Mikardis Plus yana nufin magungunan antihypertensive na baka. Magungunan yana da haɗin haɗakar mahaɗan aiki guda biyu - telmisartan da diuretic. Godiya ga wannan haɗin sunadarai, an sami sakamako mai lalacewa mai tsawo, yana ɗaukar tsawon awanni 6-12. Haɗin hydrochlorothiazide da telmisartan yana ba ku damar tsara jinin hawan jini.
ATX
C09DA07.
Mikardis Plus yana nufin magungunan antihypertensive na baka.
Saki siffofin da abun da ke ciki
An sanya magungunan a cikin nau'ikan allunan, waɗanda ke da mahaɗan aiki guda 2 - telmisartan da hydrochlorothiazide.
| Haɗin Mai aiki | Hadadden sashi hade, mg | ||
| Telmisartan | 80 | 80 | 40 |
| Diuretic | 12,5 | 25 | 12,5 |
| Kwayoyin masu launi | Red cike da ruwan hoda | Rawaya tare da inclusions na rawaya | Ruwan hoda |
Kamar yadda ƙarin abubuwan haɓaka haɓaka haɓaka gudu da cikakkiyar ƙarfi, sune:
- sitaci masara;
- sukari madara;
- microcrystalline cellulose;
- sodium hydroxide;
- baƙin ƙarfe daskararru;
- povidone;
- sihiri;
- meglumine.
Allunan an yi sufuri tare da saman biconvex. Ba a samar da wakilin antihypertensive a cikin nau'i na fesa, gel, ko mafita.
An sanya magungunan a cikin nau'ikan allunan, waɗanda ke da mahaɗan aiki guda 2 - telmisartan da hydrochlorothiazide.
Aikin magunguna
Telmisartan yana da tasiri na antihypertensive saboda jingina ga masu karɓar angiotensin II. Tare da ƙirƙirar irin wannan hadadden, sashin aiki mai aiki ya tsoma baki tare da aiki na enzyme vasoconstrictor kuma yana rage haɗuwar aldosterone a cikin jini. Angiotensin II ba zai iya haifar da rushewar bradykinin ba, saboda telmisartan ya toshe ta. Sabili da haka, haɗin bradykinin ya ci gaba - mai vasodilator yana ƙara lumen a cikin jini.
Tasirin vasodilating yana haɓaka hydrochlorothiazide saboda sakamakon diuretic. A dijital thiazide yana taimakawa rage hawan jini tare da hauhawar jini. Tare da yin amfani da dogon lokaci, hydrochlorothiazide yana rage haɗarin haɓakar cututtukan zuciya da mace-mace daga waɗannan cututtukan.
Ana samun tasirin warkewa sosai a cikin awoyi 3.5-4.
Manuniyar hawan jini ya kasance tsayayye tsawon awanni 6 zuwa 6.
Pharmacokinetics
Bayan amfani dashi, kwamfutar hannu ta karye ta hanyar tsokar enzymes.
Lokacin da aka sake shi, abubuwa masu aiki na ƙwayar Mikardis Plus suna haɗuwa da sauri cikin bango na ƙananan hanji.
Lokacin da aka sake shi, abubuwa masu aiki suna ɗaukar hanzari zuwa bangon karamin hanji kuma suna shiga cikin jini. A cikin watsa shirye-shirye na system, telmisartan da hydrochlorothiazide sun isa mafi yawan taro a cikin minti 30-90. Rashin bioavailability na nau'in na biyu na antiotensin receptor antagonist ya kai 50%, hydrochlorothiazide a tsakanin 60%. Abubuwan da ke aiki suna canzawa cikin hepatocytes.
Rabin rayuwar kusan awa 6 ne. Telmisartan yana barin jiki a cikin nau'in samfuran lalacewa ta hanyar tsarin urinary da kashi 60-70%. Hydrochlorothiazide an cire shi cikin fitsari da kashi 95%.
Alamu don amfani
Magungunan ya zama dole don rage hawan jini tare da rashin aiki na telmirsartan far kamar yadda monotherapy.
Contraindications
Ba'a yi maganin ba don maganin marasa lafiya tare da rashin haƙuri na mutum zuwa aiki da ƙarin abubuwan Mikardis Plus. Hanyoyin bincike na gaba kuma suna aiki azaman contraindication don amfani:
- bile karkatarwa tare da conlestitant cholestasis;
- cuta cuta hanta;
- alamar raguwa a cikin aikin koda;
- matsananciyar cutar sankara;
- increasedara yawan haɓakar calcium da ƙananan matakan potassium a cikin jiki;
- nau'i na rashin haƙuri zuwa ga galactose, fructose, lactose.
