Testosterone shine hormone mace na maza wanda ke taka rawa sosai wajen tabbatar da aikin maza na yau da kullun, cikar ayyukan yara.
Bugu da kari, ana samar da wannan nau'in hodar a jikin mace. A cikin mata, yana taka muhimmiyar rawa, yana tabbatar da ci gaban al'ada da kuma cikar dukkan ayyukan.
Don haka, alal misali, androgen a cikin mata yana da tasirin jima'i, yana daidaita aikin al'ada na tsarin musculoskeletal
Testosterone da cholesterol suna da alaƙa da juna. Wannan shi ne saboda gaskiyar cewa cholesterol yana ɗaukar kashi a cikin ayyukan samar da kwayoyin maza na jima'i. A cikin tsarin sa, kwayar halittar namiji asalinsa ce ta barasa.
Ainihin, androgen shine mai mai narkewa mai samar da kayan halitta mai mahimmancin gaske ga ɗan adam.
Cakuda wannan fili a cikin maza yawanci ya kama daga 11 zuwa 33 nmol / L, a cikin mata, abubuwan da ke cikin wannan kwayar halitta suna da matukar raguwa kuma suna daga 0.24 zuwa 3.8 nmol / L.
Karatuttukan likita na kwanan nan sun bayyana alaƙa tsakanin ƙarancin cholesterol da low testosterone.
Rashin hormone yana haifar da cututtuka daban-daban da rikice-rikice, duka cikin kwayoyin halittar maza da mata.
Menene cholesterol, wane nau'in halitta?
Cholesterol abu ne na kwayar halitta, barasar shan giya ta polycyclic. Wannan fili bashi da ruwa a ruwa. A matsayin ɓangare na jini, ana jujjuya shi a cikin nau'i mai cakudaddun abubuwa tare da sunadarai. Irin waɗannan hadaddun abubuwa ana kiransu lipoproteins. Lipoproteins suna narkewa a cikin plasma.
Lipophilic giya wani fili ne da ke tattare da ayyukan gina jikin membranes. Tsarin cholesterol shine tushe wanda duk wasu abubuwan haɗin jikin membrane suke aiki da su.
Cholesterol ya shiga tsakani a cikin mafi yawan kwayoyi masu aiki da ake bukata don aiki na yau da kullun.
Don haka, cholesterol shine farawa wanda daga ciki ana amfani da kwayoyin steroid a karshe. Bugu da kari, bitamin D yana da sinadarin cholesterol, wanda ke hade ne kawai a gaban shan barasa mai yawa a cikin adadin da ya isa wannan.
Abubuwan da ke cikin jini na plasma na lipoproteins sun bambanta da kansu a cikin babban sashi - yawa.
Dangane da wannan siga, lipoproteins ya kasu kashi biyu:
- Poarancin wadataccen lipoproteins suna da girman diamita na 21 zuwa 70 micron. Wannan nau'in ya ƙunshi fiye da 45% barasa na lipophilic.
- Poarancin lipoproteins mai ƙima 19 microns. Sun ƙunshi kashi 40 zuwa 45% na cholesterol.
- Manyan ƙwayoyin lipoproteins masu yawa tare da diamita na 8 zuwa 10 microns. Abun da ke tattare da wannan hadadden abubuwan hadaddun sunadaran ya hada da shan barasa har zuwa kashi 20 cikin dari.
Groupungiyoyin ƙarshe na lipoproteins galibi ana kiransu kyakkyawan cholesterol.
HDL rikice-rikice ne tare da ingantaccen ruwa a cikin ruwa da kuma ikon cire baraƙin lipophilic daga bangon bugun jini.
Wannan mallakar HDL yana hana haɓakar atherosclerosis a cikin jiki.
Cikakkun hadaddun ƙwaƙwalwa da ƙarancin ƙaura suna da tsari mai sako da kuma girma da yawa. Wadannan mahadi suna da alaqa da kirkirar lu'ulu'u tare da hazo.
Ana kiran LDL da VLDL mara kyau cholesterol. Wadannan rukuni ne na hadaddun abubuwan da ke haifar da ci gaba da cututtuka daban-daban na zuciya da na jijiyoyin jini, irin su atherosclerosis da sauran rikice-rikice masu alaƙa.
