Kimanin 6% na yawan mutanen duniya a yau suna fama da ciwon sukari mellitus - cuta wacce babban alama ita ce karuwar sukarin jini. Abubuwan da ke waje suna tasiri ga ci gaban cutar; ƙwayoyin cuta kuma suna taka rawa.
Mafi kyawun warkarwa ga masu ciwon sukari shine abinci mai ƙarancin carb: idan mutum na yau da kullun zai iya cin abinci har zuwa 400 g na carbohydrates tsarkakakku a kowace rana, to, ciwon sukari ya ƙasa da 85 g.
Amma har ma tare da kin amincewa da hatsi, dankali, kayan lambu, yawancin kayan lambu da 'ya'yan itatuwa da maye gurbinsu da kifayen dabbobi da ba sa ƙara yawan glucometer, ba kowa ba ne ke iya rama cikakkiyar cutar glycemia. Wannan gaskiyane musamman ga masu ciwon sukari masu dauke da cuta ta biyu, wanda tarihin tarihin rashin nasara na yara.
Don lura da ciwon sukari, an samar da nau'ikan magunguna 4 waɗanda ke da bambanci cikin tsarin da hanyar fallasa su ga matsalar.
- Magungunan da ke rage darajar jurewar insulin na sel shine biguanides (Metformin, Glucofage) da thiazolidinediones (Pioglitazone, Rosiglitazone).
- Kwayar halittar Pancreatic da ke tattare da sinadarin endogenous shine abubuwanda ke haifar da sulfanylureas (Diabeton, Maninil) da yumbu.
- Magunguna na jerin abubuwan ɓoye, sarrafa nauyi da ci - Galvus, Januvia, Onglisa, Viktoza, Bayeta.
- Magungunan da ke hana shan glucose a cikin hanji sune Acarbose, Glucobay.
Hakanan ana magana game da glybomet zuwa shirye-shiryen maganganu na magana na rukunin rukuni na biyu, umarnin don amfani da wanda za'a gabatar dashi don bita. Ana ɗaukar duk bayanan daga hanyoyin da ke akwai a bayyane, don haka ba kayan aiki bane don gano kansa da magani na kai.
Glybomet - abun da ke ciki
Haɗuwa a cikin kowane kwamfutar hannu na abubuwa biyu masu aiki - metformin hydrochloride (400 MG) da glibenclamide (2.5 MG) ya sa ya yiwu ba kawai don sarrafa glycemia ba, har ma don rage yawan waɗannan abubuwan. Idan kowannensu an yi amfani da shi don maganin tauhidi, to maganin zai zama mafi girma.
Ya ƙunshi tsari da filler a cikin nau'i na cellulose, sitaci masara, colloidal silicon dioxide, gelatin, glycerol, talc, magnesium stearate, acetylphthalyl cellulose, diethyl phthalate.
Abubuwan da ke tattare da magunguna
Ofayan babban sinadaran aiki, glibenclamide, shine sabon ƙarni na ƙwayar aji na ƙwaƙwalwar ƙwayar cuta wacce aka haɗo ta cikin jerin magunguna masu mahimmanci tare da ƙwaƙwalwar ƙwayar cuta da ƙari.
Ba wai kawai yana ƙarfafa aikin koda ba a matsayin gabaɗaya, har ma yana haɓaka aikin samar da insulin ƙwayoyin cuta. Hanyar aikinsu yana dogara ne da kariyar ƙwayoyin reat-sel da ke lalata ta hanyar glucose mai ƙarfi, wanda ke ƙayyade ci gaban ciwon sukari, da haɓakar insulin jijiyoyin sel.
Shan Glibomet a layi daya tare da sarrafa glycemic yana inganta haɓakar lipid kuma yana rage haɗarin haɗarin jini. Ayyukan insulin yana ƙaruwa, kuma tare da shi ɗaukar glucose ta kyallen tsoka da hanta. Magungunan yana aiki a mataki na biyu na samar da insulin.