An haramta amfani da miyagun ƙwayoyi don amfani a cikin marasa lafiya da gazawar koda da ciwon sukari tare da amfani da layi daya na Aliskiren.
Yadda ake ɗauka
Tare da digiri mai laushi zuwa matsakaici na tsinkaye, ana ɗaukar Mikardis sau 1 a rana, ba tare da tauna ba. Lokaci guda na ɗaukar abinci ba ya shafar magunguna na Mikardis.
Tare da digiri mai laushi zuwa matsakaici na tsinkaye, ana ɗaukar Mikardis sau 1 a rana, ba tare da tauna ba.
Ga manya
Daidaitaccen maganin yau da kullun yana ba da kashi ɗaya na kwamfutar hannu wanda ya ƙunshi 80 MG na telmisartan da 12.5 MG na hydrochlorothiazide. Idan tasirin hypotensive bai isa ba, amma tare da haƙuri mai kyau, kuna buƙatar sha Allunan da suka ƙunshi 80 MG na telmisartan da 25 MG na hydrochlorothiazide.
Ana lura da mafi girman tasirin sakamako 1-2 watanni bayan farawar ra'ayin mazan jiya.
Marasa lafiya tare da matsanancin hauhawar jini ya kamata su ɗauki Allunan guda 2 a rana. A wannan yanayin, sashi na hydrochlorothiazide an wajabta ta daga likitan halartar dangane da bayanan asibiti na mai haƙuri.
Alƙawarin Mikardis Plus ga yara
An contraindicated da miyagun ƙwayoyi don amfani har zuwa 18 shekara saboda rashin bayanai game da tasirin abubuwa masu aiki kan ci gaban ɗan adam a cikin makarantan nasare da kuma lokacin balaga.
An ba da magani ga Mikardis Plus don amfani dashi har zuwa shekaru 18.
Shan maganin don ciwon sukari
Marasa lafiya da ciwon sukari suna buƙatar koyaushe su duba matakan glucose nasu. Yayin yin jiyya tare da Mikardis, akwai haɗarin hypoglycemia saboda sakamakon diuretic na hydrochlorothiazide.
Side effects
Ana haifar da sakamako mara kyau saboda gwargwadon zaɓi mara kyau kuma ana rarrabe shi a mafi yawan lokuta ta hanyar rikice rikice.
Gastrointestinal fili
Akwai haɗarin haɓakar cututtukan cututtukan ciki da na ciki da na ciki. Wasu marasa lafiya suna fama da ciwon ciki, maƙarƙashiya, zawo, da amai.
Hematopoietic gabobin
Matsakaicin abubuwan da aka kirkira a cikin jini na jini yana raguwa.
Tsarin juyayi na tsakiya
Tare da ɓacin rai na tsarin juyayi na tsakiya da haɓakar rikice-rikice na mutum a cikin mutum, ƙirar halayen tana canzawa - yanayin ɓacin rai, hankalin damuwa ya bayyana.
Dizziness, ciwon kai, paresthesia, rauni na gaba ɗaya, damuwa na bacci na iya faruwa.
Daga tsarin urinary
A cikin marasa lafiya da raunin fitar fitsari (tare da benign prostatic hyperplasia, prostatitis), riƙewar urination, tashin hankalin mafitsara yana yiwuwa. A cikin mafi yawan lokuta, akwai karuwa a cikin ƙwayar plasma na uric acid.
Daga tsarin numfashi
A ƙarshen bangon angioedema, bayyanar toshewar hanyoyin iska, bayyanar bronchospasm mai yiwuwa ne.
Daga tsarin musculoskeletal
Abubuwan da ba su da kyau a cikin jijiyoyin musculoskeletal ana nuna su ta bayyanar cramps a cikin ƙwayoyin maraƙin, jin zafi a cikin gidajen abinci da tsokoki, musamman a baya.
Cutar Al'aura
A cikin tallan bayan tallace-tallace, lokuta da suka shafi bayyanar lupus erythematosus, angioedema, da halayen fata.
Umarni na musamman
A miyagun ƙwayoyi yana da m vasodilating sakamako. Tare da ƙarancin motsi na jini wanda yake yaduwa (BCC), matsin lamba a cikin jini zai ragu, tunda ruwa da ƙarar jini ba zai isa ba saboda zagayawa ta al'ada. Sakamakon yiwuwar haɓakar ƙwayar cuta, marassa lafiya a kan abincin da ke da ƙarancin ci, tare da gudawa da amai, lokacin shan diuretics kafin ɗaukar Mikardis Plus, ya zama dole a maido da BCC.
