Umarnin don amfani da Glidiab MV

Hanyar warkewar cutar sankara ba kawai canjin abinci ba ne, har ma da amfani da magunguna na musamman.

Tare da nau'in cuta ta 2, mutane suna sau da yawa ana ba da magunguna don cimma matakan al'ada na glycemia. Suchaya daga cikin irin wannan maganin shine Glidiab MV.

Bayani na gaba ɗaya, abun da ya shafi da kuma sakin saki

Magungunan Glidiab MV yana ɗaya daga cikin abubuwan da aka samo asali na sulfonylurea (ƙarni 2), saboda haka an yi niyya don haɓaka sel beta wanda ke cikin pancreas.

Kamfanin kera magunguna a garin Akrikhin ya kera magungunan kuma ana daukar shi a matsayin analog na allurai da ke haifar da cutar sikandariyar Diabeton MV, a Faransa. Wakilin yana da sashi nau'in yanayin da aka sake shi ta hanyar sakewa da aka sake shi.

Ana samun maganin a cikin nau'ikan allunan da ke da farin witish. Suna kama da bayyanar fayel silinda. Akwai magungunan a cikin fakitoci 30 ko allunan 60.

Idan aka kwatanta da Diabeton MV, wanda ke da sashi na 0.06 g, Glidiab MV ya ƙunshi rabin bangaren aiki (0.03 g).

Abun ciki:

• Gliclazide shine babban abu;
• cellulose (microcrystalline);
• hydroxypropyl methylcellulose;
• magnesium stearate;
• Aerosil;

An tsara yawancin marasa lafiya Glidiab 80, wanda ya ƙunshi kashi mai aiki, ba 30 MG ba, amma 80 MG a cikin kowane kwamfutar hannu.

Aikin magunguna

Abubuwan haɗin Glidiab MV suna shafar jikin mutum kamar haka:

• hanzarta ƙwayar insulin wanda aka samar a cikin ƙwayar cuta;
• kara jijiyar nama zuwa ga kwayar halittar da aka samar;
• rage tazara daga lokacin cin abinci zuwa sakin insulin;
• a ƙarƙashin tasirin wannan miyagun ƙwayoyi, an sake dawo da ɓoye insulin a farkon lokaci idan aka kwatanta da sauran sulfonylureas;
• haɓaka microcirculation saboda haɗuwa da ƙwayoyin platelet, maido da yanayin jijiyoyin bugun jini da ƙananan haɗarin microthrombosis;
• rage yawan ƙwayar cuta;
• ba da gudummawa ga kawar da protenuria;
• rage jinkirin ci gaban retinopathy;
• ba da gudummawa ga asarar nauyi, batun cin abincin wajibi.

Pharmacokinetics

Tsarin sha, rarrabawa a cikin jiki, metabolism da excretion na abubuwan da aka sanya a cikin jiki suna faruwa kamar haka:

1. Damuwa. Kusan maganin yana kusan samunshi ta hanyar narkewar hanji (gastrointestinal fili). Mayar da hankali yana ƙaruwa a cikin plasma a hankali, har ya kai matsakaicinsa daga lokacin gudanarwa bayan sa'o'i 6 ko 12. Abun ciye-ciye ba ya shafar yawan sha. Magungunan yana aiki tsawon sa'o'i 24.
2. Rarraba. Sadarwa tare da ƙwayoyin plasma da abubuwan haɗin magunguna an saita su a 95%.
3. Tsarin rayuwa. Wannan tsari yana faruwa a cikin hanta, ana nuna shi ta hanyar samar da daidaitattun metabolites marasa aiki.
4. Kiwo. Murmushi yana faruwa ta hanyar kodan a cikin hanyar metabolites, kawai 1% na miyagun ƙwayoyi suna fitowa tare da fitsari. Cire rabin rayuwar maganin yana faruwa ne a cikin awanni 16.

Hanyoyin da ke cikin magunguna na maganin a cikin tsofaffi marasa lafiya ba su canzawa.

Manuniya da contraindications

Allunan Glidiab MV sune magungunan hypoglycemic, sabili da haka, ana amfani dasu a cikin maganin cututtukan type 2, lokacin da sauran hanyoyin rage glucose bai dawo da mai nuna alamar al'ada ba.

Contraindications zuwa shan miyagun ƙwayoyi sune:

• ketoacidosis;
• aikin koda mai rauni;
• Nau'in cuta guda 1;
• coma (mai ciwon sukari ko hyperosmolar);
• ayyukan;
• raunin da ya faru
• toshewar hanji;
• ciki
• yanayin haifar da hypoglycemia (alal misali, cututtukan yanayi na kamuwa da cuta);
• leukopenia;
• ƙonewa mai yawa;
• hypersensitivity ga abubuwa a cikin abun da ke ciki na samfurin;
• nono.

