Hanyar warkewa don ciwon sukari na 2 ya haɗa da gudanar da magunguna na hypoglycemic na ƙungiyoyi daban-daban.
Waɗannan sun haɗa da abubuwan samo asali na sulfonylurea.
Daya daga cikin wakilan wannan rukunin shine chlorpopamide.
Babban bayani game da miyagun ƙwayoyi
Chlorpropamide shine abu mai aiki wanda ya kasance na asalin ƙarni na abubuwan da suka samo asali na sulfonylurea. Groupungiyar likitancinta shine wakilai na haɓakar ƙwayar cuta. Chlorpropamide ba mai narkewa bane a cikin ruwa, amma, akasin haka, yana narkewa a cikin giya.
Ba kamar sauran ƙarni na abubuwan da suka samo asali na sulfonylurea ba, chlorpropamide yana yin a takaice. Don cimma daidaitaccen matakin glycemia, ana amfani dashi a cikin manyan allurai.
Abubuwan da ke haifar da shan magani sun kasance mafi ma'ana idan aka kwatanta da Glibenclamide da sauran wakilan ƙarni na 2. Inganci tare da isasshen samar da kwayoyin halittar (insulin) da raguwar saukin kamuwa da shi. Jiyya tare da chlorpropamide yana da tasiri a cikin marasa lafiya da ciwon insipidus masu ciwon sukari da / ko tare da ciwon sukari na 2.
Chlorpropamide shine asalin halittar sunan magani. Yana samar da tushen maganin (sashi mai aiki ne). Akwai shi a allunan.
Aikin magunguna
Magungunan suna da tasirin hypoglycemic. Abubuwan da ke ɗaure zuwa tashoshi na potassium, yana ƙarfafa ɓoye insulin. A cikin kasusuwa da gabobin da insamura ke dauke da su, yawan masu karɓar homon ɗin yana ƙaruwa.
A gaban insulin kwayoyin halitta, matakan glucose ya ragu. Yana da maganin antidiuretic. Saboda ɓoye insulin, yawan nauyi yana faruwa.
Taimaka da cutar ta glycemia ba ta dogara da yawan sukari na jini ba. Chlorpropamide, kamar sauran maganin zaki, yana ɗaukar hatsarori na hypoglycemia, amma zuwa ƙaranƙanci.
Lokacin da aka haɗu tare da sauran wakilai na hypoglycemic (biguanides, thiazolidinediones, duba hulɗa tare da wasu kwayoyi), sashi na ƙarshen yana ɗan ƙaramin abu.
Hanyar aikin abubuwan samo asali na sulfonylurea
Pharmacokinetics
Bayan shiga narkewa, ana amfani da sinadarin chlorpropamide sosai. Bayan awa daya, abu yana cikin jini, mafi girman fifikonsa - bayan sa'oin 2-4. Abubuwan yana lalata cikin hanta. Shafaffen furotin na Plasma> 90%.
A miyagun ƙwayoyi ke aiki a ko'ina cikin yini idan akwai wani amfani guda ɗaya. Kawar rabin rayuwa kusan awa 36 kenan. An cire shi a cikin fitsari (90%).
Manuniya da contraindications
Abubuwan da ke nuna alama don amfani sune cututtukan da ba su da insulin-insulin, har ma da insipidus na sukari. An ba da Chlorpropamide a cikin lokuta inda maganin rage cin abinci, motsa jiki na warkewa bai kawo sakamakon da ya dace ba game da gyaran alamu.
Daga cikin abubuwanda suka sabawa amfani da maganin sun hada da:
- yawan shakatawa zuwa chlorpropamide;
- Nau'in cuta guda 1;
- hypersensitivity zuwa wasu sulfonylureas;
- metabolism tare da nuna bambanci ga acidosis;
- ilimin cututtukan thyroid;
- ketoacidosis;
- hanta da kashin koda;
- m cutar;
- ciki / lactation;
- magabata da coma;
- shekarun yara;
- maimaita faduwar cutar chlorpropamide;
- yanayi bayan kamanceceniya.
Sashi da gudanarwa
An saita maganin ne ta hanyar likita dangane da cutar siga da kuma taimakon glycemia. Lokacin samun biyan bashi tabbatacce a cikin haƙuri, ana iya rage shi. A matsayinka na mai mulki, tare da nau'in ciwon sukari na 2, tsarin yau da kullun shine 250-500 MG. Tare da ciwon sukari insipidus - 125 MG kowace rana. Lokacin da aka canza shi zuwa wasu kwayoyi, ana buƙatar daidaita sashi.
