Sibutramine - magani mai haɗari don asarar nauyi: umarnin, analogues, bita

Menene sibutramine?

Sibutramine magani ne mai ƙarfin gaske. Da farko, an inganta shi kuma an gwada shi azaman maganin rashin lafiyar, amma masana kimiyya sun lura cewa yana da tasiri mai tasiri na anorexigenic, wato, yana da ikon rage ci.

Tun daga 1997, aka fara amfani da shi a Amurka da wasu ƙasashe a matsayin ingantacciyar hanyar kawar da ƙima mai yawa, yana ba da magani ga mutanen da ke da cututtukan haɗuwa iri-iri. Abubuwan da ke haifar da illa ba dadewa suna zuwa.

Ya juya cewa sibutramine mai jaraba ne da bacin rai, wanda za'a iya kwatanta shi da magani. Bugu da kari, ya kara hadarin cututtukan zuciya, mutane da yawa sun kamu da bugun jini da bugun zuciya yayin shan shi. Akwai wata sanarwa a hukumance cewa amfani da sibutramine ya haifar da mutuwar marasa lafiya.

Aikin magani na magani

Sibutramine kanta shine abin da ake kira prodrug, watau, domin ya yi aiki, dole ne ƙwayar "ta lalata" cikin abubuwan da ke aiki, suna ratsa hanta. Matsakaicin maida hankali akan metabolites a cikin jini an samu shi ne bayan sa'o'i 3-4.

Idan an aiwatar da abincin a lokaci guda tare da abinci, to, maida hankali ya ragu da 30% kuma ya kai girmansa bayan awanni 6-7. Bayan kwanaki 4 na amfani da shi na yau da kullun, adadinsa a cikin jini ya zama akai. Mafi tsawon lokacin da rabin ƙwayoyi suka bar jikin shine kimanin sa'o'i 16.

Ka'idar aiki na abu ya samo asali ne ta dalilin cewa yana da ikon ƙara samar da abinci mai gina jiki, hana sha'awar cin abinci da haɓaka jin daɗin rai. Tare da tsayayyen goyon baya na zafin jiki da ake buƙata, jiki baya buƙatar yin kayan ajiyar kitse don makomar gaba, haka ma, abubuwanda ake “ƙonewa” cikin sauri.

Akwai raguwar cholesterol da mai a cikin jini, yayin da abun cikin "mai kyau" cholesterol ya hau. Duk wannan yana ba ku damar asarar nauyi da sauri kuma na dogon lokaci don kula da sabon nauyi bayan sokewar sibutramine, amma batun kula da rage cin abinci.

Alamu don amfani

Magungunan ne kawai ke wajabta maganin kuma kawai a lokuta inda hanyoyin amintattu ba su kawo sakamako na zahiri:

• Tashin kiba. Wannan yana nufin cewa matsalar kiba tayi yawa sakamakon abinci mara kyau da rashin aiki na jiki. A wasu kalmomin, lokacin da adadin kuzari ya shiga jikin mutum fiye da yadda yake sarrafawa don ciyar da su. Sibutramine yana taimakawa kawai lokacin da ƙididdigar jiki ta wuce kilogiram 30 / m².
• Alimentary kiba a hade tare da type 2 ciwon sukari. BMI ya kamata ya fi kilogiram 27 / m².

Contraindications da sakamako masu illa

Yanayi yayin da aka haramta sibutramine don shigarda ciki:

• halayen rashin lafiyan halayen da rashin haƙuri ga kowane ɗayan abubuwan da ke cikin abun da ke ciki;
• lokuta lokacin da wuce kima yana faruwa saboda kasancewar kowane dalilai na kwayoyin halitta (alal misali, tsawaita da tsauraran rashi na rashin lafiyar hodar iblis) - hypothyroidism);
• yawan wuce haddi na kwayoyin hodar iblis;
• anorexia nervosa da bulimia;
• cutar kwakwalwa;
• Cutar Tourette's cuta (cuta ta CNS, a ciki akwai wadatattun illolin kimiyya da halayen nakasa);
• amfani da magungunan antidepressants, antipsychotics da sauran magunguna na lokaci guda, da kuma lokacin da aka yi amfani da kowane ɗayan waɗannan magunguna makonni 2 kafin alƙawarin sibutramine;
• sananniyar ƙwayoyi, barasa da kuma dogara ga miyagun ƙwayoyi;
• rikice-rikice na tsarin zuciya da jijiyoyin jini (CVS): cututtukan zuciya da na jijiyoyin zuciya, gazawar mara lafiya, rikicewar haihuwar cuta, tachycardia, arrhythmia, bugun jini, hadarin cerebrovascular;
• cutar hawan jini ba a bi ba;
• mummunan takewar hanta da kodan;
• benign yaduwa na wani yanki na prostate gland shine yake;
• shekaru kafin shekara 18 da bayan 65;
• lokacin daukar ciki da shayarwa.

Abubuwan da ke haifar da sakamako masu kyau suna bayyana dalilin da ya sa ake yin umarnin sibutramine sosai.

1. CNS Sau da yawa sau da yawa, marasa lafiya suna ba da rahoton rashin bacci, ciwon kai, damuwa daga karce da canje-canje a cikin dandano, ban da wannan, bakin bushe yakan saba da damuwa.
2. . Mahimmanci ba sau da yawa, amma har yanzu akwai karuwa a cikin zuciya, karuwar hawan jini, fadada tasoshin jini, sakamakon wanda akwai jan fata da kuma jin ɗumi na gida.
3. Gastrointestinal fili. Rashin ci, rashin motsin hanji, tashin zuciya da amai, har ma da yawan zubar jini - waxannan alamu kamar na kowa ne kamar rashin bacci.
4. Fata. An lura da gumi mai yawa a kowane lokaci na shekara, da sa'a, wannan gefen yana da wuya.
5. Cutar Jiki Zai iya faruwa duka ta hanyar fitsari a kan karamin yanki na jiki, da kuma nau'in girgiza ƙwayar cuta, wanda ya kamata a nemi likita da gaggawa.

Yawancin lokaci, ana lura da duk abubuwan da ke faruwa a cikin wata 1 bayan shan maganin, basu da cikakkiyar hanyar magana kuma su wuce kansu.

A cikin keɓantattun lokuta, abubuwan da ba su da kyau na sibutramine an rubuta su bisa hukuma:

• zafin jinin haila;
• kumburi;
• baya da zafin ciki;
• fata mai ƙyalli;
• wani yanayi mai kama da abin da yaji na mura;
• m da kuma kaifi karuwa a ci da ƙishirwa;
• jihar ta rashin hankali;
• tsananin nutsuwa;
• kwatsam yanayi canzawa;
• katsewa
• raguwa a cikin farantin platelet saboda wanda zubar jini yake faruwa;
• m psychosis (idan mutum ya riga ya sami mummunan raunin kwakwalwa).

Hanyar aikace-aikace

An zabi sashi ne ta hanyar likita kuma kawai bayan la'akari da yin la'akari da duk ƙima da fa'idodi. A cikin akwati bai kamata ku sha maganin ba! Bugu da ƙari, sibutramine an ba da shi daga kantin magunguna ta hanyar takardar sayan magani!

Ana wajabta shi sau ɗaya a rana, zai fi dacewa da safe. Maganin farko na maganin shine 10 MGamma, idan mutum bai yi haƙuri da shi da kyau ba, ya faɗi zuwa 5 MG. Ya kamata a wanke kifin da gilashin ruwa mai tsabta, alhali ba a ba da shawarar a ɗanɗana shi ba a kuma zuba abin da ke ciki. Ana iya ɗauka duka biyu a kan komai a ciki da kuma lokacin karin kumallo.

Idan cikin watan farko na farkon motsi na jiki bai faru ba, sashi na sibutramine yana ƙaruwa zuwa 15 MG. Ana amfani da warkewar koyaushe tare da aikin motsa jiki na dama da abinci na musamman, wanda aka zaɓa daban-daban ga kowane mutum ta ƙwararrun likita.

