GASKIYA - UMARNIN DON AMFANI, FARASHI, SAKE DUBAWA DA KUMA ALAMUN AMFANI

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Trazhenta (sunan kasa da kasa Trajenta) wani sabon rukuni ne na magungunan maganin cututtukan cututtukan fata. An yi amfani da masu hana DPP-4 tare da hanyar baka na gudanarwa don sarrafa ciwon sukari na nau'in 2; an tattara babban hujjoji don tasiri.

Abubuwan da ke aiki da maganin suna linagliptin. Musamman godiya don fa'idodin ta shine masu ciwon sukari tare da cututtukan koda, tunda miyagun ƙwayoyi ba ya ɗaukar ƙarin nauyi a kansu.

Trazhenta - tsari da sashi

Masu kera, BOEHRINGER INGELHEIM PHARMA (Jamus) da BOEHRINGER INGELHEIM ROXANE (Amurka), suna sakin magungunan a cikin nau'ikan allunan zagaye masu launin ja. Alamar da kamfanin da ke samar da miyagun kwayoyi daga fakes aka zana shi a gefe daya, kuma an sanya alamar "D5" a gefe guda.

Kowannensu ya ƙunshi 5 MG na linagliptin mai aiki mai narkewa da filler daban-daban kamar sitaci, fenti, hypromellose, magnesium stearate, copovidone, macrogol.

Kowane gilashi mai rufe fuska yana sanya alluna 7 ko 10 na miyagun ƙwayoyi Trazhenta, hoto wanda za'a iya gani a wannan sashin. A cikin akwatin suna iya zama lamba daban - daga faranti biyu zuwa takwas. Idan akwai sel 10 tare da allunan a cikin kumburi, to za a sami irin waɗannan faranti 3 a cikin akwatin.

Pharmacology

Zai yiwu a sami nasarar maganin ne saboda hanawar ayyukan dipeptidyl peptidase (DPP-4). Wannan enzyme yana da lalacewa

a kan kwayoyin HIP da GLP-1, waɗanda ke taka muhimmiyar rawa wajen kiyaye daidaituwar glucose. Yankunan sun haɓaka haɓakar insulin, taimakawa sarrafa glycemia, da hana ɓoyewar glucagon. Ayyukansu na ɗan gajeren lokaci ne; daga baya, HIP da GLP-1 suna lalata enzymes. Trazhenta yana da alaƙa da DPP-4, wannan yana ba ku damar kula da lafiyar abubuwan da suka faru har ma da ƙara yawan ƙarfin su.

Hanyar tasiri na Trazhenty yana kama da ka'idodin aikin wasu analogues - Januvius, Galvus, Ongliza. Ana samar da HIP da GLP-1 lokacin da abubuwan gina jiki suka shiga jiki. Effectivearfin magungunan ba su da alaƙa da haɓakar haɓakar abubuwan da suke samarwa, magani kawai yana ƙara tsawon lokacin bayyanar su. Sakamakon waɗannan halaye, Trazhenta, kamar sauran incretinomimetics, ba ya tayar da haɓakawar hypoglycemia kuma wannan babbar fa'ida ce akan sauran azuzuwan magungunan cututtukan jini.

Idan matakin sukari bai wuce yin tasiri sosai ba, incretins suna taimakawa wajen haɓaka samarwar insulin da ake samu ta sel-cells-sel. Hormone GLP-1, wanda ke da mafi mahimmancin jerin abubuwan yiwuwar idan aka kwatanta da GUI, yana toshe tsarin haɗin glucagon a cikin ƙwayoyin hanta. Duk waɗannan hanyoyin suna taimakawa sosai ta kula da yawan ƙwayar cuta a matakin da ya dace - don rage glycosylated haemoglobin, yawan sukari da azumi da kuma motsa jiki bayan motsa jiki tare da tsawan sa'a biyu. A cikin ƙwaƙwalwar ƙwayar cuta tare da shirye-shiryen metformin da sulfonylurea, sigogi na glycemic suna haɓaka ba tare da samun nauyi mai mahimmanci ba.

