A zamanin fasahar sadarwa da sababbin tsararrun magungunan antidiabetic, magungunan gargajiya da aka gwada lokaci-lokaci suna kan bukata. Mafi mashahuri sune waɗanda ke motsa ƙwayar tsoka don samar da ƙarin insulin. Muna magana ne game da abubuwan da aka samo asali na jerin hanyoyin sulfonylurea da nesulfanylurea sakatariyar - bogi.
Repaglinide shima yana cikin rukunin ƙarshe. Babban bambancinsa shine tasirin sakamako na farkon sakin hormone a cikin jini, lokacin da bayan cin abinci a cikin jini akwai tsalle mai tsayi a cikin matakan glucose, kuma jikin mai ciwon sukari (tare da cutar cuta ta 2) bazai iya jurewa ba.
Bayan karanta umarnin, yin la'akari da duk ribobi da fursunoni, zaku iya tattauna tare da likitan ku game da tsarin kula da cutar sukari.
Abun ciki da bayanin maganin
Kowane kwamfutar hannu ya ƙunshi 0.5 ko 1 MG na ƙwayar aiki mai aiki na micronized repaglinide wanda aka haɗe tare da kayan taimako na taimako: alli hydrogen phosphate anhydrous, colloidal silicon dioxide, microcrystalline cellulose, sirinum croscarmellose, celslose hydroxypropyl, meglumine, magnesium stearate, da dyes.
Za'a iya gano allunan zagaye na biconvex ta hanyar zana rubutu tare da lambobi dake nuna sashi. Tare da alamar alamar 0.5, suna fari, tare da 1 MG - lavender ko rawaya. A baya zaku iya ganin taƙaitaccen RP, J da sauransu. Allunan 10 an tattara su cikin blister. Za a sami irin waɗannan faranti a cikin kwali.
Akwai takardar sayen magani. Farashin Repaglinide shine ainihin kasafin kuɗi: 30 za'a iya sayan allunan 30 na 2 MG a Moscow don 200-220 rubles. Suna sakin magunguna a Denmark, Isra'ila, Indiya da sauran ƙasashe, ciki har da a cikin yankin Soviet bayan.
Rayuwar shiryayye na miyagun ƙwayoyi, wanda masana'anta suka ayyana, yana kan shekaru 3. Magungunan ba ya buƙatar yanayi na musamman don ajiya. Bayan kayyade lokacin, dole ne a zubar da allunan.
Abubuwan da ke tattare da magunguna
Babban tasirin maganin shine hypoglycemic. Magungunan miyagun ƙwayoyi suna toshe tashoshin potassium na ATP da ke dogara da membrane na b-cell, suna ba da gudummawa ga ƙazantar su da kuma sakin tashoshi na alli. Saboda haka, sakatariyar yana haifar da ci gaban kwayoyi.
Nazarin asibiti bai sami mutagenic, teratogenic, tasirin carcinogenic a cikin dabbobi da nakasa haihuwa.
Ana farfado da Repaglinide cikin sauri kuma gabaɗaya daga tsarin narkewa, har ya kai iyakar jini a cikin awa ɗaya.
Idan an ci abinci, Cmax an rage shi da 20%. Cutar da ƙwayar ƙwayar cuta ta ragu da sauri kuma bayan sa'o'i 4 ya kai ƙaramin alama. Magungunan suna ɗaukar garkuwar plasma kusan gaba ɗaya (daga 98%) tare da bioavailability na 56%. Biotransformation tare da ƙirƙirar inert metabolites yana faruwa a cikin hanta.
Ana cire maganin a cikin sa'o'i 4-6 tare da rabin rayuwar 1 awa. A 90% ya ratsa cikin bile, kimanin 8% kodan ke cire shi.
Wanene Repaglinide akayi nufi?
An tsara magungunan don magance ciwon sukari na 2 idan salon gyaran gyare-gyare na rayuwa (abinci mai ƙarancin carb, isassun nauyin ƙwayar tsoka, kulawar yanayi) ba su samar da cikakkiyar iko na glycemic ba.
