Magungunan antihypertensive da diuretic tare da haɗuwa da abubuwa guda biyu masu aiki. An yi niyya don kula da marasa lafiya tare da alaƙar da aka nuna hade da hauhawar jijiya.
Sunan kasa da kasa mai zaman kansa
Ramipril + hydrochlorothiazide.
Sunan kasa-da-kasa mai suna Hartil-D shine Ramipril + hydrochlorothiazide.
Wasanni
Lambar ATX Code C09BA05
Saki siffofin da abun da ke ciki
Ana samun magungunan a cikin nau'ikan allunan launuka masu launin rawaya. Rubutun da aka zana akan gefe ɗaya, ya dogara da sashi:
- 2.5 MG - a gefe ɗaya da 12.5 MG - akan ɗayan, a ɓangarorin biyu na haɗarin rarrabuwa;
- 5 MG a gefe guda da 25 MG a ɗaya, a ɓangarorin biyu na haɗarin.
A cikin kwali ɗaya kwali na iya zama blisters 2 na guda 14 kowannensu.
Abubuwan da ke tattare da Allunan suna dauke da abubuwa guda 2 masu aiki:
- ramipril a cikin sashi na 2.5 ko 5 MG;
- hydrochlorothiazide - 12.5 MG ko 25 MG, bi da bi.
Additionallyarin ƙari - lokacin farin ciki, dyes da sauran abubuwa masu kama.
Aikin magunguna
Ramipril abu ne mai hauhawar jini. Yana rage jinkirin aikin ACE inhibitor (exopeptidase), yana haifar da sakamako mai banƙyama: jimlar juriya na tasoshin yanki da na huhu ya zama ƙarami, fitowar zuciya yana ƙaruwa kuma juriya ga damuwa yana ƙaruwa.
Bugu da ƙari, abu mai aiki yana inganta hawan jini zuwa cikin myocardium kuma yana hana yaduwar necrotization a cikin bugun zuciya, yana rage yiwuwar arrhythmias da tsananin bugun zuciya.
Abu na biyu mai aiki - hydrochlorothiazide - yana nufin thiazides tare da kaddarorin mai diuretic.
Yana canza daidaituwar sodium kuma ya rage martani ga norepinephrine da nau'in angiotensin II.
Tare da taimakon Hartil-D, matsin lamba a cikin jijiyar ƙararrawa yana raguwa.
A cikin marasa lafiya da ciwon sukari tare da nephropathy tare da taimakon wannan magani, an rage matsin lamba a cikin jijiyar bugun jini kuma an hana ci gaban lalacewa na koda.
Magungunan yana farawa kusan awa daya bayan gudanarwa kuma yana ɗaukar kusan kwana ɗaya.
Pharmacokinetics
Shawo kan abubuwan antihypertensive yana faruwa cikin sauri, kuma bayan awa ɗaya an kai iyakar ƙarfinsa (50-60%). Yana samarda abubuwa masu aiki da marasa aiki wadanda suke daure wa abubuwan gina jiki na jini.
Ana shan diuretic din da sauri kamar ramipril, yana da sauƙin rarraba kuma 90% daga kodan ta hanyar asalin su.
An cire shi a kusan daidai gwargwado tare da fitsari da feces.
Idan akwai rauni na aiki na koda, yawan ramiprilat (metabolite mai aiki) yana ƙaruwa, kuma idan akwai matsala na hanta, ramipril.
Alamu don amfani
An nuna Hartil D don hawan jini, amma ana amfani dashi ga wasu cututtukan zuciya da kodan.
An wajabta don magance irin waɗannan cututtukan:
- rauni na zuciya;
- hauhawar jini;
- mai ciwon sukari ko mai cutar kansa mai cutar kansa;
- IHD don rage yiwuwar infarction myocardial infarction ko bugun jini na cerebral (bugun jini).
Nunin don amfani shine buƙatar haɗuwa a cikin maganin diuretics tare da wakilai na antihypertensive.
