Atrogrel magani ne wanda ke da tasirin antiplatelet. Ana amfani dashi don magancewa da kuma hana farko, cututtukan zuciya na maimaitawa, bugun jini a cikin yanayin tsinkayar marasa lafiya. Magungunan yana taimakawa kawar da cututtukan jijiyoyin bugun gini saboda ƙirar ƙwaƙwalwar ƙwaƙwalwa na clopidogrel don hana haɗuwar platelet. Yana da mahimmanci a la'akari cewa lokacin jiyya, lokacin da za a dakatar da zubar jini yana ƙaruwa.
Sunan kasa da kasa mai zaman kansa
Clopidogrel
Ana amfani da Atrogrel don magancewa da hana na farko, cututtukan zuciya da maimaita bugun jini.
ATX
B01AC04
Saki siffofin da abun da ke ciki
Ana yin magungunan a cikin kwamfutar hannu. Nau'in magungunan an rufe shi da farar fata, fenti. 1 kwamfutar hannu 1 ya ƙunshi 75 MG na ƙwayar aiki - clopidogrel bisalte. Componentsarin abubuwan da aka haɗa sun haɗa da:
- microcrystalline cellulose;
- hydrogenated castor oil;
- sukari madara;
- croscarmellose sodium.
Harsashin kwandon ya ƙunshi carmin, hypromellose, sukari lactose, titanium dioxide, triacetin.
Ana yin magungunan a cikin kwamfutar hannu. 1 kwamfutar hannu 1 ya ƙunshi 75 MG na ƙwayar aiki - clopidogrel bisalte.
Aikin magunguna
Magungunan yana hana ɗaure adenosine diphosphate ga masu karɓa mai dacewa a saman farfajiyar platelet, sakamakon abin da ya rage yawan aikin platelet na jini. Sakamakon aikin clopidogrel, an rage yawan haɗin platelet da mannewa, lalacewa ta halitta ko ta tsokanar da wasu magunguna. An rubuta sakamako na warkewa a cikin binciken dakin gwaje-gwaje 2 sa'o'i bayan maganin baka na maganin.
Tare da kashi na biyu, sakamakon maganin yana inganta da daidaituwa kawai bayan kwanaki 3-7 na maganin ƙwaƙwalwar ƙwayoyi. Haka kuma, matsakaicin hana hadewar platelet ya kai 45-60%. Tasirin warkewa ya ci gaba har sati guda, bayan haka tarawar farantin jini da aikin magani ya koma ga dabi'unsu na asali. Wannan saboda sabuntawar sel ne (rayuwar platelet shine kwana 7).
Pharmacokinetics
Lokacin ɗauka da baka, Clopidogrel yana narkewa cikin hanji a cikin hanji. Idan ya shiga cikin jini, mahallin sunadarai ya isa matsakaicin matakan plasma 2 sa'o'i bayan gudanarwa kuma shine 0.025 μg / L. Clopidogrel yana ɗaukar canji a hepatocytes tare da samuwar samfuran samfuran metabolism waɗanda ba su da aikin miyagun ƙwayoyi (85% na farkon plasma maida hankali ne).
Concentarfafa aiki mai aiki a cikin tsofaffi ya fi ƙa'idar aiki daidai.
Bayan sarrafa bakin, kashi 50% na kashi da aka dauka ana fallasa su ta hanjin urinary, 46% barin jiki da jijiyoyin cikin hanji a cikin sa'o'i 120 bayan gudanarwar maganin. Rabin rayuwar shine 8 hours.
Concentarfafa aiki mai aiki a cikin tsofaffi ya fi ƙa'idar aiki daidai. Lokaci guda, alamomin tarawar platelet da lokacin zub da jini basu shafa.
Menene taimaka?
Ana amfani da miyagun ƙwayoyi azaman matakan kariya a cikin maganin atherothrombosis a cikin marasa lafiyar manya kuma don kawar da halaye masu zuwa:
- cututtukan cututtukan jijiyoyin jijiyoyin jijiyoyi a yayin da ake ci gaba da aiwatar da cututtukan ƙwayar cuta saboda atherothrombosis a cikin ƙananan ƙarshen;
- m jijiyoyin zuciya da bugun zuciya game da ciwon zuciya tare da rashiwar girgiza Q akan almakashi (ECG) ko kuma gaban angina mai tsayayye;
- rigakafin infarction na sakandare na myocardial da hanzarta farfadowa da ƙwayar zuciya (an yi amfani da miyagun ƙwayoyi ba bayan kwanaki 35 ba bayan faruwar cutar);
- rigakafin mutuwa kwatsam;
- m infushin myocardial infarction lokacin haɓaka sashin ST a kan ECG tare da kulawa da ra'ayin mazan jiya tare da acetylsalicylic acid;
- ischemic bugun jini a farkon farfajiya bayan kwanaki 7 (ba a wuce watanni 6 ba) daga haɓakar ƙwayar cuta.