Yana yiwuwa a yi amfani da glinide a cikin hadaddun jiyya tare da metformin da thiazolidinediones, idan monotherapy, abinci mai warkewa da aikin jiki ba su samar da sakamakon da ake so ba.
Ga wanda Repaglinide ne contraindicated
Bayan ƙuntatawa ta al'ada (rashin haƙuri, ciki, yara, shayar da nono), maganin yana cikin sabuntawa:
- Masu fama da cutar siga da nau'in cuta ta 1;
- Tare da ketoacidosis mai ciwon sukari;
- A cikin yanayin rashin daidaituwa da precoma;
- Idan mai haƙuri yana da mummunan koda da hanta na ciki;
- A cikin yanayin da ke buƙatar canzawa na ɗan lokaci zuwa insulin (kamuwa da cuta, rauni, tiyata).
Ya kamata a saka kulawa ta musamman don tsara yadda ake sanya ido ga masu maye, mutanen da ke fama da cutar koda, da zazzaɓi.. Akwai ƙuntatawa na shekaru: kar a ba da magani ga masu ciwon sukari kafin 18 da bayan shekaru 75 saboda ƙarancin shaidu ga waɗannan nau'ikan.
Hanyar aikace-aikace
Don repaglinnid, umarnin don amfani bayar da shawarar ɗaukar kwaya ta shirya gaba (kafin abinci). Likita zai zaɓi sashin da ake buƙata don ingantaccen iko na glycemic daidai da sakamakon binciken, matakan cutar, abubuwan da suka dace, shekarun, yanayin jikin mutum ga yumɓu.
Don fayyace mafi ƙarancin maganin warkewa, ya zama dole don sarrafa ƙoshin abinci da sukari postprandial duka a gida da kuma cikin dakin gwaje-gwaje. Lokacin da ake gyaran halayen miyagun ƙwayoyi, su ma suna nuna shi ta hanyar alamu na haemoglobin da ke motsa jiki.
Kulawa yana da mahimmanci don gano gazawar farko da sakandare, lokacin da glycemia matakin ya faɗi ƙasa da al'ada a farkon hanya ko bayan lokacin farko.
Lokacin daukar fansa ba tsayayye bane: mintina 15-30 kafin cin abinci ko kuma kai tsaye a farkon cin abinci. Idan an ƙara abun ciye-ciye guda ɗaya (ko kuma tsallake), sannan an ƙara wani kwaya (ko kuma tsallake).
Idan mai ciwon sukari bai karbi magungunan rage ƙwayar sukari ba, farawar yumɓu yakamata ya zama kaɗan - kashi 0.5 kafin kowane abinci. Idan ya sauya zuwa ba tare da wani magani na maganin antidiabetic ba, zaka iya farawa da 1 MG kafin kowane abinci.
Tare da maganin kulawa, shawarar da aka ba da shawarar ba ta wuce 4 MG kafin manyan abinci. Yawan adadin yumbu na yau da kullun kada su wuce 16 MG.
Tare da kulawa mai rikitarwa, kashi na repaglinide baya canzawa, kuma an zaɓi halayen wasu magunguna daidai da karatun glucometer da magunguna na warkewa na baya.
Sakamakon mara amfani
Daga cikin mummunan halayen halayen glinids, rashin lafiyar hypoglycemia yana da haɗari musamman. Lokacin da yake ba da magani, likita ya kamata ya gabatar da marasa lafiya ga alamunta da hanyoyin taimakon farko da kulawa da kai ga wanda abin ya shafa.
Daga cikin sauran abubuwanda ba'a tsammani:
- Rashin cutar dyspeptic;
- Take hakkin rudani na hanjin motsi;
- Allergic fata rashes;
- Dysfunction na hanta a cikin nau'i na karuwar transistor a cikin ayyukan transaminases;
- Rashin gani na ciki saboda bambance-bambance a matakin glycemic.