Metformin ya kasance na biguanides - wani ɓangaren abubuwan abubuwa masu karfafawa wanda ke rage ƙarancin ƙwayoyin makafi zuwa insulin nasu. Sake dawo da hankalin mutum ba shi da mahimmanci fiye da haɓakar ruɗar hormone, saboda tare da nau'in ciwon sukari na 2, ƙwayar kumburi ta haifar da ita fiye da kima.
Metformin yana haɓaka lambar sadarwar masu karɓa da insulin, yana ƙaruwa da tasirin aikin hormone. Idan babu insulin a cikin jini, ba a bayyana tasirin warkewa ba.
Metformin yana da fasali na musamman:
- Yana rushe shayewar glucose ta bangon hanji da taimaka wa amfanirsa cikin kyallen takarda.
- Yana hana gluconeogenesis;
- Yana kare b-kwayar daga hanzarin apoptosis;
- Rage haɗarin kowane nau'in acidosis da mummunan cututtuka;
- Inganta microcirculation na ruwaye, aikin endothelial da mai metabolism (yana rage tasirin cholesterol "mara kyau" da triglycerol a cikin jini);
- Gudanar da asarar nauyi - muhimmin yanayi don ingantaccen iko na sarrafa glycemic a cikin marasa lafiya da nau'in 2 DS;
- Yana rage yawan zubar jini da damuwa da damuwa;
- Yana da tasirin fibrinolytic ta hanyar hana mai kunna ƙwayar plasminogen nama;
- Yana hana ayyukan oncological (gaba ɗaya, ciwon sukari yana ƙara haɗarin cutar oncology da 40%);
- Yana rage haɗarin mutuwa daga al'amuran zuciya.
An sake yin gwaje-gwaje na masu ciwon sikila 5800 masu ciwon sukari masu nau'in 2 a kasar Sin. Mahalarta cikin gwajin sun karbi metformin a hade tare da gyare-gyare na rayuwa. A cikin rukuni mai kulawa, masu sa kai kawai sun daidaita salon rayuwarsu. Shekaru 63 a cikin rukunin farko, mace-mace sun kasance mutane 7.5 ne a cikin mutane 1000 / shekara, a karo na biyu - don watanni 45, daidai da mutane 11.
Magungunan yana fara aiki sa'o'i biyu bayan shigar esophagus, ingancinsa an tsara shi don awanni 12. Metformin baya haifar da barazanar hypoglycemic. Magunguna tare da babban tushe, ya wuce ingantaccen gwajin lokaci kuma yana buƙatar ciwon sukari a duk matakan daɗaɗɗar jiyya.
A yau, kasuwar magunguna tana ba da azuzuwan 10 na magungunan antidiabetic, amma metformin har yanzu shine mafi mashahuri magani don magance cututtukan type 2 na kowane irin cuta.
Haɗin synergistic na kayan aiki guda biyu na Glibomet yana da tasirin rikicewar jiki.
- Tasirin cututtukan ƙwayar cuta - ƙwayar ta rage "makanta" na sel, yana ƙarfafa ruɗar insulin kansa, yana kare b-sel.
- Sakamakon karin-pancreatic - biagudin kai tsaye yana rinjayar tsoka da mai nama, yana rage gluconeogenesis, yana ƙaruwa da cikakken wadataccen glucose.
A mafi kyau duka rabo daga cikin rabo daga abubuwa aiki iya muhimmanci daidaita sashi na miyagun ƙwayoyi. Don ƙwayoyin-b, ƙwayoyin ƙwaƙwalwa masu laushi suna da mahimmanci sosai: yana ƙara amincin miyagun ƙwayoyi, yana rage haɗarin rikice-rikicewar aikinsu, da rage yiwuwar tasirin sakamako.
Abubuwan da ke cikin Pharmacokinetic
Glybenclamide daga narkewa yana narkewa kuma yana rarraba shi sosai yadda yakamata - ta hanyar 84%, ana iya lura da tasirin miyagun ƙwayoyi bayan sa'o'i 1-2. Abubuwan da ke hade sunadaran sunadarai zuwa ga jini kwatankwacin kashi 97%.
