Cakuda mai kyau shine magani mai kyau wanda aka yi amfani dashi a cikin hadaddun magani na masu ciwon sukari na 2. Yana taimaka bisa al'ada suga sukari. Haɗin ya haɗa da kayan aikin 2, wanda ke ba ku damar amfani da kayan aiki da yawa.
Sunan kasa da kasa mai zaman kansa
INN: Metformin da Saxagliptin
Cakuda mai kyau shine magani mai kyau wanda aka yi amfani dashi a cikin hadaddun magani na masu ciwon sukari na 2.
ATX
Lambar ATX: A10BD07
Saki siffofin da abun da ke ciki
Ana samun maganin kawai a nau'in kwamfutar hannu. Allunan na iya samun launi dabam. Ya dogara da taro na aiki da dyes a cikinsu. An rufe su da kwasfa na musamman.
Kwamfutar hannu 1 ta ƙunshi 2.5 mg na saxagliptin da 500 ko 1000 mg na metformin hydrochloride. Allunan suna da madaidaicin siffar convex. Dogaro da haɗuwa da metformin, suna iya samun launin ruwan kasa, ruwan hoda ko launin rawaya. A ɓangarorin biyu akwai alamun sashi waɗanda aka yi da shuɗi mai ruwan shuɗi. Abubuwan taimako sune: carmellose sodium, magnesium stearate da cellulose.
Ana samun maganin kawai a nau'in kwamfutar hannu.
Allunan suna cikin muryoyin kariya na musamman na inji mai kwakwalwa 7. a kowane. Akwatin kwali na riƙe blister 4 da cikakkun bayanai don amfani.
Aikin magunguna
Magungunan yana haɗuwa a cikin kayan haɗin 2 aiki mai aiki. Wannan ya sanya shi kayan aiki na duniya a cikin maganin cututtukan type 2 na ciwon sukari. Saxagliptin yana aiki azaman mai hanawa, yana ba da gudummawa sosai ga samar da ginin peptide, kuma Metformin yana cikin rukunin biguanides. An saki metabolites mai aiki a cikin gyare-gyare daban-daban.
Metformin yana da ikon rage gluconeogenesis. Fat hada hada hada hadar abinci, kuma insulin damar inganta sosai. Yin amfani da glucose ta salula yana da sauri. A ƙarƙashin rinjayar Metformin, an inganta glycogen synthesis. Ana fara samun sukari a hankali a cikin gabobin cikin jijiyoyi, wanda ke taimaka wa jiki asarar nauyi.
Saxagliptin yana inganta sakin insulin cikin hanzari daga ƙwayoyin beta na pancreas. Wannan kayan aikin ya dogara da abubuwan glucose a cikin jini. Glucagon yana ɓoyewa, wanda ke hana haɓakar glucose a cikin wasu abubuwa na hanta. Saxagliptin yana taimaka rage inactivation na takamaiman hormones, incretins. A lokaci guda, matakin jininsu yana tashi, kuma yawan adadin glucose mai azumi yana raguwa bayan babban abinci.
Pharmacokinetics
Saxagliptin koyaushe yana canza tuba zuwa metabolite. Metformin, koda bayan kyakkyawan zane a cikin tubules na koda, an keɓe shi daga jiki a cikin canzawar gaba ɗaya. An lura da mafi yawan abubuwan aiki a cikin sa'o'i 6 bayan ɗaukar kwaya.
Metformin, koda bayan kyakkyawan zane a cikin tubules na koda, an keɓe shi daga jiki a cikin canzawar gaba ɗaya.
Alamu don amfani
Babban nuni ga amfani shine hadadden farjin cututtukan siga na 2. Ana amfani dashi azaman ƙari ga aikin motsa jiki da aka ba da shawarar da abinci. Ana ba da magani ne kawai idan jiyya tare da Metformin da Saxagliptin sun dace da marasa lafiya.
Contraindications
Ba'a amfani dashi wajen lura da cutar sukari irin ta 1, harma da batun ciwan ketoacidosis mai ciwon sukari, tunda a ƙarƙashin irin waɗannan yanayin maganin bazai sami tasirin warkewa ba.
