Wakilin antidi da ke cikin tsarin maganin Baeta yana cikin rukuni na masu maganin cututtukan fata kuma yana taimaka wajan sauƙaƙe sarrafa glucose a cikin marasa lafiya masu nau'in ciwon sukari na II na mellitus.
Incretin wani kwaro ne wanda mucosa na hanji ke samar dashi saboda daukar abinci, mai sanya kuzarin insulin-glucose mai narkewa.
Hanyar aiwatar da aiki na Byet yana ba ku damar yin yaƙi tare da mellitus-non-insulin-dogara da ciwon sukari marasa lafiya a cikin hanyoyi da yawa yanzu yanzu.- Yana hana ruɗar glucagon hormone, wanda ke haɓaka yawan glucose a cikin jiki.
- Co Yana ƙarfafa β-ƙwayoyin ƙwayar ƙwayar cuta don samar da insulin sosai.
- Yana hana kwararar abinci daga ciki, yana hana yawaitar glucose a cikin jini.
- Kai tsaye yana kula da cibiyoyin sati da yunwa, da hana ci.
Wadannan hanyoyin suna taimakawa wajen rage adadin abincin da ake ci, ba da damar mara lafiyar mai ciwon sukari ya rasa nauyi kuma yana hana tsalle-tsalle a cikin matakan glucose na jini, yana kiyaye shi a matakin kimiyyar lissafi.
A halin yanzu, ƙwararru suna nazarin tasirin tasirin abubuwan maye a tsarin jijiyoyi da jijiyoyin zuciya. Nazarin dabbobi sun nuna cewa yin amfani da magungunan jinsi na gaba-gaba yana haifar da sake dawo da ɓangaren ƙwayoyin cuta mai lalacewa.
Masu kera
Kamfanin samar da magunguna na Beat shine Eli Lilly da kamfanin magunguna na Kamfanin, wanda aka kafa a 1876 a Indianapolis (Amurka, Indiana).Wannan shine kamfanin farko na masana'antar samar da inulin a cikin 1923.
Kamfanin yana haɓakawa kuma yana samar da magunguna ga mutanen da aka samu nasarar sayar da su a cikin ƙasashe sama da ɗari, kuma a cikin jihohi 13 akwai masana'antu don kera su.
Jagoran na biyu na kamfanin shine samar da magunguna don bukatun maganin dabbobi.
Abun ciki
Mai aiki mai amfani da miyagun ƙwayoyi shine 250 microgram na exenatide.
Arearin sune sodium acetate trihydrate, glacial acetic acid, mannitol, metacresol da ruwa don yin allura.
Baeta yana samuwa a cikin nau'in sirinji na iya zubar dashi tare da magani mai ƙararrawa don allura a ƙarƙashin fata minti 60 kafin cin abinci da safe da maraice.
Baeta - 5 mcg
Alamu
An ba da shawarar Baeta a cikin maganin mellitus-non-insulin-dogara da ciwon sukari mellitus (nau'in II) don sauƙaƙe kulawar glycemic:
- a cikin hanyar monotherapy - a bango na tsayayyen abinci mai ƙarancin abinci da kuma aikin motsa jiki;
- a hade far:
- a matsayin ƙari ga magunguna masu rage sukari (metformin, thiazolidinedione, abubuwan da ake samowa na sulfonylurea);
- don amfani da metformin da insal insulin.
A wannan yanayin, abubuwan da ake amfani da su na sulfonylurea na iya buƙatar raguwar sashi. Lokacin amfani da Byeta, nan da nan zaka iya rage yawan abin da aka saba da 20% kuma daidaita shi ƙarƙashin ikon matakan glycemia.
Don wasu kwayoyi, yanayin gudanarwa na farko ba za a iya canza shi ba.
A hukumance, ana ba da shawarar yin amfani da magunguna na yau da kullun don haɗa su tare da sauran wakilai na hypoglycemic don haɓaka aikin su kuma jinkirta nadin insulin.
