C-peptide (daga Ingilishi mai haɗa peptide, ana iya fassara shi azaman "haɗa peptide") - wani abu da aka kirkira ta hanyar share ƙwayar proinsulin ta hanyar peptidases alama ce ta ɓoyewar insulin cikin ciki. Abin sha'awa ne cewa oligopeptide kanta, ba kamar insulin ba, ba shi da wani tasiri a cikin sukari na jini, duk da haka, yana da matukar mahimmanci ga mutanen da ke da ciwon sukari: an riga an tabbatar da cewa saboda rashin ingancinsa, sun fara haifar da rikicewa.
Dogaro da matakin glucose na jini a cikin ƙwayoyin beta na pancreas, an samar da preproinsulin. Bayan sharewa daga karamin reshe na oligopeptide, ya juya ya zama proinsulin. Tare da haɓaka matakin glucose, kwayoyin proinsulin suna rushe zuwa cikin C-peptide (oligopeptide tare da tsawon amino acid 31) da insulin kanta. Dukansu an sake su zuwa cikin jini. Bayan ɓoye, insulin da C-peptide ta hanyar jijiyar ƙararraki sun fara bayyana a hanta, inda kusan kashi 50% na insulin ya lalace. C-peptide ya fi jurewa - yana maganin metabolized a cikin kodan. Rabin rayuwar insulin a cikin jini na cikin mintuna 4, kuma C-peptide yana kusan 20. Saboda haka, matakin wannan abu yana nuna samar da insulin a cikin sel na tsibirin na Langerhans da kyau fiye da insulin da kanta.
Binciko
Saboda gaskiyar cewa C-peptide ya bayyana a cikin jini a cikin taro mai narkewa kamar insulin, ana iya amfani dashi azaman alamar alama don ɓoye insulin. Don haka, alal misali, tare da nau'in ciwon sukari na 1 kuma a ƙarshen ƙarshen nau'in ciwon sukari na 2, maida hankali cikin jini yana raguwa. A wani matakin farko (tun ma kafin bayyanuwar), ciwon sukari 2 yana ƙaruwa, kuma tare da insulinoma (ƙwayar ƙwayar ƙwayar ƙwayar cuta), haɗuwa da wannan abu a cikin jini yana ƙaruwa sosai. Bari mu bincika wannan tambaya dalla-dalla.
An lura da ƙara matakin tare da:
insulin-da ke fama da ciwon sukari mellitus,
na gazawar
amfani da magungunan hormonal,
insulinoma
beta cell hypertrophy.
Rage matakin halaye ne na:
insulin-da ke fama da ciwon sukari mellitus a cikin yanayin hypoglycemic,
yanayin damuwa.
Siffofin Nazarin
An gudanar da binciken ne:
Don kai tsaye ƙayyade yawan insulin tare da ƙwayoyin rigakafi, waɗanda ke canza alamu, suna sa su zama ƙarami. Hakanan ana amfani dashi don ƙeta mai ƙarfi na hanta.
Don ƙayyade nau'in mellitus na ciwon sukari da kuma abubuwan fasalin ƙwayoyin beta na pancreatic don zaɓar dabarun magani.
Don gano tumatirin ƙwayoyin cuta ta hanji bayan cirewar tiyata.
An wajabta gwajin jini don cututtukan da ke gaba:
Nau'in nau'in ciwon sukari na 1, wanda a ciki ake rage matakin furotin;
Nau'in nau'in ciwon sukari na 2, wanda a cikin abin da ke nuna alamun sama ya fi na al'ada;
Halin kawar da cutar kansa bayan kansa;
Rashin haihuwa da sanadinsa - polycystic ovary;
Cutar sankarar mahaifa mellitus (an bayyana yiwuwar cutar da yaro);
Rarraba iri-iri cikin lalacewar cututtukan farji.
Somatotropinoma;
Ciwon Cusus.
Bugu da ƙari, wannan bincike yana ba ku damar gano sanadin yanayin hypoglycemic a cikin ciwon sukari. Wannan alamar yana ƙaruwa tare da insulinoma, yin amfani da magunguna masu rage ƙwayar sukari na roba.
Ana saukar da matakin, a matsayin mai mulkin, bayan shan mai yawa na giya ko a bango na gabatarwar insulin mai wuce gona da iri a kan ci gaba.
An wajabta yin binciken idan mutum ya yi gunaguni:
na tsawon kishirwa
karuwar fitowar fitsari,
nauyi.
Idan an riga an yi binciken cutar sankarar mellitus, to za'ayi bincike don tantance ingancin magani. Ba a zaɓaɓɓen magani da kyau ba tare da rikice-rikice ba: mafi yawan lokuta a wannan yanayin, mutane suna koka da raunin gani da raguwar jijiyoyin kafafu. Bugu da kari, ana iya lura da alamun rashin aiki na kodan da hauhawar jijiya.
Ana ɗaukar jini na Venous don bincike. Tsawon sa'o'i takwas kafin binciken, mai haƙuri ba zai iya ci ba, amma zaku iya shan ruwa.
A bu mai kyau kada a sha taba awanni 3 kafin a aiwatar kuma kar a sha wahalar motsa jiki kuma kar a sanyaya. Sakamakon binciken zai iya zama sananne bayan 3 hours.
Tsarin C-peptide da fassarar
Ka'idar C-peptide iri ɗaya ce cikin mata da maza. Ka'ida ba ta dogara da shekarun masu haƙuri ba kuma tana kasancewa 0.9 - 7.1ng / ml.
