Cutar sankara (mellitus) cuta ce mai haɗari wanda zai iya zama dogaro da insulin (nau'in 1) ko wanda bai dace da insulin ba (nau'in 2). A cikin maganar ta ƙarshe, an sami nasarar magance cutar tare da taimakon masu haɓaka hypoglycemic da abinci na musamman. Amma tare da nau'in cutar ta farko kuma tare da nau'in ciwon sukari na 2 ya fara, ba za a iya rarraba maganin insulin tare da shi ba.
Sau da yawa, marasa lafiya da karuwar yawan sukari a cikin jini ana wajabta su insulin Glulizin. Wannan fararen bayani ne don allurar, babban abu wanda shine analog na narkewar jikin mutum, wanda aka haɓaka ta hanyar aikin injin.
Magungunan yana da ɗan gajeren sakamako wanda aka nufi da saurin ragewa a cikin taro na glucose a cikin jini. Apidra SoloStar da Apidra suna cikin hanyar, wanda ya ƙunshi insulin Glulisin.
Tasirin magunguna da magunguna
Maganin yana da ɗan gajeren sakamako na hypoglycemic. Bugu da ƙari, yana kunna tsarin karɓar glucose ta gabobin mahaifa (ƙoshin, tsokoki na kasusuwa), yana hana tsarin samar da glucose a cikin hanta.
Hakanan, miyagun ƙwayoyi suna ƙarfafa haɗin furotin, yana hana proteolysis da lipolysis a cikin adipocytes. Bayan gudanarwa na ƙarƙashin ƙasa, raguwa a cikin sukari yana faruwa bayan minti 10-20.
Game da batun iv, raunin hypoglycemic yana daidai da aikin insulin ɗan adam. Don haka, dangane da tasiri, 1 IU na insulin Glulisin daidai yake da 1 IU na insulin ɗan adam mai narkewa.
Idan aka kwatanta da insulin na mutum, Glulisin yana shan sa sau biyu. Wannan ya faru ne saboda maye gurbin amino acid na asparagine (matsayi 3B) tare da lysine, kazalika da lysine (matsayi 29B) tare da acid glutamic.
Nuna bayan gwamnatin sc:
- a cinya - matsakaici;
- a bango na ciki - sauri;
- a kafada - matsakaici.
Cikakken bayanin halitta shine kashi 70%. Lokacin da aka gabatar da shi a cikin yankuna daban-daban, yana da kama kuma yana da ɗan bambanci tsakanin marasa lafiya (bambancin adadin 11%).
Lokacin da ake sarrafawa a ƙarƙashin ƙasa tare da nau'in ciwon sukari na 1, 0.15 U / kg TCmax shine 55 min., Kuma Cmax kg shine 80.7-83.3 μU / ml. A cikin nau'in cuta ta biyu, bayan sc kulawa da miyagun ƙwayoyi a kashi 0.2 PIECES / kg, Cmax shine 91 mcU / ml.
A cikin watsawa na tsare-tsare, kimanin lokacin bayyana shine minti 98. Tare da kunnawa / gabatarwa, girman rarraba shine lita 13, T1 / 2 - mintuna 13. AUC - 641 mg x h / dl.
Pharmakoketiket a cikin masu ciwon sukari 'yan kasa da shekara 16 da ke da nau'in cutar iri daya ce kamar na manya. Tare da sc gwamnati T1 / 2 daga 37 zuwa 75 na minti.
Umarnin don amfani da miyagun ƙwayoyi
Ana gudanar da insulin Glulisin a ƙarƙashin ƙasa, an zaɓi sashi daban-daban ga kowane mara lafiya. Ana yin allura a cikin minti 0-15. kafin ko bayan cin abinci.
Ana amfani da Glulisin a cikin magungunan warkewa, gami da amfani da insulin matsakaici ko aiki mai tsayi, ko kuma analogues nasu. Hakanan, ana iya amfani da miyagun ƙwayoyi a hade tare da kwayoyi waɗanda ke da tasirin sakamako na hypoglycemic, waɗanda ake amfani dasu a baki.
