AKARBOZA - UMARNIN DON AMFANI, FARASHI, SAKE DUBAWA DA KUMA AMFANI DA ANALOGUES

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Acarbose wani shahararren magani ne tsakanin masu ciwon sukari: an wajabta shi don maganin ciwon suga, masu ciwon sukari na nau'ikan guda biyu, cutar sikari. A cikin hadaddun jiyya, inhibitor yana da tasiri a cikin cutar sikari da ke haifar da cututtukan hanji. Akwai magunguna da yawa da ke da irin wannan damar a kasuwar magunguna, menene fa'idar acarbose?

Yawon shakatawa na tarihi

Yunkurin kawar da '' dan Adam '' annobar cutar 'an yi shi a karni na karshe.

Gaskiya ne, kamar yadda ƙididdigar ƙididdiga ta nuna, to babu yawan masu ciwon sukari da yawa. Cutar ta fara yadu sosai lokacin da kantunan shagunanmu suka fara karyewa daga samfuran inganci, saboda Soviet GOSTs sun soke, kuma sabbin yanayin fasaha bai iya takaita masana'antar a gwaje-gwajen lafiya ba.

Fahimtar cewa babbar matsalar ciwon sukari mellitus (DM) wani cin zarafi ne game da metabolism, masana kimiyya sunyi ƙoƙarin haɓaka magani na duniya wanda ke iyakance amfani da carbohydrates, wanda ke samar da manya tare da rabin rabin adadin kuzari.

Tabbas, babu wanda ya yi nasarar cimma wannan burin har ma a yau ba tare da rage cin abinci mai ƙoshin abinci ba, amma ƙarin haɓakar mai da karuwar narkewar carbohydrate ba zai cutar da masu ciwon sukari ba, musamman tunda kaɗan daga cikinsu suna da ikon bi da shawarar masana ilimin endocrinologist.

Glucosidase inhibitors ya riga ya nuna kyakkyawan sakamako a cikin yaki da ciwon sukari. Wadannan enzymes na iya rushe suga zuwa glucose, wanda yafi sauki narkewa. Saboda haka, an ƙara su cikin jerin magunguna don maganin masu ciwon sukari.

Bayan yin lissafin abincin yau da kullun na masu ciwon sukari:

Monosaccharides (a cikin nau'i na fructose da glucose) - 25 g;
Disaccharides (sucrose) - 100g;
Polysaccharides (kamar sitaci) - 150g.

Kuna iya fahimtar cewa toshe matatar mai yawa shine mafi kyawun bayarwa a matakin farko na metabolism, a cikin hanji, daga inda zasu fito a asalin su.

Me yasa aka mai da hankali sosai ga sitaci? Amfani da sinadarin α-amylase ya ƙunshi amylose da amylopectin, kuma ana iya rugujewa zuwa disaccharides ta amfani da ƙwararren ƙwayar ciki, da ke ɗauke da enzymes α-amylase. Abubuwan disaccharides suna rushe zuwa glucose da fructose a cikin hanji a ƙarƙashin tasirin α-glucosidases. Wadannan monosaccharides ne suka shiga cikin jini daga hanji.

Tabbas cewa raguwa a cikin ayyukan ƙwayar kumburin da hanji zai rage jinkirin lalacewar adadin carbohydrates da ke shiga jiki tare da abinci. Masu hana enzymes saccharolytic, waɗanda aka samo a wasu tsire-tsire (alal misali, a cikin stevia), suna da sauƙin narkewa kuma kar a ba da sakamakon da ba a so. An samo analogs a cikin buckwheat, hatsin rai, masara, legumes da gyada. Abin takaici, karfin su bai isa ba don sarrafa glycemic na ƙididdigar jini.

An gano cewa ƙananan ƙwayoyin cuta suna da tasiri sosai, wanda daga cikinsu aka sami masu hanawa tare da nau'ikan sakamako masu illa: sunadarai, aminosaccharides, oligosaccharides, glycopolypeptides. Mafi shahararren maganin olisaccharide shine Acarbosum, wanda aka kirkira shi daga ƙananan ƙwayoyin cuta. Ta hana ƙananan hancin glucosidases na hanji, yana rage jinkirin canza sitaci cikin glucose.

