Hypoglycemic magani Invokana - sakamako akan jiki, umarnin don amfani

Invokana shine sunan kasuwanci don maganin da aka kawo don rage ƙwanƙwasa jini.

Kayan aikin an tsara shi ne ga marasa lafiya da ke fama da ciwon sukari na II. Magungunan suna da tasiri duka biyu a cikin tsarin maganin monotherapy, kuma a hade tare da sauran hanyoyin magance cutar sukari.

Bayani na gaba ɗaya, abun da ya shafi da kuma sakin saki

Invocana magani ne mai tasirin cutar hypoglycemic. Samfurin an yi nufin sarrafa shi ne na baka. An yi amfani da Invokana cikin nasara a cikin marasa lafiya da ke fama da ciwon sukari na II.

Magungunan yana da rayuwar shiryayye na shekaru biyu. Adana kwayoyi a zazzabi da bai wuce 30 ba⁰C.

Wanda ya samar da wannan magani shine Janssen-Ortho, wani kamfanin dake Puerto Rico. Samfurin yana yin ne daga kamfanin Janssen-Silag da ke Italiya. Mai riƙe haƙƙin wannan magani shine Johnson & Johnson.

Babban bangaren maganin shine Canagliflozin hemihydrate. A cikin kwamfutar hannu guda na Invokana, akwai kimanin 306 MG na wannan kayan aiki.

Bugu da ƙari, 18 MG na hyprolose da anhydrous lactose (kusan 117.78 MG) suna cikin abubuwan da ke cikin allunan magungunan. A cikin kwakwalwar kwamfutar hannu akwai kuma magnesium stearate (4.44 mg), microcrystalline cellulose (117.78 mg) da kuma sodium croscarmellose (kimanin 36 mg).

Harshen samfurin ya ƙunshi fim, wanda ya ƙunshi:

• macrogol;
• talc;
• barasa na polyvinyl;
• titanium dioxide.

Invokana yana samuwa a cikin nau'ikan allunan 100 da 300 MG. A kan allunan na 300 MG, harsashi mai launin fari yana kasancewa; akan allunan 100 MG, harsashi mai launin rawaya. A kowane nau'in allunan guda biyu, a gefe guda akwai "CFZ" mai zane, kuma a bango akwai lambobi 100 ko 300 dangane da nauyin kwamfutar hannu.

Ana samun maganin ta hanyar murhun. Blaya daga cikin kumburi ya ƙunshi Allunan 10. Packaya daga cikin fakitin zai iya ƙunsar ƙarfe 1, 3, 9, 10.

Aikin magunguna

Canagliflozin a matsayin babban bangaren magunguna yana rage reabsorption (reabsorption) na glucose. Sakamakon wannan, tocikinta da kodan yana ƙaruwa.

Sakamakon sake farfadowa, raguwa mai yawa a cikin adadin glucose a cikin jinin mai haƙuri yana faruwa. Tare da janyewar glucose, sakamako na diuretic yana faruwa. Sakamakon wannan, saukar karfin jini na systolic.

Canagliflozin yana ba da gudummawa ga asarar kalori. Ana iya amfani da Invokana azaman ƙwayar asarar nauyi. A sashi na 300 MG, yana ba da gudummawa ga ingantacciyar raguwa a cikin adadin glucose a cikin jini fiye da kashi 100 na MG. Amfani da Canagliflozin baya haifar da mummunan tasirin glucose.

Magani na taimaka wajan rage ƙwanƙwaran ƙarancin glucose. Lokacin shan magani, ƙwayar glucose ta hanta tana haɓaka. A yayin cinikin Invokana tsawon lokaci, an lura da raguwar adadin glucose a cikin jini.

Azumi yana taimakawa jinkiri don karɓar glucose a cikin hanjin. A cikin karatun, ya zama cewa matakin sukari na jini lokacin shan magunguna kafin da bayan abinci ya sha bamban. Azumi glycemia lokacin cinye 100 MG na miyagun ƙwayoyi ya canza zuwa -1.9 mmol / L, kuma lokacin ɗaukar 300 mg zuwa -2.4 mmol / L.

Bayan sa'o'i 2 bayan cin abinci, matakin sukari na jini ya canza daga -2.7 mmol / L lokacin cin 100 MG kuma daga -3.5 mmol / L lokacin shan 300 MG na magani.

Amfani da Canagliflozin yana inganta aikin β-cell.

Pharmacokinetics

Canagliflozin yana da halin ɗanɗano mai sauri. Magungunan magunguna na abu ba su da bambance-bambance lokacin da mutum mai lafiya ya ɗauke shi, ko kuma lokacin da mutumin da ke fama da ciwon sukari na II ya ɗauke shi.

Matsakaicin matakin Kanagliflosin an lura dashi bayan 1 awa bayan ɗaukar Invokana. Rabin rayuwar miyagun ƙwayoyi shine awowi 10.6 lokacin amfani da 100 MG na miyagun ƙwayoyi da awanni 13.1 lokacin ɗaukar 300 mg na miyagun ƙwayoyi.

