A cikin jerin magunguna masu amfani da hawan jini, Janumet ya cancanci a ambata. Abun fasalin shi shine haɗuwa mai haɗari, wanda ke ba da damar cimma sakamako mai girma a cikin ɗan ƙaramin farashi.
Sunan kasa da kasa mai zaman kansa
Magungunan INN - Metformin + Sitagliptin.
A cikin jerin magunguna masu amfani da hawan jini, Janumet ya cancanci a ambata.
ATX
Lambar ATX ita ce A10BD07.
Saki siffofin da abun da ke ciki
Kadai sigar magani na Janumet 50 shine Allunan, duk da haka, zasu iya samun sigar daban.
Babban abun da ke cikin miyagun ƙwayoyi ya ƙunshi abubuwa masu zuwa:
- sitagliptin phosphate monohydrate - a cikin adadin 64.25 MG (wannan abun yana daidai da 50 MG na sitagliptin);
- metformin hydrochloride - adadin wannan bangaren zai iya kaiwa zuwa 500, 850 ko 1000 MG (ya danganta da yawan maganin da aka nuna).
Abubuwa masu taimako sune:
- sodium fumarate;
- povidone;
- tsarkakakken ruwa;
- sodium lauryl sulfate.
Allunan Biconvex, masu lullube fina-finai, mai santsi a gefe guda kuma mawuyacin ɗayan Launi ya bambanta da sashi: ruwan hoda mai haske (50/500 MG), ruwan hoda (50/850 MG) da ja (50/1000 MG).
Allunan an sanya su cikin blisters of 14 inji mai kwakwalwa. Akwatin kwali na iya ƙunsar faranti 1 zuwa 7.
Aikin magunguna
Allunan Yanumet - hada magunguna. Ya ƙunshi magungunan hypoglycemic 2 waɗanda ke dacewa da juna sosai. Shan kwayoyin suna taimaka wajan shawo kan sarrafa jini a cikin marassa lafiyar da ke dauke da ciwon sukari na II.
Shan kwayoyin suna taimaka wajan shawo kan sarrafa jini a cikin marassa lafiyar da ke dauke da ciwon sukari na II.
Sitagliptin
Wannan bangaren yana da kaddarorin babban mai inzyme mai hana inzantarwa (DPP-4). Ana amfani dashi sau da yawa a cikin hadaddun jiyya na nau'in ciwon sukari na II na mellitus.
DPP-4 inhibitors suna aiki ta hanyar kunna incretins. Lokacin da yake hana ayyukan DPP-4, sitagliptin yana ƙara yawan haɗuwa da polypeptide glucose-dogara insulinotropic polypeptide (HIP) da glucagon-like peptide 1 (GLP-1). Wadannan abubuwa sune kwayoyin halittu masu aiki daga dangi na asali. Aikin su shine shiga cikin tsarin glucose homeostasis.
Tare da al'ada na jini ko hawan jini, HIP da GLP-1 suna haɓaka aikin insulin ta sel ƙwayoyin fitsari. Hakanan GLP-1 yana iya hana samar da glucagon a cikin ƙwayar hanta, wanda ke rage haɗarin glucose a cikin hanta.
Ingancin sitagliptin shine cewa a cikin shawarar magungunan da aka bayar da shawarar, wannan abun baya hana aikin enzymes masu alaƙa, gami da DPP-8 da DPP-9.
Metformin
Har ila yau, wannan bangaren yana da kaddarorin halittar jini. A ƙarƙashin tasirinsa, mutanen da ke fama da nau'in ciwon sukari na II na sukari na ƙara yawan haƙuri. An yi bayanin wannan ta hanyar rage matakan postprandial da basal plasma glucose matakan.
Hanyar da ake amfani da magunguna ta hanyar metformin ya bambanta da gaske daga aikin wakilai na maganin ƙwayar cuta, wanda ke cikin sauran rukunin magunguna. Yin amfani da miyagun ƙwayoyi yana taimakawa cimma nasarar waɗannan masu nuni:
- samar da glucose a cikin hanta an rage shi;
- kashi na shan glucose a cikin hanji yana raguwa;
- Rage wuri da kuma kawar da glucose a cikin jini yana kara saurin jikewar insulin.
Amfanin wannan bangaren (idan aka kwatanta shi da sulfonylurea) shine karancin ci gaban haila da hyperinsulinemia.
