Ana samun sitagliptin a cikin nau'in phosphate monohydrate. Fitar saki shine kwamfutar da aka rufe fim
Kayan aiki ya bambanta sosai a cikin tsarinta na kemikal da aikin magunguna daga analogues da abubuwan da aka samo na sulfonylureas, biguanides da inhibitors na alpha-glycosidase.
Inhibation na DPP 4 tare da Sitagliptin yana haifar da karuwa a cikin taro na hormones guda biyu GLP-1 da HIP. Wadannan kwayoyin halittar suna cikin dangin mahaifin. Ana aiwatar da ɓoyewar waɗannan kwayoyin halittar a cikin hanji.
Yawan tattara waɗannan kwayoyin halittar suna ƙaruwa sakamakon cin abinci. Abubuwan da ke faruwa sune bangare na tsarin ilimin halittar jiki wanda ke daidaita sukari homeostasis a jiki.
Magunguna da alamomi don amfanin maganin
Bayan shan magungunan, ƙwayar ta sha da sauri. Wannan magani yana da cikakken cikakken halitta bio 87%. Yawan cin abinci mai mai mai daɗi ba ya da tasiri ga magungunan likitancin magani.
Drawato da miyagun ƙwayoyi yana gudana ba tare da canzawa ba a cikin tsarin fitsari. Bayan dakatar da miyagun ƙwayoyi na mako guda, 87% tare da fitsari da 13% tare da feces an keɓe su.
Ana amfani da maganin a matsayin hanyar monotherapy a gaban nau'in ciwon sukari na II na mellitus a cikin haƙuri. An yarda da shan magani ba tare da la'akari da abincin ba. Za'a iya amfani da Sitagliptin tare da Metformin a matsayin magani mai rikitarwa a gaban nau'in ciwon sukari na 2 na mellitus. Matsakaicin shawarar shan shan magani a hade tare da Metformin shine 100 MG sau ɗaya a rana.
Idan ka rasa lokacin yin Sitagliptin, yakamata ku karba shi da wuri. Wannan shi ne saboda gaskiyar cewa shan sau biyu na magani ba a yarda da su ba.
An hana shi shan magani sau da yawa fiye da umarnin da aka bayar don amfani dashi.
Kayan aiki yana ba ku damar sarrafa matakin sugars a cikin jiki, amma wannan magani ba ya kula da ciwon sukari.
Ya kamata a sha miyagun ƙwayoyi ko da mara lafiya yana jin daɗi, ya kamata a dakatar da miyagun ƙwayoyi ne kawai bayan tuntuɓar likita da halartar mashawarcin.
Umarnin don amfani da miyagun ƙwayoyi
Sitagliptin magani ne wanda aka yarda da shi sosai lokacin da marasa lafiya suka sha shi, duka a lokacin monotherapy kuma a matsayin wani ɓangare na ƙwaƙƙwarar jiyya tare da wasu magunguna waɗanda ke da kaddarorin cututtukan zuciya.
Dauke da babban kashi na magani ne ta hanyar da kodan. Wannan hanyar cire abu mai aiki daga jiki yana buƙatar likita mai halartar don kimanta aikin kodan a cikin haɗarin rashin lafiyar koda a cikin haƙuri kafin amfani da miyagun ƙwayoyi. Idan ya cancanta, ana aiwatar da gyaran kashi na maganin. A gaban wani nau'i mai sauƙi na gazawar renal, ba a yin gyaran sashi na maganin da aka ɗauka.
Idan mai haƙuri yana da gazawar ɗan na koda matsakaici, kashi na maganin bai kamata ya wuce 50 MG sau ɗaya a rana ba. Ana iya amfani da miyagun ƙwayoyi a kowane lokaci, ba tare da la'akari da tsarin dialysis ba.
Lokacin amfani da miyagun ƙwayoyi a matsayin ɓangaren hadaddun farji, don hana haɓakar haɓakar jini a cikin jiki, yawan abubuwan da ake amfani da su na sulfonylurea waɗanda aka yi amfani da su dole ne a rage.
Samun magungunan da aka yi amfani da shi shine likita mai halartar binciken ya biyo bayan cikakken bincike na jikin mai haƙuri da ke fama da ciwon sukari na 2.
