Gliformin tsawanta don ciwon sukari na 2

A cewar kididdigar, ana tsara magungunan metformin ta hanyar 43% na masu ciwon sukari tare da nau'in cuta na 2 da aka gano a karon farko, idan gyaran rayuwa bai samar da cikakkiyar iko na glycemic ba. Ofayansu shine asalin Russianan ƙasar Rasha na asalin ƙwayar cuta ta Faransa mai suna Glucofage tare da sunan kasuwanci Gliformin.

Akwai nau'ikan magani guda biyu: tare da saki na yau da kullun kuma tare da sakamako mai tsawo. Ana amfani da Gliformin Prolong sau ɗaya, kuma yana aiki kwana ɗaya. Rashin amfani, inganci da amincin sun kamu da cutar sankarau da likitoci masu amfani da allunan don maganin taɓin biyun da magani mai wahala.

Abun ciki, tsari sashi, analogues

Magungunan Gliformin Prolong, kamfanin samar da magunguna na kasar Rasha na Akrikhin, ya samar da nau'ikan allunan da aka sanya fim din tare da wani sakamako mai inganci.

Kowane kwamfutar hannu mai launin rawaya biconvex ya ƙunshi 750 MG na aiki mai aiki na metformin hydrochloride da tsofaffin abubuwa: silicon dioxide, hypromellose, microcrystalline cellulose, magnesium stearate.

Allunan kwalaye na 30 ko 60 inji mai kwakwalwa. a cikin akwati fensir mai filastik tare da maɓallin dunƙule da murfin sarrafawa don buɗewa na farko. Ana sanya fakitin filastik a cikin kwali. Rayuwar shiryayye na miyagun ƙwayoyi a cikin bushe, wuri mai duhu a ɗakin zafin jiki shine shekaru 2. Don Gliformin Prolong 1000, farashin akan Intanet ya kasance daga 477 rubles.

Idan kana buƙatar maye gurbin maganin, likita zai iya amfani da analogues tare da kayan tushe guda:

• Formmetin;
• Metformin;
• Glucophage;
• Metformin Zentiva;
• Gliformin.

Fasalin magunguna na Gliformin

Magungunan Gliformin Prolong an rarraba shi azaman wakilin rage sukari a cikin rukunin biguanide. Dimethylbiguanide yana inganta haɓakar basal da postprandial glycemia. Hanyar aiwatar da metformin, shine asalin tsarin, shine don motsa hankalin mai karɓar mahaɗan sel zuwa insulin su kuma haɓaka ƙimar amfani da glucose a cikin ƙwayoyin tsoka.

Magungunan ba su da tasiri ga samar da insulin na insulin, don haka babu cutar yawan kumburi a cikin tasirin da ba a son sa ba. Rage gluconeogenesis, metformin yana toshe hanyar haɗin gulukos a cikin hanta kuma yana hana sha a cikin hanjin. Haɓaka aikin glycogen da haɓaka, ƙwayar ta ƙara yawan glycogen, yana inganta ƙarfin sufurin kowane nau'ikan jigilar glucose.

Pharmacokinetics

Bayan amfani da allunan guda biyu na Gliformin Prolong (1500 mg), matsakaicin maida hankali a cikin jini ya kai bayan kimanin 5 hours. Idan muka kwatanta maida hankali kan miyagun ƙwayoyi akan lokaci, to kashi ɗaya na 2000 MG na metformin tare da tsawan iya aiki daidai ne cikin tasiri zuwa ninki biyu na amfani da metformin tare da sakin al'ada, wanda ake ɗauka sau biyu a rana don 1000 mg.

Abun da ke cikin abincin, wanda aka ɗauka a layi ɗaya, ba ya shafar sha da ƙwayar Glyformin Prolong. Tare da maimaita amfani da Allunan a kashi na 2000 MG, cumbin ba a gyarawa ba.

Magungunan suna ɗaukar dan kadan zuwa sunadarai na jini. Volumeimar rarrabawa - a tsakanin 63-276 l. Metformin bashi da metabolites.

Ana cire miyagun ƙwayoyi a cikin ainihin sa ta hanyar da ta dace tare da taimakon kodan. Bayan kun shiga cikin narkewa kamar abinci, rabin-rayuwa ba ya wuce awanni 7. Tare da lalata koda, rayayyen rabin zai iya ƙaruwa kuma ya taimaka da tara yawan metformin a cikin jini.

