Vasilip magani ne wanda ke cikin rukunin masu rage kiba. Babban mahimmin aikinsa shi ne yin niyya don rage matakin lipids (fitsari) a cikin jini. Vasilip yana samuwa a cikin nau'i na farin allunan a cikin kwalin fim, zagaye, dan kadan convex a garesu.
Babban sinadaran aiki na wannan maganin shine simvastatin. Hakanan ya haɗa da ƙarin abubuwa kamar lactose monohydrate, sitaci pregelatinized, sittin acid na anhydrous, bitamin C, sitaci masara, magnesium stearate da celclostse microcrystalline. Shellwanin kwamfyutar da kanta ta ƙunshi talc, propylene glycol, hypromellose da titanium dioxide.
Yawan sashi na miyagun ƙwayoyi ya kasance nau'i biyu - 20 da 40 MG kowane.
Hanyar aikin vasilip
Tunda Vasilip yana cikin magungunan rage yawan lipid, tsarin aikinsa ya dace. Da farko dai, vasilip yana rage rage yawan tasirin cholesterol a cikin jini. Akwai nau'ikan cholesterol guda biyu - "mara kyau" da "kyau." “Ayan “mara kyau” yana da wadataccen tsari na lipoproteins, kuma “mai kyau” ɗaya shine wadataccen haɓakar lipoproteins.
Vasilip yana da tasiri akan matakin farko na samuwar cholesterol. Ya ƙunshi canzawar HMG-CoA (hydroxymethylglutaryl-coenzyme A) zuwa mevalonic acid. Wannan canjin yana faruwa a ƙarƙashin ƙarfin enzyme HMG-CoAreductase. Vasilip yana da tasiri mai banƙyama ga wannan enzyme, sakamakon abin da cholesterol kawai baya samar. Hakanan kwayar tana shafar cholesterol, wacce take cikin jiki. Yana rage yawan ƙwayar cholesterol da ke hade da ƙarancin lipoproteins mai yawa, sannan kuma yana rage haɗuwar triglycerides.
Wadannan abubuwa ne na dabi'ar samarda kyautuka wadanda sune ke da alhakin haifar da tarin atherosclerotic plaques a cikin lumen arteries. Amma miyagun ƙwayoyi suna ƙara adadin "mai kyau" cholesterol - hade da babban lipoproteins mai yawa. Hakanan an rage matakin apolipoprotein B - furotin na musamman wanda yake da alhakin jigilar cholesterol a jiki baki daya.
Bayan rage matakin wasu nau'in lipids, babban sinadarin Vasilip yana da tasiri a jikin bangon jijiyoyin jini da kan kansa. Abubuwan jini kamar macrophages, waɗanda ke jagorantar rawa wajen ƙirƙirar adana cholesterol, miyagun ƙwayoyi suna hana su, kuma filayen da kansu su lalace. Hakanan, aikin abubuwan da ake kira isoprenoids, wadanda ke da alhakin haɓakar sel a cikin ƙwayar murjiyoyin jijiyoyin jini, an sami raguwa sosai, saboda bangon jirgin ba ya yi kauri, kuma lumfashinsa ba ya kumbura. Hakanan kuma, Vasilip yana dirar jini sosai kuma yana inganta hawan jini.
Ana lura da babban sakamako bayan watanni daya da rabi.
Siffofin magunguna na vasilip
Vasilip yana cikin ciki. An sha sosai a jikin bangon karamin hanji. Ana lura da mafi girman yawan maganin a cikin sa'o'i biyu zuwa biyu bayan shan shi, amma bayan awanni 12 ya rage zuwa 10%. Ana iya ɗaukar magani tare da abinci, wannan ba zai tasiri tasirinsa ba. Hakanan, baya tara cikin jiki tare da amfani da tsawan lokaci. Magungunan suna ɗaure sosai zuwa sunadarai na jini, kusan 100%.
Vasilip yana canzawa zuwa aiki mai aiki a cikin hanta. Wannan fili ana kiranta beta hydroxy acid. Excaukar aikinsa (kawarwa) yana gudana ta cikin babban hanji. An cire maganin a cikin hanyar metabolites (samfuran juyawa).
Smallan karamin sashi yana kodan, amma wani sashi mai aiki da ke fita ya fita ta hannun kodan.