Metabolism na Glibenclamide yana faruwa a cikin hanta, inda aka canza shi gaba daya zuwa metabolites marasa aiki. Rabin abin da aka kashe yana fita ta hanjin kodan, sauran rabin kuma a cikin duhun bile. Rabin rayuwar yana matsakaicin awoyi 10.
Ana amfani da Metformin gaba daya cikin tsarin narkewar abinci, an rarraba shi nan take ga gabobin da kyallen takarda, baya haduwa da sunadarai na jini kwata-kwata. A bioavailability na bangaren yana daga 50-60%.
Gabaɗaya, mafi girman abubuwanda keɓaɓɓiyar ƙwayar cuta a cikin jini yana faruwa awa ɗaya ko biyu bayan ɗaukar kwayar.
Alamu don magani tare da Glybomet
Umarnin na hukuma ya nuna cewa an wajabta maganin ne don ciwon sukari na 2, wanda ya haɗa da masu ciwon sukari da ke dogara da su, idan abinci na musamman, aikin ƙoshin jiki da kuma magungunan maye gurbi ba su ba da sakamakon da aka tsara ba.
Yawancin kwayoyi suna da sakamako na jaraba, idan jiki bai amsa maganin ta hanyar da ta dace ba, sun canza algorithm na magani ta hanyar rubuta Glibomet a cikin allunan.
Ga wanda magani ne contraindicated
Tun da maganin yana da tasiri mai wahala akan matsalar, ba abin mamaki bane cewa yana da isasshen ƙuntatawa game da shigowa.
Magungunan na iya zama haɗari:
- Tare da ciwon sukari na gestational;
- Idan mai haƙuri yana da babban hankalin game da abubuwan da ke cikin tsari;
- Masu ciwon sukari da nau'in cuta ta farko;
- Tare da coma mai ciwon sukari da yanayin kan iyaka;
- Idan tarihin hanta da koda;
- Lokacin da creatinine ya hau zuwa 110 mmol / l a cikin mata kuma 135 mmol / l a cikin maza;
- Marasa lafiya tare da lactic acidosis ko ketoacidosis;
- Idan mai ciwon sukari yana da cututtukan jini wanda tsokani ke haifar da shi;
- Tare da hypoxia na asali daban-daban;
- Bayan raunin da ya faru, ƙungiya, kamuwa da cuta, ƙonewa mai tsanani;
- Tare da mummunan ra'ayin mazan jiya;
- Marasa lafiya waɗanda aka gano tare da leukopenia, porphyria;
Tare da abincin da ke fama da yunwa tare da adadin kuzari kasa da 1000 kcal / rana .;- Tare da giya da giya;
- Childrenaramin yara;
- Mata masu juna biyu da masu shayarwa.
Tare da abincin da ke fama da yunwa tare da adadin kuzari kasa da 1000 kcal / rana .;Yadda ake ɗaukar Glibomet
Akwai hani akan shan Glibomet:
- Tare da cututtukan cututtukan ƙwayar thyroid;
- Idan mara lafiya yana da zazzabi;
- Lokacin da tarihin hypofunction na ƙwayar ƙwayar cuta ta ciki tare da glandal adrenal.
An ƙaddara maganin ne ta hanyar endocrinologist gwargwadon shekarun mai haƙuri da sifofin asibiti, amma masanin ya ba da shawarar farawa tare da allunan guda biyu a kowace rana, suna ɗaukar maganin koyaushe. Matsakaicin maganin shine 2 g / day. Yana da kyau a rarraba liyafar a lokutan kullun. Idan wannan adadin ba shi da tasirin da ake tsammani, an wajabta jiyya tare da ƙari da ƙwayoyi masu ƙarfi.