Manuniya na tsawan gliformin

An tsara magungunan don sarrafa nau'in ciwon sukari na 2, musamman ga marasa lafiya masu kiba masu yawa, idan gyaran rayuwa ba ya ba da diyya glycemic 100%.

Ana amfani da maganin duka a cikin monotherapy kuma a cikin hadaddun jiyya tare da sauran allunan rigakafin ƙwaƙwalwa ko insulin a kowane mataki na cutar.

Contraindications

Kada a tsara kwayoyi tare da metformin don:

• Hypersensitivity ga abubuwan da ke cikin tsari;
• Ketoacidosis na masu fama da cutar siga, precoma da coma;
• Rashin ƙarancin azaba lokacin da keɓancewar creatinine yana ƙasa da 45 ml / min.;
• Fitsari, tare da matsanancin zawo da amai, cututtukan hanji da na jijiyoyin jiki, rawar jiki da sauran yanayin m da ke haifar da ci gaban kasa;
• Ayyukan tiyata mai tsanani, raunin da ya shafi maye gurbin magani na ɗan lokaci tare da insulin;
• Rashin ƙarfin zuciya da na numfashi, rashin ƙarfi daga cikin zuciya da sauran cututtukan na kullum da na cuta waɗanda ke taimakawa hypoxia nama;
• Dysfunctions hanta;
• Rashin giya na yau da kullun, guba mai sa maye;
• Haihuwa da lactation;
• Lactic acidosis, gami da tarihi;
• Nazarin bambanci na X-ray (na ɗan lokaci);
• Abincin hypocaloric (har zuwa dubu kcal / rana.);
• Shekarun yara saboda karancin isassun hujjoji na inganci da aminci.

Ya kamata a kula da kulawa ta musamman ga nau'ikan masu ciwon sukari, musamman waɗanda ke yin aiki ta jiki, tunda suna haɗarin ci gaban lactic acidosis.

Glyformin yayin daukar ciki

Tare da biyan diyya na wani nau'in ciwon sukari na 2, cikin ciki ya ci gaba tare da cututtukan cututtukan cuta: lalata cuta a cikinku, gami da mutuwar haihuwar, yana yiwuwa. A cewar wasu rahotanni, yin amfani da metformin ba ya tsokani cigaban nakuda a cikin tayin.

Koyaya, a matakin shirin daukar ciki, yana da kyau a canza zuwa insulin. Don hana ɓarna a cikin haɓakar yaro, yana da mahimmanci ga mata masu juna biyu don sarrafa glycemia a 100%.

Magungunan suna iya shiga cikin madarar nono. Kuma kodayake babu sakamako masu illa a cikin jarirai masu shayarwa, Gliformin Prolong baya bada shawarar ɗaukar umarnin amfani dashi lokacin shayarwa. An yanke shawarar canzawa don ciyar da mutum ba tare da la'akari da illar cutar da jariri da amfanin madarar nono a kansa ba.

Yadda ake amfani dashi yadda ya kamata

Glyformin Prolong anyi nufin amfani dashi ne a ciki. Ana ɗaukar kwaya sau ɗaya - da maraice, tare da abincin dare, ba tare da tauna ba. Maganin likita ya ƙaddara shi ne ta hanyar likita, la'akari da sakamakon gwaje-gwaje, matakin cutar sukari, cututtukan da ke da alaƙa, yanayin gaba ɗaya da amsawar mutum ga maganin.

A matsayin maganin farawa, idan mai ciwon sukari bai taɓa ɗaukar magunguna masu amfani da metformin ba, ana ba da shawarar cewa an tsara kashi na farko a cikin 750 MG / rana, tare da ɗaukar maganin tare da abinci. A cikin makonni biyu ya rigaya ya yiwu a kimanta tasiri na kashi da aka zaɓa kuma, idan ya cancanta, a yi gyare-gyare. Slow titration na sashi na taimaka jiki daidaitawa ba tare da wahala ba da rage yawan sakamako masu illa.

Tsarin daidaitaccen magani shine 1500 MG (Allunan 2), ana ɗauka sau ɗaya. Idan ba zai yiwu ba don cimma nasarar da ake so, zaku iya ƙara yawan allunan zuwa 3 (wannan shine matsakaicin adadin). An kuma ɗauke su a lokaci guda.