Ana amfani da miyagun ƙwayoyi don hana faruwar wani yanayin rashin lafiyar atherothrombotic da kuma toshewar (embolism) na lumen jirgin ruwa ta hanyar thrombus yayin atbr firamillation na atrial. A cikin wannan halin, ana bada shawara don amfani da maganin haɗin maganin acetylsalicylic acid tare da clopidogrel.
Contraindications
Ba a sanya magani ba a gaban waɗannan abubuwan haɗari masu zuwa:
- ƙara yawan mai saukin kamuwa da kyallen takarda zuwa kayan aikin Atrogrel;
- tsari mai zurfi a cikin hanta, tabarbarewar jikin mutum;
- ulcerative erosive raunuka na ciki da kuma duodenum a cikin m mataki;
- toshewar ciki, zubar jini;
- maganin ulcerative colitis.
Ba a ba da shawarar yin amfani da maganin ba yayin shayarwa da mata masu juna biyu.
Tare da kulawa
An ba da shawara mai hankali a cikin marasa lafiyar da ke cikin haɗarin zub da jini sakamakon rauni, na aikin tiyata, da kuma rashin daidaituwa a cikin ma'aunin acid-jikin. Adaddamar da Atrogrel ba a da ake so ga marasa lafiya waɗanda ke da aikin hanta ba daidai ba, saboda akwai haɗarin haɓakar cutar basur.
Yadda ake ɗaukar Atrogrel?
Magungunan an yi shi ne don gudanar da maganin baka, ba tare da la'akari da abincin ba. Daidaitaccen maganin yau da kullun shine 75 MG sau ɗaya. Marasa lafiya da ke da mummunar lalacewar jijiyoyin hanji, angina marasa ƙarfi da infarction na myocardial ana ba da shawarar su dauki 300 MG na miyagun ƙwayoyi a ranar farko - Allunan 4. M allurai masu daidaituwa.
Tsawon kwastom ɗin an ƙaddara shi ne ta hanyar halartar likitocin daban-daban, gwargwadon hoto na asibiti na tsarin ilimin cututtukan cuta. An tsara maganin haɗin gwiwa tare da wasu magunguna da wuri-wuri. Matsakaicin lokacin kulawa shine makonni 4.
Tare da ciwon sukari
Magungunan ba shi da sakamako mai guba a cikin aikin aikin ƙwayoyin beta na pancreatic kuma baya shafar taro na glucose a cikin ƙwayar jini. Masu ciwon sukari basa buƙatar canza tsarin kulawa.
Sakamakon sakamako na Atrogrel
Abubuwan da ba su dace ba daga gabobin da tsarin suna ci gaba a cikin mafi yawan lokuta idan mai haƙuri yana da tsinkaye don aiki mai aiki na gabobin ko lokacin da aka ɗauki allunan da ba su dace ba.
A wani bangare na bangaren hangen nesa
Magungunan ba ya shafar aikin gani.
Daga tsoka da kashin haɗin kai
Abubuwan da ke haifar da sakamako a cikin jijiyoyin musculoskeletal suna bayyana ta hanyar jin zafi a cikin tsokoki da gidajen abinci.
Gastrointestinal fili
Wataƙila bayyanar zafin ciki, tsawan zawo da dyspepsia. A cikin lokuta na musamman, akwai maƙarƙashiya, ciwon ciki da cututtukan duodenal.
Hematopoietic gabobin
Yawan abubuwan da aka kafa a cikin jini yana raguwa, samar da leukocytes da eosinophilic granulocytes sun tarwatse. Lokacin daina zubar jini yana ƙaruwa. Thrombocytopenic purpura, anemia, thrombocytopenia da agranulocytosis na iya haɓaka tare da lalacewar tsarin hematopoietic.
Marasa lafiya lura da ci gaban da zub da jini bayan wata daya na magani.
