Rosuvastatin Canon magani ne tare da kaddarorin masu rage kiba. Magungunan yana cikin rukunin gumakan.
Magungunan ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwayar cuta ce ta zaɓi na HMG-CoA reductase, wanda ke da alhakin canza 3-hydroxy-3-methylglutaryl coenzyme A zuwa mevalonate, wanda shine farkon abubuwan cholesterol.
Babban burin aikin maganin shine hanta, sashin jiki wanda ke aiwatar da aikin cholesterol synthesis da catabolism of low yawa lipoproteins.
Magungunan yana hana ayyukan HMG-CoA reductase. Lokacin amfani da miyagun ƙwayoyi, kusan 90% na rosuvastatin suna kewaya cikin jini.
Yin amfani da miyagun ƙwayoyi yana taimakawa wajen ƙara yawan masu karɓar LDL a kan membrane na farfajiya na hepatocytes, wanda ke ƙara kama da catabolism na lipoproteins mai yawa. Irin wannan tasiri akan jikin yana haifar da raguwa a cikin matakin LDL a cikin ƙwayar plasma.
An lura da tasirin warkewar amfani da miyagun ƙwayoyi sati daya bayan fara farfar. Bayan makonni 2, tasirin warkewa ya sami matsakaicin ƙarfi. Bayan wannan lokacin, an lura da ingantaccen raguwa a matakin ƙwayar cholesterol a cikin jiki kuma tare da ci gaba da kulawa da magunguna na yau da kullun ana kiyaye shi a matakin da aka cimma a tsawon lokaci.
Yin amfani da miyagun ƙwayoyi na iya ba da gudummawa ga asarar nauyi saboda cire ƙwayar lipids mai yawa.
Siffar da aka saki da abun da ke ciki
Mai sana'antawa yana samar da kwayoyi a cikin nau'ikan allunan. Ana lullube saman allunan tare da zane mai launin ja.
Siffar ta zagaye, biconvex. A farfaɗun wuri, ana samun saurin hadarin. A sashin giciye, miyagun ƙwayoyi suna da kusan launin fari.
Babban sinadaran aiki a cikin ƙwayar cuta shine alli mai kauri rauvastatin. Wannan ƙunshin yana kunshe ne a cikin taro wanda yake daidai da 10.4 MG, wanda dangane da tsarkakakken rosuvastatin shine 10 MG
Bayan babban fili mai aiki, ana hada wadannan sinadarai masu zuwa a cikin tsarin kwamfutar hannu:
- alli hydrogen phosphate foda;
- pregelatinized masara sitaci;
- magnesium stearate;
- povidone;
- microcrystalline cellulose.
Abun da aka shirya fim na allunan ya hada da wadannan abubuwan:
- Selecoat AQ-01032 ja.
- Hydroxypropyl methyl cellulose.
- Macrogol-400.
- Macrogol-6000.
- Titanium dioxide
- Aluminium varnish dangane da fenti Ponso 4R.
Wanda ya samar da allunan da aka kera ya sanya su a kwandon shara na PVC. A saman kunshin an rufe shi da tsare tsare na aluminium. Irin waɗannan kunshe-kunshe an rufe su a cikin kwali na kwali, inda aka sanya umarnin yin amfani da miyagun ƙwayoyi.
Ana amfani da miyagun ƙwayoyi a cikin allunan tare da sigogi daban-daban na kayan aiki masu aiki. A cikin kantin magunguna, dangane da buƙata, zaku iya siyan magani yana da magunguna masu yawa na rauvastatin 10, 20 da 40 mg a cikin kwamfutar hannu guda. Farashin miyagun ƙwayoyi ya dogara da yankin sayarwa a cikin Tarayyar Rasha, maida hankali ne babban sashi mai aiki a cikin abubuwan da ke cikin miyagun ƙwayoyi da adadin allunan a cikin kunshin ɗaya. Kudin kunshin ɗaya, dangane da sigogi da aka ƙayyade, na iya bambanta daga 350 zuwa 850 rubles.
Mai haƙuri zai iya siyar da magani ne kawai idan yana da takardar sayen magani daga likitan halartar.
Ya kamata a adana miyagun ƙwayoyi a zazzabi wanda bai wuce digiri 25 Celsius a cikin busassun wuri ba ga yara da dabbobi. Dole ne a kiyaye wurin ajiya daga hasken rana kai tsaye. Rayuwar rayuwar shiryayye shine shekara biyu.