Umarnin don amfani da chlorpropamide yana nuna amfanin shan miyagun ƙwayoyi rabin awa kafin abinci. Yana da mahimmanci a cinye shi lokaci ɗaya. Idan sashi ya samar da kasa da allunan 2, to liyafar ta yi da safe.
Bidiyo daga gwani game da ciwon sukari da yadda za a bi da shi:
Side effects da yawan abin sama da ya kamata
Abubuwanda zasu biyo baya na iya faruwa yayin gudanar da aikin chlorpropamide:
- tashin zuciya, amai, ciwon ciki, matsowar damuwa.
- hypoglycemia;
- hyponatremia;
- ɗanɗano mai ƙarfe a cikin bakin, rashin ci;
- raunin gani;
- fata rashes na wani yanayi;
- hawan jini;
- karuwa a cikin alamomin hanta;
- thrombo-, leuko-, erythro-, granulocytopenia;
- ciwon kai da farin ciki;
- rage matsin lamba;
- rauni, rashin tausayi, nutsuwa, damuwa;
- jalestice cholestatic;
- riƙewar ruwa a cikin jiki;
- amafflactic rawar jiki.
Tare da m / matsakaici digiri na hypoglycemia, haƙuri yana ɗaukar 20-30 na glucose. A nan gaba, an daidaita sashi kuma an sake inganta tsarin abincin.
A cikin lokuta masu tsauri, wanda ke haɗuwa da gudawa da raɗaɗi, ana gudanar da glucose a cikin jijiya. Bugu da ƙari, ana iya gudanar da glucagon ta hanyar intravenously ko intramuscularly. Bayan dakatar da hypoglycemia a cikin kwana biyu, ana lura da alamun ta amfani da glucometer.
Siffofin aikace-aikace
Kafin shirin daukar ciki, dole ne a bar chlorpropamide. Gudanar da nau'in ciwon sukari na 2 tare da insulin ana ɗauka mafi kyawun maganin. A lokacin shayarwa, sun yi aiki da wannan ka'idoji iri daya.
Canja wurin magunguna ana yin shi ne daga rabin kwamfutar hannu a kowace rana, sannan an wajabta shi don kwamfutar hannu ta farko. Marasa lafiya waɗanda ke da rauni na koda / aikin hepatic zai buƙaci daidaita sashi. Lokacin da aka tsara yawan sashi na miyagun ƙwayoyi ga tsofaffi, shekarunsu suna cikin la'akari.
Lokacin da ake rama cutar, ana buƙatar raguwar sashi. Hakanan ana yin gyara tare da canje-canje a cikin nauyin jiki, lodi, motsawa zuwa wani lokacin.
Saboda rashin bayanai game da amincin amfani, ba a ba da magani ga yara. Game da raunin da ya faru, kafin / bayan ayyukan, a lokacin cututtukan cututtuka, ana tura mai haƙuri zuwa ɗan lokaci zuwa insulin.
Karka yi amfani da Bozetan. Akwai shaidun cewa mummunar cutar ta shafi marasa lafiyar da suka karbi chlorpropamide. Sun lura da karuwa a cikin cututtukan hepatic (enzymes). Dangane da kaddarorin magungunan guda biyu, hanyoyin rage ƙwayar bile acid daga sel yana raguwa. Wannan yana haɗuwa da tarawarsu, wanda ke haifar da sakamako mai guba.
Yin hulɗa tare da wasu magunguna
Biguanide Metformin
Ta yin amfani da chlorpropamide tare da sauran magunguna lokaci guda, tasirin sa na iya raguwa ko ƙaruwa. Shawarwari mai mahimmanci kafin ɗaukar wasu magunguna.
Kara miyagun ƙwayoyi mataki faruwa a lokacin coadministered da insulin, sauran hypoglycemic kwayoyi, biguanides, coumarin Kalam, phenylbutazone, kwayoyi tetracycline, Mao hanawa, fibrates, salicylates, miconazole, streroidami, namiji hormones, cytostatics, sulfonamides, quinolone Kalam, clofibrate, sulfinpyrazone.
Kwayoyi masu zuwa suna raunana tasirin chlorpropamide: barbiturates, diuretics, adrenostimulants, estrogens, tableted contraves, manyan allurai na nicotinic acid, diazoxide, hormones na thyroid, phenytoin, glucocorticosteroids, sympathomimetics, phenothiazine derivide, Acetazolam.
Chlorpropamide wakili ne na hypoglycemic wanda ke nufin ƙarni na 1 na samo asali na sulfonylurea. Idan aka kwatanta shi da mabiyan sa, yana da ƙananan rage ƙarfin sukari da ƙarin sakamako masu illa. A yanzu, ba a amfani da miyagun ƙwayoyi.
