Insulinoma cuta ce dake tattare da yanayin rashin damuwa ko haɓaka da ke fitowa daga β-sel na tsibirin na Langerhans-Sobolev na ƙwanƙwasa. Harshen kumburi yana da isasshen insulin na kansa, wanda ke haifar da haɓakar ƙwanƙwasa jini a jikin mai haƙuri.
Dangane da kididdigar, kowane insulinoma na goma yana hade da ciwace-ciwacen ƙwayar ciki, glandon parathyroid, da glandon adrenal. Yana faruwa sau da yawa a cikin mutane na tsaka-tsaka, wanda ke cikin kowane ɓangare na cututtukan farji. Abubuwan da aka kewaya sun nuna fassarar insulinomas a cikin maganin shafawa, bangon duodenum da ciki, hanta, saifa (2% na neoplasms).
A matsayinka na mai mulkin, insulinoma cuta ce mai kamuwa da cutar tarin farji, amma wani lokacin kuma ana samun bambance-bambancen cututtukan cuta.
Dalilai
Insulin abu ne mai motsa jiki wanda ke da alhakin daidaituwar carbohydrates a jikin mutum, don haka ya haifar da samar da makamashi mai mahimmanci don ayyukan haɗin gabobin da tsarin. Sau ɗaya a cikin jini, insulin yana ɗaukar kwayoyin glucose waɗanda suke fitowa daga waje tare da abinci. A cikin layi daya, aiwatar da samar da mai da yalwa ta hanta an dakatar da shi na ɗan lokaci.
Abubuwan da ke haifar da ci gaba da ƙwayar insulin-insulin har yanzu ba a kammala shi ba. Akwai shawarwari waɗanda abubuwan da ke gaba suka ba da gudummawa ga bayyanar:
- dabi'ar gado;
- raguwa mai kaifi akai-akai a cikin sukari na jini;
- yawan shan magunguna don kamuwa da cutar siga.
Kwayoyin Insulinoma suna samar da insulin mai yawa, kuma kamar yadda ka sani, wuce haddi na hormone kamar haɗari ne a rashi.
Rage yawan cututtukan glucose a sakamakon cin zarafin insulin, wanda zai iya zama sakamakon irin waɗannan yanayi:
- cututtukan mahaifa;
- kasawar rashin haihuwa;
- myxedema;
- gajiya da matsananciyar yunwa (ciki har da anorexia);
- take hakkin metabolism;
- kamannin ciki;
- kumburi da cututtukan cututtukan zuciya na hanji;
- lalata lalacewar hanta.
Tsarin ilimin halittar jiki
Insulinoma wata halitta ce ta nau'ikan halittar mutum, wacce take a cikin kwalliyar. Girman sa ya fito daga cm 0,5 zuwa 3-5 cm yana da launin ruwan hoda mai haske, launin toka ko launin ruwan kasa. Kwata na ciwace-ciwacen tumbi suna cikin shugaban gland shine yake, guda a wutsiya. Kusan kashi 40 cikin dari na insulin ana gano su a jiki ko kuma isthmus na sashin jiki.
Sakamakon kasancewar kwatankwacin maganin kwalliya, tabbatar da cutar malignancy ko rashin iyawa yana da wahala. Kasancewar metastases a cikin nono, hanta, huhu, wanda shima yai aiki da jijiyoyin jiki, na iya nuna yanayin cuta.
Hoto na asibiti
Bayyanar cututtuka na insulinomas ba takamaiman bane. Sun dogara da tushen aiwatar da cututtukan cututtukan cututtukan cututtukan ƙwayar cuta, nau'in ƙari. Alamun farko na cutar suna da alaƙa da ƙwayar cutar hypoglycemic:
- Sharpayyadaddun raguwar matakan sukari da safe, tare da cin abinci mara nauyi ko bayan aiki na jiki har zuwa asarar hankali.
