Onglisa magani ne ga masu ciwon sukari, sinadarin mai aiki wanda shine saxagliptin. Saxagliptin magani ne wanda aka sanya shi don warkar da ciwon sukari na 2.
A cikin sa'o'i 24 bayan gudanarwa, yana hana aikin enzyme DPP-4. Haramcin enzyme lokacin hulɗa tare da glucose yana ƙaruwa sau 2-3 matakin glucagon-kamar peptide-1 (anan GLP-1) da glucose-polypeptide-insulinotropic polypeptide (HIP), yana rage yawan glucagon kuma yana ƙarfafa amsawar sel sel.
Sakamakon haka, abun cikin insulin da C-peptide a cikin jiki yana ƙaruwa. Bayan an fitar da insulin ta hanyar sel beta na pancreas da glucagon daga ƙwayoyin alpha, glycemia na azumi da kuma glycemia na postprandial suna ragu sosai.
Ta yaya aminci da tasiri ga amfanin saxagliptin a cikin sigogi daban-daban an yi nazari a hankali a cikin karatun guda biyu da aka sarrafa sau biyu, wanda ya ƙunshi marasa lafiya na 4148 waɗanda suka kamu da nau'in ciwon sukari na 2 na mellitus.
Yayin nazarin, an lura da babban ci gaba a cikin haemoglobin mai narkewa, glucose plasma azumi da kuma glucose postprandial. Marasa lafiya waɗanda a cikin saɓanin kyautar da ba su samar da sakamakon da ake tsammanin ba sun kasance sun haɗa ne da magunguna kamar su metformin, glibenclamide da thiazolidinediones.
Shaida daga marasa lafiya da likitoci: makonni 4 bayan farawar, kawai saxagliptin, matakin glycated hemoglobin ya ragu, kuma matakin glucose din plasma mai azumi ya zama karami bayan makwanni 2.
An rubuta waɗannan alamomi guda ɗaya a cikin rukuni na marasa lafiya waɗanda aka rubuta su tare da ƙari na metformin, glibenclamide da thiazolidinedione, analogues sunyi aiki a cikin kari ɗaya.
A cikin dukkan halayen, ba a lura da karuwa a cikin nauyin jikin marasa lafiya ba.
Lokacin amfani da ongliza
An wajabta magunguna ga marasa lafiya da masu kamuwa da cutar sukari irin na 2 a cikin irin waɗannan halaye:
- Tare da monotherapy tare da wannan magani a hade tare da aiki na jiki da kuma maganin abinci;
- Tare da haɗin gwiwa a hade tare da metformin;
- A cikin rashin ingancin monotherapy tare da metformin, abubuwan da suka samo asali na sulfonylurea, thiazolidinediones a matsayin ƙarin magunguna.
Duk da gaskiyar cewa maganin onglise ya halarta karatu da gwaje-gwaje da yawa, sake dubawa game da shi galibi tabbatacce ne, za'a iya fara amfani da magani a ƙarƙashin kulawar likita.
Contraindications zuwa yin amfani da onglise
Tun da miyagun ƙwayoyi suna tasiri sosai akan aikin beta da ƙwayoyin alpha, suna ƙarfafa aikin su sosai, koyaushe ba za'a iya amfani dashi ba. Magungunan yana contraindicated:
- A lokacin haihuwa, haihuwa da lactation.
- Matasa 'yan kasa da shekara 18.
- Marasa lafiya tare da nau'in 1 na sukari mellitus (aikin ba a yi nazari ba).
- Tare da insulin far.
- Tare da ketoacidosis mai ciwon sukari.
- Marasa lafiya tare da rashin haƙuri na galactose.
- Tare da hankalin mutum ga kowane ɓangaren magungunan.
A cikin akwati bai kamata a yi watsi da umarnin magani ba. Idan akwai shakku game da amincin amfanin sa, to sai a zaɓi hanyoyin hana analog ko kuma wata hanyar magani.
Siyarda da shawarar
Ana amfani da Onglisa a baki, ba tare da ambaton abinci ba. Matsakaicin da aka ba da shawarar maganin yau da kullun shine 5 MG.
Idan ana gudanar da aikin haɗin gwiwa, ana amfani da maganin yau da kullun na saxagliptin, ana tantance hanyoyin da suka dace da metformin da abubuwan da ke haifar da maganin sulfonylurea dabam.
A farkon haɗuwa da magani ta amfani da metformin, sashi na magungunan zai zama kamar haka:
- Onglisa - 5 MG kowace rana;
- Metformin - 500 MG kowace rana.
Idan an lura da rashin dacewar yanayin, ya kamata a daidaita sashi na metformin, yana ƙaruwa.
Idan, saboda kowane dalili, an rasa lokacin shan maganin, mai haƙuri yakamata ya ɗauki kwaya da wuri-wuri. Ba shi da mahimmanci a ninka sau biyu a rana sau biyu.