A wasu halayen, ƙwayar tana haifar da halayen fata.
Shan wakili mai narkewa na iya haifar da haɓakar haɗarin cerebrovascular ko bugun zuciya a cikin marasa lafiya da ischemia cardiac muscle.
Hydrochlorothiazide ya sami damar tsokani wani nau'in cutar myopathy ko bayyanar glaucoma na kusurwa. Alama ta farko da ke tattare da cututtukan cututtukan cuta cuta ce mai raɗaɗi a idanu, wanda ba ya barin dogon lokaci. Idan kun ɗanɗana jin zafi kuma tare da rage girman ji na gani, dole ne ku daina shan Mikardis Plus.
Amfani da barasa
Yayin maganin tsufa, ba da shawarar sha giya ba.
Ethyl barasa na iya raunana sakamako na antihypertensive, haɓaka tasirin dilatic na hydrochlorothiazide kuma yana haifar da spasm na endothelium na jijiyoyin jini a cikin tasoshin yanki.
Tasiri kan ikon sarrafa abubuwan inji
Magungunan ba ya shafar aikin aikin jijiyoyi da ƙwarewar motsa jiki. A lokaci guda, Wajibi ne a lura da taka tsantsan yayin aiki tare da keɓaɓɓun hanyoyin da lokacin tuki, saboda yana yiwuwa a rasa ƙwarewa, bayyanar tasirin sakamako (faɗuwa, rashi). Sakamakon mara kyau na iya haifar da raguwa a cikin hankali da kuma hanzarin halayen psychomotor waɗanda ke buƙatar tuki.
Yi amfani da lokacin daukar ciki da lactation
Mata a lokacin daukar ciki an hana su shan Mikardis saboda yuwuwar haɗarin mahaifa.
A cikin aiwatar da haɓakar tayi, ana iya lalata kwanciya da jijiyoyin zuciya da na urinary.
Lokacin da ake shan magani, ya zama dole a daina shayar da nono.
Lokacin da ake shan magani, Mikardis Plus dole ne ya daina shayarwa.
Yawan damuwa
Tare da kashi ɗaya na babban adadin ya wuce shawarar da aka ba da shawarar, haɗarin alamun alamun yawan ƙwayar cuta yana ƙaruwa. Kwayoyin cutar sun hada da:
- rage karfin jini;
- haɓaka ko raunin zuciya;
- tashin zuciya
- rikicewar hankali;
- nutsuwa
A wasu halaye, ingantaccen sakamako na diuretic yana haɓaka. Sakamakon asarar ƙwayar ruwa mai yawa, jiki yana ɗauke da rashin ruwa, kuma matakin electrolytes yana raguwa. Bayyanarwar hypoglycemia yana haifar da rikicewar ƙwayar tsoka ko inganta arrhythmia.
Game da yawan abin sama da ya kamata, mara lafiya na bukatar asibiti. A cikin yanayin tsaye, magani yana mayar da hankali kan kawar da alamun rashin kyau da daidaita daidaituwar ruwa-mai wutan lantarki.
Yin hulɗa tare da wasu kwayoyi
Tare da yin amfani da Mikardis a lokaci guda tare da wakilai masu dauke da lithium, zazzagewa mai iya canzawa a cikin taro na lithium mai yiwuwa
Dangane da wannan, ƙaddamar da ƙwayar renal na lithium yana raguwa kuma maye yana tasowa, wanda shine dalilin da yasa ba'a ba da shawarar yin amfani da maganin da ke dacewa da lithium da magani mai ƙyalli ba. An lura da irin wannan yanayin tare da shirye-shiryen potassium.
Magungunan da ke rage abun da ke cikin potassium a cikin jini yana taimakawa ci gaban hypokalemia. Tare da gudanarwarsu na lokaci guda tare da Mikardis, ya zama dole don sarrafa matakin potassium a jiki.
Magungunan rigakafin ƙwayar cutar mahaifa (NSAIDs) na iya haifar da ci gaban rashin ruwa, wanda shine dalilin da ya sa mutane sama da shekaru 50 ke da haɗarin kamuwa da cutar koda. NSAIDs suna rage tasirin warkewar cututtukan diuretics da magungunan antihypertensive.
Magungunan Anticholinergic tare da Mikardis Plus suna rage motsin ƙarancin ƙoshin jijiyoyi.
Abubuwan da ke haifar da barbituric acid da antipsychotics suna tsokani cigaban orthostatic hypotension tare da asarar sani mai zuwa.
