Glimecomb yana cikin rukunin hada magungunan antidiabetic. An rarrabe shi ta hanyar keɓaɓɓe, ba a haɗa shi ba a cikin haɗin haɗin haɗin Rasha. Magungunan ya ƙunshi metformin da gliclazide. Sakamakon duka waɗannan abubuwan yana ba da damar rage yawan azumi da postprandial glycemia da 3 mmol / l, ba tare da ɗaukar nauyin masu ciwon sukari ba
Amfani mai mahimmanci na Glimecomb game da shirye-shiryen haɗuwa mafi mashahuri wanda ya ƙunshi metformin da glibenclamide shine rage haɗarin cutar hypoglycemia. Glimecomb ne ke samar da masana'antar Akrikhin kusa da Moscow.
Alamu don alƙawari
Abubuwan da ke cikin Sulfonylurea (PSM) sune magunguna na nau'in 2 da aka tsara wa masu ciwon sukari bayan metformin. Haɗin PSM da metformin ana buƙata ne ga waɗanda ke fama da rashin abinci mai ƙarfi, wasanni, da metformin waɗanda ba sa rage raguwar sukari da ake so. Wadannan abubuwa suna aiki akan manyan hanyoyin haɗin pathogenesis na nau'in ciwon sukari na 2: haɓakar insulin da rashi na insulin, saboda haka suna ba da kyakkyawan sakamako a haɗe. Glyclazide, wani ɓangare na miyagun ƙwayoyi Glimecomb, PSM ne na ƙarni 2 kuma ana ɗaukarsa ɗayan mafi aminci a cikin rukuni.
Ana iya ba da allunan Glimecomb:
- Lokacin da magani na baya ya daina samar da kyakkyawan sakamako ga masu ciwon sukari.
- Nan da nan bayan gano cutar sankara, idan matakin glycemia ya yi yawa sosai.
- Idan mai ciwon sukari bai yarda da metformin a cikin babban kashi ba.
- Don rage adadin allunan a cikin marasa lafiya suna shan gliclazide da metformin.
- Masu ciwon sukari a cikin wanda glibenclamide (Maninil da analogues) ko haɗuwa da metformin (Glibomet et al.) Yana haifar da matsanancin rashin ƙarfi ko rashin tabbas a cikin ƙwayar cutar.
- Marasa lafiya tare da gazawar na koda ga wanda aka haramta glibenclamide.
- Tare da ciwon sukari rikitarwa ta hanyar cututtukan zuciya. An tabbatar da cewa gliclazide baya shafar myocardium.
Dangane da binciken, riga don wata ɗaya na magani tare da Glimecomb, glucose mai azumi yana raguwa da matsakaicin 1.8 mmol / L. Tare da ci gaba da amfani da miyagun ƙwayoyi, sakamakonsa yana ƙaruwa, bayan watanni 3 raguwa ya riga ya zama 2.9. Watanni uku na al'ada shine al'ada glucose a cikin rabin marasa lafiya tare da deellensus na sukari mai narkewa, yayin da kashi bai wuce allunan 4 a kowace rana ba. Rashin nauyi da tsananin rashin ruwa, da ke buƙatar asibiti, ba a rubuta su da wannan magungunan ba.
Ciwon sukari da hauhawar jini zai zama abin da ya wuce
- Normalization na sukari -95%
- Cirewa kan jijiyoyin mara wuya - 70%
- Cire zuciyar mai karfin zuciya -90%
- Rabu da cutar hawan jini - 92%
- Increasearuwar kuzarin rana, inganta bacci da dare -97%
Pharmacology Glimecomb
Haɗin PSM da metformin ana ɗaukar gargajiya. Duk da bayyanar da sabbin jami'ai masu alaƙar cutar, ƙungiyar masu cutar sukari ta ƙasa da kuma Ma'aikatar Lafiya ta Federationungiyar Rasha suna ci gaba da ba da shawarar wannan haɗin a matsayin mafi ma'ana. Glimecomb ya dace don amfani kuma mai araha. Abubuwan haɗinsa duka suna da inganci kuma mai lafiya.
