Cikakken aikin jikin mutum ba zai yiwu ba tare da insulin ba. Hormone ne mai mahimmanci don aiki da glucose, wanda ya zo da abinci, zuwa makamashi.
Saboda dalilai daban-daban, wasu mutane suna da karancin insulin. A wannan yanayin, akwai buƙatu don gabatar da hormone na wucin gadi a cikin jiki. A saboda wannan dalili, ana amfani da insulin Degludek sau da yawa.
Magungunan shine insulin mutum wanda ke da ƙarin sakamako mai tsawo. An samar da samfurin ta hanyar nazarin halittar DNA na rayuwa ta amfani da irin ƙwaƙwalwar Saccharomyces cerevisiae.
Pharmacology
Ka'idar aiki ta insulin Degludek ita ce daidai da ta mutum. Tasirin rage sukari ya danganta ne da motsa ayyukan yin amfani da sukari ta hanyar kyallen takarda bayan dauri ga mai karuwar mai da tsoka da kuma a lokaci guda yana rage girman gubar samar da hanta.
Bayan allura guda ɗaya na mafita a cikin sa'o'i 24, yana da tasirin launi. Tsawon lokacin yana tasiri sama da awanni 42 a cikin kewayon maganin warkewa. Yana da mahimmanci a san cewa an kafa dangantaka ta layi tsakanin haɓaka da adadin ƙwayar da kuma tasirin hypoglycemic ɗin gaba ɗaya.
Babu wani bambanci mai mahimmanci a cikin magunguna na insulin Degludec tsakanin matasa da tsofaffi marasa lafiya. Hakanan, ba a gano kirkirar kwayoyin zuwa insulin ba bayan magani tare da Deglyudec na dogon lokaci.
Tsawancin sakamakon maganin yana faruwa ne saboda tsarin musamman na kwayar halittar ta. Bayan sc gwamnatin, ana kafa ragowar maye gurbi mai narkewa, wanda yake samar da nau'in “depot" don insulin a cikin ƙwayar katako mai ƙarfi a cikin ƙasa.
Magungunan ƙwayoyin cuta da yawa suna rarrabu a hankali, sakamakon haifar da sakin ƙwayoyin hormone. Don haka, jinkirin da tsawaita magudin cikin kwararar jini na faruwa, wanda ke tabbatar da ɗorewa mai ɗaukar hoto mai ɗaukar nauyi mai ɗorewa da kuma rage ƙarfin sukari mai ƙarfi.
A cikin plasma, ana samun CSS kwana biyu ko uku bayan allurar. Rarraba magungunan kamar haka: alaƙar Degludek tare da albumin -> 99%. Idan ana sarrafa magungunan a ƙarƙashin ƙasa, to, jigon jini gaba ɗaya ya zama daidai da sashi ɗin da aka gudanar a allurai.
Rushewar miyagun ƙwayoyi daidai yake da batun insulin mutum. Duk metabolites da aka kafa a cikin tsari ba su da aiki.
Bayan sc አስተዳደር na T1 / 2 an ƙaddara shi lokacin da ya ɗauka daga ƙwayar subcutaneous, wanda kusan awanni 25, ba tare da la'akari da sashi ba.
Jinsi na marasa lafiya ba ya shafar magunguna na insulin Degludec. Bugu da ƙari, babu wani bambanci na musamman a cikin ilimin insulin a cikin matasa, tsofaffi marasa lafiya da masu ciwon sukari tare da rauni hanta da aikin koda.
Game da yara (shekaru 6-11) da matasa (12-18 years old) tare da nau'in ciwon sukari na 1, likitan magunguna na insulin Degludec iri ɗaya ne a cikin majinyata na manya. Koyaya, tare da allurar guda ɗaya na miyagun ƙwayoyi a cikin marasa lafiya da ke dauke da ciwon sukari na 1, jimlar yawan maganin a cikin marasa lafiya da ke ƙasa da shekara 18 ya fi na masu ciwon sukari tsufa.
Abin lura ne cewa ci gaba da yin amfani da kwayar insulin Degludek baya tasiri a aikin haifuwa kuma baya da tasiri mai guba a jikin ɗan adam.
Kuma rabo na aikin mitogenic da na rayuwa na Degludek da insulin na mutum iri daya ne.
Umarnin don amfani da miyagun ƙwayoyi
Iya warware matsalar ya kamata a gudanar da shi kawai a karkashin fata, kuma an ba da izinin iv. Haka kuma, don samar da ingantaccen sakamako mai narkewa, allura guda ɗaya a rana ya isa.
Abin lura ne cewa insulin Degludec yana dacewa da duk allunan da ke rage sukari da sauran nau'ikan insulin. Don haka, za'a iya amfani da kayan aikin azaman monotherapy ko kuma wani ɓangare na magani hade.
Sigar farko na maganin shine raka'a 10. Bayan an yi gyaran kwaskwarima na hankali a hankali dangane da halayen mutum na haƙuri (nauyi, jinsi, shekaru, nau'in cutar, yanayin rikicewa).
Idan mai ciwon sukari ya karɓi wani nau'in insulin ko an tura shi zuwa Degludek (Tresib), to ana lasafta matakin farko gwargwadon ƙa'idar 1: 1. Saboda haka, adadin insulin na basal ya zama daidai da na insulin Degludek.