Sauƙin rabin rayuwa - lokacin lokacin da yawan ƙwayoyi a cikin jini ya ragu daidai sau 2 - daidai yake da sa'a daya da minti hamsin da huɗu.
Manuniya da contraindications don amfani
Sau da yawa likitoci suna yin allurar vasilip don cuta kamar atherosclerosis. Manufarta a cikin hypercholesterolemia na farko ko cakuda dyspidemia (rikicewar rabo daga lipids na jini daban) ma ya zama ruwan dare gama gari, tare da aikin jiki na yau da kullun, asarar nauyi, bin tsarin da aka kafa, ko kuma rashin sakamakon wasu magunguna.
Wata alama kuma shine maganin hyzycholesterolemia na homozygous. A zahiri, a layi daya, ya kamata a bi tsarin abincin da kuma cin sauran magungunan antiatherosclerotic. Hakanan an wajabta maganin Vasilip don rigakafin cututtukan cututtukan zuciya tare da atherosclerosis da ke ciki ko ciwon sukari, tunda akwai babban haɗarin bugun zuciya, bugun jini da cututtukan jijiyoyin jiki daban-daban. Thearshe na ƙarshe shine ɗayan cholesterol a cikin rashin bayyanar cututtuka.
Vasilip yana cikin yanayi kamar:
- cutar hanta a cikin matsanancin mataki ko a cikin aiki mai aiki;
- haɓaka haɓaka cikin enzymes na hanta ba tare da ingantaccen dalili ba;
- ciki da lactation;
- karamin shekaru;
- halayen rashin lafiyan su ga simvastatin ko wasu abubuwan maganin.
Ya kamata a saka kulawa ta musamman ga waɗancan marasa lafiya waɗanda ke da cututtukan da suke biye ko wasu takamaiman yanayi:
- Tare da yawan shan barasa.
- A gaban cututtuka da suka shafi hanta.
- Kasancewar rashin daidaituwa na jiki.
- Violationsayyadaddun ƙetarewar tsarin endocrine da metabolism.
- Rage matsin lamba (hypotension) koyaushe.
- Cututtukan raunuka na jiki.
- Cututtuka na tsarin tsoka.
- Ciwon mara.
- Babban tiyata ko rauni.
- Rashin lactase, enzyme wanda ke rushe lactose (sukari madara).
- Take hakkin da aiwatar da sha daga lactose.
Yin amfani da kwayoyi a lokaci guda kamar su cyclosporine, fenofibrate, amiodarone, verapamil, diltiazem, nicotinic acid, gemfibrozin, da ruwan 'ya'yan innabi, suma suna buƙatar taka tsantsan lokacin amfani da vasilip.
Umarnin don amfani da miyagun ƙwayoyi
Kafin kowane amfani da miyagun ƙwayoyi, ya kamata ku nemi shawara tare da likitan ku game da yadda za ku sha shi daidai a gare ku kuma ku sami masaniya da tattaunawar. Tsarin kula da lafiya shine a ɗauki ɗaya ko fiye da allunan sau ɗaya a rana a lokacin bacci.
An bada shawara don shan magani daidai da daddare, saboda a cikin dare ana aiwatar da kira mafi girma na cholesterol, kuma tasirin maganin ya zama mafi ma'ana. Yawancin lokaci fara da kashi na 10 MG. Matsakaicin da aka yarda da shi shine 80 MG kowace rana. An wajabta wa marasa lafiya da cututtukan ci gaba, da babban haɗarin rikitarwa daga zuciya da jijiyoyin jini. An zaɓi kashi da ake buƙata a mafi yawan lokuta an zaɓi tsakanin wata daya. Zaɓin lokacin aikin yana da zaɓi daban-daban ga kowane mara lafiya ta likitan halarta.
Ya kamata a tuna cewa lokacin shan Wazilip, mara lafiya yayi daban-daban ya tashi rage cin abinci, wanda dole ne ya kiyaye. A wasu halaye, ana kuma tsara wasu magunguna masu rage rage kiba. Ga marasa lafiya da cuta irin su hypercholesterolemia, farawa ya fara ne da kashi 10 MG, amma ana iya ƙara zuwa 40 MG don cimma sakamako mafi ma'ana. Don nau'in gado na wannan cuta, an rarraba Vazilip zuwa sau uku idan an tsara mafi girman kashi (80 MG), ko kuma an ba da 40 MG na miyagun ƙwayoyi sau ɗaya a rana kafin lokacin kwanciya.