Glyclazide tare da nau'in ciwon sukari na 2 yana ƙarfafa samar da insulin kansa, kuma ya fara aiki a farkon kashi na ɓoye shi, lokacin da sukari ya shiga cikin jini. Wannan aikin yana ba ku damar hanzarin rage yawan glycemia bayan cin abinci, tura glucose zuwa kyallen na gefe. Glyclazide yana hana haɓakar angiopathy: yana hana thrombosis, inganta microcirculation da yanayin ganuwar tasoshin jini. An tabbatar da ingantaccen sakamako na gliclazide a kan hanya ta retinopathy da nephropathy. Allunan dake cikin kwalalin Glimecomb kusan basa haifar da wuce haddi na insulin a cikin jini, saboda haka basa haifar da nauyi. Hakanan umarnin sun lura da ikon gliclazide don inganta jijiyar insulin, amma a wannan yanayin ya yi nesa da metformin, mashahurin shugaba a cikin yaki da juriya na insulin.
Metformin shine kawai magani wanda aka ba da shawarar ga masu ciwon sukari iri 2 ba tare da togiya ba. Yana karfafa canzawar glucose daga tasoshin jini zuwa sel, yana hana samuwar glucose ta hanta, yana jinkirta sha daga hanjin. Magungunan sun yi nasarar yaƙar cuta na rashin lafiyar ƙwayar cuta, wanda ke halayyar nau'in cutar 2. Sakamakon ra'ayoyi masu yawa na masu ciwon sukari, ana amfani da metformin don asarar nauyi. Ba ya haifar da hypoglycemia, lokacin da aka yi amfani da shi tare da umarnin yana da cikakken kariya. Rashin kyawun wannan ɓangaren na Glimecomb shine babban adadin tasirin da ba a ke so ba akan narkewar abinci.
Pharmacokinetics na abubuwan da miyagun ƙwayoyi:
| Sigogi | gliclazide | metformin | |
| Bioavailability,% | har zuwa 97 | 40-60 | |
| Matsakaicin aiki sa'o'i bayan gudanarwa | 2-3 hours | 2 hours lokacin da amfani a kan komai a ciki; 2,5 awa idan kun sha maganin a lokaci guda tare da abinci, kamar yadda umarni suke ba ku. | |
| Rabin-rayuwa, sa'o'i | 8-20 | 6,2 | |
| Karbo hanyar,% | kodan | 70 | 70 |
| hanji | 12 | har zuwa 30 | |
Sashi
Magungunan Glimecomb yana da zaɓin sashi guda ɗaya - 40 + 500, a cikin kwamfutar hannu 40 MG na glyclazide, 500 MG na metformin. Don samun rabin kashi, ana iya raba kwamfutar hannu, akwai haɗari a kai.
Idan mai ciwon sukari bai dauki metformin ba kafin, 1 kwamfutar hannu ana ɗaukar matakin farawa. Makonni 2 masu zuwa ba a so a ƙara shi, saboda haka zaku iya rage haɗarin rashin jin daɗi a cikin narkewar abinci. Marasa lafiya waɗanda suka saba da metformin kuma suka yi haƙuri da shi za a iya rubuta su nan da nan har zuwa 3 Allunan Glimecomb. An ƙaddara maganin da ake so ta hanyar likita, la'akari da matakin glycemia na haƙuri da sauran magunguna da yake ɗauka.
Idan kashi na farko bai bada tasirin da ake so ba, sannu-sannu yana ƙaruwa. Don hana hypoglycemia, tazara tsakanin daidaitawa ya kamata ya zama akalla mako guda. Matsakaicin izini shine allunan 5. Idan a wannan maganin, Glimecomb baya bayar da diyya ga masu ciwon sukari, an wajabta wani magani mai rage sukari ga mai haƙuri.
Idan mai haƙuri yana da juriya na insulin, Glimecomb a cikin ciwon sukari na iya bugu tare da metformin. Ana lissafta adadin allunan a wannan yanayin don jimlar adadin metformin ba ta wuce mil 3000.
Dokoki don shan miyagun ƙwayoyi Glimecomb
Don haɓaka haƙuri da metformin kuma hana raguwa mai yawa a cikin sukari, allunan Glimecomb suna bugu lokaci guda tare da abinci ko kuma nan da nan bayan shi. Ya kamata abinci ya daidaita daidai kuma dole ne ya ƙunshi carbohydrates, zai fi dacewa da narkewa. Yin hukunci da sake dubawa, har zuwa 15% na masu ciwon sukari sun yi imanin cewa shan Glimecomb da sauran magunguna masu rage sukari suna kawar da buƙatunsu don bin abincin. Sakamakon haka, suna ɗaukar magunguna masu ɗimbin yawa, wanda ke ƙara tasirin sakamako da farashin magani, suna korafin sukari mai narkewa, da farko fuskantar matsalolin ciwon sukari.
