Ciwon sukari mellitus cuta ce ta kowa da ke buƙatar magani tsawon rayuwa. Sabili da haka, a cikin nau'in cutar ta farko kuma a cikin manyan maganganu tare da nau'in cuta na biyu, masu haƙuri suna buƙatar kulawa da insulin na yau da kullun, wanda ke taimakawa daidaitaccen glucose, da sauri canza shi zuwa makamashi.
Sau da yawa tare da ciwon sukari, ana amfani da insulin Aspart. Wannan magani ne na ultrashort.
Kayan aiki shine kwatankwacin insulin na mutum, wanda aka samo ta hanyar fasahar DNA ta sake amfani da nau'in Saccharomyces cerevisiae, inda ake maye gurbin protin a matsayin B28 (amino acid) tare da aspartic acid. Tsarin kwayoyin shine 5825.8.
Abun ciki, tsari na saki da tasirin magani
Biphasic insulin yana hade da narkewa mai narkewa mai narkewa a cikin kashi 30 zuwa 70%.
Wannan dakatarwa ce ga sc gwamnatin, da samun farin launi. 1 milliliter ya ƙunshi raka'a 100, kuma ED guda ɗaya ya dace da 35 μg na insulin na ashydrous Aspart.
Maganin insulin na mutum yana samar da hadaddun mai insulin wanda yake da mai membrane sel membrane receptor. Latterarshen yana kunna ayyukan haɗin glycogen synthetase, pyruvate kinase da enzymes hexokinase.
Rage yawan sukari yana faruwa tare da haɓaka jigilar jijiyoyin jini da haɓaka haɓaka tasirin glucose. Hakanan ana samun hypoglycemia ta hanyar rage lokacin kwantar da glucose ta hanta, glycogenogenesis da kuma kunna lipogenesis.
Ana samun asulin insulin asulin ta hanyar amfani da kwayoyin halitta yayin da aka maye gurbin kwayoyin da ke cikin kwayoyin halittar ta hanyar aspartic acid. Irin waɗannan insulins na biphasic suna da irin wannan sakamako a kan haemoglobin, kamar yadda insulin ɗan adam yake dashi.
Dukansu magunguna suna daidai da aiki a daidai molar. Ko yaya, insulin insulin yayi aiki da sauri fiye da narkewar jikin mutum. Kuma protamine mai narkewa yana da tasirin lokacin matsakaici.
Matakan bayan sc gwamnati na miyagun ƙwayoyi an cimma bayan mintina 15. Babban taro na miyagun ƙwayoyi yana faruwa awanni 1-4 bayan allura. Tsawon lokacin yana tasiri har zuwa awanni 24.
A cikin magani, Cmax na insulin shine kashi 50% fiye da lokacin amfani da insulin na mutum. Haka kuma, matsakaicin lokacin da za'a kai ga Cmax bashi da rabi.
T1 / 2 - har zuwa awanni 9, yana nuna ƙimar ƙwaƙwalwar kariyar. Ana lura da matakan insulin na kasa da sa'o'i 15-18 bayan gudanarwa.
Amma tare da nau'in ciwon sukari na 2, nasarar Cmax kusan minti 95 ne. Yana kiyayewa a matakin ƙasa da 14 kuma sama da 0 bayan sc gwamnati. Ko dai yankin gudanarwa yana shafar wurin shan shayin ba a yi nazari ba.
Sashi da gudanarwa
Sau da yawa insulin Degludek, Aspart-insulin ana gudanar dashi a ƙarƙashin ƙasa. An yi allura a wasu sassan jiki:
- buttock;
- Belly
- cinya
- kafada.
Kuna buƙatar yin allurar insulin kafin abinci (hanyar prandial) ko bayan cin abinci (hanyar postprandial).
Algorithm da sashi na gudanarwa ana ƙaddara ta likita mai halarta. Amma yawanci yawan maganin yau da kullun shine 0.5-1 UNITS ga 1 kg na nauyi.
