Yawancin shirye-shiryen insulin a Rasha sun samo asali ne. Daga cikin tsoffin analogues na insulin, Lantus, wanda ɗayan manyan kamfanonin magunguna Sanofi suka kera, ana yin amfani dashi sosai.
Duk da gaskiyar cewa wannan maganin yana da tsada sosai fiye da NPH-insulin, rabon kasuwar sa yana ci gaba. An yi bayanin wannan ta hanyar narkar da sukari mai tsawo da mai laushi. Zai yuwu ku ɗanɗana Lantus sau ɗaya a rana. Magungunan sun ba ka damar sarrafa kyawawan cututtukan cututtukan cututtukan fata guda biyu, ka guji zubar jini, da tsokani halayen rashin jin daɗi sau da yawa.
Littafin koyarwa
Insulin Lantus ya fara amfani da shi ne a cikin 2000, an yi rajista a Rasha bayan shekaru 3. A cikin lokutan da suka gabata, miyagun ƙwayoyi sun tabbatar da amincinsa da inganci, an sanya shi cikin jerin Magungunan Mahimmanci da Mahimmanci, don haka masu ciwon sukari na iya samun shi kyauta.
| Abun ciki | Abubuwan da ke aiki shine glargine insulin. Idan aka kwatanta da kwayar halittar mutum, ana canza kaɗan daga ƙwayar glargine: an maye gurbin acid ɗaya, an ƙara biyu. Bayan gudanarwa, irin wannan insulin a sauƙaƙe yana samar da hadaddun ƙwayoyi a ƙarƙashin fata - hexamers. Maganin yana da pH na acidic (kimanin 4), wanda ya sa adadin kuzarin hexamers yayi ƙasa da hasara. Baya ga glargine, Lantus insulin ya ƙunshi ruwa, abubuwan antiseptik m-cresol da zinc chloride, da glycerol stabilizer. Ana samun acidity ɗin da ake buƙata na maganin an samu ta hanyar ƙara sodium hydroxide ko acid hydrochloric. |
| Fom ɗin saki | A halin yanzu, ana samun insulin na Lantus a cikin SoloStar allon ƙwayar amfani guda biyu. An ɗora Kwatancen kwalliyan 3 ml a cikin kowane alkalami. A cikin kwali a kwali 5 alkalamun alamu da umarni. A cikin yawancin kantin magani, zaku iya siyan su daban daban. |
| Bayyanar | Iya warware matsalar a bayyane yake kuma mara launi, ba shi da hazo ko da a lokacin tsawan ajiya. Ba lallai ba ne a gauraya a gaban gabatarwar. Bayyanar duk wasu abubuwan dake faruwa, haramtawa alama ce ta lalacewa. Maida hankali ne akan abu mai aiki shine raka'a 100 a milliliter (U100). |
| Aikin magunguna | Duk da peculiarities na kwayar halitta, glargine yana da ikon ɗaure wa masu karɓar sel daidai da insulin na ɗan adam, don haka ka'idodin aiki yayi kama da su. Lantus yana ba ku damar tsara metabolism na glucose idan akwai karancin insulin kansa: yana ƙarfafa tsokoki da tsotsin nama na adipose don ɗaukar sukari, kuma yana hana aikin glucose ta hanta. Tun da Lantus wani kwazo ne mai aiki da jiki, ana allurar dashi don kiyaye glucose mai azumi. A matsayinka na mai mulkin, don ciwon sukari mellitus, tare da Lantus, an tsara gajeren insulins - Insuman na masana'antun guda ɗaya, analogues ko ultravort Novorapid da Humalog. |
| Zaman amfani | Yana yiwuwa a yi amfani da shi a cikin duk masu ciwon suga da ke da shekaru 2 waɗanda ke buƙatar insulin far. Rashin tasiri na Lantus bai shafi jinsi da shekarun marasa lafiya ba, nauyin da ya wuce kima da shan sigari. Ba shi da mahimmanci inda za a allurar da wannan magani. Dangane da umarnin, gabatarwar cikin ciki, cinya da kafada yana haifar da matakin insulin a cikin jini. |
| Sashi | Ana yin lissafin kashin insulin akan tsarin karatun azumi na glucoeter din tsawon kwanaki. An yi imani da cewa Lantus yana samun cikakken ƙarfi a cikin kwanaki 3, don haka daidaitawar kashi na iya yiwuwa ne kawai bayan wannan lokacin. Idan matsakaita na azumin yau da kullun shine 5.6,6, sashi na Lantus yana ƙaruwa da raka'a 2. Ana la'akari da kashi daidai daidai idan babu hypoglycemia, da kuma haemoglobin (HG) bayan watanni 3 na amfani <7%. A matsayinka na mai mulki, tare da nau'in ciwon sukari na 2, kashi yana sama da na 1, tunda marasa lafiya suna da juriya na insulin. |
| Canja a cikin bukatun insulin | Yawan yawan insulin da ake buƙata na iya ƙaruwa yayin rashin lafiya. Babban tasiri yana motsawa ta hanyar cututtuka da kumburi, tare da zazzabi. Ana buƙatar insulin Lantus tare da matsanancin damuwa na damuwa, canza salon rayuwa zuwa mafi yawan aiki, tsawaita aikin jiki. Barasa amfani da insulin far na iya haifar da matsanancin farin ciki. |
| Contraindications |
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| Haɗuwa da sauran magunguna | Wasu abubuwa na iya shafar tasirin Lantus, don haka duk magungunan da aka ɗauka don maganin ciwon sukari ya kamata a yarda da likita. Ayyukan insulin ya rage:
