Trypsin wani enzyme ne mai kariya (enzyme) wanda aka sashi ta wani bangare na fitsari. Da farko, ana yin magabata a cikin yanayin rashin aiki, trypsinogen.
Yana shiga duodenum 12, kuma a can an kunna shi saboda aikin wani enzyme akan shi - enterokinase.
Tsarin sunadarai na trypsin an rarraba shi azaman furotin. A aikace, ana samun sa daga shanu.
Babban mahimmancin aikin trypsin shine proteolysis, i.e. rarrabuwar sunadarai da polypeptides zuwa kananan bangarorin - amino acid. Ingantaccen enzyme ne.
A takaice dai, trypsin yana lalata kariyar sunadarai. Sauran enzymes na pancreatic an kuma san su - lipase, wanda ke cikin narkewar fats, da alpha-amylase, wanda ke rushe carbohydrates. Amylase ba wai kawai enzyme na pancreatic bane, an haɗa shi a cikin gland na salivary, amma a cikin adadi kaɗan.
Trypsin, amylase da lipase sune mafi mahimmancin abubuwa a cikin narkewa. In babu guda ɗayansu, narkewar abinci yana da illa sosai.
Baya ga shiga narkewa, enzyme na trypsin yana da tasiri sosai wajen lura da cututtukan da yawa:
- taimaka wajen rage kumburi a jiki;
- yana hanzarta warkar da ƙonewa, raunin raunuka;
- zai iya raba tsokar nama don samfuran necrosis kada su shiga cikin jini kuma su haifar da maye;
- yana sa sirrin bakin ciki, ya ɓoye ƙarin ruwa;
- sauƙaƙe shan giya na ƙarar jini;
- yana taimakawa wajen magance cututtukan tare da kumburi mara nauyi;
- inganta cirewar talakawa mai yawa;
- yana magance lahani na rashin ƙarfi na ƙwayar cuta ta baka.
A cikin yanayin rashin aiki, wannan fili yana da cikakken kariya.
Tunda trypsin yana da irin waɗannan kaddarorin warkarwa, ana amfani dashi don ƙirƙirar magunguna.
Kamar kowane abu mai aiki na kowane magani, yin amfani da trypsin yana da alamomin kansa da kuma contraindications don amfani.
Lokacin amfani da kwayoyi waɗanda suka haɗa da trypsin, ya kamata a lura da shawarar likita da umarnin don amfani da miyagun ƙwayoyi.
Tsarin Trypsin:
- Amorphous - ana iya amfani dashi kawai a saman (a iyakance yanki na fata).
- Crystalline - yana zuwa ta hanyar farin-rawaya foda, tare da rashin warin halayyar. Ana amfani dashi duka biyu kuma don gudanarwa na wucin gadi.
Ana samun trypsin a ƙarƙashin sunaye daban-daban: "Pax-trypsin", "Terridekaza", "Ribonuclease", "Asperase", "Lizoamidase", "Dalcex", "Profezim", "Irukson". Duk shirye-shiryen ya kamata a adana su a cikin bushe, wuri mai duhu a zazzabi da bai wuce digiri goma ba.
Alamu don amfani sune:
- cututtuka na kumburi daga cikin huhu da hanyoyin iska (mashako, ciwon huhu, exudative pleurisy);
- cututtukan bronchiectatic (kasancewar haɓakar m a cikin bronchi);
- kamuwa da cuta konewa da raunuka tare da purulent sallama;
- ciwon kumburi na kunne na tsakiyar kunne (otitis media);
- kumburi mai kumburi da gaban hancin da kuma sinadarin maxillary;
- kumburin kashi (osteomyelitis);
- cututtukan lokaci;
- toshewar hanyar ganyen lacrimal;
- kumburi da iris;
- matsanancin rauni;
- rikitarwa bayan tiyata ta ido.
Contraindications wa yin amfani da trypsin sune:
- Allergic dauki ga trypsin.
- Increara yawan iska a cikin huhun, ko kuma nutsuwa.
- Rashin daidaituwa na aikin zuciya.
- Canje-canje da kumburi a cikin hanta.
- Cutar tarin fuka
- Cutar koda.
- Pancreatitis yana juyawa.
- Lationsuntatawa a cikin tsarin coagulation da anticoagulation.
- Tsarin kumburi a cikin kodan (jade).
- Hemorrhagic diathesis.
Menene zai iya haifar da illa bayan amfani da trypsin?
- rashin lafiyan mutum
- bugun zuciya;
- ja da ciwo bayan allura ta ciki;
- hauhawar jini.
Bugu da kari, tsawa na iya bayyana a cikin muryar mara lafiya.
Idan ana amfani da shi kai tsaye don magani na bushe raunuka ko raunuka tare da matattun nama, ana amfani da comppsn impregnated compress
Don yin wannan, kuna buƙatar narke 50 MG na shiri na enzyme a cikin 50 MG na saline physiological (sodium chloride, ko 0.9% saline).
