Glucophage Dogon - umarnin don amfani, alamu, farashi

An yi amfani da Metformin a cikin aikin asibiti na fiye da rabin ƙarni. Kuma a yau, duk shawarwarin game da gudanar da kamuwa da cututtukan type 2 suna bayar da shawarar amfani da shi a duk matakai na ci gaban cutar, tunda yana taimakawa rage tasirin micro- da macrovascular.

Abin takaici, yawan amfani da Glucofage da analogues daga ƙungiyar biguanide an iyakance saboda sakamakon da ba a buƙaci shi ga ƙwayar gastrointestinal, wanda ke haɓaka cikin 25% na masu ciwon sukari. Dangane da bayanan da ba na hukuma ba, har zuwa 10% na marasa lafiya sun daina shan Glucofage da kwayoyin halittar ta saboda cututtukan dyspeptik, tsarin ci gaban da ba a yi nazari sosai ba.

Glucophage Dogayen Ka'idoji

Cikakken bayanin bioavailability na kowane metformin yana cikin kewayon 50-60%. Daga cikin jini, yawancinsa ana shan shi a cikin gida, a cikin ɓangaren na sama na tsarin narkewa. Kuma kawai karamin adadin abu yana cikin mafi yawan yanki na hanji. Lokacin tsotsa bai wuce awa 2 ba.

Kirkirar metformin tare da iya tsawan lokaci ba aiki mai sauki bane:

• Ana ɗaukar ƙwayar magungunan a cikin wani yanki mai iyaka na hanji na ciki;
• Tare da wuce haddi na metformin a saman wani matattara, “lura da jijiyoyin jiki” aka lura;
• Idan sakin abu mai aiki ya ragu, zai zame tare da duk tsawon hanjin.

“Cutar da kanta” yana nufin cewa tare da wuce haddi na biguanide, yawancinsa ba su fada “taga shakar” kuma baya aiki kwata-kwata. Matsakaicin shan magunguna a cikin hanji yana da nasaba da yawan fitowar sa daga ciki. Wadannan halayen suna bayyana wahalar ƙirƙirar Glucophage tare da tsawan sakamako wanda za'a iya ɗauka sau ɗaya a rana.

Magungunan gargaɗi kawai suna rage jinkirin sashin aiki mai aiki daga kwamfutar hannu tare da ɗaukar ɗaukar nauyi na kayan aiki tare da tsawon tsawon hanjin. Amma irin waɗannan kwayoyi suna da lokacin da za a sami saurin shigar da sashin jiki mai aiki a cikin jini kai tsaye bayan shan kwayoyin. Irin waɗannan ka'idodi na Glucophage Long ba a yarda da su ba, tunda ana katange ƙwayar metformin bayan ƙarshen shaƙar sha. Haka ne, kuma farkon sakin abu mai aiki zai iya “cikakke” shi kuma wani ɓangaren magungunan zai kasance ba a bayyana ba.

Bayan cinye Glucofage na yau da kullun, mafi girman maida hankali ba ya wuce awanni 3.

Don kwatanta haƙurin narkewa na metformin mai sauƙi da kuma tsawaita hoto na XR a cibiyoyin likita guda huɗu a Amurka, katunan masu ciwon sukari tare da nau'in cuta na 2, waɗanda suka ɗauki nau'ikan Glucophage, sun yi nazari. Mitar sakamakon da ba a ke so ga jijiyoyin mahaifa a cikin masu ciwon suga suna shan metformin na tsawan lokaci yana da matukar ƙarancin waɗanda suka yi amfani da maganin da suka saba.

Matsakaicin tasirin sakamako a cikin lura da nau'ikan Glucophage, da lokacin juyawa daga jinsi ɗaya zuwa wani, ana nuna su da kyau.

An gwada tasirin iko na haemoglobin a cikin makafi. Kungiyoyin mahalarta sun nuna sakamako iri guda iri guda na Glucophage.

Kimiyyar kere-kere da Glucophage Long

Sakamakon fitowar hankali na metformin XR ana bayar dashi ta hanyar tsarin kwamfutar hannu, wanda ke haifar da tsarin rarraba saboda shinge na gel. Abubuwan da ke aiki suna cikin matrix biyu na hydrophilic, suna ba da sakin metformin XR ta hanyar watsawa. Matrix na waje na waje yana rufe sashin ciki, wanda ya ƙunshi 500-750 MG na miyagun ƙwayoyi. Lokacin da ya shiga cikin ciki, kwamfutar hannu ta kumbura daga danshi, an rufe shi da gel gel daga waje, kuma yana haifar da yanayi don sakin ƙwayoyi. Babban bambanci tsakanin waɗannan allunan shine cewa raunin ƙwayar cuta ba ta da alaƙa da fasalin motsin hanji da kuma pH. Wannan yana ba mu damar ware bambancin shan magunguna a cikin tsarin narkewa na marasa lafiya daban-daban.