Ana gudanar da maganin a cikin hanyar allurar subcutaneous ko jiko ta amfani da famfo na insulin. Ana yin allurar a yankin kafada, cinya, bangon ciki na ciki. Kuma gabatarwar kudade ta hanyar ci gaba da jiko ana aiwatar da su a cikin peritoneum.
Dole ne a canza bangarorin don injections da infusions kowane lokaci. Saurin ɗaukar abubuwa, farawa da tsawon lokacin tasirin yana ƙaddara abubuwa daban-daban (aikin jiki, wurin gudanarwa). Don ɗaukar hanzari, dole ne a allurar da magani a cikin wurin gaban bangon ciki.
Yana da mahimmanci a hankali cewa insulin Glulisin baya shiga cikin jijiyoyin jini. Saboda haka, kowane mai ciwon sukari ya kamata ya zama mai iyawa cikin gudanarwar insulin. Bayan allura, an hana wurin yin allura zuwa tausa.
An yarda Glulisin ya hade da Isofan (insulin na mutum), amma dole ne a jawo Glulisin cikin sirinji da farko. Gudanar da SC ya kamata a gudanar da shi nan da nan bayan an haɗa hanyoyin. A wannan yanayin, an haramta cakuda Isofan da Glulisin da za a gudanar da su cikin ciki.
Idan ana gudanar da insulin Glulisin ta amfani da famfo, to dole ne a canza kit ɗin kowane awanni 4, da bin ka'idodin maganin antiseptik. Tare da hanyar jiko na gudanarwa, miyagun ƙwayoyi bai kamata a haɗe shi da sauran mafita ko insulins ba.
Game da amfani da famfar da bata dace ba ko kuma ta saba da aikinta, ketoacidosis mai ciwon sukari, hyperglycemia ko ketosis na iya haɓaka. Don hana faruwar irin waɗannan yanayi, kafin aiwatar da aikin, ya kamata kuyi nazarin dokoki don amfani da tsarin kuma kuyi ƙididdigar sosai.
Kafin amfani da mafita, kuna buƙatar bincika daidaiton sa, launi da tabbatar cewa babu ɓoyayyiyar ƙasa a ciki. Idan samfurin yana da gajimare, mai launi ko tare da maras kyau, to, haramun ne a yi amfani da shi.
Contraindications, sakamako masu illa, yawan zubar jini
Ba a amfani da Insulin Glulizin don kula da yara 'yan ƙasa da shekaru shida, tare da cutar rashin ƙarfi da hauhawar jini zuwa abubuwan da ke ciki. Sakamakon sakamako na yau da kullun shine hypoglycemia. Bayyanar cututtukan fata da rashin lafiyan yanayin ma hakan yana yiwuwa.
Wani lokacin bayyanar cututtukan ƙwaƙwalwar ƙwaƙwalwar ƙwayar cuta suna faruwa, irin su nutsuwa, ƙaruwa mai yawa, rauni mai ƙarfi, matsewa, da tashin zuciya. Ciwon kai, rashin maida hankali, rikicewar tunani da damuwa na gani suma suna bayyana.
Sau da yawa, kafin rikicewar neuropsychiatric, alamun cututtukan adrenergic suna faruwa. Wannan shine yunwar, rashin damuwa, tachycardia, tashin hankali, gumi mai sanyi, damuwa, fatar fata da rawar jiki.
Yana da mahimmanci a san cewa mummunan hare-hare na hypoglycemia, wanda kullun ake maimaitawa, yana haifar da lalacewar NS. Haka kuma, a wasu yanayi, wannan na iya haifar da mutuwa.
