Simvastatin magani ne tare da kaddarorin rage kiba. Samun ƙwayar ta amfani da ƙwayar sunadarai daga samfurin enzymatic metabolism na Aspergillus terreus.
Tsarin sinadaran da ke tattare da abu wani nau'in lactone ne mara aiki. Ta hanyar canzawar kwayoyin halittar, ana amfani da kwayar cholesterol. Yin amfani da miyagun ƙwayoyi yana hana haɗarin lipids mai guba sosai a jiki.
Molecules na abu suna ba da gudummawa ga rage yawan ƙwayar plasma na triglycerides, ƙananan ƙwayoyin atherogenic na lipoproteins, da kuma matakin jimlar cholesterol. Kushewar kwayoyi na liba na atherogenic lipids yana faruwa ne saboda hanawar samuwar cholesterol a cikin hepatocytes da haɓaka yawan adadin abubuwan karɓa don LDL akan membrane na sel, wanda ke haifar da kunnawa da amfani da LDL.
Hakanan yana haɓaka matakin babban lipoproteins mai yawa, yana rage yawan ƙwayoyin libids zuwa antiatherogenic da matakin cholesterol kyauta zuwa gungun antiatherogenic.
Dangane da gwajin asibiti, ƙwayar ba ta haifar da maye gurbi ba. Adadin farawa na warkewar tasirin sakamako na farko shine kwanakin 12-14, mafi girman tasirin warkewa yana faruwa wata daya bayan fara amfani. Sakamakon ya kasance na dindindin tare da tsawan magani. Idan kun daina shan magani, matakin kwayoyi masu narkewa zai koma yadda yake.
Abubuwan da ke cikin miyagun ƙwayoyi suna wakiltar abubuwan da ke amfani da Simvastatin da kayan haɗin taimako.
Abun yana da babban narkewa da karancin bioavailability. Shiga jini, yana ɗaure wa albumin. Tsarin maganin yana aiki da takamaiman halayen magunguna.
Metabolism din Simvastatin yana faruwa a cikin hepatocytes. Yana da tasirin "hanyar farko" ta cikin sel hanta. Zubar da jini yana faruwa ta hanyar narkewa (har zuwa 60%) a cikin nau'i na metabolites marasa aiki. Theaya da ƙananan ƙwayoyin sun zubar da shi ta kodan a cikin yanayin da aka lalata.
Alamu don amfani
An wajabta jiyya tare da simvastatin zuwa ƙananan lipids na jini, tunda magani yana nufin magungunan rage ƙwayar lipid.
An wajabta magani don shigarwar ta musamman daga likitan halartar, an hana kai kai na miyagun ƙwayoyi.
Alamu don amfani sune yanayi hade da babban cholesterol da lipids na atherogenic.
Wadannan cututtukan sun hada da cututtukan masu zuwa:
- Halin hypercholesterolemia na farko tare da isasshen tasiri na matakan kula da magungunan marasa magani a cikin marasa lafiya da ke cikin haɗari don haɓakar jijiyoyin zuciya atherosclerosis.
- Haɗin haɗin hypercholesterolemia da hypertriglyceridemia, wanda ba amenable bane ga abinci mai ƙarancin cholesterol da aikin motsa jiki.
- IHD don rigakafin haɗarin mace-mace daga ciwo na jijiyoyin zuciya (don rage ci gaba da jijiyoyin zuciya na atherosclerosis), tashin hankali mara zurfin jijiyoyin jini da rikicewar ƙwayar cuta na hawan jini.
- Rage haɗarin farfadowa.
Nau'in sashi na magani shine allunan baka da yawan sigari 10, 20 da 40. An zaɓi sashi na miyagun ƙwayoyi daban-daban, yin la'akari da halayen jikin mutum.
An hada magungunan a cikin jerin magungunan da ba a ba da shawarar don gudanar da kai ba.
Umarnin don amfani da simvastatin
Kafin farawa likita, an wajabta mai haƙuri magani na al'ada hypocholesterol, wanda ya kamata a tsawanta duka aikin tiyata. Simvastatin kwamfutar hannu an yi niyya don maganin baka. Dole ne a sha magungunan sau ɗaya a cikin kowane sa'o'i 24 da maraice, shan ruwa mai yawa. A lokacin shan magani bai kamata ya ci abinci ba.
Lokacin zaɓin magani tare da Simvastatin aka zaɓa shi kaɗai ta likitan haƙuri.
Tare da hypercholesterolemia, mafi ƙarancin maganin warkewa shine 5-80 MG sau ɗaya. Idan babu wani tasiri a kashi 40 MG, ya kamata a gyara farjin. Wannan shi ne saboda girman myotoxicity na miyagun ƙwayoyi a cikin sashi wanda ya wuce 40 MG. An wajabta mafi yawan maganin warkewa ga marasa lafiya waɗanda a cikin magani da 40 MG ba su da tasiri. Mafi karancin maida hankali shine 10 MG.