Yana da mahimmanci cewa linagliptin baya kara haɗarin cututtukan zuciya (yiwuwar bugun zuciya da sakamako mai kisa).

Pharmacokinetics

Bayan an shiga cikin narkewa, ana shan maganin da sauri, ana lura da Cmax bayan awa daya da rabi. Taro yana raguwa a matakai biyu.

Yin amfani da Allunan tare da abinci ko daban a kan pharmacokinetics na miyagun ƙwayoyi ba su tasiri ba. A bioavailability na miyagun ƙwayoyi ya kai 30%. Relativelyan ƙaramin isan kashi yana cikin metabolized, 5% kodan ya raba shi, 85% an toshe shi da feces. Duk wani ilimin cutar kodan baya buƙatar cire magani ko canje-canje na kashi. Ba a yi nazarin fasalin magungunan likitanci a lokacin ƙuruciya ba.

Wanene maganin don

An tsara Trazent azaman magani na farko-ko kuma a hade tare da sauran magunguna masu rage sukari.

Monotherapy. Idan mai ciwon sukari bai yarda da kwayoyi na manyan bigins ba kamar metformin (alal misali, tare da cututtukan koda ko rashin jituwa ga abubuwanda ya kunsa), kuma gyaran rayuwa baya kawo sakamakon da ake so.
Wajan bangarori biyu. An wajabta Trazent tare da shirye-shiryen sulfonylurea, metformin, thiazolidinediones. Idan mai haƙuri yana kan insulin, incretinomimetic na iya haɓaka shi.
Zaɓin ɓangarori uku. Idan hanyoyin da suka gabata na maganin ba su da tasiri sosai, an haɗa Trazhenta tare da insulin da wasu nau'ikan maganin antidiabetic tare da tsarin aikin daban.

Wanda ba a sanya wa Trazhent ba

An yi maganin Linagliptin don irin wannan nau'in masu ciwon sukari:

Nau'in cuta guda 1;
Ketoacidosis tsokani da ciwon sukari;
Ciki da lactating;
Yara da matasa;
Hypersensitivity ga abubuwan da ke cikin tsari.

Kwanaki 2 kafin yin tiyata, ana canza mai cutar daga mahaifa zuwa ga insulin, ana soke allurar ta kwana 2 bayan nasarar aikin.

Sakamakon mara amfani

A bayan shan linagliptin, sakamako masu illa na iya haɓaka:

Nasopharyngitis (wata cuta ce ta kamuwa da cuta);
Cutar da yaji;
Rashin lafiyar hankali;
Kwayar cutar kansa
Anaruwar triglycerol (lokacin da aka haɗu da magungunan aji na sulfonylurea);
Valuesara yawan dabi'un LDL (tare da gudanar da daidaituwa na pioglitazone);
Girma na jiki;
Alamar cutar hypoglycemic (a bango na tushen kashi biyu- da uku).

Mitar da adadin raunin da ke haifar bayan cinye Trazhenta daidai yake da yawan tasirin sakamako bayan amfani da placebo. Mafi sau da yawa, ana haifar da sakamako masu illa a cikin tsarin rikice-rikice guda uku na Trazhenta tare da abubuwan da suka dace da metformin da kalami na sulfonylurea.

Magungunan zai iya haifar da rikice-rikice na daidaituwa, wannan yana da mahimmanci a yi la'akari lokacin tuki motoci da ƙananan hanyoyin.

Yawan damuwa

An ba wa mahalarta allunan 120 (600 MG) a lokaci guda. Doaya daga cikin adadin da aka samu bai shafi lafiyar masu sa kai daga ƙungiyar kula da lafiya ba. A cikin masu ciwon sukari, yawan ƙuraje yawan ƙwayoyin cuta ba su yin lissafi ba. Kuma duk da haka, idan akwai haɗari ko ganganci na amfani da allurai da yawa a lokaci guda, wanda aka azabtar yana buƙatar shafa hanji da hanji don cire wani sashi na magani, ba sihirin da sauran magunguna daidai da alamun, nuna likita.