Ga marasa lafiya waɗanda ke da rauni na koda game da shi azaman cuta mai haɗari, ba lallai ba ne don daidaita sashi na onglise. Tare da dysfunction na koda na matsakaici kuma mai tsanani na onglis ya kamata a ɗauka a cikin adadi kaɗan - 2.5 mg sau ɗaya a rana.
Idan anyi hemodialysis, ana shan onglisa bayan karshen zaman. Har yanzu ba a bincika sakamakon saxagliptin ba a cikin marasa lafiyar da ke fama da matsalar dijital. Saboda haka, kafin fara magani tare da wannan magani, yakamata a gudanar da cikakken kima akan aikin koda.
Tare da gazawar hanta, za'a iya samarda onglise a amince cikin matsakaicin adadin da aka nuna - 5 MG kowace rana. Don lura da marasa lafiyar tsofaffi, ana amfani da onglise iri ɗaya. Amma ya kamata a tuna cewa hadarin haɓaka ƙarancin haɓaka a cikin wannan rukuni na masu ciwon sukari ya fi hakan yawa.
Babu sake dubawa ko nazarin hukuma game da tasirin maganin a kan marasa lafiya da ke ƙasa da shekaru 18. Sabili da haka, ga matasa masu fama da ciwon sukari na 2, an zaɓi analogues tare da wani sashi mai aiki.
Ana buƙatar rage ƙwayar ƙwayar onglise idan an sanya magani a lokaci guda tare da masu hana. Wannan shi ne:
- ketoconazole,
- Sankasari,
- atazanavir
- indinavir
- igraconazole
- nelfinavir
- ritonavir
- saquinavir da telithromycin.
Don haka, matsakaicin adadin yau da kullun shine 2.5 MG.
Siffofin lura da mata masu juna biyu da tasirinsu
Ba a yi nazarin yadda miyagun ƙwayoyi ke shafar lokacin daukar ciki ba, kuma ko yana iya shiga cikin madarar nono, saboda haka, ba a sanya maganin ba lokacin haihuwar da ciyar da jariri. An ba da shawarar yin amfani da wasu analogues ko don dakatar da shayarwa.
Yawancin lokaci, bin sigogi da shawarwari na maganin hadewar, ana yarda da maganin sosai, a cikin lokuta masu wuya, kamar yadda sake dubawa suka tabbatar, ana iya lura da masu zuwa:
- Amai
- Cutar Gastroenteritis;
- Ciwon kai;
- Samuwar cututtukan cututtukan cututtuka na hanji na sama;
- Cututtukan cututtukan cututtukan ƙwayar cuta.
Idan akwai alamun guda ɗaya ko fiye, ya kamata ku dakatar da miyagun ƙwayoyi ko daidaita sashi.
Dangane da sake dubawa, ko da an yi amfani da onglise na dogon lokaci a cikin abubuwan da suka wuce shawarar da aka ba da shawarar sau 80, ba a lura da alamun guba. Don cire miyagun ƙwayoyi daga jiki idan akwai yiwuwar maye, ana amfani da hanyar geomdialysis.
Me kuma ya kamata sani
Ba a sanya Onglis da insulin ko a cikin sau uku na maganin tare da metformin da thiazolididones, tunda ba a gudanar da nazarin hulɗar su ba. Idan mai haƙuri yana shan wahala daga matsakaici zuwa ga ƙarancin na koda, to ya kamata a rage yawan maganin yau da kullun. Masu ciwon sukari da ke fama da rashin lafiyar koda suna buƙatar kulawa da kulawa akai-akai game da yanayin kodan yayin jiyya.
An tabbatar da cewa abubuwan da ake amfani dasu na sulfonylureas na iya haifar da tsotsar jini. Don hana haɗarin hypoglycemia, sashi na sulfonylurea a hade tare da maganin onglise ya kamata a daidaita. Wato, an rage.
Idan mai haƙuri yana da tarihin rashin damuwa ga kowane iri mai kama da DPP-4 inhibitors, ba a sanya takagliptin ba. Amma game da aminci da tasiri na magani tare da wannan magani ga tsofaffi marasa lafiya (fiye da shekaru 6), babu gargadi a wannan yanayin. Onglisa an yarda da shi kuma yana aiki kamar yadda yake a cikin marasa lafiya matasa.
Tunda samfurin ya ƙunshi lactose, bai dace ba ga waɗanda ke da rashin haƙuri a cikin wannan abun, rashi lactose, glucose-galactose malabsorption.
Sakamakon magani a cikin ikon tuki motocin da sauran kayan aiki waɗanda ke buƙatar jan hankali da yawa ba a yi nazarin su ba.
Babu contraindications kai tsaye zuwa tuki mota, amma ya kamata a tuna cewa daga cikin sakamako masu illa da ciwon kai lura.
Yin hulɗa tare da wasu kwayoyi
Dangane da gwaji na asibiti, haɗarin hulɗa da onglise tare da wasu kwayoyi, idan an ɗauka lokaci guda, ƙanana ne.
Masana kimiyya ba su kafa yadda shan sigari, shan giya, amfani da magungunan homeopathic, ko abincin abinci ke shafar tasirin maganin ba, saboda karancin bincike a wannan fannin.
