Atorvastatin C3 magani ne wanda aka tsara don sarrafa matakan lipid.
Sunan kasa da kasa mai zaman kansa
Atorvastatin.
Atorvastatin C3 magani ne wanda aka tsara don sarrafa matakan lipid.
ATX
ATX - C10AA05.
Saki siffofin da abun da ke ciki
Ana amfani da miyagun ƙwayoyi a cikin nau'ikan allunan da aka rufe fim. Kowane kwamfutar hannu ta ƙunshi 10 mg, 20 MG, 40 MG ko 80 MG na kayan aiki mai aiki. Abubuwan da ke aiki da maganin shine atorvastatin.
Allunan suna ruwan hoda a launi kuma suna da zagaye, siffar biconvex. Asalin farin
Aikin magunguna
A miyagun ƙwayoyi yana da sakamako mai hana abubuwa aiki akan abubuwan da ke tattare da steroids da cholesterol. Ingancin aiki mai aiki yana da asalin halitta. Hiban wasa ne mai hanawa na enzyme HMG-CoA reductase, wanda ke taka muhimmiyar rawa a cikin haɗin mevalonate - wani abu wanda ya zama dole don haɓakar cholesterol.
Kayan aiki yana ba ku damar rage ƙwayar cholesterol, LDL, triglycerides a cikin mutanen da ke fama da cututtukan homo- ko heterozygous familial hypercholesterolemia. Hakanan yana ba ku damar ƙara matakan babban lipoproteins mai yawa, waɗanda ke da amfani ga jiki.
Kayan aiki yana ba ka damar rage cholesterol, LDL, triglycerides a cikin mutanen da ke fama da cutar heterozygous familial hypercholesterolemia.
Atorvastatin ba wai kawai yana hana ayyukan enzyme da ke tattare da tasirin cholesterol bane, amma yana taimakawa kawar da ƙarshen. Ana samun wannan ta hanyar ƙaruwa da adadin masu karɓa na wayar salula waɗanda ke daure da ƙarancin lipoproteins da yawa kuma suna samar da ƙarin kariyar sunadarai
Atorvastatin yana haifar da canji a cikin rabo na tsoka da ƙarancin yawa na lipoproteins ta hanyar hana samar da ƙarshen, amfanin su, har ma da canji mai kyau a cikin barbashi kansu. Kayan aiki yana da tasiri a cikin lokuta inda lokacin shan wasu magungunan rage ƙwayar lipid, matakin LDL baya raguwa.
A ƙarƙashin tasirin atorvastatin, yawan ƙwayar cholesterol a cikin jini ya ragu zuwa 50%, LDL zuwa 60%, apolipoprotein-B zuwa 50%, triglycerides zuwa 30%. Bayanan da aka samo yayin gwajin magungunan sun kasance kusan iri ɗaya ne a cikin mutanen da ke fama da cututtukan gado da rashin gado na hypercholesterolemia, cakuda hyperlipidemia da cututtukan da ba sa da insulin.
Karkashin tasirin atorvastatin, al'adun rheological jini suna inganta ta hanyar rage gani. Ana lura da raguwa a cikin aikin adhesion na platelet da wasu abubuwa na tsarin coagulation. Magungunan yana shafar ayyukan macrophages, yana hana rugujewar filayen atherosclerotic, wanda zai iya faruwa tare da halartar su.
Karkashin tasirin atorvastatin, al'adun rheological jini suna inganta ta hanyar rage gani.
Kayan aiki yana ba ku damar rage haɗarin mace-mace saboda ischemia na nama da kashi 15% yayin ɗaukar kashi 80 na MG. Matsakaicin raguwa a cikin abubuwan ƙarancin lipoproteins mai yawa a cikin jini ya dogara ne akan allurai da aka cinye.
Pharmacokinetics
Aiki mai guba na miyagun ƙwayoyi, lokacin da aka sha shi a baki, yana motsa jiki ta hanjin ƙwaƙwalwar ƙwayar jijiyoyin. Matsakaicin mafi girman tasiri na abubuwan aiki mai aiki a cikin plasma ana lura da shi minti 60-120 bayan gudanarwa. A cikin marassa lafiyar mata, abun da ke cikin atorvastatin a cikin jini shine kashi 1/5 ya fi na maza. Yawan magungunan ƙwayoyi suna karuwa sosai, ƙwayar plasma ta dogara da adadin ƙwayoyi masu cinyewa.
Jimlar bioavailability na kayan aiki mai aiki shine 15%. Kimanin kashi 30% na kashi da aka ɗauka gasa yana hana rage girman HMG-CoA. Matsayi na bioavailability na atorvastatin yana faruwa ne saboda canje-canje na rayuwa wanda aka fallasa abu a cikin mucosa na hanji da kuma jijiyar hepatobiliary. Lokacin cin abinci, za a rage gudu da kuma gwargwadon ƙwayar abu mai aiki.