A matsayinka na mai mulkin, motsi na peptide yana dacewa da kuzari na taro na insulin. Adadin azumi shine 0.78 -1.89 ng / ml (SI: 0.26-0.63 mmol / L).
Norms ga yara a cikin kowane takamaiman yanayin likita ne ya ƙaddara, tunda matakin wannan abu a cikin yaro yayin nazarin azumi na iya zama ɗan ƙasa da ƙananan ƙarancin ƙa'idar, tunda guntun kwayar ta proinsulin ya bar ƙwayoyin beta kawai bayan cin abinci.
Za a iya ƙara yawan C-peptide tare da:
- hauhawar jini na sel na tsibirin na Langerhans. Yankunan Langerhans ana kiransu wuraren da ke cikin damuwa wanda ke motsa insulin,
- kiba
- insulinoma
- nau'in ciwon sukari na 2
- ciwon kansa
- dogon QT tazara syndrome,
- da amfani da sulfonylureas.
- Baya ga abubuwan da ke sama, C-peptide na iya ƙaruwa yayin ɗaukar wasu nau'ikan wakilai na hypoglycemic da estrogens.
C-peptide yana raguwa lokacin da:
- barasa hypoglycemia,
- nau'in ciwon sukari guda 1.
Koyaya, yakan faru cewa matakin peptide a cikin jini akan komai a ciki na al'ada ne, ko kusa da al'ada. A wannan yanayin, ba shi yiwuwa a tantance irin nau'in ciwon sukari da mutum yake da shi. A irin waɗannan yanayi, ana ba da shawarar yin gwaji na musamman da za a karfafa don a san halin mutum na musamman ga wani mara lafiya.
Ana iya yin wannan binciken ta amfani da:
Glucagon injections (mai insulin antagonist), yana da cikakken contraindicated ga mutanen da tare da hauhawar jini ko pheochromocytoma,
Gwajin gwajin haƙuri.
Zai kyautu a wuce dukkan alamomin: duka biyun ɓataccen ciki ne da gwajin motsa rai. Yanzu dakunan gwaje-gwaje daban-daban suna amfani da kayan daban daban don tantance matakin abu, kuma dabi'ar ta dan bambanta.
Bayan samun sakamakon binciken, mai haƙuri zai iya kwatanta shi da kansa tare da ƙimomin tunani.
Peptide da ciwon sukari
Magungunan zamani sunyi imanin cewa tare da C-peptide ya fi dacewa don sarrafa insulin. Yin amfani da bincike, yana da sauƙi a rarrabe tsakanin endogenous (wanda jiki ya samar) da insulin insulin. Ba kamar insulin ba, maganin oligopeptide baya amsa maganin rigakafi ga insulin, kuma waɗannan kwayoyin ba su lalata shi.
Tun da magungunan insulin ba su da wannan abun, maida hankali ne cikin jinin mai haƙuri ya sa ya yiwu a kimanta ayyukan ƙwayoyin beta. Tunawa: Kwayoyin beta na cututtukan fitsari suna samar da insulin kwayoyin halitta.
A cikin mutumin da ke da ciwon sukari, matakin basal na peptide, kuma musamman maida hankali bayan saukar glucose, yana sa ya yiwu a fahimci ko akwai juriyar insulin. Bugu da kari, an ƙididdige matakai na yin sakaci, wanda zai ba ka damar daidaita warkaswa daidai.
Yin la'akari da waɗannan abubuwan duka, zamu iya yanke shawara cewa nazarin wannan abu yana ba mu damar kimin ɓoyewar insulin a cikin lamura daban-daban.
A cikin mutanen da ke da ciwon sukari waɗanda ke da ƙwayoyin cuta zuwa insulin, ana iya lura da matakin C-peptide na ƙarya na ɗan lokaci saboda wasu ƙwayoyin cuta waɗanda ke hulɗa da proinsulin.
Ya kamata a ba da muhimmiyar mahimmanci ga canje-canje a cikin taro na wannan abu a cikin mutane bayan aikin insulinomas. Babban matakin yana nuna ko dai ciwace-ciwacen daji ko metastases.
Lura: idan akwai hanta mai rauni ko aikin koda, rabo a cikin jinin oligopeptide da insulin na iya canzawa.
Ana buƙatar bincike don:
Cutar sankarau
Zabi nau'ikan ilimin likita,
Zabi nau'in magani da sashi,
Eterayyade matakin karancin beta,
Bayyanar cututtuka na yanayin hypoglycemic,
Kimantawa na samar da insulin,
Ma'anar juriya na insulin
Kulawa da yanayin bayan cirewar koda.
Na dogon lokaci an yi imani da cewa abu da kansa ba shi da wasu ayyuka na musamman, don haka yana da mahimmanci cewa matakinsa al'ada ne. Bayan shekaru da dama na bincike da daruruwan takardun kimiyya, sai ya zama sananne cewa wannan hadadden kwayar halitta yana da tasirin magani:
- Tare da nephropathy,
- Tare da neuropathy
- Tare da ciwon sukari na angiopathy.
Koyaya, masanan kimiyya basu sami damar gano ainihin yadda matakan kariya na wannan kayan suke aiki ba. Wannan batun zai kasance a bayyane. Har yanzu babu wani bayanin kimiyya game da wannan sabon yanayin, duk da haka, har ma da bayani game da tasirin sakamako na C-peptide da haɗarin da amfaninsa zai iya haifar. Haka kuma, likitocin Rasha da na Yamma ba su cimma yarjejeniya ba ko an yi amfani da wannan sinadarin don sauran rikice-rikice na ciwon sukari.