Pharmacokinetics
Sashi na magani Yanumet yayi daidai da tsarin metformin da sitagliptin daban. Rashin bioavailability na metformin yana da alamar nuna 87%, sitagliptin - 60%.
Abubuwan da ke aiki a cikin abun da ke ciki an keɓance su ta cikin kodan.
Matsakaicin aikin sitagliptin ana samun sa'o'i 1-4 bayan gudanarwar baka. Abincin abinci baya shafar adadin kuzarin da kuma yawanshi. Ayyukan Metformin ya fara bayyana bayan sa'o'i 2. Tare da ɗimbin abinci mai yawa, ana rage yawan sha.
Abubuwan da ke aiki a cikin abun da ke ciki an keɓance su ta cikin kodan.
Alamu don amfani
An tsara Yanumet don kafa tsarin kula da ciwon sukari a cikin marasa lafiya da ke fama da ciwon sukari na 2. Likitocin suna ba da kwayayen kwayoyi a lokuta da yawa:
- A cikin rashi sakamakon da ake so daga jiyya tare da Metformin. A wannan yanayin, haɗuwa mai haɓaka yana inganta bayanin martaba na glycemic da ingancin rayuwar masu ciwon sukari.
- A hade tare da gammawar karɓa na gamma.
- Tare da cikakken biyan diyya daga allurar insulin.
Contraindications
An ba da shawarar sosai a sha maganin tare da:
- hankali na mutum ga abubuwan da ke cikin allunan;
- nau'in ciwon sukari;
- coma mai cutar kansa;
- cututtuka daban-daban;
- halin gigicewa;
- matsanancin rauni na koda;
- na ciki na kwayoyi na kwayoyi dauke da aidin;
- tsananin lalata hanta;
- cututtuka tare da rashi oxygen;
- guba, giya;
- ciki da shayarwa;
- a karkashin shekara 18 years.
Tare da kulawa
Dangane da umarnin, an wajabta magungunan ga tsofaffi marasa lafiya tare da tsananin taka tsantsan.
Yadda za a ɗauki Janumet 50?
Allunan ana dauka da safe a kan komai a ciki tare da abinci. Tare da cin abinci sau biyu, ana shan maganin safe da yamma. Likita ya tsara sashi daban, yayin yin la'akari da yanayin mai haƙuri, shekarunsa da tsarin kulawa na yanzu:
- Idan babu iko na glycemic tare da metformin a cikin adadin da aka iya jurewa. Ana tsara wa irin waɗannan marasa lafiya Janumet sau 2 a rana. Adadin sitagliptin kada ya wuce 100 MG kowace rana, an zaɓi sashi na metformin na yanzu.
- Idan akwai sauyi daga jiyya tare da hadaddun metformin + sitagliptin. Sigar farko na Yanumet a wannan yanayin an zaɓi daidai a baya.
- A cikin rashin mahimmancin tasirin shan kayan haɗin metformin da sulfonylurea. Maganin Yankin Yanumet yakamata ya hada da mafi girman kullun kashi na sitagliptin (100 mg) da kuma kashi na yanzu na metformin. A wasu halaye, ana bada shawarar hada magunguna don haɗuwa tare da sulfonylurea, to ya kamata a rage yawan sashi na ƙarshen. In ba haka ba, akwai haɗarin hauhawar jini.
- In babu sakamakon da ake so daga shan metformin da agonist na PPAR-y. Likitoci suna tsara allunan Yanumet waɗanda ke ɗauke da maganin yau da kullun na metformin da 100mg na sitagliptin.
- Sauya wani hadadden rashin aiki na metmorphine da insulin tare da yawan awo na yau da kullun wanda ke dauke da 100 mg na sitagliptin da kashi na metformin. Willarar insulin zai buƙaci a rage shi.
Tare da ciwon sukari
Allunan an tsara su musamman ga marasa lafiya da ke dauke da ciwon sukari na 2. Mutane da ke fama da nau'in 1 na ciwon sukari suna cikin ƙwayar cuta.
Sakamakon sakamako na Yanumet 50
Wannan wakili na hypoglycemic yana da sakamako masu illa. Dole ne likita ya san mai haƙuri tare da su, tunda idan an gano ɗaya ko fiye da alamun, ya kamata ku ƙi shan maganin. Nan da nan bayan wannan, ya kamata ka nemi likita, inda zasu bincika ƙididdigar jini da kuma haɗuwa da lactate.
