Zaltrap magani ne mai maganin antitumor wanda aka yi amfani dashi wajen maganin cutar daji ta maza da mata, lokacin da ilimin cutar sankara bai bada sakamako mai warkewa ba saboda tsananin tsayayyen kumburin ko kuma idan ya sake dawowa.
Sunan kasa da kasa mai zaman kansa
ZALTRAP.
Zaltrap magani ne mai maganin antitumor da aka yi amfani dashi wajen maganin cutar daji ta maza da mata.
ATX
L01XX - sauran magungunan antitumor.
Saki siffofin da abun da ke ciki
Tattara hankali daga abin da aka shirya don jiko. Vials suna da girma na 4 ml da 8 ml. Yawan babban abu na aflibercept shine 25 MG a cikin 1 ml. Zaɓin na biyu shine maganin da aka shirya don bakararre wanda aka yi niyya don gudanar da aikin cikin ciki. Launin mafita a bayyane yake ko tare da farin launin rawaya.
Babban kayan shine furotin aflibercept. Wadanda suka kware: sodium phosphate, citric acid, hydrochloric acid, sucrose, sodium chloride, sodium hydroxide, ruwa.
Aikin magunguna
Aflibercept ya toshe ayyukan masu karɓar karɓa, waɗanda ke da alhakin ƙirƙirar sababbin tasoshin jini waɗanda ke ciyar da ƙari kuma suna ba da gudummawa ga ci gabanta mai ƙarfi. Kasancewa ba tare da samar da jini ba, neoplasm zai fara raguwa a girma. Tsarin girma da rarrabuwa daga kwayoyin halittun da basu da illa.
Aflibercept ya toshe ayyukan masu karɓar karɓa, wanda ke da alhakin ƙirƙirar sababbin hanyoyin jini.
Pharmacokinetics
Babu bayanai game da metabolism na furotin aflibercept. Wataƙila, kamar kowane furotin, babban ɓangaren magungunan ya kasu kashi amino acid da peptides. Cire rabin rayuwar shine har zuwa kwanaki 6. Ba a kebe furotin ta hanjin kodan tare da fitsari.
Alamu don amfani
Ana amfani dashi a hade tare da sinadarin folinic acid, Irinotecan da Fluorouracil don maganin ƙwaƙwalwar ƙwayar cuta na ƙwayar cuta mai ƙwaƙwalwar ƙwayar cuta tare da tsayayya da sauran magungunan antitumor. An wajabta masa magani don dawo da cutar.
Contraindications
An haramta amfani da ita don magani a irin waɗannan halaye:
- yawan zubar jini;
- hauhawar jini na nau'in jijiya, lokacin da maganin ƙwaƙwalwar magani ya kasa;
- Mataki na 3 da 4 na rauni na zuciya;
- mara lafiya yana da tabin hankali ga sassan mutum daban-daban na maganin;
- mai rauni na koda.
Tionuntatawa shekarun tsufa - marasa lafiya a ƙarƙashin 18 shekara.
Tare da kulawa
Kullum sa ido game da yanayin lafiyar marasa lafiya da gazawar koda, hauhawar jini, cututtukan zuciya, da kuma matakan farko na gazawar zuciya ana buƙatar. Tare da taka tsantsan, an wajabta magunguna ga marasa lafiya tsofaffi kuma tare da ƙarancin lafiyar lafiyar gaba ɗaya, idan sikelin ƙimar bai fi maki 2 ba.
Yadda ake ɗaukar Zaltrap
Gudanarwa na ciki - jiko na awa 1. Matsakaicin sashi shine 4 MG kowace kilo na nauyin jiki. An sanya hannu kan magani kan tushen tsarin kula da cututtukan inshora:
- ranar farko na jiyya: jiko na ciki tare da catheter mai nau'in Y-ta amfani da Irinotecan 180 mg / m² na mintina 90, Calcium folinate na minti 120 a kashi na 400 mg / m² da 400 mg / m² Fluorouracil;
- m jiko yana wuce sa'o'i 46 tare da sigar Fluorouracil 2400 mg / m².
Gudanarwa na ciki - jiko na awa 1.
Ana maimaita sake zagayowar kowace kwana 14.
Tare da ciwon sukari
Ba a buƙatar gyaran gyaɗa.
Sakamakon sakamako na Zaltrap
An lura da lokuta daban-daban na zawo, proteinuria, stomatitis, dysphonia, da cututtukan urinary tract. A cikin yawancin marasa lafiya, ci abinci yana raguwa, zubar hanci, zubar nauyi. Akwai yawan gajiya, asthenia.