Side effects da yawan abin sama da ya kamata
Akwai illoli da yawa waɗanda ba a iya so ba na iya faruwa bayan ɗaukar Glibomet, amma wannan bai kamata ya zama dalilin ƙin shan magani ba, saboda cutarwar da jiki baya ramawa game da ciwon suga ya fi ƙarfin haɗari na tasirin sakamako.
Don guje wa irin waɗannan yanayi, yana da mahimmanci don ƙididdige yawan ku. Idan ka'idar ta wuce gona da iri, masu ciwon sukari suna farkar da yunwar da ba ta dace ba, asara ƙarfi, juyayi, rawar hannu.
Kwayar cutar yawan zafin jiki na iya zama tachycardia, bushewar fata, karuwar gumi, suma.
Daga cikin mummunan sakamako masu illa bayan shan Glibomed, hypoglycemia shine mafi haɗari a cikin wannan halin ga marasa lafiya da ke raunana da rashin lafiya mai tsawo, masu ciwon sukari na tsufa tare da ciwon sukari, masu giya, mutanen da ke aiki tuƙuru, kamar yadda kuma duk wanda ke da rabin yunwa ( kasa da 1000 kcal / rana.) abinci.
Daga cikin alamun bayyanar cututtuka, mafi yawan su ne:
- Ciwon kai;
- Rashin ƙarfi a cikin epigastrium;
- Rashin cutar dyspeptic;
- Daban-daban siffofin rashin lafiyan halayen.
Idan rashin jin daɗi na ɗan lokaci ya faru bayan ɗaukar allunan, ana iya kawar dashi ta hanyar bayyanar cututtuka. Idan bayyanar cututtuka ko alamun rashin lafiyan ya bayyana, to lallai za ku zaɓi analogues don Glibomet.
Sakamakon Cutar Magunguna
An lura da karuwa a cikin sakamako na hypoglycemic na Glybomet a yayin maganin layi daya tare da abubuwan da ke haifar da decumarol, phenylbutamazone, β-blockers, oxytetracycline, allopurinol, cimetidine, ethanol, sulfinpyrazone a cikin allurai masu mahimmanci, probenecid, chloramphenicol, babban micona, injin, .
Haɗin maganin tare da kwayoyin halittar glandon thyroid, maganin hana haihuwa, barbiturates, thiazide diuretics yana hana yiwuwar Glibomet.
Umarni na musamman
An daina amfani da Glibomet nan da nan lokacin da akwai alamun lactic acidosis: rauni mai kaifi, amai, spasm tsoka, zafi a cikin rami na ciki. Wanda aka cutar ya bukaci asibiti cikin gaggawa.
Koyarwar ta ba da shawarar yin jiyya tare da Glybomet don biye da saka idanu na ƙirar creatinine a cikin gwajin jini. Ga masu ciwon sukari tare da ƙoshin lafiya, irin wannan binciken ya wajaba aƙalla sau ɗaya a shekara, marasa lafiya waɗanda ƙirar creatinine suna kusa da ƙarshen ƙayyadaddun ƙa'idodi, kuma ya kamata a gwada marasa lafiya da suka manyanta sau 2-4 a shekara.
Kwana biyu kafin aikin tiyata da aka shirya, wanda yin amfani da maganin kashin hanji ko ta hanji, shan Glibomet an soke shi kuma mai ciwon sukari ya sauya zuwa insulin. Kuna iya dawo da hanyar magani tare da Glybomet bayan an ba da haƙuri na abinci mai gina jiki. Koda koda tare da ƙwayoyin koda na yau da kullun suna aiki, likitan ya yanke wannan shawarar ne kafin kwana biyu bayan aikin.
Shan kwayoyin suna buƙatar yin taka tsantsan yayin aiwatar da aiki mai haɗari ga rayuwa da lafiya, daidai lokacin da motocin ke tuƙi. Wannan yana da alaƙa da haɗarin hypoglycemia, raguwa a cikin adadin halayen psychomotor da ikon maida hankali.