Gastrointestinal fili
Daga cikin jijiyoyi, ana iya lura da dandano mai ƙarfe a bakin. Kadan na kowa sune tashin zuciya da amai. Zazzabi da ciwan gudawa na yiwuwa a farkon jiyya. Wasu marasa lafiya suna ba da rahoton ciwon ciki.
Vomiting shine ɗayan cututtukan sakamako na miyagun ƙwayoyi.
Daga gefen metabolism
Yawancin marasa lafiya suna da cuta na rayuwa a cikin jiki. Wannan yana tare da hypoglycemia. A cikin lamurran da ba a san su ba, cututtukan zuciya, haɓakar rikicewar numfashi, bayyanar nutsuwa, zafin ciki, da hauhawar jini.
A ɓangaren fata
Abubuwan da suka shafi fata galibi suna nuna rashin jituwa ga abubuwan da ke cikin allunan. A wannan batun, dermatitis, kurji da itching na iya bayyana. Commonarancin na kowa sune cututtukan Stevens-Johnson da cutanous vasculitis.
Daga tsarin zuciya
A lokuta da dama, megaloblastic anemia na iya faruwa sakamakon malabsorption na bitamin B12 da folic acid.
Cutar Al'aura
Allergy yana bayyana ta amalar fata da ƙaiƙayi.
Tasiri kan ikon sarrafa abubuwan inji
A miyagun ƙwayoyi ba shi da wani tasiri kai tsaye a kan saurin psychomotor dauki da taro. A halin yanzu, shan sitagliptin na iya haifar da nutsuwa da rauni. Don wannan dalili, tuki mota da sauran hanyoyin hadaddun ya kamata a yi su da taka tsantsan.
Umarni na musamman
Longan shan kwaya na bukatar kula da koda koda yaushe.
Idan mai haƙuri yana da tsarin bincike ko hanyoyin warkewa ta amfani da magungunan aidin, to bai kamata a yi amfani da Janumet awanni 48 kafin da bayan ba.
A cikin marasa lafiya da cututtukan cututtukan cututtukan fata da cututtukan koda, magungunan kwayoyi na iya ƙara alamun bayyanar cutar. Don hana wannan, likita ya kamata ya daidaita sashi kuma ya lura da yanayin mai haƙuri koyaushe.
A cikin marasa lafiya da cututtukan cututtukan cututtukan cututtukan ƙwayar cuta, allunan na iya ƙara alamun rashin lafiya.
Yi amfani da lokacin daukar ciki da lactation
Mata a lokacin daukar ciki da lactation ba a ba da shawarar shan wannan maganin na hypoglycemic. A irin waɗannan halayen, magani yana dogara ne akan ɗaukar insulin.
Neman Yanumea ga yara 50
Babu bayanai na asibiti akan tasirin hada magunguna a jikin yara. Don wannan, ba a ba da umarnin Janumet ga marasa lafiya waɗanda shekarunsu ba su wuce 18 ba.
Yi amfani da tsufa
An tsara mutanen da suka tsufa wannan magani, amma kafin wannan, ana buƙatar gano yanayin ƙodan.
Aikace-aikacen aiki mara kyau
Ba a bada maganin ba ga mutanen da ke fama da cututtukan koda (gami da waɗanda ke da ƙarancin kiba).
Amfani don aikin hanta mai rauni
Game da tabarbarewa hanta mai yawa, shan Janumet ba da shawarar ba. Wannan ya faru ne sakamakon haɗarin lactic acidosis.
Adadin adadin Yanumet 50
Idan mai haƙuri ya wuce kashi na warkewa na miyagun ƙwayoyi, wannan ya ƙunshi ci gaban lactic acidosis. Don kwantar da yanayin, lavage na ciki an yi kuma an tsara allurai.
Wata alama ta yawan zubar da jini shine hypoglycemia. Tare da bayyana mai laushi, ana bada shawarar mai haƙuri don cin abinci mai girma a cikin carbohydrates. Ya kamata matsakaici ko mai raɗaɗi na hypoglycemia ta hanyar allurar Glucagon ko kuma maganin Dextrose. Bayan mai haƙuri ya dawo da hankali, ana ba su abinci mai gina jiki na carbohydrate.
Don sasanta yanayin idan akwai yawan abin sama da ya kamata, an sanya allurar hemodialysis.