Mummunan bayyanar cututtuka daga tsarin numfashi: dyspnea of tsananin bambance-bambancen, rhinorrhea, zub da jini daga sinuses sau da yawa yakan faru.
Daga tsoka da kashin haɗin kai
Wasu masu haƙuri suna haɓaka osteonecrosis.
Gastrointestinal fili
Zawo, zazzaɓi na ciki na bambancin ƙarfi, haɓakar basur, samuwar fistulas a cikin dubura, mafitsara, ƙananan hanji. Matsalar ciwon hakori, ciwon kai, jijiya a cikin dubura, farji. Fistulas a cikin narkewa da tsarin ganuwar bango da wuya ya faru, wanda hakan na iya haifar da mutuwar mai haƙuri.
Bayyanar cututtuka daga tsarin numfashi: dyspnea sau da yawa yakan faru.
Hematopoietic gabobin
Sau da yawa akwai leukopenia da neutropenia na tsananin ƙarfi.
Tsarin juyayi na tsakiya
Kusan koyaushe akwai ciwon kai na yawan bambancewa, yawan tsananin zafin zuciya.
Daga tsarin urinary
Sau da yawa - proteinuria, da wuya - haɓakar cutar nephrotic.
A ɓangaren fata
Itching, redness da kurji, urticaria.
Daga tsarin kare jini
Kamuwa da cuta, rashin haihuwa a cikin maza da mata.
A cikin marasa lafiya da yawa, shan Zaltrap na iya haifar da thromboembolism.
Daga tsarin zuciya
Tsalle a cikin karfin jini, zubar jini a ciki. A cikin marasa lafiya da yawa: thromboembolism, ischemic Attack, angina pectoris, babban haɗarin infarction myocardial. Da wuya: buɗewar ƙwayar craniocerebral, zubar da jini, zubar da jini a cikin jijiyoyin ciki, waɗanda sune ke jawo mutuwa.
A wani ɓangaren hanta da ƙwayar biliary
A ci gaba da hanta gazawar.
Daga gefen metabolism
A mafi yawan lokuta, akwai rashin ci, sau da yawa - rashin ruwa (daga m zuwa mai tsanani).
Cutar Al'aura
Mai tsananin zafin rai jiyya: bronchospasm, gajeriyar gaɓar numfashi, girgiza ƙwaƙwalwar anaphylactic.
Tasiri kan ikon sarrafa abubuwan inji
Babu bayanai game da binciken yiwuwar miyagun ƙwayoyi akan maida hankali. An bada shawara don guji tuki da aiki tare da hadadden hanyoyin idan mai haƙuri yana da sakamako masu illa daga tsarin juyayi na tsakiya, rikicewar psychomotor.
Kafin sabon sake zagayowar jiyya (kowace kwana 14), yakamata a yi gwajin jini.
Umarni na musamman
Kafin sabon sake zagayowar jiyya (kowace kwana 14), yakamata a yi gwajin jini. Ana amfani da miyagun ƙwayoyi ne a cikin asibiti kawai don amsawa na lokaci don alamun rashin ruwa, yawan ganuwar ganuwar gastrointestinal fili.
Marasa lafiya tare da jigon kiwon lafiya na gaba na maki 2 ko fiye da haka suna da haɗarin sakamako masu illa. Suna buƙatar kulawa da likita akai-akai don ganowar asali na lalacewa a cikin lafiya.
Samuwar fistulas ba tare da yin la’akari da matsayin su ba alama ce ta dakatar da warkewar cutar. Haramun ne a yi amfani da magani wajen lura da marasa lafiyar da suka yi aikin tiyata mai yawa (har sai raunuka su warke gaba daya).
Maza da mata na haihuwa haihuwa yakamata suyi amfani da hanyoyi daban-daban na hana haihuwa cikin wata shida (babu ƙasa) bayan kashi na ƙarshe na Zaltrap. Ya kamata a cire ɗaukar ciki.
Maganin Zaltrap shine mai maganin cututtukan jini. Abunda ya ƙunsa yasha amfani da magunguna don sararin samaniya. Haramun ne a gabatar da mafita a jikin mara lafiyar.
Yi amfani da tsufa
Akwai babban hadarin kamuwa da cututtukan zazzabin cizon sauro, tsananin zafin jiki, saurin asara mai nauyi da kuma rashin ruwa a cikin marassa lafiya a cikin rukunin ‘yan shekaru 65 da haihuwa Ya kamata a gudanar da aikin salulap kawai a karkashin kulawar ma'aikatan lafiya. A farkon alamar zawo ko zazzaɓi, ana buƙatar magani na gaggawa nan da nan.
Ya kamata a gudanar da aikin salulap kawai a karkashin kulawar ma'aikatan lafiya.