Baya ga raguwar matakan sukari, raunin da ke faruwa na gida na iya faruwa a wuraren da aka yi allura. Waɗannan sun haɗa da hyperemia, kumburi da itching, sau da yawa waɗannan bayyanuwar suna ɓacewa da kansu yayin ƙarin magani. Lokaci-lokaci, saboda rashin yarda da maye gurbin wurin gudanar da insulin, mai ciwon sukari na iya haɓaka lipodystrophy.
Akwai alamun yiwuwar rashin kwanciyar hankali a ciki:
- itching
- urticaria;
- rashin lafiyan dermatitis;
- kirji
- cakulan.
Giesarfin ƙwayoyin cuta na gaba ɗaya na iya zama m.
Idan akwai yawan abin sama da ya kamata, cututtukan jini na haɓaka daban-daban na iya faruwa. Tare da raguwa kaɗan cikin sukari na jini, mai haƙuri ya kamata ya sha abin sha ko samfuran da ke ɗauke da sukari.
A cikin mafi tsananin yanayin da asarar hankali, s / c ko a / m ana gudanar da Dextrose ko Glucagon. Lokacin da mai haƙuri ya sake farfaɗo, yana buƙatar cinye carbohydrates, wanda zai guji komawa baya.
Yin hulɗa tare da wasu magunguna da umarni na musamman
Tare da haɗakar insulin Glulisin tare da masu hana ACE / MAO, Disopyramide, fibrates, sulfonamides, salicylates da Propoxyphene, ana inganta tasirin hypoglycemic kuma da alama haɓakar haɓaka haɓaka.
Haɗin insulin tare da masu hana kariya, Danazole, antipsychotics, Salbutamol, Terbutaline, isoniazids, Epinephrine, Diazoxide, diuretics, Somatropin da abubuwan ƙira na phenothiazine zasu rage tasirin hypoglycemic ba da faɗi ba. Clonidine, beta-blockers, ethanol da gishiri na lithium sun raunana tasiri insulin Glulisin. Kuma haɗu da amfani da miyagun ƙwayoyi tare da Pentamidine na iya tsokani duka biyu hypoglycemia da hyperglycemia.
Nazarin masu ciwon sukari sun ce lokacin amfani da wakilai waɗanda ke nuna ayyukan juyayi, ana iya magance alamun adrenergic reflex kunnawa. Irin waɗannan kwayoyi sun haɗa da clonidine da guanethidine.
Idan an canza mai haƙuri zuwa wani nau'in insulin ko magani daga sabon mai ƙira, to dole ne a yi wannan a ƙarƙashin kulawar likita. Yana da kyau a tuna cewa ba daidai bane ko kuma dakatar da maganin insulin zai iya haɓaka cutar ketoacidosis da ciwon sikari.
Haka kuma, wasu yanayi na iya canzawa ko sanya alamun cutar rashin ƙarfin magana. Irin wadannan abubuwan sun hada da:
- tsawan lokaci na ciwon suga;
- ofarfafa jiyya tare da insulin;
- canja mai haƙuri daga dabba zuwa hormone mutum;
- shan wasu ƙwayoyi;
- mai ciwon sukari mai ciwon sukari.
Lokacin canza abinci ko motsa jiki wajibi ne don canza sashi na insulin. Koyaya, idan ana gudanar da magani nan da nan bayan wasanni, to, yiwuwar rashin lafiyar hypoglycemia yana da girma.
Game da amfani da insulin Glulisin yayin daukar ciki, ya kamata a kusantar da tsarin kulawa tare da taka tsantsan, tunda glycemia na iya haɓaka a cikin nau'in ciwon sukari na 2 da na farkon. Haka kuma, a farkon watanni 3 na ciki da bayan haihuwa, yawanci insulin yakan rage. Yayin shayarwa, ana iya buƙatar daidaita sashi kuma a buƙata.
Farashin mafita don gudanarwar sc bisa ga insulin Glulisin ya tashi daga 1720 zuwa 2100 rubles.
Bidiyo a cikin wannan labarin ya nuna yadda ake allurar insulin a ƙasa.
