Mutanen da ke shan wahala daga nau'in ciwon sukari na 2 na sukari ba koyaushe ba zasu iya kiyaye matakan glucose a matakin al'ada saboda ayyukan jiki guda ɗaya da abinci na musamman wanda ke ware carbohydrates da fitsari mai sauƙin narkewa.
Wannan sabon abu yawanci yakan faru tare da tsawan lokaci na cutar, tunda kowace shekara ayyukan ƙwayar cikin farji ke lalacewa. Sannan allunan Galvus suna zuwa ga ceto, wanda ke ragewa da jinkirta sukari tsakanin ƙimar al'ada.
Yawancin masu ciwon sukari suna sha'awar yadda tasirin maganin da ke dauke da vildagliptin yake. Sabili da haka, wannan labarin zai bayyana tsarin aikin abu da sifofin amfani dashi, ta yadda kowa zai iya yankewa kansu wajan amfani da ƙwaƙwalwar ƙwayar cuta.
Aikin magunguna
Vildagliptin (Siffar Latin - Vildagliptinum) tana cikin rukunan abubuwan da ke motsa tsibirin Langerhans a cikin ƙwayar cuta da kuma hana ayyukan dipeptidyl peptidase-4. Sakamakon wannan enzyme yana da lalacewa ga nau'in 1 glucagon-like peptide (GLP-1) da polypeptide-insulinotropic-glucose-HIP).
A sakamakon haka, aikin dipeptidyl peptidase-4 yana rage karfin abu, kuma ana inganta aikin samar da GLP-1 da HIP. Lokacin da yawan jininsu ke ƙaruwa, vildagliptin yana inganta haɓakar ƙwayoyin beta zuwa glucose, wanda ke ƙara samar da insulin. Matsakaicin karuwa a aikin sel sel kai tsaye ya dogara da matakin lalacewarsu. Sabili da haka, a cikin mutane masu dabi'un sukari na yau da kullun lokacin amfani da kwayoyi waɗanda ke ɗauke da vildagliptin, ba ya shafar samarwa da ƙwayar sukari da ke ƙasa kuma, ba shakka, glucose.
Bugu da ƙari, lokacin da miyagun ƙwayoyi ke ƙaruwa da abun ciki na GLP-1, a lokaci guda, ƙwaƙwalwar glucose yana ƙaruwa a cikin ƙwayoyin alpha. Irin wannan tsari ya ƙunshi ƙaruwa a cikin tsarin glucose mai dogaro da samar da ƙwayoyin alpha na hormone, wanda ake kira glucagon. Rage abun da ya karu yayin amfani da abinci yana taimakawa kawar da garkuwar jiki zuwa insulin din hormone.
Lokacin da rabo na insulin da glucagon yana ƙaruwa, wanda aka ƙaddara ta ƙara darajar HIP da GLP-1, a cikin yanayin hyperglycemic, glucose a cikin hanta ya fara samar da ƙarancin, duka lokacin cin abinci da kuma bayan shi, wanda ke haifar da raguwar abubuwan glucose a cikin jini na mai ciwon sukari.
Ya kamata a lura cewa, ta amfani da Vildagliptin, yawan adadin lipids yana raguwa bayan cin abinci. Increaseara yawan abubuwan da ke cikin GLP-1 wani lokaci yana haifar da raguwa a cikin ƙaddamar da ciki, kodayake ba a gano irin wannan sakamako ba lokacin farawa.
Wani binciken da aka yi kwanan nan wanda ya shafi kusan marasa lafiya 6,000 sama da makonni 52 sun tabbatar da cewa yin amfani da vildagliptin na iya rage matakan glucose a cikin komai a ciki da gemoclobin na ciki (HbA1c) yayin da ake amfani da miyagun ƙwayoyi:
- a matsayin tushen magani;
- a hade tare da metformin;
- a hade tare da sulfonylureas;
- a hade tare da thiazolidinedione;
Matsayi na glucose shima yana raguwa tare da haɗakar amfani da vildagliptin tare da insulin.
Umarnin don amfani da allunan
A kan kasuwar magunguna, zaku iya samun kwayoyi biyu masu dauke da vildagliptin.
Bambanci yana cikin abubuwan da ke aiki: a farkon magana, kawai vildagliptin ne, kuma a na biyu - vildagliptin, metformin.
Wanda ya kirkiri irin wadannan magunguna shine kamfanin kasar Switzerland mai suna Novartis.
Ana amfani da miyagun ƙwayoyi a cikin matakan sashi na gaba:
- Vildagliptin ba tare da ƙarin kayan aikin ba (a cikin allunan 28 guda a cikin kunshin 50 MG);
- Vildagliptin a hade tare da Metformin (allunan 30 a cikin kunshin 50/500, 50/850, 50/1000 mg).