A bioavailability na miyagun ƙwayoyi shine 65%. Ana iya ɗaukar shi kafin da bayan abinci, amma don mafi kyawun sakamako, ana bada shawara don shan maganin kafin abincin farko.

Canagliflozin an yadu cikin kasusuwa. Abubuwan suna da alaƙa da sunadarai na jini. Adadin shine kashi 99%. Maganin yana aiki musamman ga ɗaure zuwa ga albumin.

Kanagliflosin yana da ƙarancin tsarkakar tsarkakewar kashin jikin mutum daga gare shi. Tsarkake kodan daga abu (keɓaɓɓe koda) shine 1.55 ml / min. Matsakaicin adadin kuzarin tsarkake jikin daga Canagliflozin shine 192 ml / min.

Manuniya da contraindications

An wajabta maganin ga marasa lafiya da masu fama da cutar siga ta II.

Za a iya amfani da maganin:

• a matsayin mai zaman kanta da hanyar kawai ta magance cutar;
• a hade tare da sauran magunguna masu rage sukari da insulin.

Daga cikin abubuwan da ake amfani da su don yin amfani da su, masu ba da shawara sun fito daga:

• mai rauni na koda.
• rashin haƙuri Canagliflozin da sauran abubuwan haɗin maganin;
• rashin daidaituwa tsakanin lactose;
• shekaru har zuwa shekaru 18;
• rauni mai yawa na hanta;
• nau'in ciwon sukari;
• rashin lafiyar zuciya (wucin gadi 3-4);
• shayarwa;
• mai ciwon sukari mai ciwon sukari;
• ciki

Umarnin don amfani

Yayin rana, an yarda da kwamfutar hannu 1 na maganin (100 ko 300 MG). An bada shawara don shan miyagun ƙwayoyi da safe kuma a kan komai a ciki.

Lokacin amfani da miyagun ƙwayoyi tare da sauran wakilai na hypoglycemic da insulin, ana bada shawara don rage sashi na ƙarshen don hana faruwar cututtukan hypoglycemia.

Tun da canagliflozin yana da tasiri mai ƙarfi na diuretic, sashi na miyagun ƙwayoyi ga marasa lafiya da ke fama da rauni na aikin koda, da kuma mutanen da suka haura shekaru 75, ya kamata su zama 100 MG sau ɗaya.

Marasa lafiya tare da haƙuri mai kyau ga canagliflozin ana bada shawara don ɗaukar 300 mg na miyagun ƙwayoyi sau ɗaya a rana.

Skiyen maganin ba a so. Idan wannan ya faru, dole ne a sha magani nan da nan. Ba a ba da izinin amfani da kashi biyu na magani ba yayin rana.

Marasa lafiya na musamman da kuma Jagorori

Invokana yana contraindicated a cikin mata masu juna biyu da yara a karkashin 18 shekara. Bai kamata a sha miyagun ƙwayoyi ta hanyar shayar da mata ba, tunda Canagliflozin ya shiga cikin ƙwayar nono kuma yana iya cutar lafiyar lafiyar jariri.

Ana amfani dashi tare da taka tsantsan daga mutane sama da 75 shekara. An wajabta musu mafi ƙarancin maganin.

Ba da shawarar yin ba da magani ga marasa lafiya ba:

• tare da nakasa aikin kodan wani babban mataki;
• tare da gazawar koda na kasada a matakin karshe na karshe;
• ana fuskantar dialysis.

Ana ɗaukar maganin tare da taka tsantsan a cikin mutanen da ke fama da gazawar koda. A wannan yanayin, ana shan maganin a cikin mafi ƙarancin kashi - 100 MG sau ɗaya a rana. Tare da gazawar matsakaita matsakaici, ana kuma samar da mafi yawan adadin magunguna.

Haramun ne a sha magani a cikin marassa lafiya da ke dauke da cututtukan sukari na 1 na mellitus da ketoacidosis masu ciwon sukari. Sakamakon warkewa mai mahimmanci daga shan miyagun ƙwayoyi a matakin ƙarshe na lalacewa na koda na ainihi ba za a lura ba.

Invokana bashi da maganin cutar sankara da mutagenic akan jikin mai haƙuri. Babu wani bayani game da tasirin miyagun ƙwayoyi kan aikin haifuwar mutum.

Tare da haɗuwa da magani tare da magunguna da sauran wakilai na hypoglycemic, ana bada shawara don rage sashi na ƙarshen don hana hypoglycemia.

Rage girman ƙwayar cikin jijiya yana faruwa sau da yawa a farkon watanni da rabi daga farkon jiyya tare da Invocana.

Neman maganin yana da buqatar saboda yiwuwar abubuwan da suka faru:

• candidiasis na vulvovaginal a cikin mata;
• candida balanitis a cikin maza.

Fiye da 2% na mata da 0.9% na maza sun sake kamuwa da cuta yayin shan maganin. Yawancin lokuta na vulvovaginitis sun bayyana a cikin mata a cikin makonni 16 na farko daga farawa tare da Invocana.