Sauran hanyoyin da aka kirkireshi an kirkiresu ne ta hanyar tsarin ascarbose, amma basu da wannan tasirin.

Hanyar magunguna

Magungunan Ascarbose:

Rage gudu daga abubuwan da ke cikin carbohydrates a cikin hanji;
Rage postprandial (bayan cin abinci, "prandial" - "abincin rana") glycemia;
Ta hana hauhawar jini;
Kare yiwuwar karuwar insulin.

Lokacin cinye abinci tare da babban taro na carbohydrates, sakamakon hypoglycemic na ascarbose an lura sosai.

Mai hana daukar ciki na taimakawa wajen yakar kiba, da rage yawan ci da kuma yawan adadin kuzari na abinci na yau da kullun, da kuma rage yawan kitsen visceral.

Addu'o'i masu kitse, abinci mai-calorie mai mahimmanci yana rage tasirin acarbose, tunda tasirinsa yana nufin daidaita yanayin carbohydrate, maimakon metabolism.

Saboda halayen likitancinsa, mai hanawa yana ɗaure enzymes na gastrointestinal, yana hana fashewar carbohydrates zuwa cikin sukari mai sauƙi waɗanda ke cikin hanji cikin hanzari.

Acarbose ta hanyar aikin yayi kwatankwacin karfin zaren, alamomin da suke haifar da curi, ba a sami damar narkewa ta hanyar enzymes ba. Bambanci shine cewa miyagun ƙwayoyi suna hana ƙarfin enzymes kansu. Kamar yadda yake a cikin tantanin halitta, carbohydrates suna zama “ba za'a iya canzawa ba” saboda ruwan 'ya'yan itace na ciki da kuma fita ba canzawa, yana kara yawan girma. Daga wannan yana biye da damar inhibitor na iya haɓaka idan ana amfani da samfuran da keɓaɓɓun fiber a cikin layi daya. Wannan dabarar tana da tasiri sosai wajen rasa nauyi.

Duk da katange kayansa, mai hanawa baya keta alfarmar aiki na ciki, tunda baya tasiri amylo-, proteo- da lipolytic na abubuwan narkewar abinci.

Abubuwan da ke tattare da miyagun ƙwayoyi kuma sun dogara da kashi: tare da karuwa a cikin al'ada, alamun hypoglycemic yana da girma.

Masu ciwon sukari da ke shan acarbose da abubuwan da ta samo sun nuna sakamako mai kyau a cikin wasu sigogi masu mahimmanci:

Rage triglycerol da cholesterol a cikin jini;
Rage cikin lipoprotein lipase maida hankali a cikin nama nama.

Idan mai hana injection ya shiga cikin ciki kai tsaye, hakan yana hana ayyukan α-glucosidases. Carbohydrates ana narkewa na tsawon lokaci har zuwa wani sashi mai yawa ba a canza shi ba. Wannan yana shafan alamun da ke nuna glucose ta hanyar da ta fi dacewa: kodayake sun ƙaru, ba su da mahimmanci kamar ba tare da haɗarin acarbose ba. Ta hanyar ƙarfinsa, ana iya kwatanta shi da sanannen Metformin, wanda aka cuta a cikin masu ciwon sukari tare da gazawar koda.

Yana da mahimmanci cewa acarbose, tare da duk ƙarfinsa don yin tasiri akan metabolism na carbohydrates, baya canza damar aikin ƙwayar ƙwayar cuta. Abun cikin sugars da insulin, wanda aka haɗa shi daidai da sauƙin glycemic, an rage daidai.

Acarbose kuma an wajabta shi don nau'in ciwon sukari na farko, tunda yin amfani da shi yana rage adadin ƙarin insulin zuwa rabi.

Magungunan za su taimaka wajen daidaita al'ada, amma abincin yana buƙatar daidaita shi, tunda rashi na carbohydrate yana da haɗari kamar wuce haddi.