Gyara canjin matsakaita ana bada shawarar ba fiye da sau ɗaya a wata. Patientsarin marasa lafiya suna kula da hankali tare da ƙaramin adadin kayan.
A cikin marasa lafiya tare da hypercholesterolemia na kwayoyin, mafi kyawun maida hankali akan simvastatin shine 40 MG. Ana ba da shawarar matakin yau da kullun don kasha kashi biyu. A cikin hypercholesterolemia mai tsananin gaske, ana bada shawarar yin amfani da maganin hypoliplera.
Don lura da marasa lafiya da ke fama da cutar sankara ko kuma hadarin ci gaba da cututtukan jijiyoyin zuciya, ana samun tasirin warkewa tare da yin amfani da simvastatin daga 20 zuwa 40 MG na tsawon awanni 24. An ba da shawarar sauya kashi ba a cikin wata ɗaya ba bayan fara amfani. Ingancin aikin magani ya riga ya wuce kashi 20 na kayan.
Idan ya cancanta, ninka kashi biyu.
Yin hulɗa tare da wasu magunguna
A miyagun ƙwayoyi ne mai matuƙar aiki, rage rage kiɗa.
A wannan batun, ƙwayar ta sauƙi shiga cikin halayen da hulɗa tare da sauran magunguna.
Yin amfani da kullun na simvastatin a cikin mutane suna shan wasu kwayoyi kada su wuce 10 MG.
Irin waɗannan magunguna sune immunosuppressants (cyclosporin); roba mai kira (Danazole); fibrates; shirye-shiryen nicotinic acid;
Ga marasa lafiya da ke shan Amiodarone da Verapamil, yawan maganin zai zama bai wuce 20 MG ba. Lokacin da aka kula da shi tare da Diltiazem, matsakaicin adadin simvastatin ya zama 40 MG.
A cikin marasa lafiya na tsofaffi rukuni, kazalika a cikin marasa lafiya da rama ko subcompensated renal gazawar, babu bukatar daidaita kashi. A cikin marasa lafiya tare da gazawar ƙaddamar da ƙwayar ƙwayar cuta, tare da raguwa game da keɓantar da keɓaɓɓen kasa da 30 milliliters, ba a ba da shawarar yin amfani da magani ba a cikin adadin da ya wuce 10 MG. Idan ya zama dole a kara kashi, dole ne a tabbatar da saka idanu akan likitocin wannan rukunin marasa lafiya.
Ya kamata a yarda da hanyoyin kwantar da hankali tare da wasu magunguna tare da likita. A farkon ganawa, ya kamata a tattara tarihin mai haƙuri a hankali kuma a bayyane maganin warkewa.
M Yan adaidaita Simvastatin
Lokacin ɗaukar miyagun ƙwayoyi, ɗaukacin bakan na halayen marasa lafiya na iya bayyana a cikin haƙuri.
Abubuwan da ba a yarda da su ba game da simvastatin sune dogara da kashi.
Mafi girman adadin magungunan da aka sha, shine mafi girman hadarin sakamako masu illa.
Mafi yawan raunin da aka samu game da simvastatin sun hada da:
- Abun ciki na ciki: ciwon ciki, maƙarƙashiya ko zawo, zazzagewa, ɓarna, malalatawa, tashin zuciya, amai, amai, amai, ƙwanƙwasa, amai da gudawa, cututtukan hanta, hanta.
- Daga gefen tsarin juyayi: cututtukan asthenic, ciwon kai, paresthesia, dizziness, polyneuropathy, tashin hankali na bacci, ayyukan nakasa na ciki.
- Daga gefen bangarorin tsoka: raunin tsoka da karkatarwa, rikicewar masauki, myasthenia gravis, rauni na tsoka, myopathy; rhabdomyolysis, ciwon tsoka.
- Daga tsarin azanci: cin zarafin ɗanɗano.
- Hypersensitivity reaction: Quincke's edema, rheumatic reaction, vasculitis, dermatomyositis, urticaria, pruritus, fashin ruwa, karuwar haɓakar jijiyoyin UV.
- Daga haemopoiesis: raguwa a cikin adadin platelet, eosinophils, karuwa a cikin yawan tashin hankali na erythrocyte, anaemia.
- Daga tsarin musculoskeletal: amosanin gabbai, arthrosis, ciwon gwiwa
- Daga CCC: tachycardia, hauhawar jini.
- Rare halayen: lalata jima'i a cikin maza, alopecia.
Mafi rikitaccen rikice rikice shine rashin lalacewa na ƙarancin ƙwaƙwalwa saboda ƙarancin zubar jini na myoglobin saboda lalacewar tsoka yayin rhabdomyolysis.
Idan kowane alamun su ya bayyana, ya kamata ka sanar da likitanka nan da nan. Ana buƙatar likita mai halartar don daidaita sashi na maganin.
Contraindications da ƙuntatawa akan amfani
Nadin simvastatin yana da iyakoki da yawa.
Wannan shi ne saboda gaskiyar cewa kayan aiki yana da wani tasiri ga jiki gabaɗaya, yana daidaita tsarin metabolism na fats.