Idan mai ciwon sukari yana cikin tsarin biyu na tsarin insulin na baya ko mara lafiyar yana da glycated hemoglobin abun da kasa da 8%, to ana zazzage maganin ne daban-daban. Sau da yawa ya zama dole don rage sashi tare da gyara na gaba.
Abubuwan da likitocin ke dubawa sun nuna gaskiyar cewa yana da kyau a yi amfani da ƙananan allurai na insulin. Wannan ya zama dole saboda idan kuna fassara girman zuwa analogues, to don samun glycemia da ake so, kuna buƙatar koda ƙananan ƙwayoyi.
Ana iya yin gwajin na gaba na yawan adadin insulin sau ɗaya a kowane kwana 7.
Titration ya danganta ne da matsakaitan ma'aunin kashi biyu na glucose na azumi.
Contraindications, yawan abin sama da ya kamata, hulɗa da miyagun ƙwayoyi
Ba a ɗaukar insulin Degludec a cikin ƙuruciya, kamar yadda tare da rashin haƙuri na mutum zuwa abubuwan da aka gyara, lokacin shaƙatawa da ciki.
Babu wani takamammen kashi wanda zai iya tsokani yawan zubar jini, amma wannan yanayin na iya haɓaka a hankali. Tare da ɗan ƙarami a cikin sukari, mai haƙuri yana buƙatar shan abin sha mai dadi ko cin wani samfurin wanda ke ɗauke da ƙwayoyin carbohydrates mai sauri.
A cikin tsananin rashin ƙarfi, idan mai haƙuri bai san komai ba, an allura shi da maganin glucagon ko maganin glucose. Idan bayan amfani da glucagon mara lafiyar bai sake murmurewa ba, to an bashi dextrose, kuma ana bayar da rancen ne don abinci mai dauke da carbohydrate.
Bukatar insulin ya ragu lokacin da aka ɗauke shi da:
- ARG na peptide-1;
- allunan rigakafin jini;
- MAO / ACE inhibitors;
- masu hana beta zaɓi;
- sulfonamides;
- magungunan anabolic steroids;
- salicylates.
Thiazide diuretics, hana maganin hana haihuwa, Danazol, GCS, Somatropin, sympathomimetics, hormones na thyroid suna ba da gudummawa ga karuwar bukatar insulin. Bayyanar cututtukan hypoglycemia na iya zama ƙarancin sanarwa idan aka ɗauki Degludec tare da masu hanawa.
Lanreotide, Octreotide, da ethanol na iya haɓaka ko rage buƙatar insulin. Abin lura ne cewa idan an ƙara wasu magunguna zuwa maganin insulin, wannan na iya haifar da lalata wakilin hormonal.
Bugu da ƙari, ba a yarda da ƙara Degludec zuwa mafita na jiko ba.
Tasirin sakamako da umarni na musamman
Sakamakon sakamako na yau da kullun shine hypoglycemia. Yawancin lokuta alamun ta suna bayyana ba zato ba tsammani. Irin waɗannan bayyanar sun haɗa da fatar jiki, yunwar, bayyanar da gumi mai sanyi, bugun zuciya, gajiya, rawar jiki, ciwon kai, damuwa, tashin zuciya, damuwa, matsananciyar damuwa, rashin daidaituwa da rashin kulawa. Hakanan zai yiwu raunin gani na ɗan lokaci a cikin cutar sankara.
Hakanan za a iya magance matsalar rashin lafiyan, gami da haɗarin haɗarin anaphylactic. Da wuya a kan tsarin rigakafi, cutar urticaria ko rashin kwanciyar hankali na iya faruwa. Ana nuna wannan yanayin ta hanyar ƙoshin fata, kumburi na lebe, harshe, gajiya da tashin zuciya.
Wani lokacin lipodystrophy yana faruwa a wurin allurar. Koyaya, yin biyayya da ka'idodi don canza yankin allura, da alama irin wannan raunin zai iya zama kaɗan.
A fannin gudanar da mulki, rikice-rikice na gaba ɗaya da rikice-rikice na iya faruwa. Wani lokaci, tawayen farji na tasowa, yawancin lokuta a wurin allurar suna bayyana:
- lissafi;
- hematoma;
- haushi
- zafi
- itching
- bashin gida;
- canza launin fata;
- erythema;
- kumburi
- haɗa ƙwayoyin nama.
Binciken insulin na Deglyudeke insulin ya ce miyagun ƙwayoyi suna da sauƙi kuma suna dacewa don amfani, kuma saboda tsawaita aikin bayan gabatarwar mafita, matakin glycemia ya kasance al'ada na dogon lokaci.
Mafi shahararrun magungunan da suka danganci Degludek shine samfuri a karkashin sunan kasuwanci Tresiba. Ana samun magungunan azaman kit ɗin da ke dauke da katako wanda za a iya amfani da su a allonn Novopen sirinji don amfani da amfani.
Hakanan ana iya samun Tresiba a cikin allon da za'a iya zubar dashi (FlexTouch). Sashi na maganin shine 100 ko 200 PIECES a cikin 3 ml.
Kudin alƙalin Treshiba Flex Touch ya bambanta daga 8000 zuwa 1000 rubles. Kuma bidiyon da ke cikin wannan labarin, zai gaya muku yadda ake amfani da insulin.