Yadda ake shan magani

Trazent daidai da umarnin don amfani ya kamata a sha sau uku a rana, kwamfutar hannu 1 (5 MG). Idan ana amfani da maganin a cikin hadaddun magani a layi daya tare da metformin, to ana kiyaye sashi na karshen.

Masu ciwon sukari tare da koda ko kuma hepatic kasawa basa buƙatar daidaita sashi. Nora'idojin ba su banbanta ga marasa lafiya na tsufa. A cikin tsufa (daga shekaru 80) tsufa, ba a ba da Trazhent saboda ƙarancin ƙwarewar asibiti a wannan rukunin shekarun.

Idan lokacin shan magani ya baci, yakamata ku sha kwaya da wuri-wuri. Ba shi yiwuwa a ninka na yau da kullun. Amfani da maganin bai dace da lokacin cin abinci ba.

Tasirin trazhenti akan ciki da lactation

Ba a buga sakamakon amfani da miyagun ƙwayoyi ta mata masu juna biyu ba. Ya zuwa yanzu, an gudanar da binciken ne kawai akan dabbobi, kuma babu alamun cututtukan haihuwa da ke rubuce. Kuma duk da haka, yayin daukar ciki, ba a sanya mata magunguna ba.

A cikin gwaje-gwajen tare da dabbobi, an gano cewa maganin yana iya shiga cikin madarar mahaifiyar mace. Sabili da haka, a lokacin ciyar da mata, ba a sanya Trazhent ba. Idan yanayin kiwon lafiya yana buƙatar irin wannan ilimin, an tura yaro zuwa abinci mai wucin gadi.

Ba a gudanar da gwaje-gwajen game da tasirin kwayoyi ba game da ikon yin juna biyu ba. Irin wannan gwajin da aka yi akan dabbobi bai bayyana wani hatsari ba a wannan bangaren.

Hulɗa da ƙwayoyi

Amfani da lokaci guda na Trazhenta da Metformin, koda kuwa kashi ɗaya ya wuce matsayin, ba ya haifar da babban bambance-bambancen a cikin magungunan magunguna.

Amfani da na guda na Pioglitazone shima baya canza magungunan magungunan duka magunguna.

Cikakken jiyya tare da Glibenclamide ba shi da haɗari ga Trazhenta, don ƙarshen, Cmax yana raguwa kaɗan (ta hanyar 14%).

Wani sakamako makamancin wannan a cikin hulɗar an nuna shi ta wasu kwayoyi na rukuni na sulfonylurea.

Haɗin ritonavir + linagliptin yana ƙaruwa Cmax ta sau 3, irin waɗannan canje-canjen ba sa buƙatar daidaita sashi.

Haɗuwa da Rifampicin suna tsokani raguwa a Cmax Trazenti. Wani bangare, ana kiyaye halayen asibiti, amma magani ba ya aiki 100%.

Ba haɗari bane a rubuta Digoxin a lokaci guda kamar lynagliptin: magungunan magunguna na magunguna biyu ba su canzawa.

Trazhent ba ya tasiri da ikon Varfavin.

Ana lura da ƙananan canje-canje tare da amfani da layi ɗaya na linagliptin tare da simvastatin, amma incretin mimetic baya tasiri sosai game da halaye.

Ban da tushen jiyya tare da Trazhenta, ana iya amfani da maganin hana haihuwa.

Recommendationsarin shawarwari

Ba a wajabta wa Trazent don kamuwa da cututtukan type 1 ba kuma don ketoacidosis, rikitarwa na ciwon sukari.

Halin da ke tattare da yanayin hypoglycemic bayan magani tare da linagliptin, wanda aka yi amfani dashi azaman maganin monotherapy, ya isa zuwa adadin waɗannan lokuta tare da placebo.

Gwaje-gwaje na asibiti sun nuna cewa yawan yanayin tashin hankali yayin amfani da Trezhenta a cikin maganin haɗin gwiwa ba a la'akari da shi, tun da yanayin mai mahimmanci ba ya haifar da linagliptin, amma metformin da kwayoyi na rukunin thiazolidinedione.