Abubuwan da wasu masu maye gurbin jini tare da Gliformin Prolong

Idan mai ciwon sukari ya riga ya dauki magungunan tushen tushen Metformin waɗanda ke da tasirin sakin al'ada, to lokacin da ake maye gurbinsu da Gliformin Prolong, dole ne mutum ya mai da hankali kan maganin yau da kullun da ya gabata. Idan mai haƙuri ya ɗauki metformin na al'ada a cikin kashi fiye da 2000 MG, sauyawa zuwa glyformin mai tsawo ba shi da amfani.

Idan mai haƙuri ya yi amfani da wasu wakilai na hypoglycemic, to, lokacin da ake maye gurbin maganin tare da Gliformin Prolong, ana iya jagorantar su da ka'idodi.

Hakanan ana amfani da Metformin a cikin nau'in ciwon sukari na 2 a hade tare da insulin. Yawan farawa na Glyformin Tare da irin wannan hadaddun jiyya shine 750 mg / rana. (liyafar maraba guda daya). Sashi na insulin an zabi shi ne don yin la'akari da karatun glucoseeter.

Matsakaicin gwargwadon damar halayen na tsawon sa shine 2250 MG (3 inji mai kwakwalwa). Idan ciwon sukari bai isa cikakken ikon cutar ba, an canza shi zuwa nau'in magani tare da sakin al'ada. Don wannan zaɓi, matsakaicin kashi shine 3000 MG / rana.

Matsakaicin hanya ya dogara da ganewar asali: idan kwayar polycystic tare da metformin za a iya warkar da wasu lokuta a cikin wata daya, to masu ciwon sukari tare da nau'in cuta na 2 na iya ɗaukar shi don rayuwa, ƙari ga tsarin kulawa da madadin magunguna idan ya cancanta. Yana da mahimmanci a sha maganin a lokaci guda, yau da kullun, ba tare da tsangwama ba, yayin da ba a manta game da kula da sukari, ƙarancin carb, motsa jiki, da yanayin motsin rai.

Shawara don takamaiman rukunin masu ciwon sukari

Don matsalolin koda, ba a sanya daɗaɗɗun tsari ba don kawai siffofin masu cutar ba, lokacin da keɓancewar creatinine ba ƙasa da 45 ml / min ba.

Adadin farawa ga masu ciwon sukari tare da cututtukan koda shine 750 mg / day, iyakar yana zuwa 1000 mg / day.

Dole ne a bincika aikin kodan tare da yawan watanni 3-6. Idan keɓantaccen ɗaukar hoto ya faɗi ƙasa da 45 ml / min., An soke maganin cikin gaggawa.

A cikin lokacin balaga, lokacin da aka rage ƙarfin koda, to, ana aiwatar da titration na kashi na Gliformin Prolong akan gwaje-gwaje na creatinine.

Side effects

Metformin ɗayan magungunan amintattu ne, gwada-lokaci da kuma karatu da yawa. Hanyar tasirin sa ba ya motsa samar da insulin nasa ba, saboda haka, hypoglycemia tare da monotherapy baya haifar da glyformin tsawan lokaci. Babban haɗari mafi haɗari shine rikicewar gastrointestinal, wanda ya dogara da halayen mutum na jiki da wucewa bayan daidaitawa ba tare da maganin likita ba. Ana kimanta yawan tasirin sakamako daidai da ƙimar WHO:

• Mafi yawan lokuta - ≥ 0.1;
• Sau da yawa - daga 0.1 zuwa 0.01;
• Ba tare da ɓata lokaci ba - daga 0.01 zuwa 0.001;
• Da wuya, daga 0.001 zuwa 0.0001;
• Da wuya dai - <0.0001;
• Idan ba a sani ba - idan ba za a iya tantance yawan adadin bayanan da ake samu ba.

Sakamakon binciken ƙididdigar an gabatar dasu a cikin tebur.

Tsawon lokaci na Glyformin Prolong na iya haifar da lalacewa a cikin sha na bitamin B12. Idan an gano megaloblastic anaemia, yakamata a kula da yiwuwar etiology.

Don rage bayyanuwar cututtukan cututtukan cututtukan cututtukan ƙwayar cuta, an fi dacewa da kwamfutar hannu tare da abinci.

Rashin lafiyar hepatic, tsokani ta hanyar amfani da Gliformin, yana wucewa ta kansa bayan maye gurbin maganin.

Idan an gano waɗannan canje-canje a cikin lafiya bayan ɗaukar Gliformin Prolong, mai ciwon sukari yakamata ya gargadi likitan halartar.