Lokacin da ya shiga cikin jini zuwa jini, ƙwayar ƙwayar cuta kusan an ɗaura ta don ɗaukar peptides. Abubuwan da ke aiki a cikin ƙananan sun ratsa ta cikin membranes na sel jini.
Matsayin bioavailability na miyagun ƙwayoyi yana faruwa ne saboda canje-canje na rayuwa wanda aka fallasa shi a cikin mucosa na hanji.
A yayin juzuwar metabolism na atorvastatin, abubuwa biyu ke kasancewa. Ayyukan metabolites yana daidai da na kayan farawa. Kusan kashi 70% na sakamakon maganin an bayar dashi ne saboda ayyukan metabolites.
Canjin sinadarai na atorvastatin a cikin hepatobiliary fili yana faruwa a ƙarƙashin ikon CYP3A4 isoenzyme. Abubuwan da ke aiki na miyagun ƙwayoyi zuwa wasu matakan yana hana aikinta.
Drawato da miyagun ƙwayoyi yakan faru ne tare da kwararar bile. Rabin-rayuwar kadan ne awanni 12. Tasirin warkewar atorvastatin yana kusan kwana guda.
Alamu don amfani
Alamu masu amfani da wannan kayan aikin sune:
- familial da rashin familial hypercholesterolemia;
- hadewar hyperlipidemia;
- cututtukan da ke hade da rashin daidaituwa na cin amana;
- maganin haihuwar jini.
Ana amfani da Atorvastatin a matsayin magani don rigakafin cututtuka na tsarin zuciya. Hakanan ana amfani dashi don hana rikicewar sakandare a cikin marasa lafiya da cututtukan zuciya. Yana taimakawa rage haɗarin mace-mace a cikin marasa lafiya na wannan rukunin.
Contraindications
Contraindications wa alƙawarin wannan kayan aikin sune:
- daidaikun mutane game da aiki mai aiki da sauran abubuwan da aka gyara;
- pathologies na hepatobiliary fili, tare da karuwa a matakin hanta transaminases a cikin jini;
- shekarun yara;
- take hakkin sha daga cikin lactose;
- rashin hankali ga kayayyakin soya;
- lokacin ciki da lactation.
Tare da kulawa
Ya kamata a lura da kulawa ta musamman a lokacin jiyya a cikin marasa lafiya da gazawar hanta. Abinda ke da alaƙa shi ne shan giya, tunda shan giya na iya zama sanadin bayyanuwar cututtukan cututtukan hepatobiliary.
Atorvastatin ba da shawarar ga mutanen da suke da waɗannan matsalolin ba:
- hargitsi a cikin daidaituwar abubuwan lantarki;
- hawan jini;
- cuta cuta na rayuwa;
- septicemia;
- karancin jini;
- Ciwon sukari;
- epilepsy;
- kwanan nan tiyata.
Yadda ake ɗaukar Atorvastatin C3
Ana ɗaukar maganin a baka, ba tare da la'akari da lokaci na rana ba. Ana yin maganin Atorvastatin bayan an yi ƙoƙari don sarrafa matakan cholesterol ta amfani da abinci na musamman. Idan ba shi da inganci, ban da hana abinci, mai haƙuri ya kamata ya ɗauki wannan magani.
Ana ɗaukar allunan Atorvastatin C3 sau ɗaya a rana.
Lokacin zabar mutum kowane sashi na yau da kullun, ana la'akari da tsananin cutar. Kamar yadda zai yiwu, za a iya tsara 80 MG na miyagun ƙwayoyi kowace rana. Ana ɗaukar allunan sau ɗaya a rana.
Zaɓin sashin da ake buƙata galibi yana farawa tare da zaɓin ƙarancin mitar 10 mg. Bayan haka, kowane rabin wata ko wata daya, mara lafiya ya kamata ya yi nazari don abubuwan da ke cikin lipids a cikin magudanar jini. Dogaro da tasiri na jiyya, sashi zai karu ko ya kasance daidai da matakin.
Tare da ciwon sukari
Tsarin matakan lipid a cikin mutane masu ciwon sukari yana faruwa kamar yadda yake a cikin marasa lafiya ba tare da wannan ilimin ba. A yayin jiyya, ya kamata a sa ido kan matakan sukari na jini lokaci-lokaci dangane da yiwuwar canji.
Side effects
Gastrointestinal fili
Zai iya amsawa ga warkewa tare da tasirin masu zuwa:
- narkewa cikin fushi;
- bloating;
- zafin epigastric;
- hyperactivation na enzymes hepatic;
- jaundice
- kumburin koda;
- tashin zuciya
- amai
Shan Atorvastatin C3 na iya haifar da zubar jini.