Ko da a cikin manyan maganganu, tare da ciwon sukari mai lalacewa, lokacin da insulin ya rama sukari, bayan hanya guda na maganin acarbose, masu ciwon sukari sun lura da raguwa a cikin glucosuria (kasancewar glucose a cikin fitsari).

Yana haɓaka magunguna da haƙurin glucose, amma ba sauyawa 100% bane don magunguna na yau da kullun don maganin ciwon sukari. An wajabta shi azaman ƙarin magani a hade tare da jiyya. Misali, acarbose zai inganta tasirin sulfonylurea.

Hakanan ana nuna magungunan ga masu matsalar rashin lafiyan da basa iya jure wa insulin.

Yana da mahimmanci cewa wannan nau'in inhibitor bashi da cututtukan carcinogenic, embryotoxic da mutagenic.

An magance maganin a cikin narkewa, ƙwayoyin cuta da enzymes suna taimaka ƙirƙirar abubuwa iri 13. Acarbose wanda ba a amfani dashi an saki shi ta cikin hanjin cikin awa 96.

Ga wanda aka nuna acarbose da contraindicated

An wajabta mai hanawa:

Nau'in cuta guda 2;
Matsalar ƙwayar ƙwayar ƙwayar ƙwayar motsi;
Rashin lafiyar metabolism;
Cutar sukari;
Kiba;
Rashin haƙuri da haƙuri;
Take hakkin azumi glycemia;
Lactate da ciwon sukari acidosis;
Type 1 ciwon sukari.

Yin amfani da acarbose an hana shi cikin:

Cirrhosis na hanta;
Ketoacidosis;
Kumburi da jijiyoyin mahaifa;
Cutar mahaifa;
Abin toshewar ciki;
Cutar amai da gudawa;
Haihuwa, lactation;
Shekarun yara.

Tare da taka tsantsan, an wajabta maganin acarbose da abubuwan da ke tattare da shi bayan raunin da ya faru, a lokacin cututtukan cututtuka, tun da jikin da ya raunana bashi da isasshen ƙarfin da zai murmure. Tare da rashi na glucose ko tarewarsa, hypoglycemia ko ciwo na acetonemic mai yiwuwa ne.

Daga cikin sakamako masu illa suna yiwuwa:

Rashin rikicewar motsi na hanji;
Rashin cutar dyspeptic;
Concentara yawan taro na transaminases;
Ragewa a cikin hematocrit;
Rage abun ciki na bitamin da alli a cikin jini;
Kumburi, itching, rashin lafiyan halayen.

Rashin damuwa na ciki, ciwon ciki, da sauran matsaloli tare da ciki da hanjin ka na iya faruwa sakamakon gaskiyar jinkirin narkewar ƙwayar carbohydrates yana ba da gudummawa ga yadda wasunsu suka haɗu a cikin narkewar abinci kuma suna can tsawon lokaci kafin su shiga babban hanjin. Abubuwan da ake tarawa masu daɗi suna haifar da haɓakar ƙwayoyin cuta wanda ke haifar da fermentation, flatulence, da sauran cututtukan cututtukan ɗoki.

Ana lura da irin wannan sakamako a cikin samar da shampen, lokacin da ƙwayoyin carbohydrate da ke dogara da ƙwayoyin cuta suna yin innabi na sukari, suna barin sakamakon rayuwarsu ta wucin gadi. Wataƙila, da tunanin wannan hoton, da yawa za su daina shan giya.

Za a iya gurɓatar da guguwa a cikin hanji ta hanyar metronidazole, wanda likita ya tsara a layi ɗaya tare da acarbose. Carbon da aka kunna da sauran sihirin da ke kwantar da microflora na hanji suna da irin wannan sakamako.

Yana rage tasirin maganin acarbose na lokaci-lokaci:

Abubuwan Diuretics;
Corticosteroids;

Estrogen;
Magungunan Hormone don glandar thyroid;
Na hana haihuwa;
Masu adawa da Calcium;
Phenothiazines da sauran magunguna.