- Kwayar cutar Autonomic wanda ke faruwa a cikin martani game da samar da adrenaline da norepinephrine - sweating, mai rauni mai rauni, pallor na fata, rawar jiki, farin ciki da cephalalgia, damuwa, matsananciyar yunwar.
- Yanayin yana ingantawa kwatankwacin bayan gudanarwar glucose.
Bayyanar cututtuka na hypoglycemia - babban bayyanar insulinoma a jikin mutum
Sake murmurewa, marasa lafiya galibi basa tuna abinda ya same su. A lokacin irin wannan harin, rikice-rikice na iya haɓakawa a cikin hanyar infarction myocardial, alamun lalacewar gida ga tsarin juyayi, wanda aka ɗauka don mummunan haɗarin cerebrovascular (bugun jini).
Insulinoma na Pancreatic yana da wahalar ganewa, sabili da haka, sama da rabin marasa lafiyar da ke fama da wannan cuta suna shan magani a karkashin bincike daban-daban:
- ciwan kwakwalwa;
- bugun jini;
- fargaba
- tsire-tsire na dystonia na tsire-tsire;
- psychosis, neurasthenia;
- maye;
- bayyanuwar neuroinfection.
Binciko
Binciken mai haƙuri ko danginsa na ba ka damar bayyanar da kasancewar mawuyacin hali, alaƙar abinci tare da abinci. Diagnosisarin binciken cutar insulinoma yana faruwa a asibiti.
Mahimmanci! Ana bincika marasa lafiya ta hanyar endocrinologist, neurologist, likita mai fiɗa.
Yi amfani da gwaje-gwaje masu tayar da hankali tare da matsananciyar yunwa. Marasa lafiya ba ya cin abinci a lokacin rana, a wannan lokacin ne kwararru ke lura da shi. Abinda ya faru na takamaiman alamun hypoglycemia alama ce ta gwajin jini don insulin da glucose.
Don fayyace asalin, girman kumburin, lissafawa, hoton tsayar da Magnetic, duban dan tayi, kuma, in ya cancanta, zazzabin laparotomy wanda ke biye da kwayoyin halitta ana yin su. Hakanan ana amfani da dabarar ƙirar catalterization hanyoyin don tantance adadin insulin din immunoreactive a cikin jijiyoyin farji.
MRI zai sa ya yiwu a tsayar da cututtukan insulinoma
Matakan warkewa
Kula da insulinomas yana buƙatar tsarin haɗin gwiwa. Tsoma bakin tilo hanya ce mai tsattsauran ra'ayi kuma ana aiwatar da ita ta waɗannan siffofin:
- kishi - cire ƙwayoyin tumor, waɗanda ake amfani da su a farkon matakan aiwatarwa ko kuma yanayin wurin insulinomas a saman ginin;
- distal kwatankwacin - an cire ƙwayar cuta da ɓangaren sashin ƙwayar cuta;
- laparoscopic tiyata - cirewa cikin neoplasm yana faruwa ta amfani da kayan aiki na musamman ta hanyar ƙananan yatsu a cikin tsinkayen kwayoyin.
Mahimmanci! Ana kimanta tasirin shiga tsakani yayin aikin, ƙayyade matakin glucose a cikin jini.
A cikin layi daya, ana amfani da matakan dakatar da hare-haren hypoglycemia. Kwararrun ya tsara glucagon, catecholamines (adrenaline, norepinephrine), glucocorticosteroids. Ana nuna alamun abinci mai yawan carbohydrate akai-akai.
Rashin lafiyar tsari yana buƙatar yin amfani da "Streptozotocin" ko "Doxorubicin" (tare da juriya ga ƙwayar farko).
Bayyanar cututtuka da wuri, magani na lokaci-lokaci yana dawo da yanayin tsarin juyayi na tsakiya kuma yana ba da gudummawa ga farfadowa na asibiti. Rashin insulinomas mai rauni yana da tsinkayar ƙaranci - yawan mace-mace fiye da 60% a cikin 'yan shekarun daga fara ilimi.