Magungunan Glucofage mai tsayi

Ofaukar da kayan aiki mai aiki daga kwamfutar hannu ya zama mai sauƙi kuma ya fi tsayi idan aka kwatanta da sauƙi mai sauƙi. A cikin gwaje-gwajen, an kwatanta tsohuwar analog tare da sashi na 200 MG / rana. da kuma glucophage mai sauki tare da kashi 2 r. 1000 mg / rana. a kan kai wa daidaitaccen taro. Matsakaicin matakin jini na Tmax bayan cinye metformin XR ya fi ƙarfin metformin sauƙi (sa'o'i 7 maimakon sa'o'i 3-4). Cmax, iyakancewar hankali, a farkon lamarin ya kasance kwata kwata. Tasirin gaba ɗaya akan sukarin jini a cikin nau'ikan magunguna iri ɗaya ne. Idan muka bincika yankin a ƙarƙashin ɓoyewa da ke bayanin nauyin aikin maida hankali akan lokaci, to zamu iya yanke game da yanayin rayuwar nau'ikan Glucofage biyu.

Babu shakka, bayanin martabar pharmacookinetic na miyagun ƙwayoyi tare da damar tsawan lokaci yana sa ya yiwu a ware mai saurin tsalle a matakin metformin XR a cikin plasma, wanda yake shi ne kamfani na metformin mai sauƙi.

Abubuwan da suke ɗauka na ɗaukar suttura masu aiki suna taimakawa wajen nisantar da sakamako masu illa ga hanji da na hanji da haɓaka haƙurin magani.

Alamu, contraindications, ƙuntatawa

An ƙayyade Glucophage Long ga masu ciwon sukari tare da nau'in cuta na 2 idan salon salon ba ya samar da cikakkiyar iko na glycemic. An nuna magungunan musamman ga marasa lafiya masu kiba. Ana amfani da Metformin azaman magani na farko-farko don maganin monotherapy ko magani mai wahala tare da wasu magungunan maganin cututtukan, ciki har da insulin.

Glucophage magani ne mai amintacce tare da tabbataccen shaidar tushe na tasiri, amma amfani da shi wanda bai dace ba yana iya samun sakamako mara kyau. Magungunan yana contraindicated:

• Tare da rashin kwanciyar hankali ga abubuwan da ke cikin tsari;
• A cikin yanayin ketoacidosis na ciwon sukari, coma da precoma;
• Marasa lafiya tare da cututtukan cututtukan koda (keɓancewar creatinine - har zuwa 60 ml / min.);
• A cikin yanayin m (hypoxia, rashin ruwa a jiki), tsokani dysfunction na koda;
• Yayin aiki da lura da raunin da ya faru (an canja mai haƙuri zuwa insulin);
• A cikin cututtukan da ke haifar da yunwar oxygen na kyallen takarda (bugun zuciya, sauran cututtukan zuciya, rikicewar numfashi);
• Masu ciwon sukari tare da dysfunctions hanta;
• Tare da tsarin kula da giya, maye maye;
• Iyaye masu juna biyu da masu shayarwa;
• A cikin yanayin lactic acidosis, ciki har da tarihi;
• Mutane a kan hypocaloric (har zuwa 1000 kcal / rana) rage cin abinci.

A cikin lokacin gwajin rediyotopepe ko X-ray ta amfani da alamomin tushen aidin, masu ciwon sukari 48 hours kafin aikin da kuma awanni 48 bayan an canza shi zuwa insulin.

Musamman hankali a cikin nadin Glucophage Long ya kamata a bai wa rukuni na masu ciwon sukari na tsufa, tare da rashin abinci mai gina jiki, da waɗanda ke cikin aiki na jiki, saboda waɗannan abubuwan suna haifar da ci gaban lactic acidosis.

Glucophage Tsayi da juna biyu

Koda a matakin ƙirar yaro, mace mai ciwon sukari ana canja shi zuwa insulin. Yana da ma'ana don kula da wannan tsarin kulawa na tsawon lokacin shayarwa, saboda metformin yana kasancewa cikin ciki da lactation. Idan lafiyar mahaifiyar ta buƙaci canzawa zuwa Glucofage Long, an canza yarinyar zuwa ciyar da mutum.