Da farko dai, mara lafiya da ke dauke da cutar rashin insulin-da ke fama da cutar kansa ya kamata ya tattauna da wani kwararren likita wanda zai rubuta takardar sayen magani ba tare da faduwa ba. Ba tare da shi ba, ba za ku iya samun magani. Sannan mara lafiya yakamata a karanta sarin kuma, idan kuna da tambayoyi, tambayi likitan su. Umarnin don yin amfani da miyagun ƙwayoyi ya ƙunshi jerin magunguna masu bada shawarar da likita zai iya daidaitawa.
Vildagliptin 50 MG, a matsayin babban kayan aiki, ko dai a hade tare da thiazolidinedione, Metformin ko maganin insulin, ana ɗaukar shi a cikin maganin yau da kullun na 50 ko 100 MG. Masu ciwon sukari, waɗanda cutar ta ci gaba a cikin wani nau'i mafi tsananin wahala tare da maganin insulin, suna ɗaukar 100 MG kowace rana.
Haɗarin kwayoyi guda biyu (magungunan vildagliptin da abubuwan sulfonylurea) suna ba da shawarar kashi 50 a kowace rana da safe.
Haɗin magunguna sau uku, i.e. Vildagliptin, Metformin da abubuwan asali na sulfonylurea, suna ba da shawarar kashi 100 na yau da kullun.
Ana amfani da maganin yau da kullun na 50 MG a lokaci a cikin safe, da kuma 100 MG a cikin allurai biyu da safe da maraice. Ana buƙatar buƙatar daidaita sashi a cikin mutanen da ke fama da rauni na matsakaici ko matsanancin rauni na yara (musamman, tare da ƙarancin rashin ƙarfi).
Ana ajiye magungunan a wani wuri wanda ba za'a iya jure wa yara ƙanana ba, a zazzabi bai wuce 30C ba. Lokacin ajiyar ajiya shine shekaru 3, lokacin da lokacin da aka nuna ya ƙare, baza'a iya amfani da magani ba.
Contraindications da yiwuwar lahani
Vildagliptin bashi da contraindications da yawa. Suna da alaƙa da rashin haƙuri na haƙuri zuwa abu mai aiki da sauran abubuwan da aka gyara, kazalika da rashin haƙuri game da ƙwayoyin galactose, rashi lactase da glucose-galactose malabsorption.
Ya kamata a tuna cewa saboda ƙarancin bincike, amincin yin amfani da maganin a cikin yara da matasa (waɗanda ke ƙasa da shekara 18) ba a yi nazarin su sosai ba.
Babu bayanan bincike game da amfani da vildagliptin yayin daukar ciki da shayarwa, saboda haka an haramta amfani da miyagun ƙwayoyi a wannan lokacin.
Ya danganta da ko an yi amfani da Vildagliptin azaman maganin monotherapy ko tare da wasu hanyoyi, sakamako masu yawa na iya faruwa:
- monotherapy (Vildagliptin) - wani yanayi na rashin ƙarfi na jini, ciwon kai da bushewar zuciya, maƙarƙashiya, gurɓataccen edema;
- Vildagliptin, Metformin - yanayin zubar da jini, rawar jiki, farin ciki da ciwon kai;
- Vildagliptin, abubuwan da suka samo asali na sulfonylurea - yanayin zubar jini, rawar jiki, farin ciki da ciwon kai, asthenia (rashin lafiyar psychopathological);
- Vildagliptin, abubuwan da aka samo daga thiazolidinedione - yanayin hypoglycemia, ƙananan karuwa a cikin nauyi, ƙananan edema;
- Vildagliptin, insulin (hade tare da ko ba tare da metformin ba) - yanayin hypoglycemia, ciwon kai, gastroesophageal reflux (jefa abubuwan da ke ciki a cikin esophagus), jin sanyi, tashin zuciya, yawan hakar gas, gudawa.
A lokacin binciken bayan-tallace-tallace, masu ciwon sukari da yawa da ke shan Vildagliptin sun lura da irin wannan halayen masu haɗari kamar hepatitis, urticaria, fitar fata, ƙirar blisters da haɓakar ƙwayar ƙwayar cuta.
Koyaya, kodayake wannan magungunan yana da babban sakamako na sakamako masu illa, yuwuwar faruwar lamarin ƙanana ne. A yawancin yanayi, halayen ɗan lokaci ne kuma har ma da bayyanar su, ba a buƙatar shafe magani.
Doauke da yawa da shawarwari don amfani
Gaba ɗaya, Vildagliptin yana da haƙuri da haƙuri ta hanyar yawan adadin yau da kullum na 200 MG, amma babu ƙari. Lokacin amfani da mafi girma fiye da yadda ake buƙata, akwai babban yiwuwar alamun alamun yawan ƙwayar cutar ƙwayoyi.
Ya kamata a lura cewa lokacin da kuka dakatar da shan maganin, duk alamu sun shuɗe.
