NovoRapid Penfill wani wakili ne mai wucin gadi wanda yake aiki da insulin. Latterarshen ya bambanta da insulin na ɗan adam na mutum ta hanyar kasancewar acid aspartic daga ƙwayar mai yisti wanda ke maye gurbin ci gaba. Wannan jujjuyawar kwayar halitta ta rage lokacin don cimma sakamako mai warkewa da tsawon lokacin maganin, wannan shine dalilin da yasa aka bada shawarar shan maganin kafin abinci.
Sunan kasa da kasa mai zaman kansa
Insulin kewayawa.
ATX
A10AB05.
An sanya miyagun ƙwayoyi a cikin hanyar samar da mafita don gudanarwa cikin ƙasa da ciki, a cikin ciki, an sanya katako a cikin blisters na 5 inji mai kwakwalwa.
Saki siffofin da abun da ke ciki
Ana yin magungunan a cikin hanyar samar da mafita don gudanar da aiki tare da cutarwa. Da gani, ruwa bayyananne ne, mara wari mara launi. 1 ml na miyagun ƙwayoyi ya ƙunshi IU 100 na abu mai aiki, wanda ya dace da 3500 μg. Kamar yadda ake amfani da ƙarin kayan aikin:
- glycerol;
- hydrochloric acid;
- sodium hydroxide;
- ruwa bakararre don allura;
- phenol;
- zinc da sodium chloride;
- sinadarin sodium hydrogen phosphate dihydrate;
- metacresol.
Ana amfani da miyagun ƙwayoyi a cikin gilashin gilashin gilashin 3 ml. Ana sanya katako a cikin fakiti mai bakin ciki na 5 inji mai kwakwalwa.
Aikin magunguna
Insulin aspart shine analog na roba na kwayar halittar mutum wanda ke kwance ta jikin kwayar beta ta hanji. A cikin aikin samarwa a cikin tsarin kwayoyin insulin, ana maye gurbin proline da aspartic acid, don haka rage lokacin don samun sakamako na warkewa.
NovoRapid Penfill wani wakili ne mai wucin gadi wanda yake aiki da insulin.
Tsarin hormone na aiki yana hulɗa tare da masu karɓar waɗanda ke kan saman ƙasan sel. Tare da wannan hulɗa, an samar da hadadden insulin-receptor wanda ke ƙarfafa samar da hexokinase, enzyme wanda ke da alhakin haɗarin glycogen, da pyruvate kinase.
Tasirin hypoglycemic shine saboda haɓakar metabolism na ƙwayar ƙwayar ƙwayar ciki da ɗaukar sukari ta kyallen, ƙara lipogenesis da glycogen samuwar, da raguwa a cikin gluconeogenesis a cikin hanta hepatocytes. Abubuwan da ke cikin magunguna na kayan aiki suna kama da insulin ɗan adam na halitta. Amma a lokaci guda, ƙimar cimma nasarar tasirin warkewa a cikin NovoRapid Penfill ya fi hakan girma.
Insulin kamar yadda yake narkewa daga ƙwayar subcutaneous mai ta dermis lokacin da aka gudanar da subcutaneously da sauri kuma ya sami sakamako na hypoglycemic a cikin ɗan gajeren lokaci fiye da insulin ɗan adam mai narkewa.
Pharmacokinetics
Tare da gabatarwar NovoRapid subcutaneously, lokacin da zaka isa mafi yawan maida hankali a cikin jini ya ragu sau 2 idan aka kwatanta da daidaitaccen gudanarwar insulin na narkewa. Ana yin rikodin ƙima mafi girma tsakanin minti 40 bayan isar da allura. Yawan maida hankali a cikin jini ya koma ga dabi'unsa na asali bayan sa'o'i 4-6 bayan gudanar da magani. A cikin marasa lafiya waɗanda ba su da insulin-da ke fama da ciwon sukari mellitus, yawan sha yana ƙasa, wanda shine dalilin da yasa lokacin isa zuwa mafi yawan ƙwayar plasma na aspart insulin ya kai minti 60.
Alamu don amfani
Ana amfani da miyagun ƙwayoyi don cimma ikon sarrafa glycemic kuma daidaita al'ada sukari na jini a gaban nau'in 1 da nau'in ciwon sukari na 2. A cikin maganar ta karshen, an cire maganin a cikin haɓaka cikakkiyar jure magunguna na maganganu na maganganu na maganganu. M jurewa yana buƙatar haɗawar NovoRapid a hade tare da jiyya.
An haramta amfani da miyagun ƙwayoyi NovoRapid ga yara 'yan ƙasa da shekaru 2.