Sashi da gudanarwa

A cikin nazarin ingantaccen kashi na glucophage na tsawon lokaci, an tabbatar da ingancin amfani da kashi-kashi tare da amfani da magani guda. An bayyana iyakar sakamako tare da yin amfani da 1500-2000 mg / rana. Gwajin ya kuma kwatanta yiwuwar tsawan glucophage tare da tsarin kulawa na 2 p / Rana. 1000 mg da 1 r / Rana. 2000 MG kowane. A farkon lamari, glycated haemoglobin cikin rukuni na masu ba da agaji ya ragu da 1.2%, a karo na biyu - da 1%.

Magungunan an yi nufin amfani dashi ne na ciki. Ana cin kwamfutar hannu da ruwa ba tare da murƙushewa ba. A endocrinologist lissafi da jadawalin da kuma la'akari la'akari da sakamakon gwaje-gwaje, mataki na cutar, concomitant pathologies, da shekaru masu ciwon sukari da kuma dauki jiki jiki ga miyagun ƙwayoyi.

Glucophage Tsayi - 500 MG

A sashi na 500 MG / rana. shan Allunan tare da abincin dare. Idan aikace-aikacen ya ninka biyu, to, tare da karin kumallo da abincin dare, amma koyaushe tare da abinci.

Idan an canza haƙuri daga Glucophage na yau da kullun zuwa tsawan tsari, an zaɓi ƙimar farko daidai da jimlar maganin yau da kullun na maganin da ya gabata.

Bayan makonni biyu, zaku iya kimanta tasiri, idan sakamakon rashin gamsuwa ne, sashi zai karu da 500 MG, amma ba fiye da 2000 mg / rana ba. (4 inji mai kwakwalwa.), Wanda yayi dace da matsakaicin matsakaici. Hakanan ana ɗaukar allunan hudu sau ɗaya, tare da abincin dare. Idan wannan tsarin kulawar baiyi tasiri sosai ba, zaku iya rarraba allunan zuwa allurai 2: rabi da safe, na biyu da yamma.

Glucophage Long 500 don asarar nauyi yana haifar da ma'ana ne kawai ga masu ciwon sukari da kuma mutanen da ke da matsala na rayuwa. Akwai dalilai da yawa da ke haifar da kiba, magani na kai-tsaye tare da mummunan magani da kuma binciken kai na iya samar da sakamako wanda ba a tsammani.

Yana da mahimmanci a sha magani a lokaci guda. Karin kumallo ko abincin dare ya cika. Tare da kowane tsarin kulawa, ana shawarar mai ciwon sukari a rage yawan abinci - sau 5-6 a rana, tare da abun ciye-ciye masu sauƙi tsakanin manyan abinci. Idan saboda wasu dalilai kun rasa lokacin shan maganin, ba za ku iya ninka daidai ba, saboda jiki yana buƙatar lokaci don cikakken aiwatar da kashi. Kuna iya ɗaukar kwayar a farkon damar. Ba a ɗaukar miyagun ƙwayoyi a cikin darussan, amma koyaushe. Idan mara lafiya ya dakatar da jiyya tare da metformin, likitan da ke halartar ya kamata ya san wannan.

Idan ana amfani da Glucofage Long a cikin hadaddun tsari tare da insulin, farawar umarnin don amfani yana ba da shawarar zaɓar abin da bai wuce 1 kwamfutar hannu ba (500 mg / rana). Ana yin lissafin sashi na insulin hormone lokacin yin la'akari da tsarin abinci da karatun karatun glucometer.

Glucophage Tsayi - 750 mg

Hakanan ana ɗaukar maganin kafe 750 MG sau ɗaya, tare da abincin dare ko kuma bayan shi. Sigar farawa bai wuce kwamfutar hannu ɗaya ba, ana iya ɗaukar lakabin kashi bayan rabin wata. Increaseara yawanta a hankali yana sauƙaƙa dacewa da daidaita jiki kuma yana rage yiwuwar sakamako masu illa ga hanji.

Matsayin da aka ba da shawarar na glucophage mai tsawo shine allunan 2 / rana. (1500 mg), idan sakamakon da ake so ba shi ba, ana daidaita ƙa'idar zuwa 3 pcs./day. (2250 mg - matsakaici). Lokacin da ƙarfin magungunan jinkirin ba su isa ba, sai su canza zuwa Glucophage na yau da kullun, wanda ke da iyaka na 3000 MG / rana.