Yawan yawan bayyanar cututtuka

Lokacin amfani da g 85 na metformin (kashi ɗaya ya wuce warkewa ɗaya bayan sau 42.5), cutar rashin ruwa ta faru. A cikin irin wannan yanayin, lactic acidosis ya haɓaka. Idan wanda aka azabtar ya nuna alamun irin wannan yanayin, an soke amfani da Gliformin Prolong, mai ciwon sukari yana asibiti, matakin lactate da bayyanar cututtuka an tabbatar da shi. Wuce hadadden metformin da lactate ana cire su ta hanyar dialysis. A layi daya, ana gudanar da aikin tiyata.

Sakamakon Cutar Magunguna

Abubuwan haɗin gwiwa

Alamar bambanci X-ray, wacce take dauke da iodine, tana da ikon tsoratar da tsarin lactic acidosis a cikin masu ciwon sukari tare da tabin hankali na koda. A cikin gwaje-gwajen amfani da irin waɗannan kwayoyi, an tura mai haƙuri zuwa insulin har kwana biyu. Idan yanayin kodan ya gamsu, kwana biyu bayan gwajin, zaku iya komawa tsarin kulawar da suka gabata.

Nagari hadaddun

Tare da giya mai guba, da yiwuwar lactic acidosis yana ƙaruwa. Suna haɓaka damar haɓaka ƙarancin kalori, lalatawar hanta. Magungunan Ethanol suna haifar da irin wannan sakamako.

Zaɓuɓɓuka don yin hankali

Lokacin amfani da kwayoyi tare da tasirin hyperglycemic kai tsaye (glucocorticosteroids, tetracosactide, β-adrenergic agonists, danazole, diuretics), saka idanu akai-akai na abubuwan haɗin jini wajibi ne. Dangane da sakamako na glucometer, kashi Glyformin Prolong shima an daidaita shi. Diuretics yana haifar da matsalolin koda, kuma, saboda haka, da alama ta lactic acidosis.

Magungunan rigakafin ƙwayoyin cuta na iya canza alamun hypoglycemic. Tare da yin amfani da lokaci daya, titing na kashi na metformin na da zama dole.

Tare da magani a layi daya tare da insulin, acarbose, magungunan sulfonylurea, salicylates, Glyformin Prolong na iya haifar da cutar hypoglycemia.

Na haɓaka sha da ƙwayar metformin nifedipine.

Magungunan cationic, waɗanda su ma ke ɓoye a cikin canal na koda, yana rage jinkirin haɗarin metformin.

Tasiri kan taro

Tare da kulawa mai rikitarwa tare da madadin magunguna, musamman a hade tare da ƙungiyar sulfonylurea, repaglinide, insulin, hypoglycemia mai yiwuwa ne, sabili da haka, ayyukan da suke da alaƙa da haɗarin kiwon lafiya ya kamata a zubar.

Reviews game da Gliformin Prolong

Duk da cewa kowa yana da ciwon sukari kuma yana ci gaba daban, algorithm na ayyuka sun zama ruwan dare, musamman ga irin nau'in ciwon suga na biyu. Game da Gliformin Ci gaba a cikin ciwon sukari na mellitus, sake dubawa suna da tabbas, amma yana da wuya a kimanta tasirin magungunan a ɓoye ba tare da yin la’akari da duk yanayin cutar da salon rayuwa ba.

Likitocin sun mayar da hankali kan gaskiyar cewa Glyformin Prolong SD ya biya diyya, amma yana buƙatar taimako. Wanda ya fahimci cewa rage cin abinci da ilimin ta jiki shine har abada, zai zama al'ada tare da Gliformin. Dole ne a sarrafa nauyi ta kowane hanya, wannan fifiko ne. Tare da rage cin abinci mai narkewa, ƙuntatawa yana da sauƙin ɗauka kuma sakamakon yana da sauri.

Idan babu isasshen abin ƙarfafa, yi tunani game da ƙafafun da aka yanke, matsalolin hangen nesa da matsalolin koda, kar a faɗi bugun zuciya ko bugun jini, wanda na iya faruwa a kowane lokaci da kowane zamani. Kuma waɗannan ba kawai shawarar wata jaridar iyali ta Lahadi ba ce - waɗannan ka'idojin aminci ne, waɗanda, kamar yadda ka sani, an rubuta su cikin jini.