Yanzu ba magani guda ɗaya na ƙwaƙwalwar ƙwayar cuta don ciwon sukari ba wanda zai iya maye gurbin abincin. Tare da nau'in cuta ta 2, ana nuna abinci mai gina jiki ba tare da carbohydrates mai sauri ba, tare da ƙuntatawa na carbohydrates mai jinkirin, kuma sau da yawa tare da rage yawan adadin kuzari - nau'in ciwon sukari na 2. Tsarin kulawa yana haɗawa da tilasta daidaituwa na nauyi da karuwar aiki.
Don tabbatar da daidaiton sakamako na Glimecomb a lokacin rana, an raba allurai zuwa kashi biyu - safe da maraice. Dangane da sake dubawa, ana lura da kyakkyawan sakamako na magani a cikin marasa lafiya waɗanda ke shan maganin sau uku (bayan kowace abinci), duk da cewa umarnin don amfani ba su ba da irin wannan zaɓi.
Side effects
Yawancin sakamako masu illa na iya raunana idan kun bi ƙa'idodi don ɗauka da haɓaka kashi daga umarnin. Ba a buƙatar maye gurbin Glimecomb saboda rashin haƙuri ba da wuya.
| Sakamakon mara amfani na miyagun ƙwayoyi | Sanadin sakamako masu illa, abin da za su yi idan sun faru |
| Hypoglycemia | Yana faruwa tare da sigar da aka zaɓa yadda yakamata ko kuma rashin isasshen abinci. Don hana shi, ana rarraba abinci a ko'ina cikin rana, carbohydrates dole ne ya kasance a kowane ɗayan. Idan hypoglycemia ya faru da annabta a lokaci guda, ƙaramin abun ciye-ciye zai taimaka don nisantar da shi. Akai-akai saukad da sukari - wani lokaci don rage sashi na Glimecomb. |
| Lactic acidosis | Wani matsanancin rikitarwa, sanadin shine yawan wucewar metformin ko shan Glimecomb a cikin marasa lafiyar wanda aka sawa shi. A cikin cututtukan koda, ana buƙatar saka idanu akai-akai game da aikin su. Wannan yana da mahimmanci don soke magungunan a cikin lokaci idan an gano babban digiri na rashin isasshen magani. |
| Abubuwan jin dadi marasa dadi a cikin narkewa, narkewa, zawo, dandano na ƙarfe. | Wadannan sakamako masu illa suna haɗuwa da farkon metformin. A cikin mafi yawan marasa lafiya, sun ɓace da kansu a cikin makonni 1-2. Don haɓaka haƙuri na Glimecomb, kuna buƙatar sannu a hankali haɓaka adadinsa, farawa daga farawa. |
| Lalacewar hanta, canji a cikin kayan jini | Buƙatar soke magungunan, bayan wannan cin zarafin ya ɓace a kan nasu, da wuya a nemi magani. |
| Rashin gani | Su na ɗan lokaci ne, ana lura dasu a cikin masu ciwon sukari tare da farko suna da yawa. Don hana su, dole ne a ƙara yawan ƙwayar Glimecomb a hankali don hana raguwa mai yawa a cikin glycemia. |
| Allergic halayen | Ba wuya. Lokacin da suka bayyana, yana da kyau a maye gurbin Glimecomb tare da analog. Masu ciwon sukari tare da rashin lafiyan gliclazide suna cikin haɗarin haɗari iri ɗaya ga sauran PSM, don haka ana nuna su haɗuwa da metformin tare da gliptins, alal misali, Yanumet ko Galvus Met. |
Contraindications
Lokacin da baza ku iya sha Glimecomb:
- nau'in ciwon sukari na 1;
- yawan haila. Magungunan ba zai bugu ba har sai da sukarin jini ya tashi zuwa al'ada;
- rikice-rikice masu ciwon sukari mai muni, mummunan cututtuka da raunin da ke buƙatar maganin insulin. A shari'ar lactic acidosis a baya;
- ciki, shayarwa;
- X-ray tare da iodine-dauke da wakilan bambanci;
- rashin jituwa ga kowane ɓangarorin magungunan;
- na koda, gazawar hanta, hypoxia, da cututtukan da ke haifar da haifar da waɗannan rikice-rikice;
- barasa, giya mai yawa na barasa.