Idan an canza haƙuri zuwa ga glucophage mai tsawo tare da analogues dangane da metformin, lokacin da zaɓin farawa zai yi musu jagora gwargwadon ƙwaƙwalwar magani na baya. Idan magani kuma yana da tasiri na tsawon lokaci, ana buƙatar ɗan hutawa yayin maye gurbin maganin, la'akari da lokacin da aka cire shi daga jiki. Masu ciwon sukari suna shan Glucophage na yau da kullun a cikin adadin 2000 MG ko fiye, maye gurbin shi da Glucophage Long bashi da amfani.

Tsarin Glucofage ® Tsarin Tsagewa da Sakin Tsarin

MERCK SANTE, wani kamfanin kera Faransawa, ya saki Glucophage® tsawon lokacinda aka ci gaba da allunan sakin layi.

Dogaro da sashi, suna dauke da 500 ko 750 MG na aiki metformin hydrochloride. An inganta capsules tare da fillers: sodium carmellose, hypromellose, cellulose, stenes magnesium.

Za'a iya bambance allunan fararen rubutu ta farin hoto ta hanyar zanen kashi da tambarin kamfanin ta kowane bangare. A cikin allunan alkuki na aluminium ana kunshe cikin 15. A cikin akwatin ɗaya za'a iya samun 2 ko 4 irin faranti.

Suna sakin maganin gwargwadon abin da aka tsara ta; baya buƙatar yanayi na musamman. A Glyukofazh Long, farashin yana da araha sosai: a cikin kantin magani na kan layi ana ba shi don 204 rubles. (sashi na 500 MG). Rayuwar shiryayye na miyagun ƙwayoyi shine shekaru 3.

Side effects

Dangane da ka'idojin WHO, ana kimantawa yawan sakamako mara amfani akan ma'auni:

• Sau da yawa sosai - ≥ 0.1;
• Akai-akai - daga 0.01 zuwa 0.1;
• Rashin daidaituwa - daga 0.001 zuwa 0.01;
• Rare - daga 0.0001 zuwa 0.001;
• Da wuya sosai - daga 0.00001 zuwa 0, 0001.

Idan ƙididdigar da ke akwai na alamu ba ta dace da tsarin da aka ƙayyade ba, ana yin rikodin guda ɗaya.

Yawancin sakamakon da ba a so su tafi da kansu bayan daidaitawa, idan rashin jin daɗi ba tare da ɓata lokaci ba, ya zama dole a sanar da endocrinologist game da wannan. Zai iya rage kashi ko sanya alamar analog. Wasu lokuta ana rage yawan rikicewar cuta ta dyspeptic ta tsayayyun mizani ga ka'idodin abinci mai karancin-abinci da kuma rarraba kashi-kashi na yau da kullun a cikin allurai 2.

Duaukar hankali kan hankali (musamman sama) a cikin irin waɗannan halayen wajibi ne.

A cikin masu ciwon sukari suna shan kwayoyi na tushen metformin kullun, bitamin B12 ba shi da matsala. Idan an gano megaloblastic anemia, wannan yakamata ayi la'akari dashi.

Dysfunctions hanta na faruwa ba da jimawa ba tare da shafe shafewar Glucofage Long.

Sakamakon rashin haɗarin hypoglycemia, ɗaukar miyagun ƙwayoyi a matsayin monotherapy ba shi da haɗari ga direbobi da masu ciwon sukari, waɗanda aikinsu yana da alaƙa da haɓakar jawo hankali da kuma yawan tasirin sakamako. Tare da magani mai rikitarwa, dole ne a la'akari da yuwuwar wasu wakilai na hypoglycemic.

Taimaka tare da alamun yawan overdose

An gwada zafin guba na metformin na gwaji: masu sa kai sun karɓi kashi 42.5 sau mafi girma daga ƙasan ƙasan babba na yau da kullun (85 g). Hypoglycemia a cikin mahalarta ba ya haɓaka, alamun bayyanar lactic acidosis ya nuna.

Idan ba'a gano irin waɗannan alamun a cikin ma'aikatar likita ba, an dakatar da karbar Glucophage Long kuma ana kiran motar asibiti.

Bayan ƙayyadaddun matakin lactate a cikin jiki, an wajabta mai haƙuri a cikin hemodialysis. Hakanan an wajabta maganin cututtukan mahaifa.