A cikin lokuta masu wahala, ana gudanar da insulin Aspart biphasic a iv. Ana aiwatar da hanyar ta amfani da tsarin jiko a cikin injin na ciki ko inpatient.
M halayen, contraindications da overdose
Yin amfani da insulin Asparta na iya shafar aikin Majalisar Dokoki ta ƙasa, tunda saurin daidaituwa na sigogin sukari wani lokaci yana haifar da ciwo mai zafi. Koyaya, wannan yanayin ya wuce lokaci.
Hakanan, insulin biphasic yana haifar da bayyanar lipodystrophy a cikin allurar. A wani ɓangaren ƙwayar azanci, ana lura da kasawar gani da kyalkyali a cikin shakatawa.
Contraindications shine rashin jituwa ga mutum da abubuwan da ke tattare da miyagun ƙwayoyi da cututtukan jini.
Bugu da ƙari, yin amfani da Insulin Aspart ba shi da kyau har zuwa shekara 18. Tunda babu wani bayanan asibiti da ke tabbatar da inganci da amincin magunguna ga kwayoyin da ke fitowa.
Game da yawan abin sama da ya kamata, wadannan alamomin suna faruwa:
- katsewa
- raguwa mai kaifi a cikin glucose;
- ƙwayar cutar rashin ƙarfi ta yara a cikin ciwon sukari.
Tare da excessan abin da ya wuce na kashi, don daidaita daidaiton ƙwayar glucose, ya isa ya ɗauki carbohydrates mai sauri ko sha mai dadi. Zaka iya shigar da glucagon subcutaneously ko intramuscularly ko kuma maganin dextrose (iv).
Game da cutar mahaifa, daga 20 zuwa 100 ml na dextrose (40%) ana shigar da shi ta hanyar jet-ciki har sai yanayin mai haƙuri ya zama al'ada. Don hana haɓakar ire-iren waɗannan halayen, ana kara bayar da shawarar yin amfani da maganin ƙwaƙwalwar ƙwayar fata.
Yin hulɗa tare da wasu kwayoyi da umarni na musamman
Za'a iya inganta tasirin hypoglycemic idan an hada aikin insulin na insulin insulin tare da gudanar da maganin baka na kwayoyi masu zuwa:
- barasa mai amfani da giya;
- MAO / carbonic anhydrase / ACE inhibitors;
- Fenfluramine;
- Bromocriptine;
- Cyclophosphamide;
- somatostatin analogues;
- Theophylline;
- Sulfonamides;
- Pyridoxine;
- Maganin steroid din anabolic.
Yin amfani da tetracyclines, Mebendazole, Disopyramide, Ketonazole, Fluoxetine da Fibrates suma suna haifar da raguwa sosai a cikin sukari. Kuma maganin tricyclic antidepressants, hana maganin hana haihuwa, nicotine, sympathomimetics, glucocorticosteroids, thiazide diuretics, hormones thyroid da sauran magunguna suna taimakawa ga rauni na tasirin hypoglycemic.
Wasu kwayoyi na iya karuwa da rage matakan sukari. Waɗannan sun haɗa da shirye-shiryen lithium, beta-blockers, salicylates, clonidine da reserpine.
Yana da mahimmanci a lura cewa Flekspen da aka yi amfani da shi ya kamata a adana shi a zazzabi a ɗakin, da sabon alkalami mai sirinji a cikin firiji. Kafin gudanarwa, abubuwan da ke cikin murfin suna da mahimmanci don haɗuwa sosai.
Tare da ƙara yawan aiki na jiki, kumburi ko cututtukan cututtuka, haɓaka yawan sashin insulin ya zama dole. Kuma a farkon farawa, ba a ba da shawarar sarrafa abubuwa masu rikitarwa da abubuwan hawa ba. Bidiyo a wannan labarin zai yi magana game da hormone din.