Sakamakon Cutar Magunguna
Tare da yin amfani da layi ɗaya na repaglinide tare da β-blockers, ACE inhibitors, chloramphenicol, giya, MAO inhibitors, maganin kaikaice na NSAIDs, probenecid, salicylates, sulfonamides, steroids anabolic, tasirin yumɓu yana ƙaruwa.
Gudanar da sabis na lokaci daya na repaglinide da allunan tashar alli, corticosteroids, thiazide diuretics, isoniazid, nicotinic acid a cikin sashin da ba daidai ba, isrogen (wanda ke cikin abubuwan hanawa), jinƙai mai juyayi, kwayoyin halittar jini, phenytoin, cututtukan thyroid yana rage yiwuwar glinides.
Taimaka tare da yawan wuce haddi
Wannan yanayin ana iya gane shi ta:
- Abincin da ba a sarrafawa;
- Gajiya;
- Babban excitability;
- Anxietyara damuwa;
- Rashin lafiyar bacci;
- Canza halayen halayen (yanayin kama da maye na giya);
- Magana da raunin gani;
- Rashin daidaituwa da hankali;
- Rashin sani;
- Kodadde fata;
- Tachycardia;
- Muscle spasms;
- Wuce kima;
- Fainat, coma.
Taimako ga wanda abin ya shafa na nuna alama da taimako. Idan mai ciwon sukari yana sane, to yana buƙatar a bashi carbohydrates mai sauri (sukari, alewa), bayan ɗan lokaci, jiki ya cika da glucose yakamata a sake, tunda akwai yiwuwar sake komawa.
Idan mai haƙuri ba shi da alamun tsinkaye, ana gudanar da maganin glucose (50%) a cikin ciki, don kula da matakin glycemic sama da 5.5 mmol / l, an saka dropper tare da 10% glucose bayani. A cikin lokuta masu wahala, asibiti mai gaggawa ya zama dole.
Recommendationsarin shawarwari
Musamman hankali (iko da azumi da kuma postprandial sukari, wasan kwaikwayon na gabobin manufa) lokacin da ake rubuta laka ana buƙatar masu ciwon sukari tare da cututtukan koda da na hepatic. Ya kamata su san cewa idan akwai wani batun cin zarafi da tsarin magani, yin amfani da giya, ƙarancin kalori, yawan saurin ƙwaƙwalwa, damuwa, ya zama dole don daidaita sakin maganin, tunda irin waɗannan yanayi na iya haifar da hauhawar jini.
Dangane da mummunan sakamako masu illa, dole ne a yi taka tsantsan lokacin tuki motoci da hadaddun, injiniyoyi masu haɗari, lokacin aiki a tsaurara, da sauransu.
Don hana hypoglycemia, masu ciwon sukari tare da raunana bayyanar cututtuka, kazalika da waɗanda ke da irin wannan yanayin ba sabon abu bane, dole ne a ɗauki ƙarin matakan yin riga-kafi, tantance yiwuwar haɗarin da kuma yiwuwar hakan.
Sauya - analogues
Ana fitar da Repaglinide a ƙarƙashin sunayen kasuwanci iri daban-daban: NovoNorm, Diclinid, Iglinid, Repodiab.
Dangane da lambar ATX ta matakin 4, wakilan maganin rigakafi a cikin Bayeta injections tare da aikin exenatide mai aiki da Viktoza tare da kayan aiki mai aiki na liraglitide yayi daidai da shi.
Wasu masu ciwon sukari suna ɗaukar cutar su a matsayin rashin fahimta mara kyau, ba tare da sanin cewa wannan rashin lafiyar na iya aikawa da sauran duniya a kowane lokaci ba.
Repaglinide babban wakili ne na jini, yin gwaji tare da keɓance kansa da sauyawa yana da haɗari ga lafiya, tunda ƙwayar tana aiki da sauri, tare da mummunan jerin abubuwanda suka haifar da sakamako masu illa. Idan ana kamuwa da cutar sankarar mellitus, kuna buƙatar kulawa sosai, ba tare da yanke jiki ba sai daga baya.
A kan zaɓuɓɓukan likitanci don maganin cututtukan type 2 ana iya samun su akan bidiyon.