Tsarin juyayi na tsakiya
Zai iya amsawa ga jiyya ta hanyar bayyanar:
- ciwon kai;
- rashin damuwa;
- vertigo;
- paresthesia;
- asarar ƙwaƙwalwar ɗan lokaci;
- tinnitus;
- zub da jini daga kogon hanci.
Daga tsarin numfashi
Akwai yiwuwar jin kirji.
A ɓangaren fata
Zai iya bayyana:
- itching
- rashes;
- asarar gashi
- bullae;
- jan fata.
A wasu halayen, magani yana haifar da jan fata.
Daga tsarin kare jini
Wadannan alamu na iya faruwa:
- rage libido;
- na gazawar.
Daga tsarin zuciya
Wadannan m halayen na iya faruwa:
- karuwar zuciya;
- kari rudani;
- na kusa da jijiyoyin jiki;
- phlebitis;
- raguwa ko karuwa a hawan jini.
Daga tsarin musculoskeletal
Zai iya bayyana:
- ciwon tsoka
- hadin gwiwa zafi
- katsewa
- jijiyar lalacewa.
Atorvastatin C3 kuma na iya haifar da ciwon tsoka.
Cutar Al'aura
Bayyanar bayyanar:
- halayen anaphylactic;
- necrolysis mai guba.
Umarni na musamman
Yayin jiyya tare da atorvastatin, ana lura da sakamako akan ƙwayar tsoka. Wannan gaskiyar tana buƙatar saka idanu akan matakin creatine phosphokinase. Idan alamun myopathy sun bayyana, dakatar da shan magani. Mai haƙuri yakamata ya nemi likita nan da nan idan akwai jin zafi a cikin tsokoki ko rauni na tsoka.
Amfani da barasa
Ba'a ba da shawarar a haɗa amfani da Atorvastatin tare da amfani da giya ba.
Tasiri kan ikon sarrafa abubuwan inji
Idan akwai haɗari mara kyau daga tsarin mai juyayi, yakamata ku iyakance lokacin da kuka ɓata a bayan dabarar saboda dalilai na aminci.
Idan mummunan halayen daga tsarin juyayi ya faru, ya kamata a iyakance ikon kula da sufuri.
Yi amfani da lokacin daukar ciki da lactation
Ba a sanya Atorvastatin don wannan rukuni na marasa lafiya ba saboda yuwuwar haɗari ga lafiyar yaro.
Adana Atorvastatin C3 ga yara
Magungunan an yi shi ne domin kula da mutanen da shekarunsu suka wuce 18.
Yi amfani da tsufa
Idan babu contraindications ko ƙuntatawa don amfani a cikin tsofaffi marasa lafiya, ana aiwatar da ilimin a cikin daidaitaccen hanya.
Aikace-aikacen aiki mara kyau
Kodan ba sa shiga cikin metabolism ko excretion (har zuwa 2%) na kayan aiki.
Amfani don aikin hanta mai rauni
Ya kamata a gudanar da kulawa da marasa lafiya tare da daskararwa na koda tare da saka idanu akan matakin enzymes na hanta. Ya danganta da matakin aikinsu, an tsara matakan sashi na miyagun ƙwayoyi.
Kodan baya shiga cikin metabolism ko excretion na miyagun ƙwayoyi.
Yawan damuwa
Idan akwai batun yawan ƙwayar cuta ta atorvastatin, nemi likita. An dakatar da bayyanar cututtuka ta hanyar gabatarwar diuretics, magungunan lantarki. Ba a zartar da cutar sankara ba. A cikin lokuta masu tsanani, ya zama dole don saka idanu kan mahimmancin ayyukan haƙuri.
Yin hulɗa tare da wasu kwayoyi
Amfani da haɗin gwiwa tare da phenazone ba a hade tare da canji a cikin kayan aikin magunguna na wakilan biyu ba.
Yin amfani da antacids a lokaci guda yana haifar da rage yawan abubuwan atorvastatin a cikin jini. Wannan shi ne saboda rashin kyawun sashi mai amfani.
Magunguna waɗanda ke haɓaka ayyukan CYP3A4 isoenzyme suna rage yawan wannan magani a cikin jini na jini. Rifampicin yana da tasiri mai dual akan enzymes na koda, saboda haka ba zai shafi kantin magani na maganin ba.
Gudanar da lokaci-lokaci na Atorvastatin da Cyclosporine na iya kara haɗarin cututtukan tsoka.
Amfani da ciki tare da digoxin a cikin ƙananan matakan ba ya canza kaddarorin magungunan. A iyakar adadin yau da kullun na atorvastatin, ƙaruwa 1/5 a cikin ƙwayoyin narkewa na plasma yana yiwuwa.