Bugu da kari, akwai tsauraran matakan contraindications don shan maganin:
- karancin aikin koda;
- lactic acidosis;
- rashin daidaituwa na lactose da amfani don lura da manyan allurai na insulin;
- rikicewar zuciya;
- bugun zuciya, tashin zuciya;
- m rashin ƙarfi infarction;
- hypersensitivity ga aiki aka gyara daga cikin miyagun ƙwayoyi;
- m da na kullum metabolic acidosis;
- shekaru har zuwa shekaru 18;
- karancin abincin kalori;
- ciki da lactation;
- amfani don lura da iodine-dauke da wakilan masu bambanci, wanda zai iya haifar da haɓakar ƙarancin renal.
Duk waɗannan abubuwan ba gaskiya bane. Mafi sau da yawa, tare da irin wannan cutar, ana amfani da insulin don magance ciwon sukari.
Tare da kulawa
Tare da taka tsantsan, kuna buƙatar ɗaukar magani ga tsofaffi, marasa lafiya da hanta da gazawar koda. Lokacin da alamun farko marasa kyau suka bayyana, gyaran kashi na farko da aka wajabta zai iya zama dole.
Yadda ake ɗaukar combogliz?
Game da amfani da maganin antiglycemic therapy, ya kamata a tsara adadin Combogliz daban-daban ga kowane mara lafiya, gwargwadon yanayin lafiyar gaba ɗaya. Ana ba da shawarar magani don sha da yamma, mafi kyau tare da abinci. Girman adadin guda na Saxagliptin bai kamata ya wuce 2.5 MG ba ko kuma a cikin manyan lokuta 5 MG kowace rana.
Yana da kyau a haɗiye allunan gaba ɗaya ba tare da taunawa ba. Ya kamata a wanke shi da yalwar ruwan zãfi.
Lokacin da aka haɗu tare da maimaita amfani da cytochrome isoenzymes, shawarar da aka ba da shawarar ita ce kwamfutar hannu 1 na 2.5 MG kowace rana.
Yana da kyau a haɗiye allunan gabaɗaya ba tare da taunawa ba.
Ciwon sukari
Maganin duniya don lura da ciwon sukari na 2. Na farko nau'in irin wannan magani ba zai yiwu a bi da shi ba. Kafin ka fara maganin ƙwayar cuta, lallai ne a nemi shawarar endocrinologist. A wannan halin, duk cututtukan da ke tattare da cututtukan ciki dole ne a la'akari da su.
Side effects na hadawa
Marasa lafiya sau da yawa suna lura da haɓakar halayen da ba a so:
- ciwon kai, har zuwa bayyanar migraines akai-akai;
- bayyanar cututtuka na maye, wanda ya nuna ta hanci, amai da tsananin zawo;
- zafi a cikin ciki na yanayin ja;
- rikicewar cututtuka na tsarin urinary;
- kumburi fuska da wata gabar jiki;
- ƙarancin kasusuwa yana ƙaruwa, bi da bi, wannan ma yana ƙara haɗarin fashewa yayin ɗaukar Saksagliptin (ƙungiyar bincike game da sashi daga 2.5 zuwa 10 MG) da placebo;
- hypoglycemia;
- bayyanar rashin lafiyan a cikin nau'in rashes na fata da urticaria;
- rashin tsoro;
- cin zarafin dandano na wasu samfura yana yiwuwa.
Irin waɗannan bayyanar cututtuka ya kamata su ɓace gaba ɗaya bayan gyaran kwastomomi ko kuma cikakken cire maganin. Idan alamun maye ya kasance, ana iya buƙatar warkewar maganin hana haihuwa.
Tasiri kan ikon sarrafa abubuwan inji
Magungunan ba ya shafar tsarin jijiya kai tsaye. Amma zai fi kyau a bar tuki, tunda wasu sakamako masu illa da suka faru kwatsam na iya shafar taro.
Umarni na musamman
Lokacin shan maganin, yana da mahimmanci a dauki gwaje-gwaje don lura da canje-canje a cikin kodan. Akwai babban hadarin lactic acidosis. Gaskiya ne game da tsofaffi.
Lokacin amfani da Saksagliptin, raguwa-dogara da kashi a cikin matsakaicin adadin lymphocytes na iya faruwa. Ana lura da wannan tasirin lokacin ɗaukar kashi na 5 MG a cikin tsarin farko tare da Metformin idan aka kwatanta da monotherapy tare da Metformin kaɗai.