Contraindications
Kar a sha magani idan:
- maganganu ga kowane daga cikin abubuwan da ke tattare da miyagun ƙwayoyi ko don abubuwan da ke haifar da ƙungiyar sulfonamide;
- gaban edema na zurfin yadudduka na dermis da kasusuwa na kasusuwa a cikin anamnesis;
- kunkuntar hepatic arteries tare da wahala a cikin jini ya kwarara ko takaita hanyoyin da jijiya guda;
- cholestasis;
- jijiyoyin jini;
- har zuwa shekaru 18, saboda karancin bayanai kan tasirin cutar kan jikin yara;
- lokacin da adrenal cortex ya ɓoye ƙarin aldosterone fiye da yadda ake buƙata;
- na gazawar.
Ba da shawarar jiyya tare da mata ba a cikin ciki da lokacin shayarwa.
Tare da kulawa
Tare da babban daidaito kuma a karkashin kulawa na likita, an wajabta shi don maganin aldosteronism na farko, rashin haƙuri ko malabsorption na glucose ko galactose, yayin hemodialysis,
Yadda za'a dauki Hartil D
An umurce ta da likita ta kowane yanayi daban-daban.
Allunan ana shan su sau da yawa da safe, ba tare da tauna ba. A lokaci guda suna cinye ruwa da yawa. Kada ku yi tarayya da abincin.
Ana ɗaukar allunan Hartila-D sau da yawa da safe, ba tare da tauna ba.
Matsakaicin adadin yau da kullun kada ya wuce 10 MG.
Sashi don cututtuka daban-daban:
- Hauhawar jijiyoyin jini - 2.5-5 MG kowace rana, gwargwadon sakamakon da aka samar.
- Ciwon zuciya na lokaci-lokaci - 1.25-2.5 mg. Tare da karuwar adadin da ake buƙata ya wuce 2,5 mg ana iya raba shi zuwa allurai 2.
- Bayan infarction na myocardial, an tsara haɗuwa da ramipril + hydrochlorothiazide ba kafin ranar ta uku bayan mummunan yanayin. Sashi - 2.5 MG 2 sau a rana. M ƙaruwa zuwa 5 MG 2 sau a rana.
- Don rigakafin cututtukan zuciya, satin farko shine 2.5 MG, daga baya ya ninka bayan makonni 2 na gudanarwa, har ma sau 2 bayan makonni 3. Matsakaicin kiyayewa na yau da kullun bai wuce 10 MG ba.
Tare da ciwon sukari
A farkon farawa, ana ɗauki rabin kwamfutar hannu na 2.5 MG a lokaci 1 kowace rana. A nan gaba, idan ya cancanta, yana yiwuwa a ƙara yawan yau da kullun zuwa 5 MG cikin allurai biyu.
Sakamakon sakamako na Hartila D
Mafi sau da yawa, bayyanar da ba a ke so ta aiki da miyagun ƙwayoyi ta danganta da aikin narkewa, jijiyar jini, tsarin juyayi na tsakiya, tsarin urinary da tsarin jijiyoyi, tsarin numfashi, fata, tsarin endocrine, hanta da bile bututu.
Gastrointestinal fili
Nausea, amai, bushe baki, stomatitis, gurguwar cuta.
Hematopoietic gabobin
Daga gabobin hemopoietic, canje-canje a cikin nazarin alamun yana yiwuwa:
- matakin hawan jini (digo, faruwar cutar);
- yawan sel jini, fararen jini da farantin jini (raguwa);
- matakan kazamar (sauke).
Tsarin juyayi na tsakiya
Farkon rashin tausayi, karuwa da nutsuwa, damuwa, ringi a cikin kunnuwa, jin daɗi da rauni ba ya yanke hukunci.
Daga tsarin urinary
Fitar da kodan na iya haifar da oliguria,
Daga tsarin numfashi
Matsalar zuciya na zuciya, rhinitis, bushe tari, gazawar numfashi.
A ɓangaren fata
Rash, paresthesia, karuwar gumi, jin zafi a wasu wuraren fata, alopecia.
Yin amfani da Hartila-D na iya haifar da karin ɗumi.
Daga tsarin kare jini
Rage libido, datti mai raguwa.
Daga tsarin zuciya
Zubewa cikin karfin jini yayin tsayawa ko tsayawa, bugun zuciya, rikicewar cutar Raynaud.
Game da digo mai kauri kuma mai karfi sosai a cikin karfin jini, karancin rauni na jini ko bugun jini na iya tasowa.
Tsarin Endocrin
Asedara yawan ƙwayar magani da kuma uric acid.
A wani ɓangaren hanta da ƙwayar biliary
Jaundice cholestatic, hepatitis, hanta hanta, cholecystitis, hanta necrosis.
