi amfani tare da taka tsantsan a cikin cututtukan ƙwayar thyroid, yanayin febrile, rashin ƙarfi. Babu wani magani da aka tsara don yara. Ba a yarda da haɗuwa da glucovans tare da giya ba.
Yakamata a warke tare da hanya don auna sukari kafin / bayan abinci. Hakanan ana bada shawara don bincika taro akan creatinine. Game da lalacewa na aiki a cikin tsofaffi, ana aiwatar da saka idanu sau 3-4 a shekara. Tare da aiki na al'ada na gabobin, ya isa a bincika sau ɗaya a shekara.
Awanni 48 kafin / bayan tiyata, an soke maganin. Awanni 48 kafin / bayan gwajin X-ray tare da abu mai aikin rediyo, ba a amfani da Glucovans.
Mutanen da ke fama da ciwon zuciya suna da haɗarin haɓakar haɓakar koda da hypoxia. Ana bada shawarar sosai game da aiki da zuciya da aikin koda.
Side sakamako da yawan abin sama da ya kamata
Daga cikin illolin sakamako yayin cin abinci an lura da su:
- wanda aka fi sani shine hypoglycemia;
- lactic acidosis, ketoacidosis;
- take hakkin dandano;
- thrombocytopenia, leukopenia;
- karuwar creatinine da urea cikin jini;
- karancin ci da sauran rikice-rikice na hanji;
- urticaria da itching na fata;
- lalacewa a aikin hanta;
- hepatitis;
- hyponatremia;
- vasculitis, erythema, dermatitis;
- damuwa na gani na yanayi na ɗan lokaci.
Idan akwai batun yawan cutar Glucovans, yawan jini zai iya haɓaka saboda kasancewar glibenclamide. Shan 20 g na glucose yana taimakawa wajen dakatar da huhun tsananin tsananin zafin jiki. Bugu da ƙari, ana aiwatar da daidaita sashi, ana sake nazarin abincin. Mai tsananin rashin ƙarfi na buƙatar kulawa ta gaggawa da yiwuwar asibiti. Overarancin overdose na iya haifar da ketoacidosis saboda kasancewar metformin. Ana kulawa da irin wannan yanayin a asibiti. Hanyar mafi inganci ita ce maganin hemodialysis.
Yin hulɗa tare da wasu magunguna
Kada a haɗa magungunan tare da phenylbutazone ko danazole. Idan ya cancanta, mai haƙuri ya sa ido sosai a kan aikin. ACE inhibitors suna rage sukari. --Ara - corticosteroids, chlorpromazine.
Ba a shawarar Glibenclamide don haɗuwa tare da miconazole - irin wannan hulɗa yana ƙara haɗarin haɗarin hypoglycemia. Ngarfafa aikin abu abu mai yiwuwa ne yayin ɗaukar Fluconazole, steroids na anabolic, clofibrate, antidepressants, sulfalamides, hormones na maza, abubuwan da aka sanya coumarin, abubuwan cytostatics. Kwayoyin halittar mata, hormones na thyroid, glucagon, barbiturates, diuretics, sympathomimetics, corticosteroids suna rage tasirin glibenclamide.
Tare da gudanar da aiki tare da metformin tare da diuretics, yiwuwar haɓaka lactic acidosis yana ƙaruwa. Abubuwan radiopaque lokacin da aka haɗasu zasu iya haifar da gazawar koda. Guji yin amfani da barasa ba kawai, har ma da kwayoyi tare da abubuwan da ke ciki.
Informationarin bayani, analogues
Farashin magungunan Glukovans shine 270 rubles. Bai buƙatar takamaiman yanayin ajiya. An sake shi ta hanyar takardar sayan magani. Rayuwar shelf shine shekaru 3.
Production - Merck Sante, Faransa.
Cikakken analogue (kayan aiki masu aiki daidai) sune Glybomet, Glybofor, Duotrol, Glukored.
Akwai sauran haɗuwa na abubuwan aiki masu aiki (metformin da glycoslide) - Dianorm-M, metformin da glipizide - Dibizid-M, metformin da glimeperide - Amaryl-M, Douglimax.
Sauyawa zai iya zama kwayoyi tare da abu ɗaya mai aiki. Glucofage, Bagomet, Glycomet, Insufort, Meglifort (metformin). Glibomet, Maninil (glibenclamide).
Nazarin masu ciwon sukari
Yin bita da haƙuri yana nuna tasiri na Glucovans kuma game da farashi mai karɓa. Hakanan an lura cewa ma'aunin sukari yayin shan magani ya kamata ya faru sau da yawa.
Da farko ta ɗauki Glucophage, bayan da aka wajabta mata Glucovans. Likita ya yanke hukuncin cewa zai zama mafi inganci. Wannan magani yana rage sukari mafi kyau. Kawai yanzu dole ne mu dauki matakan sau da yawa don hana hypoglycemia. Likita ya sanar dani game da hakan. Bambanci tsakanin Glucovans da Glucophage: magani na farko ya ƙunshi glibenclamide da metformin, na biyu kawai ya ƙunshi metformin.
Salamatina Svetlana, shekara 49, Novosibirsk
Na kasance ina fama da ciwon sukari na tsawon shekaru 7. Kwanan nan an umurce ni da haɗin maganin Glucovans. Nan da nan akan ribobi: inganci, sauƙin amfani, aminci. Har ila yau farashin bai ciji ba - don marufi na ba kawai 265 r, ya isa rabin wata. Daga cikin gazawar: akwai contraindications, amma ni ba na wannan rukuni ba.
Lidia Borisovna, 56 years old, Yekaterinburg
Anyi maganin ga mahaifiyata, ita mai cutar sankara ce. Yana ɗaukar Glucovans na kimanin shekaru 2, yana jin daɗin lafiya, Na gan ta yana aiki da farin ciki. Da farko, mahaifiyata ta sami baƙin ciki - tashin zuciya da rashin cin abinci, bayan wata ɗaya komai ya ɓace. Na kammala cewa maganin yana da tasiri kuma yana taimaka sosai.
Sergeeva Tamara, shekara 33, Ulyanovsk
Na dauki Maninil a gabani, sukari yana riƙe da kusan 7.2. Ya sauya zuwa Glucovans, a cikin mako guda sukari ya ragu zuwa 5.3. Na haɗu da jiyya tare da motsa jiki da abinci da aka zaɓa musamman. Ina auna sukari sau da yawa kuma bana bada izinin tsauraran yanayi. Wajibi ne don canzawa zuwa ƙwayar kawai bayan tuntuɓar likita, lura da allurai ƙayyadaddun matakai.
Alexander Savelyev, ɗan shekara 38, St. Petersburg