Ba a nuna amfani da exenatide don:
- mutum mai saukin kamuwa zuwa abubuwan da maganin ya kunsa;
- mellitus-insulin-da ke fama da ciwon sukari (nau'in I);
- decompensated na koda ko gazawar hanta;
- cututtuka na tsarin narkewa, tare da paresis (rage yawan kwanciyar hankali) na ciki;
- ciki da lactation;
- m ko pancreatitis na baya.
Kada a rubuta wa yara har sai sun kai girma.
Mitar muguwar al'amuran yayin amfani da Byet daga 10 zuwa 40%, ana nuna su ne musamman cikin tashin zuciya da amai a cikin farkon lokacin jiyya. Wasu lokuta halayen gida na iya faruwa a wurin allurar.
Analogues na miyagun ƙwayoyi
Tambayar maye gurbin Bayet tare da wani magani, a matsayin mai mulkin, na iya tasowa a ƙarƙashin halaye masu zuwa:
- magani ba ya rage glucose;
- sakamako masu illa suna bayyana sosai;
- Farashin ya yi yawa.
Magungunan Baeta da ke tattare da ƙwayoyin cuta - magunguna tare da ingantaccen warkewa da daidaitawar ilimin halitta - ba.
Cikakkun analogues ɗin ƙarƙashin lasisi daga Lilly da Kamfanin Kamfanin Bristol-Myers Squibb Co (BMS) da AstraZeneca ne suka samar da su.
Wasu ƙasashe suna sayar da Byetu a ƙarƙashin alamar Indureon.
Baeta Long wakili ne na hypoglycemic tare da wakili mai aiki guda ɗaya (exenatide), kawai tsawan aikin. Cikakken analog ɗin Baeta. Yanayin amfani - allurar guda biyu kowane kwana 7.
Har ila yau, rukuni na magungunan da ake kamuwa da su kamar Victoza (Denmark) - magani ne mai rage sukari, sinadarin mai aiki shine liraglutide. Ta hanyar kayan kwantar da hankali, alamu da contraindications, yana kama da Baete.
Incretin agonists suna da nau'i ɗaya kawai - allura.
Secondungiya ta biyu na aji na magungunan gargajiya suna wakilta ta hanyar magunguna waɗanda ke hana samar da enzyme dipeptidyl peptidase (DPP-4). Suna da nau'ikan kwayoyin halitta da kayan aikin magunguna.
Masu hana masu shiga cikin DPP-4 sun hada da Janavia (Netherlands), Galvus (Switzerland), Transgenta (Jamus), Ongliza (Amurka).
Kamar Baeta da Victoza, suna haɓaka matakan insulin ta hanyar ƙara tsawon lokacin incretins, hana haɓakar glucagon da haɓaka sabbin ƙwayoyin ƙwayar cuta.
Kawai kada ku shafi yawan sakin ciki kuma kada ku taimaka wajen asarar nauyi.
Nuna don amfani da wannan rukuni na kwayoyi su ne m-insitus-dogara da ciwon sukari mellitus (nau'in II) a cikin hanyar monotherapy ko tare tare da sauran magunguna masu rage sukari.
Ofaya daga cikin fa'idodin ita ce siffar sashi a cikin nau'ikan allunan don maganin baka, wanda ke ba ka damar shigar da miyagun ƙwayoyi a cikin jiki ba tare da yin allura ba.
Baeta ko Victoza: Wanne ya fi kyau?
Duk waɗannan magunguna suna cikin rukuni ɗaya ne - analogues na analogues na incretin, suna da tasirin warkewa iri ɗaya.Amma Victoza yana da tasiri mai ƙarfi wanda ke taimakawa rage nauyi na masu haƙuri da ke ɗauke da ciwon sukari na II.
Victoza yana da tasiri mai tsayi, kuma an ba da shawarar a ba da allurar rigakafin magungunan sau ɗaya a rana kuma ba tare da la'akari da abincin ba, yayin da ya kamata a ba da Bayetu sau biyu a rana sa'a daya kafin abinci.
Farashin siyarwa na Viktoza a cikin magunguna ya zama mafi girma.
Likitocin da ke halartar sun yanke shawara game da zabi na miyagun ƙwayoyi, la'akari da halaye na mutum na haƙuri, tsananin girman sakamako masu illa da kimanta darajar cutar rashin lafiyar.