Cutar Al'aura
Allergic halayen na iya faruwa ta hanyar:
- urticaria;
- karuwar daukar hoto;
- angioedema na fuska ko larynx;
- kumbura da gwiwoyi.
- erythema na exudative;
- conjunctivitis, da sauransu.
Yin amfani da Hartila-D na iya haifar da rashin lafiyan ciki ta hanyar cutar urtikaria.
Tare da mummunan halayen rashin lafiyan, ana soke allunan.
Tasiri kan ikon sarrafa abubuwan inji
Tunda yin aiki tare da kayan aiki masu rikitarwa yana buƙatar kulawa, to, idan aka ba wa mutum damar amsa maganin, ya kamata mutum ya guji tuki da motocin da ke aiki aƙalla a farkon jiyya.
Ana iya haifar da sakamako masu illa a cikin hanyar:
- hyperkalemia
- hyperazotemia;
- hypercreatininemia;
- karuwar nitrogen saura;
- canza a cikin wasu alamun gwaji.
Tsarin musculoskeletal yana amsawa ga miyagun ƙwayoyi tare da cramps muscle, arthritis kuma, da wuya, gurgu.
Umarni na musamman
Yi amfani da lokacin daukar ciki da lactation
A miyagun ƙwayoyi ne tsananin contraindicated a karo na biyu da na uku trimesters na ciki. A wannan lokacin, mafi girman yiwuwar maye maye ga amfrayo. Sakamakon tasirin abubuwan da ke cikin ƙwayoyi, tayin na iya:
- rashi mai aiki;
- koma baya;
- oligohydramnios;
- jinkirta ossification na kwanyar.
Hartil-D ya saba sosai a cikin shekaru uku da na uku na ciki.
A nan gaba, cututtukan jarirai na iya haɓaka:
- karancin jini;
- hyperkalemia
- thrombocytopenia.
Tunda akwai sakin ƙwayoyi tare da madara, dole ne a bar shayar da nono.
Alƙawarin Hartil D ga yara
Ba a gudanar da bincike kan tasirin magungunan ga yara ba, sabili da haka, har zuwa shekaru goma sha takwas ba'a tsara shi ba.
Yi amfani da tsufa
Yi wajan tsananin taka tsantsan da kuma a mafi ƙasƙancin allurai.
Aikace-aikacen aiki mara kyau
A cikin gazawar koda, da kashi kuma hanya ta lura ya kamata a gyara.
Matsakaicin adadin yau da kullun kada ya wuce 5 MG.
A cikin gazawar koda, kashi Hartila-D da hanyar magani ya kamata a gyara.
Amfani don aikin hanta mai rauni
Matsakaicin adadin yau da kullun idan akwai aiki na hanta mai rauni bai kamata ya zama mafi girma daga 2.5 MG ba, kuma magani, saboda yiwuwar rashin daidaituwa game da miyagun ƙwayoyi, ana aiwatar da shi ne kawai karkashin tsananin kulawa na likita.
Yawancin abin da ya shafi Hartil D
Ya bayyana:
- katsewa
- raguwa mai kaifi a cikin karfin jini;
- riƙewar urinary;
- toshewar hanji;
- zuciya tashin hankali, da dai sauransu.
Matsayi na fifiko na gaggawa shine amfanin carbon da sodium sulfate mai aiki.
Treatmentarin magani yana dogara da bayyanar cututtuka, da tsawon lokacin magani da sashi.
Yin hulɗa tare da wasu kwayoyi
Ana iya amfani dashi tare da thrombolytics, beta-blockers, acetylsalicylic acid.
Ana buƙatar kulawa ta musamman a cikin yanayin haɗin gwiwa na maganin da aka bayyana tare da:
- kamuwa da cuta;
- maganin sa barci;
- tricyclic antidepressants;
- kwayoyin nitrates;
- vasodilators;
- magungunan ƙwayoyin cuta
Wataƙila amfani da Hartila-D tare da acetylsalicylic acid.
Don haka, gudanarwa a lokaci guda tare da diuretics yana haifar da raguwar wuce kima a cikin karfin jini.
Lokacin amfani da thiazide diuretics, haɓaka matakan alli na jini yana yiwuwa.