LDL da HDL suna iya musanya cholesterol a tsakanin su. HDL sami lipophilic barasa daga LDL kuma jigilar shi zuwa ƙwayoyin hanta wanda aka haɗa bile acid.
Tsarin waɗannan mahadi daga ƙwayar cholesterol yana haɓaka kawar da giya mai narkewa.
Tasirin cholesterol a kan samarwar testosterone
Ana amfani da cholesterol Plasma a matsayin kayan albarkatun ƙasa a cikin kira na abubuwan da ake buƙata na kayan aiki masu rai.
Suchaya daga cikin irin wannan kwayar ita ce ƙwaƙwalwar hormone. A cikin kwayar wannan kwayar mai aiki, sinadarin cholesterol yana aiki kamar tsari. Tare da rashin yawan lipids ko tare da kwayoyi waɗanda ke rage cholesterol. Akwai raguwa a cikin libido da bayyanar matsaloli tare da iko.
Ana samar da hormone a cikin sel na Leydig a cikin gwaje-gwajen. Wadannan kwayoyin suna cinye mafi yawan kwalagin kwayoyi.
Mahimman lafiya da tanadinta, duka cikin maza da mata, suna taka rawa sosai a rayuwa. Ga maza, iko yana tasiri ba kawai matakin jiki ba, ƙarfin maza yana da tasiri mai ƙarfi ga lafiyar ruhaniya.
Binciken bincike a cikin shekarun da suka gabata ya haifar da sakamakon da ba a zata ba wanda ke nuna tasirin tasirin cholesterol a kan tasirin maza.
Ana aiwatar da samar da kwayoyin halittar jima'i tare da halakar giya na lipophilic, wanda ke nufin cewa mafi yawan kwayoyi a cikin jiki, mafi girma shine samar da kwayoyin testosterone.
Sakamakon binciken ya kuma nuna dangantaka mai shiga. Kasancewar a cikin jikin kwalayen matakan cholesterol na iya cutar da tsarin aikin inrogen idan akwai yawan LDL a cikin plasma.
LDL yana da tasiri mara kyau duka biyu a jiki gaba ɗaya kuma akan ayyukan haɓaka na mutum.
Domin testosterone a cikin jikin mutum don yaduwar da yawa a cikin jiki, ana buƙatar matakan cholesterol ya zama al'ada. Matsakaici tsakanin LDL da HDL ya kamata ya kasance cikin goyon baya ga rukunin ƙarshe na hadaddun cholesterol.
Akwai hanyoyi da yawa don rage yawan lipoproteins da yawa mai yawa. Hanya mafi sauƙi kuma mafi arha shine amfani da abincin hypocholesterol. Bugu da kari, za a iya amfani da saiti na motsa jiki na musamman don runtse cholesterol mara kyau.
Abincin abinci mai gina jiki ya ƙunshi rage yawan abincin da ke ɗauke da kitse na dabba kaɗan.
Rage raguwar LDL yana haifar da canji a cikin rabo tsakanin mummuna da mai kyau na lipoproteins a cikin goyon bayan ƙarshen. Yin amfani da abinci da motsa jiki yayin rashin damuwa a cikin tafiyar matakai na rayuwa na iya kara adadin cholesterol mai kyau.
Bugu da ƙari, zaku iya rage adadin LDL:
- ta amfani da takamaiman magunguna;
- saboda amfani da abubuwan cakuda bitamin;
- ta hanyar shan lipoic acid daga cholesterol;
- yayin amfani da hanyoyin magungunan gargajiya.
Idan akwai rikice-rikice waɗanda ke taimakawa wajen haɓaka LDL, to, ana fara samar da testosterone a cikin ƙananan ƙananan abubuwa, wanda ke haifar da ci gaban lalata.
Testosterone biosynthesis da haɗin cholesterol
A cikin maza, yawancin ƙwayoyin androgenic suna haɗuwa da ƙwayoyin testicular na musamman, a cikin mata, samar da wannan kwayar yana gudana ne ta hanyar ƙwayoyin kwayoyi. A ƙaramin ƙara, abu a cikin mata da maza yana haɗuwa da cortex adrenal.