Sakamakon Cutar Magunguna

Abubuwan haɗin gwiwa

Alamar radiyo-tushen Iodine na iya haifar da lactic acidosis, musamman ma masu ciwon sukari tare da cututtukan koda. Tsawon lokacin karatun kimiyyar iska, an soke Glucophage Long. Idan yanayin kodan ba ya haifar da damuwa, bayan kwana biyu mai haƙuri zai iya komawa tsarin kulawa da saba.

Ba'a shawarar zaɓuɓɓuka

Glucophage da giya ba su da cikakken jituwa, tunda giya na ethyl na iya haifar da lactic acidosis, musamman tare da matsaloli tare da hanta da rashin daidaitaccen abinci. Magungunan Ethanol ma suna kara saurin kamuwa da wannan matsala.

Maƙeran da ke buƙatar kulawa ta musamman

A layi daya tare da metformin, wasu magunguna suna buƙatar taka tsantsan da kula da sukari na jini akai-akai.

1. Danazole - haɓaka tasirin hyperglycemic, yana buƙatar titration na kashi na metformin;
2. Chlorpromazine - yana haifar da yanayin glycemic, yana hana samar da insulin, yana buƙatar daidaita kashi na Glucofage Long;
3. Glucocorticosteroids - mai haɗari ta raguwa a cikin haƙuri, karuwa a cikin sukari, rikitarwa a cikin nau'in ketosis;
4. Diuretics (loopback) - suna ba da gudummawa ga haɓakar lactic acidosis da gazawar renal;
5. β-sympathomimetics - saboda haɓakar masu karɓar β-masu karuwa da haɓakar glycemia, canjin zuwa insulin yana yiwuwa;
6. Jami'an antihypertensive, insulin, salicylates, acarbose, magunguna na ƙungiyar sulfonylurea - haɓaka damar haɓaka glucose na Glucofage Long, suna buƙatar titing sashi;
7. Nifedipine - yana ƙara yawan haɗarin metformin da Cmax.

Theungiyar cationic na kwayoyi kamar morphine, amiloride, digoxin, procainamide, quinidine, quinine, ranitidine, triamteren, trimethoprim, vancomycin an ɓoye a cikin tubules na koda, sabili da haka, ya kasance mai gasa da Glucophage a cikin gwagwarmayar tsarin jigilar kayayyaki.

Glucophage na kimantawa ta Kwastomomi

Binciken masu ciwon sukari suna shan Glucofage Long, sake dubawa sun nuna hade.

1. Babban inganci. Rage nauyi a cikin sauri saboda rashin abincin abinci kuma galibi duk wasu canje-canje a rayuwa sun tilasta min ganin likita. Gano juriya insulin da hypothyroidism, wanda ya kara matsalar da nauyi. An tsara Glucophage, da farko na yau da kullun - 3 rubles kowace rana. 850 MG kowane. A layi daya, ta bi da thyroid gland shine yake. Tsawon watanni 3, komai ya koma kamar yadda aka saba: ana dawo da nauyi da aikin insulin. Yanzu an canza ni zuwa Glyukofazh Long (yanzu don rayuwa).
2. Tasirin matsakaici. Mun dauki Glucophage Long tare da matarmu. Sun ce yana karfafa jijiyoyin jini, yana tsawaita rayuwa, ni ma ina da sukari. Da zaran abubuwa suka sami sauki, sai na fara tsallake shan kwayoyin, amma cikina duk lokacin da ya rama ni saboda irin wannan hargitsi. Dole ne in rage kashi kuma in tsayar da abincin. Na lura cewa tasirin sakamako yana ƙaruwa tare da amfani da maganin rashin daidaituwa na miyagun ƙwayoyi.
3. Resultarancin sakamako. An gano nau'in ciwon sukari na 2 a cikin ni a watan da ya gabata, an wajabta wa Glucofage Long, tunda aikin ba ya ba ni damar yin tunani game da kwayoyin game da kullun. Ya sha maganin har tsawan sati uku sannan ya ci gaba, sai aka sami karin sakamako. Na daure har na isa asibiti. An soke maganin, a hankali yana murmurewa.

Theara aminci ga masu ciwon sukari zuwa far, rage faruwar abubuwan da ba a zata ba don ƙwayar jijiyoyin jiki sune mahimmancin mahimmancin Glucofage Long, amma babban ma'aunin ingancin maganin ƙwayar cuta shine duk da haka alamomin glycemic a cikin masu ciwon sukari tare da cutar ta 2.