Zilt magani ne mai inganci na antiraplet wanda ke rage jinkirin hada platelet. Kwararru suna ba da shi ga marasa lafiya don hana thrombosis, bugun jini da bugun zuciya.
Suna
Sunan Latin shine Zyllt. INN magani: clopidogrel.
Zilt magani ne mai inganci na antiraplet wanda ke rage jinkirin hada platelet.
ATX
B01AC04.
Saki siffofin da abun da ke ciki
An samar da maganin a cikin allunan 75 MG na ƙwayar mai aiki (Clopidogrel hydrosulfate). Sauran abubuwan sun hada da:
- MCC;
- prolylene glycol;
- talc;
- baƙin ƙarfe;
- pregelatinized iri-iri sitaci;
- titanium dioxide;
- macrogol-6000;
- nau'in anhydrous na lactose;
- hydrogenated castor oil;
- maganin.
An samar da maganin a cikin allunan 75 MG na ƙwayar mai aiki (Clopidogrel hydrosulfate).
Ana sayar da kwayoyin a cikin fakitoci 14, 28, 30, 56, 84 da 90 inji mai kwakwalwa.
Aikin magunguna
Magungunan suna cikin rukunin abinci na Clopidogrel. Yana da cikakken ikon hana ADP wa masu karɓa platelet da kuma ƙara kunnawa na GPIIb / IIIa hadaddun (glycoprotein), wanda ke tsoratar da hanawar haɗakar platelet.
Wannan tsari yana gudana har tsawon makonni 1-1.5. Metabolite mai aiki yana bayyana a sakamakon kunna CYP450 isoenzymes. Koyaya, ba kowane mai haƙuri yana da halayen da suka dace ba, saboda wasu isoenzymes suna da polymorphism, canji a ƙarƙashin rinjayar wasu kwayoyi, ko kuma suna da digiri na daban na hana ADP.
Magungunan yana nuna inganci a cikin rigakafin tasirin atherothrombotic a cikin marasa lafiya tare da lalacewar tasoshin jini na asali daban-daban, musamman a cikin ilimin ilimin halittar mahaifa, jijiyoyin zuciya da jijiyoyin wuya.
Magungunan yana nuna inganci a cikin rigakafin sakamakon atherothrombotic a cikin marasa lafiya tare da lalacewar tasoshin jini na asali.
Pharmacokinetics
Magungunan yana hanzarin shan magani bayan maganin baka. Matsakaicin ƙwayar ƙwayar plasma na kayan aiki mai gudana ana cimma shi zuwa minti 40-45 bayan shan kashi na 75 MG.
Abubuwan da ke cikin miyagun ƙwayoyi a cikin hanta sune metabolized. Rabin rayuwar kusan awa 6 ne. Kashi 46% na maganin yana dauke da hanjin kansa, sauran kuwa da kodan.
Alamu don amfani
Ana amfani da maganin don hana rikicewar atherothrombotic a cikin tsofaffi marasa lafiya waɗanda aka gano su da irin waɗannan cututtukan:
- karancin lalacewa;
- ischemic bugun jini;
- cututtukan zuciya da na jijiyoyin jini;
- cututtukan mahaukata mara jijiya (yanki);
- babban nau'i na ciwo na jijiyoyin jini (tare da karuwa a cikin rukunin ST kuma ba tare da shi ba).
Bugu da ƙari, ana amfani da maganin don hana thromboembolic da atherothrombotic rikice rikice na atrial fibrillation, bugun jini.
Contraindications
- rashin hankali ga abubuwan da ke cikin magani;
- ciki da lactation;
- zub da jini (m);
- mai tsanani da kuma m hepatic Pathology;
- shekaru kasa da shekaru 18;
- Cutar ta mahaukata, rashin haƙuri, da rashin lactase.
Tare da kulawa
- matsaloli na hanta da matsakaici;
- rashi mai aiki;
- yanayi wanda akwai haɗarin zubar jini;
- haɗuwa tare da Heparin, Warfarin da glycoprotein hana jami'ai;
- rashin haƙuri ga sauran ƙwayoyin cuta (Prazogrel, Ticlopidine, da sauransu).
Yadda ake ɗaukar Zilt?
Dole ne maganin ya bugu sau 1 a rana. Abinci baya tasiri a cikin aiki da kuma shan maganin.