Kamar sauran mahadi steroid, testosterone wani asali ne na giyar lipophilic.
Adadin abubuwan da ake kira androgen ana kayyade su ta hanyar kwayoyin halittun kwakwalwa - kayan gwari. Abun haɗuwa da ke daidaita adadin androgen da aka samar ana ɗaukar su ta hanyar ayyukan ƙwayoyin neuroendocrine da hypothalamus suka samar.
Wadannan mahadi na hypothalamus sune:
- Liberins.
- Statins
Tare da ƙarancin androgen matakin, hypothalamus ya fara haɓaka gonadorelin - GnRH, wanda ke ƙarfafa ƙwayar ƙwayar pituitary don samar da ƙwayar follicle-mai motsa jiki - FSH da hormone na luteinizing - LH. Wadannan mahadi ne ke taɓar da ƙwayoyin Leydig na gwaje-gwajen don haɓaka testosterone.
Bayan haka, kwayoyin halittun da ke tattare da ƙwayoyin ƙwayoyin pituitary suna shiga cikin tsarin abubuwan da ake kira androgen a cikin jini. Anara yawan matakan androgen ta hanyar dangantaka mai jujjuyawar yana shafar hypothalamus da glandon ƙwayar cuta. Irin wannan tasiri akan ƙwayar cuta shine yake haifar da hanawar samarwa da kwantar da GnRH, FSH da LH. Don haka, tsarin kwayar halittar androgen kira yana kunshe da wani sakamako wanda ya kunshi tasirin testosterone akan gland wanda ke samar da kwayoyin halittun da ke daidaita kwayoyin halittar testosterone.
Babban matakin wannan hormone yana hana samar da GnRH, FSH da LH.
Tsarin sinadarin androgen yana tasiri sosai a yawan adadin cholesterol a jiki. Mafi girman matakin kwalagen, mafi kwazo shine samar da hodar. Amma wannan doka aiki ne muddin jikin yana cikin wani aiki na ci gaban aiki da cigaba.
A ƙarshen wannan lokaci, ƙwayar cholesterol yana ba da gudummawa ga kiba, wanda a cikin sa yana haifar da raguwar adadin testosterone da aka samar.
Dalilai don raguwa da haɓaka androgen
Decreasearin rage yawan matakan testosterone ana tsokani ne ta hanyar cin zarafin biosynthesis na hodar ibadan gonadotropin.
Hakanan zai iya rage yawan biosynthesis ta hanyar ɗaukar glucocorticoids.
Glucocorticoids yana rage yawan ji da jijiyoyi zuwa tasirin abubuwan jima'i, wanda ke kara girman androgen a cikin jini da rage karfin samar da kwayar halittar.
Bugu da kari, raguwa a samar da kayan halitta na kwayar halitta cholesterol za'a iya jawo ta:
- karancin wadatattun abubuwa na adrenal;
- ci gaban prostatitis na kullum a cikin ciwon sukari;
- kiba, tsokani da hauhawar matakin lipids a cikin maza;
- shan wasu magunguna irin su Buserin, Carbamazepine, Cimetidine, Cyclophosphamide, Cyproterone, Dexamethasone, Goserelin, Ketoconazole, Pravastatin.
Za'a iya ƙaruwa da matakan Androgen ta hanyar ƙara yawan motsa jiki. Motsa jiki yana tilasta hanta su samar da ƙarin HDL, wanda ke haɓaka tsarin halittar maza.
Increasedara yawan matakan testosterone yana ƙara yawan libido, amma wuce haddi na hormone yana haifar da matsalolin fata, matsalolin jini - hematocrit ya tashi, kuma yana ƙaruwa da haɓakar cutar kansa.
Babban ƙwayar hormone namiji yana faruwa yayin samuwar neoplasms a cikin ƙwayar halittar jiki wanda ke haɓaka ayyukan aikin androgen synthesis. Bugu da ƙari, an inganta biosynthesis lokacin ɗaukar wasu magunguna kuma a yanayin kasancewar cutar da cututtukan Itsenko-Cushing a cikin jiki.
Abubuwan da ke haifar da rage matakan testosterone an tattauna a cikin bidiyo a cikin wannan labarin.