Vasilip yana da tasirin da ake so duka a amfani guda kuma a cikin haɗin tare da sauran wakilai na maganin anticholesterolemic, musamman, tare da masu bin bile acid. Wadannan kwayoyi irin su colestyramine, colestipol.
Tare da amfani da conconitant na cyclosporine, gemfibrozil, acid nicotinic ko kwayoyi daga rukuni na fibrates, sun fara da kashi 5 MG, kuma mafi girman izini shine 10 MG. A wannan yanayin, bai kamata ku wuce wannan maganin ba. Idan mai haƙuri ya ɗauki ƙwayoyi a kan arrhythmia da hawan jini, kamar su Amiodarone da Verapamil, to, kashi na Vasilip ya zama bai wuce 20 MG kowace rana ba, tunda ba a kafa cikakken karfinsu ba.
Idan mutum yana fama da matsanancin mataki na lalacewa na koda, wanda a cikin ƙirar fillet ɗin bai wuce 30 ml / min ba., Sannan an wajabta Vasilip a cikin adadin da bai wuce 10 MG kowace rana ba. Ya kamata a ƙara yawan ƙwayar sosai a hankali, kuma a wannan yanayin ya kamata a kula da mai haƙuri koyaushe.
Idan an kafa gazawar matsakaici matsakaici, sashi ba ya canzawa. Haka yake ga tsofaffi.
Sakamakon sakamako na vasilip da yawan zubar jini
Kamar yawancin magunguna, Vasilip na iya tayar da bayyanar wasu sakamako masu illa a jikin mai haƙuri.
Abubuwan da ba a yarda da su ba daga amfani da vasilip suna da wuya.
Akwai sakamako masu illa daga tsarin kwayoyin halitta daban-daban.
Tsarin narkewa: wahalar gurɓata, jin zafi a ciki, haɓakar gas, wuce gona da iri, tashin zuciya, matsanancin amai, gudawa, canje-canje a cikin hanta da ƙwayar ƙwayar cuta, haɓaka sigogin dakin gwaje-gwaje na hanta enzymes, alkaline phosphatase da creatine phosphokinase.
Tsarin jijiya da gabobin azanci: jin zafi a kai, tsananin farin ciki, raunin jijiyoyi, ƙwayar jijiya, matsalolin barci, bayyanar da damuwa, hangen nesa da dandano.
Tsarin Musculoskeletal: myopathies (cututtukan ƙwayar tsoka), fushin tsoka, raɗaɗin tsoka da maƙarƙashiya.
Bayyanar bayyanar cututtuka: cikakkiyar hoto game da yanayin wuce gona da iri ga miyagun ƙwayoyi, wanda akwai kumburi, bayyanar lupus, jin zafi mai yawa, dermatomyositis, raguwa a cikin ƙididdigar platelet, karuwa da yawan eosinophils, vasculitis, haɓakar ƙwayar erythrocyte sedimentation, zafi da tafiyar matakai mai kumburi a cikin gidajen abinci, hauka hankali, haske, zazzabi, fuska mai rauni, rauni gaba daya, wahalar numfashi.
Bayyanar fata: rashes, itching, gashin kai (alopecia).
Bugu da kari, ana iya samun raguwar adadin sel sel na jini da haemoglobin (anaemia), gazawar koda, gazawar libido, da kuma cututtukan fata.
Ana lura da yawan zubar da ciki na Vasilip lokacin da aka wuce kashi 3.6 g A wannan yanayin, ya wajaba a kurkura ciki, ɗaukar gawayi ko laxative saboda ragowar magungunan ba su da lokacin da za a iya sha, kuma mai shigowa da sauri an cire shi daga jiki. Ya kamata a kula da mai haƙuri koyaushe.
Akwai irin waɗannan analogues na Vasilip kamar Atorvastatin, Krestor, Lovastatin, Rosuvastatin, Akorta. Dukkaninsu suna cikin rukunin gumakan. Za'a iya siyan magungunan a kowane kantin magani ta takardar sayan magani. Vasilip abu ne mai arha - tsakanin 250 rubles. Kafin amfani dashi, tabbatar da karanta littafin aikin.
Kwararre a cikin bidiyon a cikin wannan labarin zai yi magana game da simvastatin da kwayoyi dangane da shi.