Akwai shaidu game da tasirin maganin a kan ma'adinan ƙasusuwa na ƙasusuwa a cikin mutanen da ke fama da cutar zuciya. Magungunan yana da ikon rage ƙarfin kashi, haifar da haɗarin fashewa a cikin ƙungiyar marasa lafiya da aka ƙayyade. Ana buƙatar magani mai mahimmanci.

Sakamakon babban haɗarin haɓakar ƙwararrakin ƙwayar cuta tare da haɗuwa da magani na Invokana da insulin, ana bada shawarar guji tuki.

Side effects da yawan abin sama da ya kamata

Daga cikin illolin sakamako daga shan magungunan sune:

• jin ƙishirwa;
• raguwa a cikin jijiya na ciki a cikin nau'i na rashin ruwa, bushewar jiki, rage karfin jini, kasawa;
• candidiasis na vulvovaginal a cikin mata;
• maƙarƙashiya;
• polyuria;
• tashin zuciya
• urticaria;
• bushe bakin
• balanitis, balanoposthitis a cikin maza;
• cystitis, cututtukan koda;
• hypoglycemia tare da haɗin gwiwa tare da insulin;
• haɓaka matakin haemoglobin;
• ƙananan matakan uric acid;
• mai ciwon sukari mai ciwon sukari;
• rage karfin kashi;
• ƙara matakan potassium mai;
• karuwa a cikin cholesterol a cikin jini.

A cikin lokuta mafi ƙarancin shan wahala, shan magunguna ya haifar da gaɓar koda, tashin hankalin anaphylactic, da angioedema.

Babu wasu maganganun yawan yawan shan ruwa fiye da wannan magani. Kashi na 1600 MG ya samu nasarar jurewa ta mutane masu lafiya da kashi 600 na mgn kowace rana ga mutanen da ke dauke da ciwon sukari na 2.

Idan ya wuce kima, ana gudanar da aikin ta, kuma ana kula da mara lafiyar. Dialysis idan akwai yawan abin sama da ya kamata ba shi da amfani.

Yin hulɗa tare da wasu magunguna da analogues

Aiki abu na miyagun ƙwayoyi ne dan kadan mai saukin kamuwa zuwa oxidative metabolism. A saboda wannan dalili, tasirin wasu kwayoyi akan aikin canagliflozin yana da ƙarancin ƙarfi.

Magungunan yana hulɗa da magungunan masu zuwa:

• Phenobarbital, Rifampicin, Ritonavir - raguwa a cikin tasiri na Invokana, karuwa a cikin kashi ya zama dole;
• Probenecid - rashi babban tasiri akan tasirin maganin;
• Cyclosporin - rashi babban tasiri akan maganin;
• Metformin, Warfarin, Paracetamol - babu wani tasiri mai tasiri akan magungunan likitancin canagliflozin;
• Digoxin shine ɗan haɗin gwiwa wanda ke buƙatar saka idanu akan yanayin haƙuri.

Magunguna masu zuwa suna da sakamako iri ɗaya kamar Invokana:

• Glucobay;
• NovoNorm;
• Jardins;
• Glibomet;
• Piroglar;
• Guarem;
• Victoza;
• Glucophage;
• Methamine;
• Formmetin;
• Glibenclamide;
• Glurenorm;
• Glidiab;
• Glykinorm;
• Glimed;
• Trazenta;
• Galvus;
• Glutazone

Mai haƙuri ra'ayi

Daga bita daga masu ciwon sukari game da Invokan, zamu iya yanke hukuncin cewa miyagun ƙwayoyi suna rage sukarin jini sosai kuma tasirin sakamako yana da ɗanɗano, amma akwai babban farashi ga maganin, wanda ke tilasta mutane da yawa su canza zuwa magungunan analog.

Likita na halarta ya umurce ni da wani kwadagon domin na kamu da ciwon sukari na 2. Pretty tasiri magani. Kadancin sakamako. Ban lura da wani abin mamaki ba a tsawon lokacin magani. Daga cikin minuses, Ina so in lura da babban farashin sa.

Tatyana, shekara 52

Likita ya ba da shawarar maganin don ciwon sukari na Invokan. Kayan aiki ya tabbatar da inganci. An lura da rage yawan sukari na jini. Akwai wasu sakamako masu illa a cikin nau'in karamin hanji, amma bayan gyaran kashi, komai ya tafi. Rashin kyau shine babban farashin. Akwai ƙarin ƙarin analogues samuwa.

Alexandra, 63

Na daɗe ina fama da ciwon sukari kuma na yanke shawarar canzawa zuwa Invocana. Kayan aiki mai tsada, ba kowa bane zai iya wadatar shi. A kan inganci ba sharri. Na yi farin ciki da ƙananan adadin contraindications da sakamako masu illa idan aka kwatanta da sauran magunguna masu ciwon sukari.

Oleg, mai shekara 48

Abubuwan bidiyo akan nau'ikan, alamu da magani na ciwon sukari:

Kudin magungunan a cikin kantin magunguna sun kama daga 2000-4900 rubles. Farashin analogues na miyagun ƙwayoyi shine 50-4000 rubles.

Ana bayar da samfurin ne kawai ta takardar sayen magani na ƙwararrun likitoci.