Wasu magungunan motsa jiki, nitrates na kwayoyin halitta (yawancin nitroglycerin), magungunan antipsychotic, da magungunan maganin tricyclic antidepressants suna ba da sakamako iri ɗaya.
Magunguna waɗanda ke haɓaka matakin potassium a cikin jini (alal misali, dattattattun ƙwayoyin potassium kamar su Spironolactone, Triamteren, Renial, da sauransu), cyclosporins na iya ba da tasirin hyperkalemia.
Gwanin lithium ya zama mai guba lokacin da aka sha shi tare da masu hana ACE, sabili da haka, kada a hada a kashi daya.
Hypokalemia na iya haɓaka lokacin ɗauka tare da cardiac glycosides da wasu magungunan antipsychotic.
Tasirin antihypertensive yana raunana haɗuwa tare da juyayi tare da amfani na dogon lokaci tare da magungunan anti-mai kumburi.
Amfani da barasa
Zai yiwu a ƙara tasirin giya, saboda haka ba a bada shawarar haɗarin haɗuwa ba.
Analogs
Akwai magungunan analogues tare da kwayoyi iri daya masu aiki kuma iri daya ne:
- Amprilan nl (Slovenia) - Allunan 30;
- Ramazid n (Malta ko Iceland) - 10, 14, 28, 30 da 100.
Haka kuma ana samun magunguna iri daya, amma tare da sauran abubuwa masu aiki ko kuma sashi:
- Tritace da;
- Enalapril;
- Enap R;
- Prestarium da sauransu
Magunguna kan bar sharuɗan
An sake shi kan takardar sayan magani.
Zan iya siye ba tare da takardar sayan magani ba
Babu takardar sayen magani da ba a ba shi.
Farashin Hartil D
Farashin tattara alluna a cikin adadin guda 28 shine:
- daga 455 rubles - 2.5 mg / 12.5 mg;
- daga 590 rubles - 5 MG / 25 MG.
Yanayin ajiya na miyagun ƙwayoyi
An ba da shawarar adana miyagun ƙwayoyi a zazzabi da ba ya wuce + 25º C a wurin da ba dama ga yara da dabbobi.
An ba da shawarar adana Hartil-D a zazzabi da bai wuce + 25º C.
Ranar karewa
An sanya alamar ranar ƙarewa akan marufi. Kada kayi amfani bayan shekara 3 daga ranar samarwa.
Mai masana'anta
Kamfanin samar da Jamusanci na kamfanin "Alfamed Farbil Artsnaymittel GmbH" a cikin Gottingen.
An samar dashi a masana'antar masana'antar Magunguna ta EGIS CJSC a Hungary.
Hartil D sake dubawa
Likitocin zuciya
Anton P., likitan zuciya, Tver
Waƙwalwar ƙwaƙwalwa ta nuna tasiri na magunguna a cikin lura da hauhawar jini. Zai dace mu yi amfani da lokacin da aka nuna hadin-gwiwar ACE inhibitors da diuretics.
Elena A., likitan zuciya, Murmansk
Wani ingantaccen maganin antihypertensive, wanda kuma za'a iya amfani dashi don hana cututtukan zuciya. Kadai kawai shine raunin da yawa, wasu lokuta mai tsanani.
Marasa lafiya
Vasily, 56 years old, Vologda
Na dade ina fama da hauhawar jini. Kimanin watanni 2 da suka gabata na karɓi takardar sayen magani daga wannan likita daga likita. A farkon zamanin, tsananin wahala azaba da kadan nauseous. Ya gaya wa likita kuma bayan sashi ya canza kadan, komai ya lalace, kuma yanzu lafiyata tana al'ada.
Ekaterina, dan shekara 45, garin Kostroma
Lokacin da likita ya tsara waɗannan kwayoyin, ya yi bayanin cewa tunda ana buƙatar magani mai haɗari don magani, wannan alama alama ce mafi dacewa a wannan yanayin. Ya dace da ɗauka sau ɗaya a rana, kuma babu buƙatar tunawa kafin ɗauka, lokacin ko bayan. Idan kun manta kafin karin kumallo, to, zaku iya sha daga baya. Abinda kawai ke damuna - a cikin fewan kwanakin farko na daina tuki, kamar yadda kaina ya ɗan yi sanyi. Amma sai komai ya tafi, kuma yanzu ina shan wannan maganin a kowace rana.