Sakamakon magani tare da Glybomet zai dogara ne akan daidaito na yarda da shawarwarin da aka tsara a cikin umarnin da umarnin likitancin endocrinologist: biye da abinci da bacci da hutawa, motsa jiki na yau da kullun, sarrafa glycemic system, ciki har da a gida.
Lokacin amfani da magani, ya zama dole a iyakance yawan shan giya gwargwadon iko (al'ada shine gilashin bushewar giya sau ɗaya a mako), tunda ethanol ya tsokani ci gaban glycemia, da kuma rikice-rikice-rikice-rikice-rikice-rikice a cikin yankin epigastric, rikicewar dyspeptik, fitilu masu zafi a saman jiki da kai, asara. daidaituwa, ciwon kai, bugun zuciya.
Kudin magunguna da dokokin adanawa
Shin Glybomet mai araha ne a sarkar kantin magani? Dangane da yankin, ana iya siyan magungunan don 200-350 rubles. Kowace kunshin na Glibomet, hoton wanda za'a iya gani a wannan sashin, yana dauke da allunan 40.
Don kada magani ya rasa tasiri, dole ne a kiyaye shi daga hasken rana kai tsaye da babban zafi.
Haka magunguna
Idan Glibomed ko da a cikin ƙwaƙwalwar ƙwayar cuta ba ya ba da sakamako da ake so, wata alerji ko wasu mummunan sakamako masu illa sun bayyana, an maye gurbin maganin tare da analogues tare da kayan aiki masu dacewa.
Don Glibomed, irin waɗannan magungunan na iya zama Allunan Diabeton, babban fili mai aiki wanda yake a cikin glyclazide, ko Dimaril, a cikin kwaren aiki mai aiki daidai yake da ɗayan abubuwan Glibomed, glimepiride.
Daga sauran magungunan antidiabetic tare da sakamako iri ɗaya, Gluconorm, Bagomet Plus, Glucovans, Glibenclamide a hade tare da Metformin, Glucofast an tsara shi.
Masanin ilimin kimiyar halittun yayi sauyawa, zai kuma yi lissafin sashi. Canji a cikin tsarin kulawa yana yiwuwa: ana ƙulla maganin analogues duka a cikin hadaddun jiyya da kuma a cikin hanyar monotherapy, ƙari ga abinci mai ƙanƙan da keɓaɓɓu da aikin jiki.
Ba shi yiwuwa 100% a hango amsar jikin mutum game da sababbin magunguna, don haka karo na farko shine saurara ga dukkan alamu kuma ku sanar da likita game da canjin nauyi na kwatsam, malalata, Sakamakon duba ƙwayar cutar glycemia tare da glucometer da wasu mahimmanci yayin lokacin karbuwa ga madadin hanyoyin abubuwan da suka faru.
Neman bita kan kayan Glibomet
Game da miyagun ƙwayoyi Glycomet sake dubawa game da masu ciwon sukari sun fi damuwa da algorithm na aikace-aikacensa fiye da tasiri.
Idan aka zaɓi sashi daidai, amsoshin suna da kyau, a wasu lokuta akwai maganganu kan ƙananan sakamako masu illa. Amma tunda waɗannan ƙididdigar sun kasance mutum ɗaya, dangane da nazarin asibiti da kuma halayen hanyar cutar a cikin wani mai haƙuri, musayar ƙwarewa a wannan batun ba shi da amfani, har zuwa ɗan har ma da lahani.
Takaita dukkan hanyoyin, zamu iya yanke hukuncin cewa Glibomed shine mafi kyawun magani na farko don maganin ciwon sukari na 2: araha mai tsada, bayanin martaba mafi ƙaranci, tsaka tsaki dangane da nauyin jiki, sakamako mai amfani akan sakamakon jijiyoyin jini da sakamako na cututtukan zuciya.
Tabbas, yin amfani dashi ba zai yiwu ga kowa ba (kamar sauran magungunan hypoglycemic), amma maganin yana daidai da matsayin zamani na inganci da dacewa.