Dole ne a lura da hankali yayin nada Trazhenta a hade tare da kwayoyi na aji na sulfonylurea, tunda suna haifar da cutar rashin ƙarfi. A babban haɗari, ya zama dole don daidaita sashi na magunguna na ƙungiyar sulfonylurea.

Linagliptin baya shafar yiwuwar haɓakar cututtukan zuciya da jijiyoyin jini.

A haɗuwa da warkewa, ana iya amfani da Trazhent ko da tare da aiki mai rauni mai rauni.

A cikin marasa lafiya na manya (fiye da shekaru 70), lura da Trezenta ya nuna kyakkyawan sakamako na HbA1c: farkon glycosylated haemoglobin ya kasance 7.8%, karshe - 7.2%.

Magungunan ba ya haifar da karuwar haɗarin zuciya. Endarshen ƙarshen nuna halin da yawan lokuta da ke faruwa na mutuwa, bugun zuciya, bugun jini, angina pectoris mara izini wanda ke buƙatar asibiti, masu ciwon sukari waɗanda suka ɗauki linagliptin ba su da yawa kuma daga baya fiye da masu sa kai a cikin ƙungiyar masu kulawa waɗanda suka karɓi placebo ko kwatanta kwayoyi.

A wasu halaye, yin amfani da linagliptin ya haifar da hare-hare na matsanancin ƙwayar cuta.

Idan akwai alamun (m ciwo a cikin epigastrium, dyspepsia, rauni na gaba daya), ya kamata a dakatar da maganin kuma a nemi likita.

Ba a gudanar da nazari kan tasirin Trazhenta kan ikon tuki motocin da keɓaɓɓun hanyoyin ba, amma saboda yiwuwar daidaituwa mai lalacewa, ɗauki ƙwayar idan ya cancanta, tare da jan hankali da jan hanzari tare da taka tsantsan.

Analogs da farashin magani

Ga Trazhenta na miyagun ƙwayoyi, farashin ya tashi daga 1500-1800 rubles don allunan 30 tare da sashi na 5 MG. An sake bayar da magani.

Analogues na rukuni guda na DPP-4 inhibitors sun haɗa da Janavia bisa tushen synagliptin, Onglizu dangane da saxagliptin da Galvus tare da sashi mai aiki vildagliptin. Wadannan magungunan sun dace da lambar 4 na lambar ATX.

Ana amfani da irin wannan sakamako ta hanyar magungunan Sitagliptin, Alogliptin, Saksagliptin, Vildagliptin.

Babu yanayi na musamman don adana Trazenti a cikin umarnin. Shekaru uku (daidai da ranar karewa), ana ajiye allunan a zazzabi a daki (har zuwa +25 digiri) a cikin wani wuri mai duhu ba tare da izinin yara ba. Ba za a iya amfani da magungunan da suka ƙare ba, dole ne a zubar dasu.

Masu ciwon sukari da likitoci game da Trazhent

Babban binciken Trazenti a cikin haduwa daban-daban an tabbatar da shi ta hanyar nazarin kasa da kasa da kuma aikin likita. Endocrinologists sun fi son yin amfani da linagliptin a matsayin magani na farko-ko kuma a haɗuwa da warkewar jiyya. Tare da hali zuwa hypoglycemia (matsanancin ƙoƙari na jiki, abinci mara kyau), maimakon magungunan aji na econylurea, an wajabta su ga Trazent, akwai sake dubawa game da takardar sayen magani don juriya da kiba. Yawancin masu ciwon sukari suna karɓar ƙwayar a matsayin ɓangare na magani mai rikitarwa, saboda haka yana da wuya a kimanta ƙimar ta, amma gaba ɗaya, kowa yana farin ciki da sakamakon.