Idan akwai tuhuma game da ci gaba a jikin mai haƙuri na pancreatitis, ya zama dole a dakatar da shan Sitagliptin da sauran magunguna waɗanda ke iya haifar da cutar da cutar.
Kafin amfani da miyagun ƙwayoyi, likita dole ne ya sanar da mara lafiya game da alamun farko na alamun cututtukan cututtukan fata.
Contraindications da sakamako masu illa
Yin amfani da miyagun ƙwayoyi na iya haifar da mummunan cuta mai haɗari ga rayuwa a cikin jikin mutum.
Tare da yin amfani da maganin da ba ta dace ba, yana da damar tsokanar abin da ya faru da yawan sakamako masu illa a jiki. Lokacin da alamun farko na cin zarafi suka bayyana, tuntuɓi likita kai tsaye.
Lokacin amfani da miyagun ƙwayoyi, umarnin umarnin da likitan halartar ya kamata ya bi sosai.
Lokacin amfani da miyagun ƙwayoyi, mutum zai iya samun yawan sakamako masu illa. Manyan sakamako masu illa sune:
- angioedema;
- anaphylaxis;
- kurji
- fata vasculitis;
- urticaria;
- cututtukan fata na exfoliative, ciwo na Stevens-Johnson;
- m pancreatitis;
- lalacewa daga cikin kodan, raunin ƙwayar ƙwayar ƙwayar yara wanda ke buƙatar dialysis;
- nasopharyngitis;
- cututtukan mahaifa;
- amai
- maƙarƙashiya
- ciwon kai
- myalgia;
- arthralgia;
- ciwon baya
- jin zafi a gabar;
- itching
Lokacin amfani da miyagun ƙwayoyi, ya kamata a ɗauka a cikin zuciya cewa akwai kewayon contraindications mai yawa don amfani da wannan magani.
Babban contraindications don shan miyagun ƙwayoyi sune kamar haka:
- rashin ƙarfi;
- gaban ciwon sukari mellitus na nau'in farko;
- mai ciwon sukari mai ciwon sukari;
- shekarun haƙuri ba ƙasa da shekaru 18 ba;
- lokacin lactation;
- lokacin haihuwar yaro.
Lokacin amfani da magani, duk shawarwari yakamata a bi sosai; magani bai kamata a ɗauka ba idan wani daga cikin abubuwan contraindications ya kasance. Idan yawan abin sha ko yawan guba ya faru sakamakon shan miyagun ƙwayoyi, dole ne a kira motar asibiti nan da nan.
Doaukar yawa ko guban jiki tare da ƙayyadadden ƙwayar cuta na iya haifar da mummunan matsalolin kiwon lafiya har zuwa mummunan sakamako.
Analogs, farashi da hulɗa tare da wasu hanyoyi
A lokacin gwaji na asibiti, shirye-shiryen da suka danganci sitagliptin ba su da tasiri mai mahimmanci a cikin maganin ƙwaƙwalwar ƙwayoyi na magunguna irin su rosiglitazone, metformin, glibenclamide, warfarin, simvastatin, da rigakafi na baka.
Lokacin amfani da wakilai dangane da sitagliptin, hana CYP2C8, CYP3A4, CYP2C9 isoenzymes baya faruwa. Bugu da kari, kwayoyi ba sa hana irin wannan enzymes CYP1A2, CYP2D6, CYP2B6, CYP2C19.
Haɗewar yin amfani da sitagliptin da metformin ba su da wani canji mai mahimmanci a cikin magunguna na sitagliptin a cikin ciwon sukari mellitus.
Magungunan da suka fi yawa ita ce Janavia. Takaitaccen tarihin kwayoyi na Rasha shine Yanumet, wanda farashinsa a Rasha ya kusan 2980 rubles.
Yin hukunci da sake dubawa na marasa lafiya waɗanda suka yi amfani da wannan magani don magani, yana da tasiri a kan matakin sukari a cikin jiki, amma yana buƙatar tsayayyen ikon kula da halin jikin mutum saboda yiwuwar faruwar yawan adadin sakamako masu illa.
Farashin miyagun ƙwayoyi ya dogara da yankin ƙasar da kuma shirya magungunan kuma yana tsakanin 1596 zuwa 1724 rubles. Bidiyo a cikin wannan labarin zai yi magana game da hanyoyin da za a bi da cutar glycemia.