Tare da ischemia, infyoction na myocardial infarction da cututtukan jijiyoyin bugun zuciya, matsakaicin kashi shine 75 MG (kwaya 1) sau ɗaya a rana.
Ga marasa lafiya da ƙwayar cutar atrial, an tsara maganin a cikin sashi na 75 MG. Matsakaicin adadin yau da kullun shine 300 MG. A wannan yanayin, ana amfani da Acetylsalicylic acid wani lokaci kuma.
Idan kun tsallake amfani da kashi na gaba na maganin, zaku iya ɗauka a cikin awanni 12. Bayan wannan, tsarin magani bai kamata a keta doka ba. Kar a ninka kashi biyu.
Dole ne maganin ya bugu sau 1 a rana.
Shan maganin don ciwon sukari
Idan kuna da ciwon sukari, koyaushe ku nemi shawara tare da ƙwararren likita kafin ku sha maganin.
Har yaushe za a ɗauka?
Tsawan lokacin magani bai kamata ya wuce shekara 1 ba.
Side effects
Magungunan zai iya haifar da halayen da ba a so. Idan waɗannan suka bayyana, ya kamata ka tuntuɓi likitanka nan da nan.
Gastrointestinal fili
- jin zafi a ciki;
- gudawa da maƙarƙashiya;
- farashi;
- maganin ciwon huhu
- zub da jini a cikin sassan ciki (na bayawar jini);
- tashin zuciya
- amai
- dyspepsia.
Hematopoietic gabobin
- leukopenia;
- anemia
- agranulocytosis;
- granulocytopenia;
- thrombocytopenia;
- neutropenia (a cikin mafi yawan lokuta).
Tsarin juyayi na tsakiya
- ciwon kai
- zazzabi
- hankali mai ruhi;
- auditory da gani hallucinations;
- Dizziness
- rawar jiki.
Daga tsarin urinary
- glomerulonephritis (a cikin matsanancin yanayi);
- hematuria;
- rashi mai aiki;
- increasedarin ƙwaƙwalwar ƙwayar plasma creatinine.
Daga tsarin numfashi
- jini daga hanci;
- narkewar gamsai da jini daga hanji.
- nau'in cutar huhun ciki;
- baƙin ƙarfe spasms.
A wani bangare na bangaren hangen nesa
- rage tsinkaye tsinkaye;
- karuwar matsin lamba cikin ciki;
- hangen nesa biyu.
A wani ɓangaren hanta da ƙwayar biliary
- yanayin lalacewa da sauran aikin hanta mai rauni;
- hepatitis.
Daga tsoka da kashin haɗin kai
- toshewar tsoka;
- hemarthrosis;
- myalgia;
- arthralgia;
- amosanin gabbai.
Bugu da ƙari, halayen anaphylactoid na iya faruwa lokacin ɗaukar allunan.
Umarni na musamman
Marasa lafiya waɗanda suka yi gwaji ta hanyar cutar ɗabi'a da kuma aiki suna buƙatar saka idanu sosai lokacin ɗaukar magani don guje wa rikice-rikice sakamakon zub da jini kwatsam.
Magungunan na tsawan tsawon lokacin zub da jini. Sabili da haka, an umurce shi da taka tsantsan ga marasa lafiya da babban haɗarin irin wannan yanayin.
Kafin ayyukan da aka ƙaddara, lokacin da ba a buƙatar matakin antiplatelet, dole ne a dakatar da miyagun ƙwayoyi aƙalla kwanaki 5-6 kafin tiyata. Wannan ya hada da hanyoyin hakori.
Amfani da barasa
Haɗin maganin tare da barasa na iya haifar da rudani a zuciya, haɓakar tachycardia da bradycardia. Sabili da haka, tare da maganin ƙwayar cuta, irin wannan haɗuwa ya kamata a guji shi.
Haɗin maganin tare da barasa na iya haifar da rudani a zuciya, haɓakar tachycardia da bradycardia.
Tasiri kan ikon sarrafa abubuwan inji
Magungunan ba shi da wani tasiri a kan ikon tuka mota da ayyukan da ke buƙatar saurin amsawa da kulawa.
Yi amfani da lokacin daukar ciki da lactation
A lokacin haila, ana rubuta magani ne kawai a lokuta idan amfanin da ake tsammanin zai wuce haɗarin haɗari.