Aiki yara
An kiyaye lafiyar Zaltrap a cikin yara.
Yi amfani da lokacin daukar ciki da lactation
Ba a samun bayanai kan amfani da Zaltrap a cikin mata masu juna biyu da masu shayarwa ba. Ganin irin yiwuwar haɗarin haɗari na lalacewar yarinyar, ba a ba da magani ga maganin antitumor don waɗannan nau'ikan marasa lafiya. Babu wani bayani kan ko bangaren maganin zai shiga cikin madarar nono. Idan ya cancanta, yi amfani da magani wajen warkar da kansa a cikin wata mace mai shayarwa, dole ne a soke aikin tiyata.
Aikace-aikacen aiki mara kyau
An ba da damar amfani da Zaltrap a cikin marasa lafiya tare da gazawar sassaucin sassauci da matsakaici. Babu wani bayani game da amfani da miyagun ƙwayoyi a cikin marasa lafiya tare da raunin matsanancin rauni.
Amfani don aikin hanta mai rauni
Babu bayanai game da amfani da miyagun ƙwayoyi a cikin marasa lafiya da mummunar raunin hepatic. An ba da izinin kula da marasa lafiya tare da gazawar hanta mai ƙarfi, amma tare da tsananin taka tsantsan kuma a ƙarƙashin kulawa na likita, an yarda.
An ba da izinin maganin marasa lafiya tare da gazawar hanta mai ƙarfi.
Yawan yawan adadin Zaltrap
Babu wani bayani game da yadda maganin miyagun ƙwayoyi ya wuce 7 mg / kg ana gudanar dashi sau ɗaya a cikin kowane 14 na rana ko 9 mg / kg sau ɗaya a cikin kowane kwanakin 21 yana shafi jiki.
Za a iya bayyana yawan yawan zubar da jini ta hanyar hauhawar girman bayyanar cututtuka. Jiyya - lura da kulawa, kulawa akai-akai game da karfin jini. Babu maganin rigakafi.
Yin hulɗa tare da wasu kwayoyi
Gudanar da karatun pharmacokinetic da bincike na kwatancen ba su nuna ma'amala da maganin Zaltrap tare da wasu magunguna ba.
Amfani da barasa
Ba a haramta shan giya yayin farwa ba.
Analogs
Shirye-shirye tare da irin rawar gani na aikin: Agrelide, Bortezovista, Vizirin, Irinotecan, Namibor, Ertikan.
Irinotecan magani ne mai irin wannan rawar.
Magunguna kan bar sharuɗan
Kawai ta hanyar samar da takardar sayan magani daga likita.
Zan iya saya ba tare da takardar sayan magani ba?
An cire tallace-tallace na OTC.
Farashi
Daga 8500 rub. kowace kwalba
Yanayin ajiya na miyagun ƙwayoyi
A yanayin zafin jiki daga +2 zuwa + 8 ° C.
Ranar karewa
Shekaru 3 An cigaba da amfani da miyagun ƙwayoyi.
Mai masana'anta
Sanofi-Aventis Deutschland GmbH, Jamus.
Nasiha
Ksenia, mai shekara 55, Moscow: "An wajabta wa mahaifina Zaltrap maganin cutar kansa. Magungunan yana da kyau, yana da tasiri, amma yana da matuƙar rauni. Yana da kyau koyaushe yana da kyau ana amfani da shi sau ɗaya a kowane mako 2, saboda bayan maganin ƙwaƙwalwar ƙwayar cuta mahaifin mahaifinsa koyaushe ne na ɗan lokaci. ya kara dagulewa, amma binciken da aka gudanar ya nuna ingantacciyar hanyar rage cutar neoplasm. "
Eugene, mai shekara 38, Astana: “Na ji wasu sakamako masu illa daga Zaltrap. Na kasance cikin mummunan yanayi: tashin zuciya, amai, ciwon kai kullun, rauni mai rauni .. Amma maganin yana aiki da warin cikin hanzari. Sakamakon amfani da shi wajen magance cutar kansa ya cancanci mu tsira daga wannan azaba. "
Alina, ɗan shekara 49, Kemerovo: "Wannan magani ne mai tsada, kuma bana jin kamar in zauna tare dashi bayan maganin cutar sankara. Amma yana da tasiri .. A cikin hanya ta 1, kusan cutar ta warke .. Likita ya ce akwai damar sake dawowa, amma ƙaramin Kafin Zaltrap, an yi amfani da wasu magunguna, amma tasirin yana da gajeru, kuma bayan hakan na kasance tsawon shekaru 3 ban da alamun cutar kansa. "