Umarnin don amfani da umarni na musamman

Sashi na magungunan ya dogara da halaye na hanyar ciwon sukari da kuma bayyanannunsa, saboda haka likita ya zaɓi shi daban-daban ga kowane haƙuri.

A farkon shan miyagun ƙwayoyi, ana bada shawarar sashi na 30 MG ko kwamfutar hannu 1. Ya danganta da yanayin mai haƙuri yayin maganin, ana iya ƙara adadin abu mai aiki a kowace rana zuwa 120 MG (matsakaicin adadin).

Allunan ana daukar su a baki yayin karin kumallo (sau daya a rana). Rashin rauni na koda (tare da creatinine daga 15 zuwa 80 ml / min) baya buƙatar daidaita sashi.

A farkon farawar magani kuma har sai an zaɓi kashin da ake buƙata, marasa lafiya koyaushe suna fuskantar matsalar rashin ƙarfi a cikin jiki ya kamata su yi aikin da ke buƙatar saurin amsawa ko kuma ba da hankali.

Mata ba za su iya amfani da maganin ba yayin lokacin haihuwar yaro, har ma da shayarwa.

Babban rauni na lalacewar kodan ko hanta ya haramta amfani da miyagun ƙwayoyi har ma da ƙarancin magunguna.

Dokokin Aikace-aikacen:

1. Abubuwan da ake buƙata don cimma tasirin aikace-aikacen shine bi abinci da motsa jiki matsakaici. A cikin abincin yau da kullun, carbohydrates ya kamata ya kasance a cikin ƙaramin adadin.
2. Yana da mahimmanci cewa ana kula da glycemia kafin da bayan abinci, don a iya daidaita sashi gwargwadon sakamakon aunawa.
3. Don tiyata ko cutar sikari da ta lalata, yakamata a maye gurbin maganin da allurar insulin.
4. Don guje wa faruwar cututtukan jini, da fitsarin disulfiram, kar ku sha barasa.
5. Haramun ne tsallake abinci, watsi da abubuwan ciye-ciye a lokacin yunwar.
6. Kafin aiki mai wahala, ya kamata a rage kashi.

Mafi hankali ga magungunan cututtukan jini sune:

• mutane a cikin tsufa;
• marasa lafiya waɗanda ba su iya cin abinci daidai;
• mutane masu rauni a jiki;
• marasa lafiya da ke kama da cuta kamar ƙarancin ƙwaƙwalwar ƙwayar cuta na ciki-rashin ƙarfi.

Side effects da yawan abin sama da ya kamata

Shan Allunan na iya haifar da halaye kamar haka:

• dangane da tsarin endocrine - hypoglycemia tare da halayyar jijiyoyin kai, zazzagewa, rauni, kasala, tashin hankali, rashi, hangen nesa da rauni da hangen nesa;
• daga narkewa daga ciki - dyspepsia, anorexia, hargitsi a cikin hanta;
• leukopenia, thrombocytopenia, anemia;
• Bayyanar rashin lafiyan (itching, kurji, ko urticaria).

Tare da yawan ƙwayar ƙwayar ƙwayar cuta, hypoglycemia na faruwa. Don kawar da alamun ta, ya isa ya cinye carbohydrates da yawa, muddin mutumin yana sane. A cikin yanayin da mai haƙuri ba zai iya ɗaukar abinci da kansa ba, ya kamata a ba shi maganin glucose na ciki (40%) da allura ta ciki na glucagon. Bayan dawo da hankali ga mutumin da ke fama da ciwon sukari, kuna buƙatar wata abun ciye-ciye don guje wa sake faɗuwa a cikin glucose.

Yin hulɗa tare da wasu magunguna da analogues

Yin amfani da wasu magunguna a cikin haɗin gwiwa tare da Glidiab MV na iya haɓaka ko rage tasirin hypoglycemic.

Hada magunguna tare da kwayoyi kamar:

• ACE masu hanawa;
• jami'in antifungal (fluconazole);
• NSAIDs;
• antihistamines;
• Fibrates;
• magungunan tarin fuka;
• Salicylates;
• Pentoxifylline;
• Ethanol;
• kwayoyi masu hana tubular ɓoye ɓoye.

Ana magance tasirin hypoglycemic lokacin da aka haɗa shi da kwayoyi masu zuwa:

• barbiturates;
• thiazide diuretics;
• Furosemide;
• hormones don kula da aikin thyroid;
• shirye-shiryen lithium;
• estrogens;
• wajen maganin hana haihuwa.

Daga cikin magungunan da ke da tasiri iri ɗaya kamar allunan Glidiab MV, ana lasafta abubuwa masu zuwa:

• Meglimide;
• Alfika
• Glibetic;
• Clay;
• Glimepiride;
• Eglim;
• Glairie
• Glibenclamide;
• Glurenorm.