Marasa lafiya tare da karancin insulin nasu suna buƙatar allura ta tsawon rayuwa ta magungunan da ke ɗauke da wannan ƙwayar. Ana amfani da insulin na ɗan gajeren lokaci a matsayin wani ɓangare na haɗaɗɗun ƙwaƙwalwar maganin cutar sankara don ciwon sukari. Idan an zaɓi magunguna, sashi da lokacin gudanarwa daidai, za a iya daidaita sukarin jini na dogon lokaci, wanda ke guje wa rikitarwa masu yawa na "mai daɗi".
Hakanan, ana iya amfani da gajeren insulin don dakatar da sukari daga mai haƙuri a lokacin lokutan karuwar buƙatar hormone: tare da ketoacidosis, mummunan cututtuka da raunin da ya faru. Lokacin amfani da famfon na insulin, watakila shine magani kawai da aka tsara.
Wani irin insulin ne gajere
Short insulin an tsara shi ne don maimaita asirin kwayoyin a cikin martani don karuwar glucose din jini. Yawancin lokaci sukan saka shi rabin sa'a kafin cin abinci. A wannan lokacin, yana kulawa don ɗaukar jini daga nama mai ƙiba kuma ya fara aiki don rage sukari. Kwayoyin insulin na gajere suna da tsari iri daya kamar wanda ake samar da kwayar halitta a cikin jiki, saboda haka ana kiran wannan rukunin magungunan na 'insulin na mutum. Babu wasu abubuwan kara a cikin kwalba face abubuwan kiyayewa. Ana nuna gajeren insulin ta hanyar hanzari, amma gajeriyar hanya. Da zaran da miyagun ƙwayoyi ya shiga cikin jini, sukari na jini yakan ragu sosai, bayan wannan sai an lalata hormone.
Ciwon sukari da hauhawar jini zai zama abin da ya wuce
- Normalization na sukari -95%
- Cirewa kan jijiyoyin mara wuya - 70%
- Cire zuciyar mai karfin zuciya -90%
- Rabu da cutar hawan jini - 92%
- Increasearuwar kuzarin rana, inganta bacci da dare -97%
Masu ciwon sukari suna gudanar da gajeran insulin a jikinsu, daga nan ake samunshi cikin jini. A cikin yanayin farfadowa, ana amfani da gudanarwa na ciki. Wannan hanyar tana ba ku damar hanzarta dakatar da matsanancin rikice-rikice na ciwon sukari kuma ku amsa cikin lokaci don canjin da ake buƙata ta hanzarta farawa a lokacin murmurewa.
Alamu don gudanar da gajeren insulin
Daidaita, gajeren insulin tare da kwayoyi masu matsakaici da aiki na yau da kullun: ana yin gajere kafin abinci, kuma mai tsawo - da safe da kuma kafin lokacin kwanta barci. Yawan injections na hormone ba iyaka kuma yana dogara ne akan bukatun mai haƙuri. Don rage lalacewar fata, ma'aunin shine injections 3 kafin kowane abinci da mafi girman allura 3 don daidaita cututtukan cututtukan fata. Idan sukari ya tashi jim kaɗan kafin cin abinci, ana haɗar da gyara tare da allurar da aka shirya.
Lokacin da kuke buƙatar gajeren insulin:
- 1 nau'in kamuwa da cutar siga.
- 2 nau'in cuta yayin da magunguna masu rage sukari ba su da amfani sosai.
- Cutar sankarar mahaifa tare da matakan glucose mai yawa. Don mataki mai sauƙi, allura 1-2 na dogon insulin yawanci sun isa.
- Cutar tiyata, wanda ya haifar da ƙarancin ƙwayar halittar mahaifa.
- Farfad da rikitarwa na matsananciyar cutar siga: ketoacidotic da coperosmolar coma.
- Lokaci na karuwar bukatar insulin: cututtuka masu zafi sosai, ciwon zuciya, lalacewar jikin mutum, raunin raunin da ya faru.
Pharmacokinetics na Short Insulin
Hanya mafi kyawu don sarrafa insulin a cikin maganin yau da kullun na ciwon sukari subcutaneous. Saurin sauri da cikakkiyar ƙarfin sha a cikin wannan yanayin ana iya faɗi game da su, wanda zai ba ka damar ƙayyade daidai adadin ƙwayoyi. Ana lura da ragewar sukari cikin sauri idan allura ta yi a ciki, dan kadan a kafaɗa da cinya, har ma da saurin juji a gindi.
Short insulins fara aiki rabin sa'a bayan gudanarwa, mafi girman tasiri shine 2 hours. Bayan kololuwa, an hanzarta daukar matakin. Sakamakon saura ya dogara da kashi ɗaya da aka gudanar. Idan raka'a 4-6 na miyagun ƙwayoyi sun shiga cikin jini, ana lura da raguwar sukari a cikin 6 hours. A cikin adadin fiye da raka'a 16, aikin zai iya zuwa awa 9.
An yarda da insulin a lokacin daukar ciki da shayarwa, saboda baya shiga cikin jini da nono.