Yi amfani da lokacin daukar ciki da lactation
Ba'a bada shawara don ɗaukar lokacin haihuwar ɗa. A yau, babu isasshen bincike a kan ko allunan suna da tasirin teratogenic ko tayi cikin tayin. Wani magani zai iya ba da gudummawa ga bayyanar ƙarancin ci gaban mahaifa da jinkirta ci gabanta. Idan ya cancanta, ana tura duk mata masu juna biyu zuwa aikin insulin da ƙarancin magani.
Ba'a ba da shawarar shan ƙwayoyi ba yayin lokacin gestation.
Babu wani ingantaccen bayanai akan ko miyagun ƙwayoyi zasu iya shiga cikin madarar nono. Sabili da haka, masana suna ba da shawarar dakatar da lactation.
Alƙawura Hada da yara
Yara kada su dauka. Ba a taɓa yin amfani da ita don kula da yara da marasa lafiya da ke ƙasa da shekara 18 ba.
Yi amfani da tsufa
Tare da kulawa ta musamman, ana ba da magani ga tsofaffi. Suna da haɓakar haɗarin haɓaka rikice-rikice iri daban-daban, sabili da haka, ana buƙatar saka idanu akai-akai game da yanayin kiwon lafiya ta hanyar ilimin kwantar da hankali da kuma endocrinologist. Idan akwai irin wannan buƙatar, to an rage kashi zuwa mafi ƙanƙanta, wanda akan samu sakamako na warkewa har yanzu ana samunsa. Don ƙirƙirar aikin motsa jiki, ana tsara ƙarin ƙwayoyin bitamin ga wasu tsofaffi marasa lafiya, musamman waɗanda ke da raunin kwakwalwa.
Aikace-aikacen aiki mara kyau
Akwai haɗarin haɗarin acidosis na rayuwa tare da tsawaita amfani. Zai fi kyau ga marasa lafiya da raunin ƙwayar cuta na koda don rage kashi zuwa ƙarami ko gaba ɗaya sun ƙi ɗauka.
An hana shi sosai don ɗaukar marasa lafiya da cututtukan hanta na hanta.
Amfani don aikin hanta mai rauni
An hana shi sosai don ɗaukar marasa lafiya da cututtukan hanta na hanta.
Doauke da yawan Comboglize
Magungunan suna da haƙuri da kyau. Akwai karancin lokuta na yawan shan ruwa. Kawai tare da gudanar da haɗari na babban adadin na iya bayyanar wasu alamun bayyanar da ke nuna ci gaban lactic acidosis. Mafi na kowa daga gare su:
- matsaloli tare da tsarin numfashi;
- gajiya da matsanancin fushi;
- ƙwayar tsoka;
- tsananin zafin ciki;
- fitowar kamshin acetone daga bakin.
A wannan yanayin, lavage na ciki ko hemodialysis na iya taimakawa. Tare da ƙarancin digiri na hypoglycemia, ana bada shawara a ci mai daɗi ko sha shayi mai zaki.
Yin hulɗa tare da wasu kwayoyi
Haɗakar amfani da Comboglize tare da wasu kwayoyi na iya ƙara yawan ƙwayar plasma na lactate. Wadannan magungunan sun hada da:
- shirye-shiryen magnesium;
- Acid na Nicotinic;
- Rifampicin;
- kamuwa da cuta;
- Isoniazid;
- kwayoyin hodar iblis;
- alli tubule blockers;
- estrogens.
Haɗin haɗin tare da Pioglitazone baya tasiri kan magunguna na Saxagliptin. Bugu da ƙari, haɗuwa shine amfani guda na Saksagliptin, sannan bayan 3 hours 40 MG na Famotidine, halayen magunguna ma ba su canzawa.
Lokacin shan Combogliz, tasirin irin waɗannan kuɗaɗen na iya raguwa:
- Fluconazole;
- Erythromycin;
- Ketoconazole;
- Furosemide;
- Verapamil;
- ethanol.
Idan mai haƙuri ya ɗauki ɗayan abubuwan da aka lissafa, to lallai ne ku sanar da likitanka.
Amfani da barasa
Alkahol haramun ne ga marasa lafiya da masu dauke da cutar sankarau. Zai iya shafar tasirin maganin.
Analogs
Yana nufin cewa ya bambanta a cikin abun da ke ciki, amma cikakke iri guda ne cikin tasirin warkewa:
- Kwancen Combogliz;
- Bagomet;
- Janumet;
- Karfe Galvus;
- Glibomet.