Acarbose - umarnin don amfani

A cikin umarnin, an kayyade sashi daidai da nauyin mai haƙuri. Idan, alal misali, mai ciwon sukari yana da nauyin jiki na kilogiram 60, kashi 25-25 mg ya ishe shi, tare da mafi girma tsarin, an tsara 100 MG 3 / Ranar. Dole ne a kara yawan inhibitor a matakai, domin jiki ya iya daidaitawa, kuma zai yuwu a gano halayen da ba a dace ba a lokaci.

Shan magani kafin abinci ko a lokaci guda. Ana wanke shi da kowane ruwa, idan abun ciye-ciye ne da ba a da fitsari, ba za a iya ɗaukar acarbose ba.

Idan jiki ya amsa rashin ƙarfi ga ƙwayar da aka zaɓa, ana iya haɓaka shi zuwa 600 MG / rana. kuma harma idan lafiya ta bada dama.

An ba da shawarar yin gwaji tare da sashi a cikin marasa lafiya na tsufa (daga 65 shekara) da kuma marasa lafiya da gazawar hanta.

Inhibitor Analogs

Mafi shahararren analog na acarbose shine Glucobay. Hypoglycemic wakili an samar da shi a Jamus. Fitar saki - allunan da ke nauyin 50-100 MG, kowane kunshin ya ƙunshi guda 30 zuwa 100.

Baya ga asalin magani a China da Turai, zaku iya siyan janareta tare da sunan Glucobay, a Amurka da Ingila - Precose, a Kanada - Prandase. Ga masu fama da cutar sankara tare da abinci na gabas, magani ya fi tasiri, kuma ya shahara sosai a China, a cikin Amurka - akasin haka, amfani da shi yana da iyaka saboda zazzabin cizon sauro da ƙonewa.

Nasihu game da acarbose

Game da miyagun ƙwayoyi tare da acarbose Glucobay, sake dubawa game da rasa nauyi sune rarrabuwa. Ba a yi nufin maganin don asarar nauyi ba, an wajabta shi ga masu ciwon sukari, sau da yawa na nau'in na 2.

Lazurenko Natalia “Ina fitar da sanarwa game da amfani da magani na kowane wata tare da acarbose Glucobay. An fara da 50 MG a kowane kashi, bisa ga umarnin da aka kawo zuwa 100 MG. Don abincin rana, Ina ƙara ɗaukar 5 MG na Novonorm. Yanzu na sami damar sarrafa sukari bayan cin abinci. Idan a baya bayan cin abin da bai wuce 10 ba, yanzu ya zama 6.5-7 mmol / l. A madadin gwajin, na ci abinci uku don abincin rana (kimiyya ba ta yin ba tare da sadaukarwa ba) - alamomin glucometer sune al'ada. Yanzu na fahimci dalilin da yasa aka fi son Glucobai a Amurka tare da sha'awar abinci mai sauri da asarar nauyi a lokaci guda. "

Vinnik Vlad “Farashin dandajan da ke dauke da acarbose Glucobai a Ukraine shine $ 25, a cikin Kyrgyzstan - $ 8, a Rasha - magani mafi ƙarancin jabu - daga 540 rubles. Tabbas ba zai warke da ciwon sukari ba, amma zai sanya ni a hankali. Na yanke shawarar ƙara miyagun ƙwayoyi a matsayin ƙarin a lokacin cin abincin rana, lokacin da nayi zunubi tare da cin abincin sau da yawa (dankali, beets), Ina tsammanin cewa wannan maganin yakamata ya sami matsayin shi a cikin kula da ciwon sukari. ”

Tun da yawa daga cikin mu sun sami makamashi daga carbohydrates, magani na doka yana taimaka wa masu ciwon sukari da waɗanda ke asarar nauyi suna kiyaye abinci kuma basu da mummunar illa kamar su analogues, saboda ana iya ɗauka da ma'ana kafin wani yanki na cake ko wani jaraba na carbohydrate.

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