Bayan aiwatar da ayyukanta, gajeran insulin ya lalace tare da samar da amino acid: 60% na hormone an zubar dashi a cikin kodan, 40% a cikin hanta, ƙaramin sashi yana shiga fitsari ba canzawa.
Short shirye-shiryen insulin
An samo gajeren insulin ta hanyoyi guda biyu:
- Injiniyancin asali, kwayoyin cuta ne ke hade shi.
- Semi-roba, ta amfani da canjin enzyme na kwayoyin aladu.
Dukkan nau'ikan magungunan ana kiransu ɗan adam, saboda ta amino acid ɗin an keɓance su gaba ɗaya suna maimaita hormone da ke cikin ƙwayoyin mu.
Magunguna gama gari:
Kungiyar | Sunayen Magunguna | Lokacin aiki bisa ga umarnin | ||
Fara, min | Awanni | Tsawon lokaci, awanni | ||
aikin injiniya | Nakamaka NM | 30 | 1,5-3,5 | 7-8 |
Gensulin r | 30 | 1-3 | har zuwa 8 | |
Rinsulin P | 30 | 1-3 | 8 | |
Tsarin Humulin | 30 | 1-3 | 5-7 | |
Insuman Rapid GT | 30 | 1-4 | 7-9 | |
Semi-roba | Biogulin P | 20-30 | 1-3 | 5-8 |
Humodar R | 30 | 1-2 | 5-7 |
Ana fitar da gajeren insulin a cikin nau'i na mafita tare da taro na 100, ƙasa da raka'a 40 a kowane milliliter. Don yin allura ta amfani da sirinji, an tattara magungunan a cikin gilashin gilashin tare da marufi na roba, don amfani a cikin alkalannin sirinji - a cikin katako.
Muhimmi: Yadda za a adana gajeren insulin a gida, kan hanya da kuma wane zafin jiki, mun bayyana daki-daki a nan.
Ultrashort insulin
Idan aka kwatanta da hormone din da yake kewaya a jikin mutum, gajarta insulin shine yake bayyaninsa kuma daga wani lokacin kuma da tsawan lokaci na aiki. Don kawar da waɗannan gazawar, an ƙirƙiri shirye-shiryen ultrashort. Kwayoyin wadannan insulins an daidaita su, ya bambanta da na mutane a tsarin amino acid.
Fa'idodin insulin ultrashort:
- saurin hauhawar jini.
- gwamnati nan da nan kafin abinci.
- yiwuwar amfani da shi nan da nan bayan cin abinci. Wannan yana da mahimmanci musamman a cikin maganin cututtukan cututtukan yara, tunda ba a san shi a gaba ba ko yaro zai shawo kan duk ɓangarorin.
- sauƙaƙa da normalization na glycemia a cikin sabon yanayi.
- da ikon haɓaka adadin carbohydrates mai sauri a cikin abincinku ba tare da yin lahani ga masu ciwon sukari ba.
- rage yiwuwar hauhawar jini.
- mafi kyawun sukari bayan cin abinci.
Marasa lafiya da ke fama da cututtukan sukari, haɓakar ƙin jinin da ba a aiki ba, ana tura su zuwa insulin. Hakanan ana ba da shawarar ga yara ƙanana da ke da canjin ci da ci a lokacin balaguro mai aiki.
Sunayen Insulin na gajere da ke aiki:
Nau'in insulin | Siffar | Shirye-shirye | Lokacin aiki | ||
Fara, min | Ganiya, h. | Tsawon lokaci h | |||
lizpro | Yana cikin sauri yana shiga cikin jini kuma ya shiga cikin kololuwa, tsawon lokacin aikin ba dogaro-da-magani bane, wanda ke rage hadarin cututtukan jini. | Humalogue | 15 | 0,5-1 | 2-5 |
kewayawa | Yana ba ku damar iya sarrafa glycemia mafi kyau bayan cin abinci, rage mahimmancin yau da kullum na glucose, ba ya ba da gudummawa ga yawan nauyi. | Rubutun NovoRapid | 10-20 | 1-3 | 3-5 |
NovoRapid Flexpen | |||||
glulisin | Lyspro yana kama da insulin, ana rushe shi cikin sauƙi, wanda ke ba da damar amfani da shi na dogon lokaci ba tare da lalacewar lafiya ba. | Apidra | 15 | 1-1,5 | 3-5 |
Hanyoyi don yin lissafin gajeren insulin
Yawan gajeren insulin da ake buƙata don rage sukari zuwa al'ada bayan cin abinci ya dogara da abun da ke cikin carbohydrate a cikin tasa. Don saurin lissafi, an gabatar da manufar "bangaren abinci". Wannan darajar daidai take da 12 g na carbohydrates ko burodi 1 na burodi. Yawan insulin don rama XE guda daya ne. Yana canzawa yayin rana. Da safe, buƙatar ta kasance mafi girma: don raka'a 1 XE - 1.5-2.5 na miyagun ƙwayoyi. Rana da maraice, yana raguwa kuma yana zama raka'a 1-1.3. Za'a iya zaɓar ainihin coefficients na wani mai haƙuri a sarari.