Ana amfani da maganin lokacin da ba zai yiwu ba a rubuto wasu wakilai na hypoglycemic a kan asalin ci gaban wata cuta ta hanyar cuta mai kama da cuta - tsari ne na rikitarwa ta yanayin bayyanar cutar sakandare.
Contraindications
An haramta amfani da miyagun ƙwayoyi a gaban hypoglycemia da karuwar mai saurin kamuwa da kayan aiki, yara 'yan shekaru 2 da haihuwa.
Tare da kulawa
An ba da shawarar yin hankali ga mutanen da ke da aikin hanta da ba daidai ba, a gaban ƙwayoyin neoplasms, da kuma ga tsofaffi masu shekaru sama da 65.
Yadda ake ɗaukar NovoRapid Penfill?
Ana sarrafa magungunan a ƙarƙashin ƙasa ko a cikin tazara. Matsayin NovoRapid na yau da kullun yana ƙaddara ta hanyar halartar masu halartar likita daban-daban dangane da matakin sukari da bukatun yau da kullun don insulin. An bada shawara don haɗa magungunan a cikin maganin haɗuwa tare da magungunan hypoglycemic na matsakaici ko tsawon lokaci, ana ɗauka sau ɗaya a rana.
Don cimma daidaitaccen iko na glycemic, ya zama dole don auna alamun glucose jini a kai a kai, gwargwadon yadda za a daidaita tsarin aikin.
Yadda ake yin allura?
Ba za ku iya shiga cikin ƙwayar intramuscularly ba. An ba da shawarar canza yankin allura tare da kowane allura domin a rage yiwuwar ƙyallen kai da fata a cikin wannan wurin.
Tare da kulawa da kai, ana gudanar da insulin a ƙarƙashin ƙasa. Ana aiwatar da jiko na IV a karkashin kulawa na kwararren likita. Don aiwatar da allurar sc, ya zama dole a bi algorithm da aka kirkira:
- Wajibi ne a riƙe allura a ƙarƙashin fata na akalla aƙalla 6 ta latsa maɓallin farawa (an sake shi bayan cire allura). Wannan dabarar za ta samar da kashi 100% na yawan insulin kuma zai hana jini shiga kicin.
- Abubuwan allura sune don amfanin kawai. Tare da sake maimaita insulin tare da allura guda ɗaya, mafita na iya zubowa daga kicin ɗin, saboda abin da jiki zai sami sashi ba daidai bane na ƙwayar.
- Kar a cika kwalin.
An ba da shawarar cewa koyaushe kuna ɗaukar kayan inshorar gaba tare da ku lokacin da katangar batattu ko lalacewar injina.
Ciwon sukari
Bukatar insulin kowace rana ga marasa lafiya da yara sun bambanta daga ɓangaren magani na 0.5 zuwa 1 a kowace kilo 1 na nauyi. Tare da gabatarwar miyagun ƙwayoyi kafin cin abinci, jiki yana karɓar 50-70% na kashi na hormone na pancreatic. Ragowar yana sake cika ta jiki ko wasu ƙwayoyi masu saurin aiki. Tare da karuwa a cikin aikin jiki, canji a cikin abincin, kasancewar cututtukan sakandare, daidaita sashi ya zama dole.
Insulin aspart, ba kamar insulin ɗan adam mai narkewa ba, yana da babban gudu da gajeriyar aiki, saboda haka ana bada shawarar yin magani ta hanyar abinci. Sakamakon ƙarancin lokacin aiki, ana rage yiwuwar rashin lafiyar dare.
Don gudanarwa na cikin ciki a cikin tsararren yanayi, wajibi ne don shirya dropper.
Don gudanarwa na cikin ciki a cikin tsararren yanayi, wajibi ne don shirya dropper. Shiryawar jiko ya ƙunshi dilice 100 UNITS na NovoRapid a cikin 0.9% isotonic bayani na Sodium chloride wanda yaduwar insulin aspart ya bambanta daga 0.05 zuwa 1 UNITS / ml.
Sakamakon sakamako na NovoRapida Penfill
Abubuwan da ke haifar da sakamako masu illa suna faruwa a mafi yawan lokuta saboda tsarin allurai marasa inganci. Don rage haɗarin cutar hypoglycemia, ya wajaba don zaɓar ainihin adadin NovoRapid.
Daga tsarin rigakafi
Wataƙila bayyanar urticaria, rashes a kan fata, halayen anaphylactic.
A bangaren metabolism da abinci mai gina jiki
Babban haɗarin hauhawar jini tare da matakan da ba su dace ba.
Tsarin juyayi na tsakiya
A cikin mafi yawan lokuta, polyneuropathy na jijiya na faruwa.