Bayyanar cututtukan ƙwayar cuta sama-ƙasa kai tsaye ya dogara da digiri, misali:
- Lokacin da aka yi amfani da 400 MG, zafin ƙwayar tsoka, kumburi, tingling da ƙayyadaddun ƙarshen (huhu da kuma kwanciyar hankali), ƙarancin lokaci a cikin abubuwan lipase yana faruwa. Hakanan, zazzabi zai iya tashi tare da ciwon sukari.
- Lokacin amfani da 600 MG, kumburi daga hannaye da kafafu ya bayyana, da ƙyallensu da jijiyoyin wuya, haɓakar abun ciki na ALT, CPK, myoglobin, har da furotin na C-reactive.
A farkon farawar, ya kamata a bincika nazarin sigogin biochemical na hanta. Idan sakamakon ya nuna ƙara yawan aikin transaminase, tilas ne a sake maimaita binciken sannan a riƙa gudanarwa akai-akai har sai alamu sun tabbatuwa. Idan sakamakon binciken ya nuna aikin ALT ko AST, wanda ya ninka sau 3 fiye da VGN, lallai ne a soke maganin.
Idan mai haƙuri yana da cin zarafin hanta (alal misali, jaundice), amfani da miyagun ƙwayoyi nan da nan ya tsaya. Duk da yake hanta ba ta al'ada ba, an haramta magani.
Lokacin da ake buƙatar maganin insulin, ana amfani da vildagliptin tare da hormone. Hakanan, ba a ba da shawarar amfani da shi sosai ba a cikin jiyya na cututtukan da suka danganci insulin na sukari (nau'in 1) ko rikicewar metabolism na metabolism - ketoacidosis na ciwon sukari.
Ba a fahimci ikon vildagliptin don yin tasiri ga taro ba da hankali. Koyaya, idan rikice-rikice ya faru, marasa lafiya waɗanda ke tuƙi motoci ko yin wasu ayyuka tare da kayan aikin suna buƙatar barin irin wannan aikin mai haɗari har tsawon lokacin farwa.
Kudin, sake dubawa da kuma analogues
Tunda an shigo da magungunan Vildagliptin (Switzerland mai ƙira), saboda haka farashinsa ba zai zama ƙasa da ƙasa ba. Koyaya, kowane haƙuri tare da matsakaicin kudin shiga zai iya samun maganin. Za a iya siyan kayan aiki a kantin magani ko kuma an ba da umarnin a kan layi.
Kudin magungunan (allunan 28 na allunan 50 MG) sun bambanta daga 750 zuwa 880 rubles na Rasha.
Amma game da ra'ayin likitoci da marasa lafiya game da amfani da maganin, sake dubawa galibi tabbatacce ne.
Marasa lafiya da ciwon sukari mellitus na nau'in na biyu waɗanda suka sha magungunan suna haskaka waɗannan fa'idodin magungunan:
- rage saurin sukari da kuma sanya shi tsakanin iyakoki na yau da kullun;
- sauƙi na yin amfani da nau'in sashi;
- musamman wahalolin bayyanuwa da mummunan halayen da miyagun ƙwayoyi.
Dangane da wannan, za a iya ɗaukar miyagun ƙwayoyi a matsayin ingantaccen ƙwayar maganin ƙwaƙwalwar ƙwayar cuta a cikin yaƙi da ciwon sukari na 2 Amma wani lokacin dangane da contraindications ko cutarwa mai yiwuwa, dole ne ku ƙi amfani da maganin. A cikin irin waɗannan yanayi, ƙwararren likitan yana ba da maganin analogues - wakilai waɗanda ke da tasirin warkewa iri ɗaya kamar Vildagliptin. Wadannan sun hada da:
- Onglisa. Abunda yake aiki shine saxagliptin. Kudin ya banbanta da iyaka na 1900 rubles.
- Trazenta. Abunda yake aiki shine linagliptin. Matsakaicin matsakaici shine 1750 rubles.
- Januvius. Abunda yake aiki shine sitagliptin. Matsakaicin matsakaici shine 1670 rubles.
Kamar yadda kake gani, analogues sun ƙunshi bangarori daban-daban a cikin kayan haɗin su. A wannan yanayin, likita yana buƙatar zaɓar irin wannan ƙwayar don kada ya haifar da halayen mummunan sakamako a cikin haƙuri. Ya kamata a lura cewa ana zaɓa analogues dangane da farashin farashin, Hakanan yana taka rawar gani.
Magungunan Galvus vildagliptin (Latin - Vildagliptinum), ana iya ɗaukar magani mai amfani da ƙwayar cutar hypoglycemic, wanda aka ɗauka a matsayin tushen kuma a hade tare da wasu kwayoyi. Misali, hadewar vildagliptin, metformin tare da abubuwanda suka samo asali na sulfonylurea. An haramta amfani da miyagun ƙwayoyi, koyaushe yakamata a bi shawarar likita. A, a cikin yanayin yayin da ba za a iya ɗaukar maganin ba saboda wasu dalilai, likita ya ba da izinin analogues. Bidiyo a cikin wannan labarin zai ci gaba da batun maganin don ciwon sukari.