- Labarinmu game da lissafin sashi - //diabetiya.ru/lechimsya/insulin/raschet-dozy-insulina-pri-diabete.html
Misalin lissafi: a lokacin karin kumallo, ana shirin cin 200 g na kayan gwari, wanda zai buƙaci g 40 na oatmeal da gic ɗin naman alade, yanki mai burodi ya kai 25 g. A cikin 100 g na hatsi - 60 g na carbohydrates, a cikin 40 - 24 g = 2 XE. A cikin burodin 100 g, 50 g na carbohydrates, a cikin 25 - 12.5 g = 1 XE. Ham a zahiri ba ya dauke da carbohydrates, don haka ba mu la'akari da shi. Don daidaita sukari, kuna buƙatar raka'a 3 XE * 2 = 6 na miyagun ƙwayoyi.
Lissafin da ke sama yana ba ku damar rama ci gaban glycemia kawai bayan cin abinci. Idan sukari kafin cin abinci ya fi yadda aka saba, kashi na gajeran insulin yakamata a ƙara. An yi imani cewa ana buƙatar ƙarin unitaya guda ɗaya na hormone don rage sukari ta 2 mmol / L.
Misalin lissafi: Ana buƙatar raka'a 6 don rama don karin kumallo. da miyagun ƙwayoyi. Glycemia kafin abinci 9 mmol / L, al'ada shine 6 mmol / L Kuna buƙatar shiga (9-6) / 2 = 1.5 ƙarin raka'a insulin, raka'a 7.5 kawai.
Don ƙarin ƙididdigar cikakken daidaituwa na adadin daidaitawa, zaku iya amfani da tsarin forsham. Don canza mmol / L zuwa mg%, suna buƙatar ninka da 18.
Glucose Manyamg% | Tsarin tsari | Misalin lissafi |
150 <Glu <216 | (Glu-150) / 5 | Lokacin da sukari shine 9 mmol / L (9 * 18 = 162 mg%), ana buƙatar insulin (162-150) / 5 = 2.4, zagaye har zuwa raka'a 2.5. |
Glu ≥ 216 | (Glu-200) / 10 | Lokacin da sukari shine 15 mmol / L (15 * 18 = 270 mg%), ana buƙatar insulin (270-200) / 10 = 7 raka'a. |
Kullum maganin insulin
Matsakaicin yawan izinin insulin yau da kullun ba'a tabbatar dashi ba. Babban ka'idojin da suka dace don magance cututtukan sukari sune sukari na yau da kullun da sukarin glycated, maimakon adadin hormone da ake buƙata don wannan.
Kimanin kashi ɗaya a kowace kilo kilogram na nauyin haƙuri, raka'a | Halin jihar |
0,1-0,2 | Bayan farawar insulin, idan "amaryar" ta zo. |
0,3-0,5 | A farkon insulin far don kamuwa da ciwon sukari na 2. |
0,5-0,6 | A halarta na halarta na farko cutar 1. |
0,7-1 | Tare da rashin lafiya na tsawan lokaci da kuma cikakkiyar rashi na kansa. |
0,5-2 | A lokacin samartaka. |
2-2,5 | Lokaci na wani lokaci na karuwar buƙatar hormone (ketoacidosis, juriya na insulin, rauni da kamuwa da cuta). |
Idan buƙatar insulin ya wuce matsakaiciyar matakin, wannan yana nuna juriyawar insulin. Ana iya cin nasara tare da taimakon magungunan da endocrinologist ya tsara.
Matsakaicin gajeren insulin a cikin adadin yawan ƙwayoyi shine 8-50%, gwargwadon tsarin aikin da aka zaɓa. Tare da insulin-tushen farfajiyar famfo, kawai ana amfani da insulin gajere da sikelin-ins.
Yadda ake gudanar da gajeren insulin
Game da yadda ake yin insulin - //diabetiya.ru/lechimsya/insulin/kak-kolot-insulin-pri-diabete.html
Yadda ake yin allura (umarni):
- Zaɓi wurin yin allura. Yawancin ciki wanda aka saba amfani dashi, baya kusan 3 cm daga cibiya.
- Saki da sirinji da sigar zubar da kayan daga marufin.
- Soya roba mai roba na kwalakin kuma zana adadin maganin da aka riga aka lissafa a cikin sirinji.
- Matsowa kara suna cire dukkan iska daga sirinji.
- Theara fata a man shafawa ta hanyar da fata kawai da kitsen mai ƙamshi ya shiga ciki. Kada a shafa tsokoki.
- Saka allura a cikin ruwan ka kuma sanya allurar.
- Ba tare da fitar da allura ko cire fure ba, jira na dan lokaci.
- Cire allurar a hankali, sannan a saki fatar.
Nisa daga wurin allurar da ta gabata kada ta kasance ƙasa da santimita 2. Ba a kula da fata ko allura da giya ba, tunda yana iya yin tasiri sosai ga tasirin insulin.