A wani bangare na bangaren hangen nesa
Rashin gani na bayyana kanta a cikin matsala ta farfadowa ko ci gaban retinopathy na ciwon sukari.
Daga tsarin numfashi
A wasu halayen, gajeriyar numfashi yana bayyana.
A ɓangaren fata
Wataƙila haɓakar lipodystrophy.
Cutar Al'aura
A cikin lokuta na musamman, akwai wasu maganganu na rashin lafiyar jiki, tare da rashes da itching, rashin jin daɗi, haɓaka gumi, edema na Quincke, tachycardia, hypotension. Ayyukan anaphylactoid sune barazanar rayuwa ga mai haƙuri.
Tasiri kan ikon sarrafa abubuwan inji
Tare da asarar iko na glycemic, tare da hypoglycemia ko hyperglycemia, ikon maida hankali yana da rauni kuma saurin hanzari ya ragu. Wannan na iya zama haɗari yayin tuki ko kuma kula da kayan aiki masu wuyan.
Penaukar NovoRapid Penfill na iya zama haɗari yayin tuki.
Umarni na musamman
Tare da ƙarancin sashi na insulin ko cire magani, ci gaban hypoglycemia da ketoacidosis mai yiwuwa ne a kan tushen karuwa a cikin taro na jikin ketone da sukari a cikin jini na jini, musamman a cikin marasa lafiya da ke da nau'in ciwon sukari na 1 na sukari. Hyperglycemia na iya faruwa a hankali tsawon mako guda. Na farko bayyanar cututtuka na ci gaban da pathological tsari zai zama:
- bushe bakin
- nutsuwa
- jan a fata;
- polyuria;
- tsananin yunwa;
- tashin zuciya, amai, da ƙishirwa;
- warin acetone daga bakin.
Wani fasalin masana'antar magunguna ta insulin aiki a takaice shine mafi saurin haɓakar hypoglycemia, sabanin insulin ɗan adam mai narkewa.
A cikin marasa lafiyar da ke fama da hanta da aikin koda, an rage rage yawan shan insulin aspart.
Yi amfani da lokacin daukar ciki da lactation
A cikin binciken asibiti a kan dabbobi, insulin aspart bai nuna rashin tayi ko teratogenicity ba. Lokacin da suke rubuta NovoRapid, mata masu juna biyu suna buƙatar kulawa da kulawa akai-akai game da yawan ƙwayar plasma na glucose. Likita yakamata ya lura da yanayin marasa lafiyar.
A cikin watanni na farko na ci gaban tayi da kuma lokacin aiki, bukatar insulin ya ragu, yayin da a karo na biyu da na uku abubuwa suke canzawa a hankali.
Yayin shayarwa, wajibi ne don daidaita sashin insulin.
Amfani da barasa
Ethanol yana haɓaka tasirin insulin wanda ya lalace, saboda haka, shan giya a lokacin maganin ta'ammali da ita haramun ne. Al'adar giya na Ethyl na iya haifar da haɓakar ƙwayar cutar hypoglycemia da hauhawar jini.
Yawan adadin NovoRapida Penfill
Hypoglycemia na iya haɓaka sannu a hankali a bango na tsawaita aikin gudanar da babban allurai na NovoRapid. A wannan yanayin, ainihin adadin wanda zai haifar da hoton asibiti na yawan abin sama da ya wuce ba a kafa shi ba, saboda yanayin rashin lafiyar ɗan adam ya nuna kansa dangane da halaye na mutum na haƙuri.
Hyarancin hypoglycemia, mai haƙuri yana da ikon kawar da kansa ta hanyar ɗaukar samfura tare da babban sukari ko glucose a ciki.
Mai tsananin rashin ƙarfi yana haɗuwa da asarar hankali. A wannan yanayin, asibiti, gabatarwar intramuscularly ko subcutaneously 0.5-1 mg na glucagon. An ba da izinin yin jiko na maganin glucose. Idan bayan minti 10-15 bayan gudanar da Glucagon, hankali bai dawo ba, dole ne ka shigar da 5% na Dextrose. Lokacin dawo da yanayin da farkawa da mara lafiya, ya zama dole a ba wa mai haƙuri abincin tare da adadin carbohydrates. Wannan ya zama dole don hana ci gaban komawar.
Mai tsananin rashin ƙarfi yana haɗuwa da asarar hankali.