Bayan wannan lokacin, an haramta amfani da maganin, dole ne a zubar dashi.
Manuniya da contraindications don amfani
Kafin amfani da miyagun ƙwayoyi Rosuvastatin Canon, yakamata kuyi nazarin umarnin don amfani, sake duba magunguna ta likitoci da masu haƙuri, kuma ku san kanku da farashin maganin tare da sashi na daban na sashi mai aiki.
Jagora game da amfani da miyagun ƙwayoyi yana bada shawarar ɗaukar miyagun ƙwayoyi ne kawai bayan tuntuɓar likitanku.
Likita ya kayyade mafi kyawun sashi, la'akari da duk bayanan da ke akwai game da lafiyar mutum da sifofin jikin mai haƙuri.
Babban alamu don amfanin magani daidai da umarnin yin amfani da su sune halaye masu zuwa:
- kasancewar Fredrikon hypercholesterolemia na farko (nau'in IIa, wanda ya hada da famteal heterozygous hypercholesterolemia) ko hadewar hypercholesterolemia (nau'in IIb) a matsayin ƙari ga abincin, a cikin waɗannan halayen amfani da hanyoyin rashin magunguna na magani (motsa jiki, nauyi asara) bai isa ba;
- kasancewar familial homozygous hypercholesterolemia, a matsayin kari ga abinci da sauran hanyoyin rage kiba (alal misali, LDL apheresis), ko kuma a yanayin da amfani da irin wannan maganin bashi da inganci sosai;
- kasancewar hypertriglyceridemia (nau'in IV a cewar Fredrickson) azaman ƙari ga abincin da ake amfani dashi.
Contraindications don yin amfani da miyagun ƙwayoyi suna da bambance-bambance dangane da maida hankali a cikin Allunan babban kayan aiki mai aiki.
Don haka ga allunan da ke dauke da 10 da 20 na rosuvastatin, mai haƙuri yana da contraindications masu zuwa:
- Cututtukan hanta a cikin aiki na ci gaba, gami da karuwar aikin transaminase.
- Ciwon rauni na aikin koda.
- Kasancewar cutar sankara a cikin haƙuri.
- Yin amfani da magani tare da cyclosporine.
- Wannan lokacin lokacin haila da lokacin lactation.
- Tsinkaya ga ci gaban cutar rikice-rikice.
- Shekaru kasa da shekara 18.
- Hypersensitivity ga abubuwan da ke cikin miyagun ƙwayoyi.
Lokacin amfani da Allunan tare da taro na rosuvastatin 40 MG, contraindications don amfani sune:
- na koda da kuma hanta gazawar;
- dauke da yaro da shayarwa;
- amfani da jituwa tare da cyclosporine;
- kasancewar cutar hanta a cikin yanayin ci gaba;
- kasancewar a cikin jikin bayyanar rashin yarda ga abubuwan da ke cikin miyagun ƙwayoyi.
Yawan shaye-shayen magunguna a cikin mara lafiya yana faruwa yayin shan allurai na yau da kullun.
Idan ana samun ƙarin yawan ƙwayar cuta, ana wajabta maganin cututtukan ƙwayar cuta kuma ana yin ayyukan hanta, da aikin CPK.
Babu takamaiman maganin rigakafi da aka yi amfani da shi lokacin da yawan zubar jini ya faru. Hanyar hemodialysis ba shi da tasiri.
Umarnin don amfani da miyagun ƙwayoyi
Ana gudanar da maganin a baki, a kowane lokaci na rana, ba tare da la'akari da abincin ba.
Ya kamata a hadiye kwamfutar hannu duka ba tare da an murƙushe ba, yayin shan samfurin dole ne a haɗe shi da shan ruwa mai yawa.
Game da saduwa da miyagun ƙwayoyi a cikin sashi na 5 MG, kwamfutar hannu tare da taro mai aiki na 10 MG za'a iya raba su rabi.
Kafin gudanar da aikin likita tare da Rosuvastatin, Canon ya buƙaci mai haƙuri ya bi kyakkyawan tsarin hypocholesterol na ɗan lokaci. Ana buƙatar yarda da irin wannan abincin bayan fara magani.
An zabi sashi na allunan cholesterol ne ta hanyar kwararrun likitocin da ke halarta suna yin la’akari da sakamakon bincike da nazari a jikin mai haƙuri bayan sanya abincin abincin da halaye na mutum.