Yin hulɗa tare da wasu kwayoyi
Tare da hadaddun jiyya na haƙuri, likita ya kamata la'akari da jituwa na Allunan tare da wasu kwayoyi.
Ayyukan Yanumet ya raunana a gaban magungunan masu zuwa:
- Phenothiazine;
- Glucagon;
- thiazide diuretics;
- nicotinic acid;
- corticosteroids;
- kwayoyin hodar iblis;
- Isoniazid;
- estrogens;
- m
- masu maganin tashin zuciya;
- Phenytoin.
An inganta tasirin hypoglycemic lokacin amfani dashi tare da magungunan masu zuwa:
- magungunan anti-mai hana kumburi;
- Insulin
- beta-blockers;
- Abubuwan da suka samo asali na sulfonylurea;
- Oxytetracycline;
- Acarbose;
- Cyclophosphamide;
- ACE da MAO masu hanawa;
- abubuwan asali na clofibrate.
Tare da cimetidine, akwai haɗarin acidosis.
Tare da abubuwan da suka samo asali na sulfonylurea ko insulin. Sau da yawa akwai hypoglycemia a cikin rashin daidaituwa na kashi.
Amfani da barasa
A hade tare da barasa, haɗarin sakamako masu illa suna ƙaruwa.
Analogs
Daga cikin analogues ana kiranta:
- Amaryl M;
- Yanumet Tsayi;
- Douglimax;
- Velmetia;
- Avandamet;
- Glucovans;
- Glibomet;
- Karfe Galvus;
- Gluconorm;
- Tripride.
Magunguna kan bar sharuɗan
A cikin kantin magunguna, takardar sayen magani ce sosai.
Zan iya saya ba tare da takardar sayan magani ba?
Ba za a iya sayen magani na wannan rukunin ba tare da takardar sayan likita ba.
Farashin Yanumet 50
Kudin maganin a cikin Ukraine, Russia da wasu ƙasashe ya dogara da abin da aka bayar a allunan kuma nawa aka bayar a cikin kunshin. A cikin kantin magunguna a Moscow, farashin Yanumet kamar haka:
- 500 MG + 50 MG (50 inji mai kwakwalwa.) - 2780-2820 rubles;
- 850 MG + 50 MG (50 inji mai kwakwalwa.) - 2780-2820 rubles;
- 1000 mg + 50 mg (28 inji mai kwakwalwa.) - 1750-1810 rubles;
- 1000 mg + 50 mg (56 inji mai kwakwalwa.) - 2780-2830 rubles.
Yanayin ajiya na miyagun ƙwayoyi
Ya kamata a adana maganin a cikin wurin da aka kiyaye shi daga hasken rana kai tsaye da danshi. Matsakaicin zafin jiki da ake buƙata har zuwa + 25 ° C.
Ranar karewa
Ana iya amfani da maganin na shekaru 2.
Mai masana'anta
Allunan ɗin suna keɓance su tare da kamfanin magunguna Patheon Puerto Rico Inc. a Puerto Rico. Shirya magunguna ana aiwatar da shi ta kamfanoni daban-daban:
- Merck Sharp & Dohme B.V, wanda ke a cikin Netherlands;
- OJSC “Kamfanin sarrafa magunguna” AKRIKHIN ”a Rasha;
- Frosst Iberica na Spain.
An bayar da maganin daga kantin magunguna daidai da takardar sayen magani.
Reviews game da Yanumet 50
Alexandra, endocrinologist, kwarewa a cikin aikin likita na shekaru 9, Yaroslavl.
Magungunan sun yi nasarar tabbatar da ingancinsa a gwaji na asibiti kuma a aikace. Sau da yawa ina yin waɗannan magungunan don marasa lafiya na dogaro da insulin. Abubuwan sakamako suna da wuya. Babban abin da ake bukata shine sigar da ta dace.
Valery, endocrinologist, kwarewa a cikin aikin likita na shekaru 16, Moscow.
Yanumet yana ba ku damar cimma sakamako da ake so a yawancin lokuta idan ba za a iya sarrafa matakan sukari tare da Metformin ba. Wasu marasa lafiya suna jin tsoron canzawa zuwa wannan nau'in magani saboda yiwuwar sakamako masu illa da haɗarin cutar hawan jini. A halin yanzu, a aikace, irin waɗannan maganganun ana iya kiransu ƙarancin abinci, musamman idan an lura da matakan da suka dace da sauran shawarwarin likita.