Gabaɗaya, maganin ba shi da haɗari idan an tsara shi kuma ba ayi amfani dashi ba.
Waɗannan halaye masu zuwa contraindications wa Simvastatin:
- ilimin halittar hanta a cikin tsari mai aiki;
- babban aikin hanta enzymes na asalin da ba'a san shi ba;
- gudanarwa na lokaci daya na Itraconazole, Ketoconazole, HAART, macrolides;
- cututtukan tsoka da giciye;
- ciki da shayarwa;
- shekarun yara;
- low cholesterol;
- karancin maganin lactase,
- carbohydrate malabsorption;
- rashin jituwa ga aiki mai aiki ko zuwa abubuwan taimako,
- rashin hankali ga statins.
Yin amfani da simvastatin yayin daukar ciki da lactation ba da shawarar ba. Wannan shi ne saboda gaskiyar cewa miyagun ƙwayoyi suna da tasirin teratogenic mai faɗi. Hakanan, ƙwayar tana cikin ƙwayar shayarwa, saboda yana iya shiga cikin madara.
Ya kamata a kare mata masu haihuwa yayin haihuwa yayin jiyya tare da Simvastatin.
A cikin marasa lafiya na ƙungiyar tsufa, musamman, a cikin mata, yakamata a iyakance maganin.
Maganin yana contraindicated a cikin yara.
A farkon farawa tare da simvastatin, an lura da karuwar jigilar adadin transaminases. Kafin fara liyafar kuma a lokacin da ake gudanar da dukkan aikin, ya zama dole a kula da ayyukan hanta a kai a kai.
Tare da karuwa a cikin adadin transaminases fiye da sau 3, ya kamata a dakatar da aikin jiyya tare da Simvastatin.
Siffofin amfani da simvastatin
Dole ne a rubuta wannan magani ta mai ilimin hanyoyin kwantar da hankali ko likitan zuciya. Simvastatin magani ne na sabon ƙarni, umarnin umarni don amfani yana ba da shawarar halayen jiyya, wanda ke ƙayyade babban farashin magani.
Samfurin ya haifar da damuwa game da magunguna na duniya "Zentiva", wanda ke cikin Czech Republic. Mai sana'antawa ya samarda magunguna iri iri.
Magunguna cikin sauri kuma yana rage ƙarancin cholesterol, yana haifar da asarar nauyi da kuma ingantawa gaba ɗaya cikin yanayin marasa lafiyar da ke fama da matsalar ƙwayar ƙwayar ƙwayar cuta.
Magunguna magani ne.
Don adana kuɗi, zaku iya siyan madadin magani. Ana nan analogues na Simvastatin sune Aterostat, Zokor, Simvakard, da dai sauransu. Sunaye na iya bambanta dangane da masana'anta.
Lalacewar miyagun ƙwayoyi, a mafi yawan lokuta, yana faruwa ne saboda keta tsarin gudanarwa da kuma yin allurai.
Gabaɗaya, kayan aikin sun sami tabbataccen ra'ayi da yawancin ra'ayoyi masu kyau daga ƙwararrun masana a fannin magani. Magungunan shine sabon ƙarni na babban aiki kuma tare da ƙarancin guba.
Koyaya, duk jagororin don amfani ya kamata a bi. Haramun ne a sha giya yayin warkarwa. Yana da mahimmanci don sarrafa matakin cutar glycemia yayin kulawa ga marasa lafiya da ke fama da ciwon sukari, tunda statins suna shafar matakan sukari na jini.
Ya kamata tsarin kula da lafiyar hypercholesterolemia da atherosclerosis ya zama cikakke. Shan Simvastatin ya kamata a haɗe shi tare da tsarin m abinci da ƙoshin abinci na yau da kullun.
Tare da rashin ingancin maganin rashin lafiya tare da Simvastatin, ana iya tsara rukuni na rukuni na gaba kamar haka:
- Sauran wakilan ƙungiyar statin sune Atorvastatin, Rosuvastatin, Rosulip, da dai sauransu.
- Fibrates.
- Ayyukan Nicotinic acid.
- Omega mai kitse.
Kowace rukuni na miyagun ƙwayoyi suna da guda ɗaya ko wata guba. Omega-3 da omega-6 mai kitse masu lafiya ba su da hadari. Suna da tasiri don dalilai na kariya. Tare da farkon gabatarwarsu a cikin abinci, haɗarin mace-mace daga cututtukan zuciya da matsalolin jijiyoyin jiki an rage su da 40%. Akwai tsarkakakken tasoshin jini daga manyan filayen atherosclerotic da raguwa a matakin libids na atherogenic.
Farashin ya bambanta a cikin Rasha dangane da sarkar kantin magani da ranar siye. Magungunan da Czech suka yi sun karɓi kyakkyawan bita. Kudin a Rasha yana farawa daga 93 rubles.
An bayar da bayani game da magungunan Simvastatin a cikin bidiyo a cikin wannan labarin.