A cikin marasa lafiya da cututtukan hormonal, tsofaffi masu ciwon sukari tare da tsawaita aiki mai tsawo, haɗarin cutar sakamako yana ƙaruwa, don haka lokacin ɗaukar Glimecomb, yakamata suyi hankali sosai game da lafiyarsu.
Yarda da wasu kwayoyi
Sakamakon Glimecomb na iya inganta ko raunana lokacin ɗauka tare da wasu kwayoyi. Jerin hulɗa da miyagun ƙwayoyi yana da yawa babba, amma yawancin sauye sauye da tasiri ba su da mahimmanci kuma ana iya daidaita su ta hanyar canza sashi.
| Tasiri kan tasirin glimecomb | Shirye-shirye |
| Rage tasiri, yiwuwar hyperglycemia. | Glucocorticoids, yawancin kwayoyin, ciki har da hana haihuwa; adrenostimulants, magungunan sankarau, diuretics, acid nicotinic. |
| Suna da tasirin hypoglycemic, ana iya buƙatar raguwa cikin kashi na Glimecomb. | ACE inhibitors, juyayi, antifungal, anti-tarin kwayoyi, NSAIDs, fibrates, sulfonamides, salicylates, steroids, microcirculation stimulants, bitamin B6. |
| Theara yiwuwar lactic acidosis. | Duk wani barasa Yawan kwayoyin metformin a cikin jini ana yin sa ne yayin shan furosemide, nifedipine, glycosides cardiac. |
Abin da analogues don maye gurbin
Glimecomb bashi da cikakkun alamun analogues a cikin Federationungiyar Rasha. Idan magungunan ba a cikin kantin magani ba, kwayoyi biyu tare da abubuwa masu aiki iri ɗaya zasu iya maye gurbin ta:
- Metformin yana cikin ingantaccen Glucofage wanda aka samar a Faransa, Siofor na Jamusanci, Metformin na Rasha, Merifatin, Gliformin. Duk suna da sashi na 500 MG. Ga masu ciwon sukari tare da mummunan haƙuri na metformin, an fi son nau'in magungunan da aka canza, wanda ke tabbatar da shigowar abu ɗaya cikin jini kuma yana rage haɗarin sakamako masu illa. Wadannan kwayoyi sune Metformin Long Canon, Metformin MV, Formin Long da sauransu.
- Gliclazide shima sanannen sanannen jini ne. Kayan yana daga cikin Glidiab na Rasha da Diabefarm. Gliclazide wanda aka Gyara yanzu ana ɗauka shi ne mafi kyawun tsari. Amfani da shi na iya rage mita da tsananin cutar tarin fitsari. Gliclazide wanda aka canza yana cikin shirye-shiryen Diabefarm MV, Diabeton MV, Gliclazide MV, Diabetalong, da sauransu. Lokacin sayen, kuna buƙatar kula da sashi, kuna iya buƙatar rarraba kwamfutar hannu a rabi.
Akwai da yawa analogues na kungiyar Glimecomb a kasuwar Rasha. Yawancin su sune haɗin metformin tare da glibenclamide. Wadannan kwayoyi ba su da hadari fiye da glimecomb, saboda yawanci suna haifar da cututtukan jini. Kyakkyawan sauyawa don Glimecomb shine Amaril (metformin + glimepiride). A halin yanzu, wannan shine mafi girman magunguna biyu masu haɓaka tare da PSM.
Farashi
Farashin fakitin allunan 60 na Glimecomb daga 459 zuwa 543 rubles. Gliclazide da metformin daga masana'anta guda ɗaya zasu kashe 187 rubles. don guda ɗaya (allunan 60 na Glidiab 80 MG kudin 130 rubles, allunan 60. Gliformin 500 MG - 122 rubles). Farashin haɗuwa na shirye-shiryen asali na gliclazide da metformin (Glucofage + Diabeton) kusan 750 rubles, duka biyun suna cikin tsari na gyara.