Lokacin shayarwa da shan maganin, yakamata a shayar da jarirai nonon.
Zilt ya yi wa yara
Ba a yi maganin ba don maganin ƙananan marasa lafiya.
Yi amfani da tsufa
Ga tsofaffi marasa lafiya, sashi ba a daidaita. Koyaya, ya kamata su watsar da ɗimbin ɗibar.
Ga tsofaffi marasa lafiya, sashi ba a daidaita.
Yawan damuwa
A cikin allurai masu yawa, magungunan na iya haifar da tsawaita tsawon lokacin zubar jini da rikicewar basur. Don daidaita yanayin wanda aka azabtar, an wajabta zubar da jini a platelet. Magungunan ba shi da maganin rigakafi.
Yin hulɗa tare da wasu kwayoyi
Ba a so a hada magunguna da maganin anticoagulants na baki saboda haɗarin haɗarin hauhawar jini.
Yana nufin cewa yana hana ayyukan aikin famfon na proton suna da ɗan tasiri a cikin CYP2C19 isoenzyme - Lansoprazole da Pantoprazole. Ana iya haɗe su tare da maganin a cikin tambaya.
Abun da ke aiki na maganin ba ya shafar kaddarorin magani na warfarin. Amma irin wannan haɗuwa yana ƙara haɗarin zubar jini saboda lalacewar coagulation jini.
Lokacin da aka haɗu da maganin tare da Theophylline da Digoxin, magungunan likitancinsu ba su canzawa.
An bada shawara don guje wa amfani da lokaci daya tare da omeprazole.
Ba a so a hada magunguna da maganin anticoagulants na baki saboda haɗarin haɗarin hauhawar jini.
Analogs
- Aterocardium;
- Abun Ciwo;
- Agrel;
- Brilinta;
- Deplatt;
- Avix;
- Diloxolum;
- Jendogrel;
- Clopact;
- Klopigrel.
Magunguna kan bar sharuɗan
Zan iya saya ba tare da takardar sayan magani ba?
Ba za a iya samun magani ba tare da takardar sayen magani ba.
Farashin Zilt
Kudin maganin yana farawa daga 120 rubles don allunan 14 na 75 MG na kayan aiki a cikin kwali.
Ba za a iya samun magani ba tare da takardar sayen magani ba.
Yanayin ajiya na miyagun ƙwayoyi
Yana da kyau a adana maganin a zazzabi da bai wuce + 20 ° C ba, a cikin sanyi mai bushe a inda hasken rana bai samu ba.
Ranar karewa
Watanni 24.
Reviews for Sylt
Likitoci
Igor Kvashnin (therapist), dan shekara 40, Barnaul.
Wakili mai tasiri da iko daga rukunin wakilan antiplatelet. Abubuwan da ke aiki a cikin abun da ke ciki sun sami damar rage AT. Yi amfani da waɗannan kwayoyin magunguna don dalilai na likita kuma daidai da umarnin likita. Idan an yi watsi da wannan, to mutum na iya fuskantar halayen da ba a so da wahala sosai.
Marasa lafiya
Anton Wigman, dan shekara 45, Moscow.
Shekaru da yawa sun sha wahala daga angina pectoris. Kimanin shekaru 3 da suka gabata na sha wahala. Bayan hanya, Ina ɗaukar kwamfutar hannu 1 na wannan magani kowace rana. Kwanan nan ya ƙaddamar da gwaje-gwaje, likita bai bayyana wani take hakki ba, akasin haka, ya lura da haɓaka yanayin yanayin gaba ɗaya. Lafinta kuma ya inganta, kuma cutar angina ba ta bayyana ba.
Vladimir Dubov, dan shekara 47, Lipetsk.
Na yi mamakin kwarewar kwararru a asibitinmu wadanda suka hanzarta tantance yanayin cutar ta kafin buguwa ta kuma ceci rayuwata. Dole na je likitoci na kusan watanni 12. Likitan zuciya ya gargaɗe ni game da haɗarin yiwuwar amfani da wasu ƙwayoyi da shawarar yin amfani da wannan magani saboda jiki yana lura da shi sosai kuma da wuya ya haifar da mummunan sakamako. Yanzu tasoshin da jijiyoyina na al'ada ne.