Kafin fara dabarun canza magani, kuna buƙatar karanta umarnin a hankali don maganin da aka zaɓa, tunda kowannensu na iya samun mummunar contraindications da halayen m. Bugu da kari, sashi na maganin ya sha bamban.
Magunguna kan bar sharuɗan
Ana iya siyan magani a kantin magani tare da takardar sayan magani.
Zan iya saya ba tare da takardar sayan magani ba?
Ana fito dashi ne kawai bayan gabatar da takardar sayan magani daga wurin likitan da ke halartar.
Farashi don combogliz
Kudin maganin yana da tsada sosai. Ana iya siyanta farawa daga 2400 rubles. Farashi na ƙarshe ya dogara da alamar ƙirar da mai maganin za ta sa da kuma a kan alluna nawa zasu kasance cikin kunshin.
Yanayin ajiya na miyagun ƙwayoyi
Adana a wurin da hasken rana kai tsaye ba ya faɗi. Zafin ajiya - daki. Ya kamata a adana maganin a cikin busassun wuri kuma a kiyaye shi daga ƙananan yara kamar yadda zai yiwu.
Ana iya siyan magani a kantin magani tare da takardar sayan magani.
Ranar karewa
Tare da ingantaccen ajiya, rayuwar shiryayye shine shekaru 3 daga ranar ƙirar da aka nuna akan marufi na asali.
Mai masana'anta
Bristol Myers Squibb, Amurka.
Ra'ayoyi game da Haduwa
Likitoci
Stanislav, dan shekara 44, masanin diabetologist, St. Petersburg: "Na dade ina amfani da maganin a aikace na. Tasirin yana da kyau. Matsanancin matakin jini a cikin marassa lafiya da ke dauke da nau'in ciwon sukari na biyu ya ragu bayan kammala magani. Ya kasance a matakin al'ada na dogon lokaci, wanda ke sa maganin ya zama gama gari. "Kudinsa ba kasa da tsawaita, amma tasirin su ɗaya ne, har ma da abun da ke ciki iri ɗaya ne. Wasu marasa lafiya suna da halayen rashin lafiyan a cikin cutar urticaria. Amma komai yana tafiya da sauri. Sabili da haka, ina ba da shawarar magancewa ga duk marassa lafiya na."
Varvara, mai shekaru 46, masaniyar ilimin halittar dabbobi, Penza: "Na kasance ina rubuta magani don daidaita matakan sukari na jini .. Amma akwai maganganu da yawa na marasa lafiya daga marasa lafiya .. Wannan shine saboda gaskiyar mummunan tasirin da ake samu akai-akai. A irin waɗannan halayen, kuna buƙatar soke magani kuma kuyi tunani game da maye gurbinsa. Saboda haka, ina ba da shawarar marasa lafiya su fara da mafi ƙarancin kashi don duba halin da jiki ke ciki. Idan komai na al'ada, za a iya ci gaba da jiyya kuma a hankali ana ƙaruwa da kashi. "
Mara lafiya
Valery, dan shekara 38, a Moscow: "Na rubuta magunguna ta likitancin endocrinologist. Ina fama da ciwon sukari na nau'ikan. Sakamakon sukari ya dawo daidai da sauri.Wannan dabi'u ya kasance na dan wani lokaci bayan daina aikin jiyya .. A farkon kwanakin, na ji ciwon zazzabi. Na ji tashin zuciya kuma na sami ciwon kai. komai ya tafi, sakamakon magunguna ya fara hauhawa. Magani ya yi kadan.
Andrei, dan shekara 47, Rostov-on-Don: "Magungunan ba su dace ba. Bayan kwaya ta farko na ji mara kyau. Na fara amai, ciwon kai bai daina tsawan lokaci ba. Dole ne in ga likita." Ya ba da umarnin yin amfani da wasu maganganu marasa kyau. Bayan komai ya koma daidai, an wajabta maganin wannan maganin, amma kuma bayansa akwai mummunar halayen da ke cikin mummunar maye. Bugu da kari, fitsari na fata ya bayyana akan fatar. Saboda haka, an rubuta insulin. "
Julia, 'yar shekara 43, Saratov: "Na gamsu da tasirin magani. Matakin da ke cikin sukari da sauri ya koma al'ada. Na rasa nauyi ba tare da abinci ba. Zuciyata ta daina zafi. Gaba daya lafiyar na ta inganta. A cikin kwanakin farko kaina na ciwo kadan, amma sai komai ya daidaita. Ina ba da shawarar shi ga kowa."