Tsarin juyayi na tsakiya
Tare da sakamako mai guba na miyagun ƙwayoyi akan tsarin mai juyayi, ciwon kai, tsananin farin ciki da asarar jijiyoyin haɓaka. A cikin halayen da ba a sani ba, asarar iko, tunanin mutum, rikicewa da asarar hankali, raunin dandano mai yiwuwa.
Daga tsarin numfashi
Tare da tsawanta amfani da miyagun ƙwayoyi, gajeriyar numfashi da makogwaro na iya ci gaba.
A ɓangaren fata
Fata na fyaɗe, ja, da itching.
Daga tsarin kare jini
A cikin lokuta na musamman, glomerulonephritis da haɓaka cikin ƙwayar ƙwayar jini na ƙwayar halittar jini na iya faruwa.
Daga tsarin zuciya
Tare da sakamako mai guba na miyagun ƙwayoyi akan tsarin wurare dabam dabam, tachycardia ya bayyana, rushewa da jijiyoyin zuciya da jin zafi a cikin kirji.
Daga gefen metabolism
Magungunan ba su da tasiri kai tsaye a kan metabolism, amma tare da haɓaka sakamako masu illa a cikin ƙwayar gastrointestinal, rage yawan ci yana yiwuwa.
Cutar Al'aura
A cikin marasa lafiya sun yi niyya ga ci gaban halayen anaphylactoid, a lokuta mafi ƙarancin gaske akwai haɗarin haɓakar girgiza cutar anaphylactic, edema Quincke, zazzabi. Yawancin marasa lafiya suna da amya, rashes, da itching fata.
Amfani da barasa
A lokacin da ake shan magani, ba da shawarar sha giya ba. Ethyl barasa yana cutar da yanayin jijiyoyi na tsakiya da jijiyoyin jini, yana kara yawan tasirin sakamako a cikin narkewar abinci da kuma tsawan lokacin zubar jini. Ethanol na iya haifar da rauni na ganuwar ciki.
Umarni na musamman
Tare da ayyukan da aka tsara, ya kamata ku daina shan Allunan a cikin kwanaki 5-7 kafin fara aikin tiyata. Mai haƙuri ya kamata ya sanar da likitan tiyata da likitan motsa jiki game da amfanin Atrogrel.
Idan zub da jini kwatsam (hematuria, cingam na cuta, menorrhagia), ya zama dole a yi bincike don kasancewar canje-canje na cututtukan cuta a cikin hemostasis. Nazarin zai taimaka wajen tantancewa da kuma aiki na platelet, lokacin zubar jini.
Yi amfani da tsufa
Magungunan ƙwayar cuta ga mutanen da suka haura shekaru 75 suna farawa ba tare da yin bayanin adadin kuɗaɗe ba. Ba a buƙatar ƙarin canje-canje ga tsarin ciyarwa ba.
Aiki yara
Sakamakon rashin ingantaccen binciken asibiti game da tasirin Clopidogrel akan girma da haɓaka jiki a cikin ƙuruciya da samartaka, ba a ba da shawarar magunguna ga marasa lafiya da ke ƙasa da shekara 18.
Yi amfani da lokacin daukar ciki da lactation
An sanya maganin ne don amfani da mata masu juna biyu, saboda Clopidogrel na iya hana kwanciya da gabobin da tsarin yayin tayi, ko kuma zai sami damar zub da jini yayin aikin, wanda ke haifar da mawuyacin hali ga rayuwar mahaifiyar.
An tattara magungunan a cikin gland na dabbobi masu shayarwa kuma an keɓe shi a cikin madara, sabili da haka, yayin jiyya tare da Atrogrel, ana ba da shawarar dakatar da shayarwa.
Ba a buƙatar ƙarin daidaitawa na kashi don lalacewar koda.
Aikace-aikacen aiki mara kyau
Ba a buƙatar ƙarin daidaitawa na kashi don lalacewar koda.
Amfani don aikin hanta mai rauni
Idan hanta ba ta aiki da kyau, ya zama dole a nemi shawara tare da likitanka game da buƙatar magani.
Yawan abinciki na Atrogrel
Tare da cin zarafin miyagun ƙwayoyi, haɓakar halayen da ba su da kyau a cikin narkewa na ciki (rauni na huhun ciki, jin zafi a cikin yankin epigastric, zawo da amai, gudawa zuwa gaɓoɓin ƙwayoyin hanji) da kuma tsawan lokaci na zub da jini zai yiwu. Tare da kashi ɗaya na babban kashi, wanda aka azabtar dole ne ya kira motar asibiti. A cikin tsakaitattun wurare, ana yin jigilar jini ne don a sauƙaƙe abubuwan gado na jini.