Yin hulɗa tare da wasu kwayoyi

Kafin ɗaukar sibutramine, ya kamata ku tattauna tare da likitan ku duk magungunan da aka karɓa akan ci gaba ko lokaci-lokaci. Ba duk magunguna bane hade da sibutramine:

1. Magunguna masu haɗari waɗanda ke ɗauke da ephedrine, pseudoephedrine, da sauransu, suna ƙara lambobin hawan jini da bugun zuciya.
2. Magunguna sun haɗu da haɓakar serotonin a cikin jini, kamar kwayoyi don kula da rashin jin daɗi, anti-migraine, painkillers, abubuwa masu narkewa a lokuta masu wuya na iya haifar da "cutar serotonin." Yana da mutuƙar mutuwa.
3. Wasu ƙwayoyin rigakafi (ƙungiyar macrolide), phenobarbital, carbamazepine suna haɓaka rushewa da ɗaukar sibutramine.
4. Raba antifungals (ketoconazole), immunosuppressants (cyclosporin), erythromycin sun sami damar haɓakar ɗaukar hankali na sibutramine tare da haɓakawa da yawaitar bugun zuciya.

Haɗuwa da barasa da ƙwayoyi ba ta cutar da lafiyar jiki dangane da abin da suka sha, amma an haramta shan giya mai ƙarfi ga waɗanda ke bin wani abinci na musamman da ke neman rasa nauyi.

Me yasa haramcin sibutramine kuma mai haɗari

Tun daga 2010, an ƙuntata kayan ɗin zuwa ƙasashe da yawa: Amurka, Ostiraliya, ƙasashen Turai da yawa, Kanada. A Rasha, takaddamarsa tana da cikakken iko da ƙungiyoyin jihohi. Ana iya allurar da maganin kawai a kan takardar takardar sayan tare da dukkan hatimin da suka wajaba. Ba shi yiwuwa a saya shi da doka ba tare da takardar sayan magani ba.

An haramtawa Sibutramine a Indiya, China, New Zealand. A cikin dokar, an haifar da shi ta hanyar sakamako wanda ya yi kama da "rushewar miyagun ƙwayoyi": rashin bacci, damuwa na kwatsam, yanayin rashin ƙarfi da tunanin kashe kansa. Dayawa daga mutane sun zavi rayuwarsu ta ci gaba da banbancin tushen amfani da shi. Yawancin marasa lafiya da cututtukan zuciya sun mutu daga bugun zuciya da bugun jini.

Ga mutanen da ke da matsala ta hankali, an hana shi sosai! Da yawa sun cika cutar anorexia da bulimia, akwai masu tabin hankali da canje-canje a cikin tunani. Wannan magani ba wai kawai yana hana ci abinci ba, amma har da zahiri yana shafar kai.

Sibutramine yayin daukar ciki

Matar da aka wajabta wannan magani ya kamata a sanar da cewa babu isasshen bayani game da amincin sibutramine ga jaririn da ba a haifa ba. Dukkanin analogues na miyagun ƙwayoyi an soke su har ma a matakin shirin daukar ciki.

A yayin jiyya, ya kamata mace ta yi amfani da ingantattun magungunan hana haihuwa. Tare da ingantaccen gwajin ciki, ya kamata ka sanar da likitanka nan da nan kuma ka daina amfani da sibutramine.

Binciken hukuma na magani

Wani kamfani na farko na sibutramine (Meridia) ya fito daga wani kamfani na ƙasar Jamus. A cikin 1997, an ba da izinin amfani da shi a Amurka, da kuma a cikin 1999 a Tarayyar Turai. Don tabbatar da ingancinsa, an kawo sunayen karatun da yawa, wanda mutane sama da dubu 20 suka shiga, sakamakon ya kasance tabbatacce.