Alina, Ryazan, 'yar shekara 32 “Ina cikin shan wata ɗaya ina shan Trazhent. Na zo wadannan kwayoyin ne bayan dogon gwaje-gwaje da rashin nasara tare da lafiya. Bayan na haihu, na sami nauyi mai yawa. Watanni shida bayan haka, sai aka cire maniyyina a ciki kuma aka wajabta abinci. A baya can, da a ce an yi asarar nauyi nan da nan akan irin wannan abincin, amma daga baya na murmure, duk da jaririna mara hutawa Likita ya ba da shawarar in duba sukari. Bayan gwajin haƙuri haƙuri ya bayyana juriya insulin. Masanin ilimin kimiyya na endocrinologist ya ce tare da irin wannan nazarin ba shi da amfani a azabtar da kanka da yunwar, kuma ya nada Trazhent. Tsawon wata daya, tare da abinci da magunguna, na rasa kilo 4. Wannan kyakkyawan sakamako ne a gare ni. Don haka ina ba da shawarar duk wanda ke da matsalar wuce kima ya fara da gwaje-gwaje, ba abinci ba. ”

Tatyana, Belgorod “Miji na da matsalar matsalar nauyi. Bayan hadarin, ya kwanta na dogon lokaci tare da karyewar kafa, sannan ya yi tafiya a dunkule. Yayinda nauyin ya kasance kaɗan, Na sami kilogiram 32 na nauyi. Da zaran ya murmure, ya fara yakar kiba, amma babu ma'ana. Anyi magana da endocrinologist a ƙarshe. Ya gode wa Allah, bashi da ciwon suga, amma yanayin asalin wannan shine akalla kabeji daya ya ciyar dashi don asarar nauyi. Hadarin, magunguna, canje-canje a cikin rayuwar yau da kullun - duk sun taka rawa. Ya fara shan Trazhenta kuma yana zuwa dakin motsa jiki. Weight ya fara barin - 15 kg a cikin watanni 2. Sun ce ba shi yiwuwa a rasa nauyi sosai, amma ba zai iya rayuwa da shi ba. Abu mai kyau ne cewa muna da magani na lokaci: farashin Trazhenta cizo, tare da shigar da kullun, Dole ne in karɓi analogs na kasafin kuɗi. ”

Anatoly Ivanovich, mai shekara 55, Naberezhnye Chelny “Ina shan mamacin da safe, da kuma kwamfutar hannu ta Trazhenta da dare. Sugar yana cikin kewayon 6 zuwa 8 mmol / L. Don gogaggen mai ciwon sukari, wannan kyakkyawan sakamako ne. Yayin shan Diabeton kadai, glycated haemoglobin shine 9.2%, kuma yanzu ya zama 6.5%. Ina da cutar pyelonephritis, amma maganin yana aiki a hankali a kan kodan. Farashin, a hakika, ba don masu fensho ba ne, amma kwayoyin suna da daraja da kudin su. ”

Nina Petrovna, mai shekara 67, Voskresensk “Da safe ina shan kwamfutar hannu ta Trazhenta kuma sau biyu a rana - Glucofage. Na kasance ina yin amfani da sabon alƙawarin na tsawon watanni 4, a gabani, Siofor ya ɗauka, komai ya yi kyau tare da ni har sai matakin creatinine da urea a cikin gwajin jini ya tashi, kuma a cikin fitsari - furotin. A endocrinologist ya ce a kan tushen ciwon sukari, na haɓaka wani rikitarwa - nephropathy. Ta rubuta allunan guda daya ga Trazent. Sauƙaƙe - Na sha da safe kuma ban yi tunani game da magani ba duk rana. Na ji dadi, amma babban abinda ya faru shi ne cewa gwaje-gwajen sun inganta kuma babu sakamako masu illa, ko da na yi nauyi kadan. ”

Masu rarrabuwa na DPP-4, wanda Trazhenta suke, ana rarrabe shi ba kawai ta hanyar ƙarfin antidiabetic ba, amma har da ƙaruwa na aminci, tunda ba su haifar da tasirin hypoglycemic ba, ba da gudummawa ga karuwar nauyi, kuma kar su lalata cinikin renal. Zuwa yau, wannan aji na kwayoyi an dauki shi a matsayin ɗayan alƙawarin da ke kan kula da ciwon sukari na 2.

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