Idan mai haƙuri ya saka kwalayen ƙwayoyi masu yawa a cikin awanni 4 da suka gabata, to, mai haƙuri yana buƙatar shigar da tashin hankali, matse ruwan ciki kuma ya ba da wani abu mai narkewa don rage yawan ƙwayoyin cuta.
Yin hulɗa tare da wasu kwayoyi
Ta amfani da Arthrogrel na lokaci guda tare da wasu kwayoyi, ana lura da ma'amala tsakanin magunguna masu zuwa:
- Yayin shan magungunan hana-steroidal anti-mai kumburi, akwai karuwa a cikin yiwuwar zub da jini a cikin gastrointestinal tract. Ityarfafawar basur a cikin gabobin mara nauyi ta inganta ta aikin Warfarin.
- Yawan plasma na phenytoin da tolbutamide suna ƙaruwa. A wannan yanayin, ba a lura da mummunan halayen daga jiki ba.
- Heparin da acetylsalicylates ba su tasiri tasirin warkewar Atrogrel.
Babu halayen sunadarai a hade tare da masu hana karɓa na beta-adrenergic receversor, diuretics, antiepilepti da magungunan hypoglycemic.
Tasiri kan ikon sarrafa abubuwan inji
Magungunan ba ya keta motsin motsi da yanayin aiki na tsokoki mai narkewa. Sabili da haka, yayin lokacin jiyya, an ba da izinin tuki, ikon sarrafa abubuwa masu rikitarwa da sauran ayyukan da ke buƙatar saurin haƙuri na halayen psychomotor da taro.
Analogs
Abubuwan da aka maye gurbin atrogrel sun haɗa da magunguna masu zuwa, tare da sashi mai aiki mai kama da tasiri na magunguna:
- Sylt;
- Clopacin;
- Clopidogrel;
- Acecor Cardio;
- Agrelide;
- Cormagnyl;
- Ecorin;
- Cardiomagnyl.
Idan babu sakamako na warkewa lokacin shan Atrogrel, ya zama dole a nemi shawara tare da likitanka game da maye gurbin maganin. Sauyawa zuwa wani magani akan kansa ba shi da shawarar.
Magunguna kan bar sharuɗan
Ana sayar da maganin ta hanyar takardar sayan magani.
Zan iya saya ba tare da takardar sayan magani ba?
Magani yana rage yawan haɗuwa da jini kuma yana ƙara haɗarin zubar jini, wanda ke da haɗari ga rayuwa a cikin mawuyacin yanayi. Don amincin haƙuri, sayar da maganin kyauta yana da iyaka.
Farashi
Matsakaicin farashin maganin antiplatelet a cikin kantin magani ya bambanta daga 344 zuwa 661 rubles.
Yanayin ajiya na miyagun ƙwayoyi
An bada shawara don adana miyagun ƙwayoyi a wani wuri mai kariya daga danshi da hasken rana, a zazzabi zuwa + 25 ° C.
Ranar karewa
Shekaru 2
Mai masana'anta
Cibiyar Kimiyya da Lafiya ta JSC "Borshchagovsky Chemical da Magungunan Magunguna", Ukraine.
Nasiha
Oleg Hvorostnikov, shekara 52, Ivanovo.
A kan shawarar likita, ya fara shan 1 kwamfutar hannu na 75 MG da dare dangane da ganewar asali na atherosclerosis na ƙananan ƙarshen. Magungunan sun taimaka, tsananin ya fara jin kasa. Amma a rana ta 5 na magani na kira motar asibiti. Ciwon ciki a cikin kogon ciki ya fara. Ba na ba da shawarar mutane da ke daɗaɗar ci gaba da cututtukan ƙwayar cuta da cututtukan fata. A halin da nake ciki, wannan kuskure ne.
Victor Drozdov, dan shekara 45, Lipetsk.
Aboki wanda, bayan fama da bugun jini, ya zama nakasa, an wajabta shi 1 kwamfutar hannu na Atrogrel na makonni 2. Bayan bugun jini, ischemia ya fara, don haka da wuya hannun dama ya ji. A ƙarshen makon farko na far, farawar ya fara ne a cikin reshe. Magungunan sun ba da sakamako. Likitocin sun ce maganin ya lalata tasoshin jini da kuma kara yawan jini a cikin yankin ischemic. Na bar magana mai inganci.