Bugu da kari, sashi na magungunan da aka yi amfani da shi na iya shafar dalilin dalilin warkewa da yanayin yadda jiki zai amsa maganin amfani da Canon a cikin maganin Rosuvastatin.
Dangane da umarnin don amfani, shawarar da aka bayar don fara amfani da maganin shine 5 ko 10 MG sau ɗaya a rana.
Tare da yin amfani da rosuvastatin na lokaci daya tare da fibrates ko nicotinic acid a cikin sashi ba fiye da gram 1 a rana ba, sigar farko shine 5 MG sau ɗaya a rana.
Lokacin zabar wani kashi, likitan yakamata ya bishe shi ta hanyar sakamakon ma'aunin adadin cholesterol a jikin mai haƙuri kuma yayi la'akari da haɗarin yiwuwar haɓaka rikitar cututtukan zuciya. Bugu da kari, ƙwararren dole yayi la’akari da yuwuwar haɗarin sakamako masu illa daga amfani da magunguna yayin gudanar da aikin.
Idan ya cancanta, ana daidaita yawan maganin da aka yi amfani dashi kowane mako 4.
Yin amfani da sashi na 40 MG ana aiwatar da shi ne kawai a cikin marasa lafiya tare da babban matakin ci gaba na hypercholesterolemia kuma a gaban haɗarin haɗari na rikitarwa a cikin aikin tsarin jijiyoyin jini na jiki, kazalika da gano cutar hawan jini a cikin haƙuri. A cikin batun amfani da mafi girman izinin kashi a yayin aikin jiyya, yakamata a kula da mai haƙuri koyaushe.
Yin amfani da miyagun ƙwayoyi a cikin mafi yawan suturar an hana shi cikin marasa lafiya tare da gazawar renal da rashin daidaituwa na koda.
Don wannan rukuni na marasa lafiya, maganin da aka bada shawarar shine 5 MG kowace rana a cikin kashi ɗaya.
Sakamakon sakamako da analogues na Rosuvastatin Canon
Yayin amfani da miyagun ƙwayoyi, sakamako masu illa na iya haɓaka a jikin mai haƙuri.
Mitar sakamako masu illa sun dogara da sashin da aka yi amfani da shi da kuma halayen mutum na mutum na haƙuri.
Daga gefen tsarin juyayi na tsakiya, ciwon kai, farin ciki da, a cikin lokuta mafi wuya, asarar ƙwaƙwalwar ajiya na iya faruwa.
A wani ɓangaren narkewa, ana nuna tasirin sakamako ta hanyar maƙarƙashiya, tashin zuciya, raunin ciki, a lokuta masu wuya, ci gaban cututtukan pancreatitis da jaundice.
Tsarin numfashi na iya amsawa ga miyagun ƙwayoyi tare da irin waɗannan bayyanar cututtuka kamar tari da gazawar numfashi.
Daga tsarin musculoskeletal, bayyanar myalgia mai yiwuwa ne. Myopathies da, a cikin lokuta mafi saurin, arthralgia.
A wani ɓangare na tsarin urinary, amsawa na gefe na iya bayyana kanta a cikin hanyar proteinuria, kumburi na gefe kuma, a cikin mafi yawan lokuta, hematuria.
Sakamakon shan miyagun ƙwayoyi, mai haƙuri na iya fuskantar alamun alamun cutar guda 2.
Idan an gano wani sakamako na jikin mutum daga shan maganin, ana iya maye gurbin sa akan shawarar kwararrun masu halartar tare da tsoffin likitocin da ake dasu.
Zuwa yau, masana'antun magunguna suna ba da fiye da 10 magunguna daban-daban wadanda sune analogues na Rosuvastatin Canon.
Wadannan kayan aikin sune:
- Akorta,
- Mertenil.
- Rosart.
- Harshen Ros
- Rosuvastatin Sotex.
- Rosuvastatin SZ.
- Rosulip.
- Rosucard.
- Roxer.
- Rustor.
- Tevastor
Duk waɗannan magunguna suna da sakamako iri ɗaya a jiki, amma suna da bambance-bambance masu yawa a cikin farashi, wanda ke ba mai haƙuri damar zaɓin magani mafi dacewa, duka biyu cikin farashi da kuma tasirin warkewa a jiki.
Game da miyagun ƙwayoyi Rosuvastatin an bayyana shi a cikin bidiyon a cikin wannan labarin.