Cyclosporine na iya ƙara haɗarin ƙwaƙwalwar tsoka.
Babu wata ma'amala mai mahimmanci ta hanyar magani tare da terfenadine da aka lura.
Analogs
Wadanda zasu maye gurbin wadannan magunguna:
- Atoris;
- Atorvastatin Teva;
- Rosuvastatin;
- Liprimar;
- Tulip
Ta yaya Atorvastatin C3 ya bambanta da Atorvastatin?
Tasirin waɗannan kwayoyi iri ɗaya ne.
Yanayin hutu Atorvastatin C3 daga magunguna
Dangane da takardar likita.
Zan iya siye ba tare da takardar sayan magani ba
A'a.
Farashi
Ya dogara da wurin siye.
Yanayin ajiya na miyagun ƙwayoyi
Dole ne a adana shi a cikin wuri mai duhu a zazzabi wanda bai wuce +25 ° C ba.
Ranar karewa
Ya dace da amfani da shekaru 3.
Kamfanin Atorvastatin C3
CJSC "Arewa Star".
Ya kamata a adana maganin a cikin wani wuri mai duhu a zazzabi da bai wuce +25 ° C ba.
Neman bita akan Atorvastatin C3
Likitoci
Gennady Ishchenko, likitan zuciya, Moscow
Atorvastatin magani ne wanda ba ku damar iya sarrafa matakin lipids a wasu cututtuka. An wajabta shi duka biyu ga mutanen da ke da ƙwaƙwalwar ƙwaƙwalwar ƙwayar cuta ta plasma na cholesterol da sauran mai, da kuma ga marasa lafiya waɗanda suka sami wannan ilimin.
Kayan aiki yana ba da izinin hana rikice-rikice na zuciya da jijiyoyin jini. A haɗuwa tare da tsarin abincin da ya dace, marasa lafiya na iya kula da madaidaicin nauyin jikin su kuma jagoranci rayuwar da kuka saba ba tare da damuwa game da matsalolin zuciya ba.
Larisa Oleshchuk, Likita, Ufa
Wannan kayan aiki yana ba wa mutane da ke fama da cututtukan hypercholesterolemia damar samun rayuwa ta al'ada. Na wajabta atorvastatin ba kawai a gare su ba, har ma da sauran marasa lafiya waɗanda ke da haɗarin haɗari na adana atherosclerotic da kuma cututtukan da ke rakiyar su.
Ba na ba da shawarar siyar da maganin a kanku a kantin magani ba. Jiyya yana buƙatar zaɓin daidai na sashi na yau da kullun da saka idanu na lokaci-lokaci na matakin hepatic transaminases. Idan ba'a bi shi ba, magani na iya haifar da sakamako masu illa.
Marasa lafiya
Andrey, dan shekara 48, St. Petersburg
Kyakkyawan magani. A haɗe tare da abinci na musamman, yana taimakawa ci gaba da matakan cholesterol tsakanin iyakoki na al'ada. Na dauke shi kamar yadda likitan ya umurce ni, na wuce dukkan gwaje-gwaje kan lokaci. Zuwa yanzu, babu korafi da suka taso. Idan kun yi komai kamar yadda aka bayyana a cikin umarnin don amfani, to babu matsala a lokacin jiyya. Kada ku sami magungunan kai a kowane hali. Kulawa ta likita koyaushe shine mabuɗin maganin lafiya.
Alisabatu, shekara 55, Perm
Na yi ƙoƙari in ɗauki atorvastatin. Farfesa din yayi tsawon sati biyu. Sai ta fara lura da rauni a cikin tsokoki, raɗaɗi ya bayyana. Da farko ban haɗu da wani mahimmanci ba game da wannan, amma lokacin da alamun suka tsananta, sai na tafi likita. Sunyi duk gwaje-gwajen da suka dace kuma sun sanya su a asibiti. An dakatar da shan maganin.
Don haka ba wai kawai ban murmure ba, har ma kusan rasa sauran lafiyar na. Yi hankali da wannan ƙwayar kuma nemi ƙwararren likita wanda zai kula da kai sosai yayin aikin jiyya.
Daniyel, ɗan shekara 29, Omsk
Na sha wahala daga yanayin gado na hypercholesterolemia. Ya kamata a rage yawan abubuwan rage kiba a cikin jini. Ina yin wannan da kwayoyi kamar Atorvastatin. Marufi ba shi da tsada sosai idan aka kwatanta shi da takwarorinsu na ƙasashen waje, amma tasirin hakan ɗaya ne. Zan iya bayar da shawarar wannan kayan aiki ga duk mutanen da suka ci karo da irin wannan cuta. Idan ana bi da ku bisa shawarar likita, zaku iya rayuwa cikakke.