Yawancin lokaci yi amfani da goge-fiƙe uku.
Bayan an shafa damfara, an saita shi tare da bandeji kuma an bar shi tsawon awa ashirin da huɗu.
Gudun cikin wucin gadi 5 MG na trypsin an narke shi a cikin 1-2 ml na Saline, lidocaine ko novocaine. A cikin manya, ana yin allura sau biyu a rana, ga yara - sau ɗaya kawai.
Amfani na ciki Bayan gabatarwar miyagun ƙwayoyi, ba za ku iya kasancewa a cikin matsayi ɗaya na dogon lokaci ba, saboda wannan yana sa ya zama da wuya a tsaftace asirin. Yawancin lokaci, bayan kwana biyu, wannan asirin yakan fito ta hanyar magudanar ruwa.
Aikace-aikacen Inhalation. Ana amfani da inhalation na Trypsin ta amfani da inhaler ko bronchoscope. Bayan aiwatarwa, zai fi kyau ka shafa hanci ko bakinka da ruwa mai ɗumi (dangane da yadda aka gudanar da aikin).
A cikin yanayin ido saukad da. Suna buƙatar nutsar da kowane sa'o'i 6-8 don kwanaki 3.
Siffofin amfani da trypsin:
- An hana Trypsin amfani da raunuka na zub da jini.
- Ba za a iya amfani da shi don magance ciwon daji ba, musamman tare da rauni na nama.
- Ba a sarrafa cikin intravenously.
- Lokacin kulawa da yara ƙanana, ana tsara tsarin mutum ɗaya.
- Mata masu juna biyu ko masu shayarwa yakamata su sha wannan maganin kawai idan hatsarin mutuwarta ko mutuwar tayi tayi matukar tasiri.
Pharmacokinetics, i.e. Har yanzu ba a yi nazarin rarraba magunguna a cikin jikin ba. Abin sani kawai cewa lokacin da kare ya shiga cikin jiki, trypsin yana ɗaure wa alpha macroglobulins da antitrypsin alpha-1 (mai hana shi).
A halin yanzu, akwai adadi da yawa na sake dubawa game da kwayoyi masu ɗauke da trypsin. Musamman mahara kewarsa na aikace-aikace a ophthalmology. Tare da shi, cututtukan jini, adhesions, kumburi da dystrophic matakai na iris ana bi da su, saboda waɗannan cututtukan, ba tare da isasshen jiyya ba, na iya haifar da makanta mai maye. Haɗuwa a cikin lura da shirye-shiryen enzyme tare da magungunan antiallergic, ƙwayoyin rigakafi, hormones, magungunan glaucoma suna da tasiri sosai, wanda ke ƙaruwa da haɓaka sabbin ƙwayar cuta.
Trypsin ya taimaka wajen rage cututtukan haɗin gwiwa, irin su cututtukan arthritis, polyarthritis, arthrosis, da cutar rheumatic. Yana sauƙaƙa ciwo, yana hana kumburi, ya maido da cikakkiyar ƙungiyoyi.
Tare da raunin da ya faru mai zurfi, yanke mai zurfi, ƙonewa, enzyme yana ba da izinin, aƙalla, don rage lafiyar lafiyar wanda aka azabtar, da kuma ƙara hanzarta warkarwa.
Matsakaicin farashin shirye-shiryen trypsin a cikin Russia ya tashi daga 500 rubles.
A cikin jini, an ƙaddara abin da ake kira "immunoreactive" trypsin tare da wani abu wanda ke dakatar da ayyukanta - alpha-1-antitrypsin. Matsakaicin trypsin shine 1-4 μmol / ml.min. Ana iya lura da ƙaruwarsa a cikin kumburi mai kumburi da farji, cututtukan ƙwayoyin cuta a ciki, tare da cystic fibrosis, gazawar koda, kuma yana iya tafiya tare da cututtukan hoto. Rage yawan adadin enzyme na iya nuna nau'in ciwon sukari na 1, ko kuma cututtukan da ke sama, amma a cikin nau'ikan yanayi da kuma matakan na gaba.
Baya ga gwajin jini, ana yiwa likitocin rubutaccen tsarin kwaroro. Kafin wannan binciken, ba a ba da shawarar maganin rigakafi 3 na kwana 3 ba. Lokacin da za a gano gano ƙirin a cikin feces. Wannan shi ne alama sau da yawa wata alama ce ta fibrous tafiyar matakai a cikin farji. An lura da raguwa mai mahimmanci tare da cystic fibrosis, amma wannan ba yana nufin cewa an tabbatar da bayyanar cutar ba, kuma ana buƙatar ƙarin bincike don fayyace. A halin yanzu, an yi imanin cewa ƙudurin ayyukan trypsin a cikin feces yana nuna kusan komai.
An ba da taƙaitaccen bayani game da trypsin da sauran enzymes a cikin bidiyon a cikin wannan labarin.