A shekara ta 2002, an yanke shawarar gudanar da nazari kan TASBATARWA don gano ko wace ƙungiyar yawan haɗarin kamuwa da cutar tasu take. Wannan gwajin ya kasance makanta biyu, mai kula da sarrafawar kwakwalwa. Kasashe 17 suka shiga ciki. Mun yi nazarin alaƙar da ke tsakanin asarar nauyi yayin jiyya tare da sibutramine da matsaloli tare da tsarin zuciya.

A karshen shekarar 2009, an sanar da sakamakon farko:

• Yin magani na dogon lokaci tare da Meridia a cikin tsofaffi waɗanda suke da nauyi kuma sun riga sun sami matsaloli tare da zuciya da jijiyoyin jini kara hadarin kamuwa da bugun zuciya da bugun jini da kashi 16%. Amma ba a rubuta abubuwan da suka mutu ba.
• Babu wani bambanci a cikin mutuwa tsakanin ƙungiyar da ta karɓi placebo da babban rukuni.

Ya bayyana a fili cewa mutanen da ke fama da cututtukan zuciya suna cikin haɗari fiye da kowa. Amma ba zai yiwu a gano waɗanne rukuni na marasa lafiya za su iya ɗaukar magani tare da asarar lafiyar ba.

Kawai a cikin 2010, umarnin hukuma ya haɗa da tsufa (sama da shekaru 65) a matsayin maganin hana haihuwa, kazalika: tachycardia, gajiyawar zuciya, cututtukan zuciya, da sauransu. A ranar 8 ga Oktoba, 2010, masana'antun da yardar kansu sun karɓi magunguna daga kasuwar harka har sai an daidaita dukkan yanayi. .

Kamfanin har yanzu yana jiran ƙarin nazarin, wanda zai nuna wane rukuni na marasa lafiya da miyagun ƙwayoyi zai kawo ƙarin fa'idodi da ƙarancin lahani.

A cikin 2011-2012, an gudanar da binciken a Rasha a karkashin lambar lambar "VESNA". Anyi rikodin wanda ba a so ba a cikin 2.8% na masu aikin sa kai; ba a gano mummunan sakamako wanda zai buƙaci karɓar sibutramine ba. Fiye da mutane dubu 34, masu shekaru 18 zuwa 60 ne suka halarci taron. Sun sha maganin rage kwayoyi a cikin maganin da aka wajabta har tsawon watanni shida.

Tun daga 2012, an gudanar da bincike na biyu - "PrimaVera", bambanci shine lokacin amfani da miyagun ƙwayoyi - fiye da watanni 6 na ci gaba da warkewa.

Slimming Analogs

Sibutramine yana ƙarƙashin waɗannan sunaye:

• Goldline;
• Goldline Plus;
• Rage abinci;
• Metxin Metxin;
• Slimia
• Lindax;
• Meridia (a halin yanzu an soke rajistar).

Wasu daga cikin wadannan kwayoyi suna da haɗuwa hade. Misali, Goldline Plus bugu da kari ya hada da microcrystalline cellulose, kuma Reduxin Met yana dauke da kwayoyi 2 a lokaci guda - sibutramine tare da MCC, a cikin blisters daban - metformin (hanya ce don rage matakan sukari a cikin nau'in ciwon sukari na 2).

A lokaci guda, babu sibutramine a cikin rage Haske kwata-kwata, kuma ba ma magani ba.

Yadda za'a maye gurbin sibutramine

Magunguna don asarar nauyi:

Farashi

Kudin sibutramine kai tsaye ya dogara da sashi, yawan allunan da kuma masu kera magunguna.

Nazarin asarar nauyi

Ra'ayoyin mutane game da sibutramine:

Mariya Ina so in raba gwanina a amfani. Bayan ta haihu, ta warke sosai, Ina so in rage nauyi cikin sauri. A yanar gizo, na ga wani magani Lida, akwai sibutramine a cikin abun da ke ciki. Na dauki 30 MG kowace rana, asarar nauyi da sauri. Mako guda bayan da aka dakatar da miyagun ƙwayoyi, matsalolin lafiya suka fara, ta je asibiti. A can ne aka gano ni da gazawar na koda.