Yin hulɗa tare da wasu kwayoyi
Wasu kwayoyi na iya haɓaka tasirin cutar NovoRapid:
- monoamine oxidase, ACE inhibitors, carbonic anhydrase inhibitors;
- magunguna masu dauke da lithium;
- marasa zaɓi na beta-blockers;
- sulfonamides;
- Fenfluramine;
- ethanol-da ke ciki da kuma hypoglycemic jamiái;
- Bromocriptine;
- maganin tetracycline;
- Octreotide;
- Pyridoxine.
Ana lura da rauni na warkewar tasirin tare da gudanar da aikin NovoRapid na lokaci guda tare da allunan tashar alli, diuretics, Heparin, antidepressants, glucocorticosteroids, Morphine, da kuma jami'ai dauke da hodar iblis.
Reserpine da salicylates na iya haifar da asarar sarrafa glycemic.
Shan taba saboda sinadarin nicotine na iya rage tasirin hypoglycemic.
Magungunan Thiol da ke dauke da sinadarai na sulfite lokacin hulɗa tare da insulin suna haifar da lalata ƙarshen.
Analogs
Tsarin analogues na kwayoyi da kwayoyi tare da kaddarorin magunguna iri ɗaya sun haɗa da:
- Aiki;
- Alƙalar sirinji ta NovoRapid;
- Apidra
- Biosulin;
- Gensulin;
- Insulin.
Magunguna kan bar sharuɗan
Ana sayar da miyagun ƙwayoyi ne saboda dalilai na likita kai tsaye.
Zan iya saya ba tare da takardar sayan magani ba?
Wani wakili na glycemic, idan aka yi amfani da shi ba tare da kyau ba, na iya tayar da hauhawar jini, wanda zai iya haɓakawa zuwa gawar cikin jiki. Wannan halin yana da haɗari, saboda haka an haramta amfani da miyagun ƙwayoyi ba tare da takardar izinin likita ba.
Farashi don NovoRapid Penfill
Matsakaicin farashin katako shine 1850 rubles.
Yanayin ajiya na miyagun ƙwayoyi
Wajibi ne a adana maganin a zazzabi na + 2 ... + 8 ° C. An bada shawara a ci gaba a cikin firiji, amma ba za a iya daskarewa ba. Dole ne a ajiye katako a cikin kayan kwali don kariya daga hasken rana. Ana adana harsashin da aka buɗe a zazzabi na + 15 ... + 30 ° C kuma ana amfani dashi tsawon wata guda.
Analog na maganin zai iya zama maganin Apidra.
Ranar karewa
Watanni 30
Mai masana'anta
Novo Nordisk A / S, Denmark.
Neman bita don NovoRapida Penfill
A lokacin tallace-tallace, insulin aspart ya ba da shawarar tasirinsa a kasuwar magunguna, sakamakon abin da akwai maganganu masu kyau daga marasa lafiya da likitocin a kan rukunin yanar gizo.
Likitoci
Zinaida Siyuhova, endocrinologist, Moscow.
Magungunan yana da matsanancin gajeren mataki, yana ba ku damar shiga insulin ba kawai mintuna 10-15 kafin cin abinci, amma har lokacin da bayan abincin. Samun nasara na saurin warkewa yana da mahimmanci a cikin yanayin gaggawa. Godiya ga insulin aspart, mutumin da ke da nau'in ciwon sukari na 2 na mellitus ko ciwon sukari da ke dogara da insulin ba zai iya dacewa da cutar ba, daidaita tsarin abincin yadda yake so.
Ignatov Konstantin, endocrinologist, Ryazan.
Kamar aikin insulin ya keɓe. A cikin mawuyacin yanayi, yana taimaka wajan rage ƙananan glucose jini.A lokaci guda, mai haƙuri dole ne ya bi sashi gwargwadon umarnin, in ba haka ba haɗarin haɓakar haɓakar jini yana ƙaruwa. Mai haƙuri zai iya sarrafa insulin ƙananan ƙwaƙwalwar ƙwayar ƙasa.
Marasa lafiya
Artemy Nikolaev, 37 years old, Krasnodar.
Ina da cutar sukari irin ta 1 tun ina dan shekara 18. Farashin Actrapid, wanda bai taimaka cimma nasarar sarrafa glycemic - sukari ya kasance mai girma. Likita ya maye gurbin Actrapid tare da hade tare da NovoRapid Penfill gajere kuma Levemir na dogon lokaci. NovoRapid ya dace da jikina. Godiya ga masana'anta don ingancin insulin.
Sofia Krasilnikova, dan shekara 24, Tomsk.
Na kasance ina amfani da harsashi sama da shekara guda. Matsakaicin sukari koyaushe yana cikin kewayon al'ada. Da zarar ta tashi, sai na ɗora nan da nan. Na mintina 10-15, ya koma al'ada. Ban lura da wani mummunan halayen ba.