Metformin yana kara haɗarin lactic acidosis lokacin hulɗa tare da hydrochlorothiazide.
Sauran magungunan antihypertensive a hade tare da Mikardis sune synergistic - ana inganta tasirin hypotensive sau da yawa dangane da halayen mutum na haƙuri.
Cholesterol resins yana rage jinkirin yawan hydrochlorothiazide. Magungunan Anticholinergic suna kara bioavailability na diuretics thiazide, saboda wanda akwai raguwa a cikin jijiyoyin jiki mai santsi na jijiyoyin cikin hanji.
Mai masana'anta
Beringer Ingelheim Ellas A.E., Koropi, Girka.
Mikardis Plus Analogs
Idan babu tasirin sakamako, ana iya maye gurbin Mikardis tare da ɗayan analogues:
- Wadannan
- Firimiya;
- Lozap Plus;
- Telmisartan;
- Telmisartan Richter;
- Telmista.
Magunguna kan bar sharuɗan
Za'a iya siyar da maganin ta hanyar takardar sayan magani.
Farashi
Matsakaicin farashin kwamfutar hannu ya bambanta daga 1074 zuwa 1100 rubles.
Yanayin ajiya Mikardis Plus
An ba da shawarar cewa an adana antihypertensive a cikin wani wuri da aka ware daga radadin ultraviolet a zazzabi na + 8 ... + 25 ° C.
Ranar karewa
Shekaru 3
Ra'ayoyi game da Mikardis Plus
Dangane da masana kimiyyar zuciya da marasa lafiya, Mikardis kayan aiki ne mai inganci wajen yakar hauhawar jini.
Likitocin zuciya
Elena Bolshakova, likitan zuciya, Moscow
Na gudanar da bincike a matsayin wani ɓangare na tatsuniyoyi game da tasirin maganin, don haka zan iya amincewa da magana game da tasirin Mikardis. Magungunan yana taimakawa wajen daidaita matsin lamba na tsakiya kuma yana rage saurin yaduwar rafukan zuciya, wanda ke tsoratar da ci gaban cututtukan zuciya. Magungunan yana da tasiri ga yara da tsofaffi. Abubuwan da ke haifar da sakamako waɗanda zasu buƙaci maye gurbin, a aikace ba su cika ba. Magungunan ba ya shafar taro.
Sergey Mukhin, likitan zuciya, Tomsk
Ina tsammanin magani shine ingantaccen kayan aiki don rage hawan jini. Lokacin ɗauka sau ɗaya a rana, tasirin warkewa ya ci gaba har kwana ɗaya. Farashin yana da girma. Babban jerin contraindications. Amma miyagun ƙwayoyi suna da tasiri ga ciwon sukari na 2, cututtukan zuciya da ke kwance. Haramun ne a yi amfani da shi a cikin marasa lafiya da raunin zuciya. Ba a taɓa lura da matsalar ƙwayar ƙwayar cuta a cikin aikina na asibiti ba.
Za'a iya maye gurbin Mikardis Plus tare da Pritor, wanda aka adana shi a cikin wani wuri wanda aka ware daga radadin ultraviolet a zazzabi na + 8 ... + 25 ° C.
Marasa lafiya
Dmitry Gavriilov, ɗan shekara 27, Vladivostok
Hauhawar jijiyoyin jini ya fara, saboda wanda a cikin maraice akwai rashin ingantacciyar lafiya, rashin isasshen iska, yanayin ci gaba. Likitoci sun ba da allunan Mikardis. Magungunan ya fara aiki a ranar farko. 3 sa'o'i bayan shan allunan, matsanancin ya tsawan tsawan awanni 20 masu zuwa. Yana da mahimmanci a sha wasu magunguna waɗanda zasu taimaka ci gaba da wannan tasirin. Ina bayar da shawarar yin shawarwari tare da likitanku game da hanyoyin cin abinci mai cin abinci tare da abubuwan bitamin.
Alexandra Matveeva, dan shekara 45, St. Petersburg
An fuskance shi da hauhawar jini bayan tiyata a kan glandon thyroid. Likitan likitan zuciya ya ba da allunan MikardisPlus na tsawan aikin. Ina son maganin, yana rage karfin jini a hankali. Tasirin miyagun ƙwayoyi ba ya tasiri a jikin mutum kuma baya haifar da illa, halayen anaphylactic. Matsin lamba ya kai 130/80 kuma ya kasance a wannan matakin. Ina ba ku shawara ku ɗauki hutu na makonni 2 lokacin shan maganin.