Ana inganta tasirin insulin na Lantus ta:
Magungunan Sympatholytics (Raunatin, Reserpine) na iya rage yawan jijiyoyin jiki, wanda hakan ke da wahalar ganewa. |
| Side sakamako | Jerin tasirin sakamako na Lantus bai bambanta da sauran abubuwan rashin hankali na zamani ba:
Shekaru da yawa da suka wuce, akwai wata shaidar cewa Lantus yana ƙara haɗarin cutar oncology. Binciken da ya biyo baya ya karyata duk wata ƙungiya tsakanin cutar kansa da kuma ƙarancin insulin. |
| Ciki | Lantus baya tasiri a lokacin daukar ciki da lafiyar yarinyar. A cikin umarnin don amfani, an bada shawarar amfani da miyagun ƙwayoyi tare da taka tsantsan yayin wannan lokacin. Wannan ya faru ne saboda yawan canjin da ake buƙata na hormone. Don samun sakamako mai dorewa na cutar sankara, za ku riƙa ziyartar likita sau da yawa kuma ku canza sashi na insulin. |
| Yaran zamani | Tun da farko, an yarda da Lantus SoloStar ga yara daga shekaru 6. Tare da zuwan sabon bincike, an rage shekarun zuwa shekaru 2. An tabbatar da cewa Lantus yana aikatawa akan yara kamar yadda yake akan manya, baya shafar ci gaban su. Bambancin da aka samo shine mafi girman lokuta na rashin lafiyan gida a cikin yara, yawancinsu suna ɓacewa bayan makonni 2. |
| Adanawa | Bayan fara aiki, ana iya kiyaye alkairin sirinji na tsawon makonni 4 a zazzabi a ɗakin. Ana kiyaye sabon sirinji a cikin firiji, rayuwar shiryayye shine shekaru 3. Abubuwan da ke cikin miyagun ƙwayoyi na iya yin rauni lokacin da aka fallasa su ga radadin ultraviolet, ƙarancin zafi (30 ° C). |
A kan sayarwa zaka iya samun zaɓuɓɓuka 2 don insulin Lantus. Na farko an yi shi ne a cikin Jamus, cike yake a Rasha. Karo na biyu na cikakken samarwa ya faru ne a Rasha a kamfanin Sanofi da ke yankin Oryol. Dangane da marasa lafiya, ingancin magungunan daidai suke, sauyawa daga zaɓi ɗaya zuwa wani ba ya haifar da matsala.
Bayani Aikace-aikacen Lantus
Insulin Lantus dogon magani ne. Yana da kusan babu kololuwa kuma yana aiki a matsakaici a cikin sa'o'i 24, aƙalla 29 hours. Tsawon lokaci, ƙarfin aiki, buƙatar insulin ya dogara da halaye na mutum da nau'in cutar, sabili da haka, an zaɓi tsarin kulawa da sashi don kowane mai haƙuri daban-daban.
Ciwon sukari da hauhawar jini zai zama abin da ya wuce
- Normalization na sukari -95%
- Cirewa kan jijiyoyin mara wuya - 70%
- Cire zuciyar mai karfin zuciya -90%
- Rabu da cutar hawan jini - 92%
- Increasearuwar kuzarin rana, inganta bacci da dare -97%
Umarnin don amfani da shawarar bada allurar Lantus sau ɗaya a rana, a lokaci guda. A cewar masu ciwon sukari, tsarin sau biyu ya fi tasiri, saboda yana ba da damar yin amfani da magunguna daban-daban na dare da rana.
Lissafin lissafi
Yawan Lantus da ake buƙata don daidaita al'ada glycemia na azumi ya dogara da kasancewar insulin ciki, jurewar insulin, halayen sha daga cikin ƙwayoyin halittar jiki daga ƙwayar subcutaneous, da kuma matakin ayyukan masu ciwon sukari. Ba za a yi amfani da tsarin koyon maganin ta duniya ba. A matsakaici, jimlar buƙatar insulin daga 0.3 zuwa 1 raka'a. kowace kilogram, rabon Lantus a wannan yanayin ya kai 30-50%.
Hanya mafi sauƙi ita ce yin ƙididdigar yawan Lantus ta hanyar nauyi, ta amfani da madaidaicin tsari: 0.2 x nauyi a cikin kilogiram = kashi ɗaya na Lantus tare da allura guda. Irin wannan ƙidaya ba daidai ba kuma kusan koyaushe na bukatar gyara.
Lissafin insulin a cewar glycemia yana ba, a matsayin mai mulkin, mafi kyawun sakamako. Da farko, ƙayyade adadin don allurar maraice, saboda ya ba da asalin yanayin insulin a cikin jini a cikin dukan dare. Yiwuwar cutar hypoglycemia a cikin marasa lafiya akan Lantus yana da ƙasa da kan NPH-insulin. Koyaya, saboda dalilai na aminci, suna buƙatar saka idanu na sukari na lokaci-lokaci a mafi haɗari - a farkon safiya, lokacin da aka kunna samar da kwayoyin halittar insulin antagonist.
Da safe, ana gudanar da Lantus don kiyaye sukari a cikin komai a ciki kullun. Matsakaicinsa baya dogaro da adadin carbohydrates a cikin abincin. Kafin karin kumallo, kuna buƙatar kwantar da Lantus da gajeren insulin. Haka kuma, bashi yiwuwa a kara allurai kuma a gabatar da nau'in insulin guda daya ne kawai, tunda yanayin aikinsu ya sha bamban. Idan kana buƙatar allurar dogon bacci kafin lokacin bacci, kuma glucose yana ƙaruwa, yi allura 2 a lokaci guda: Lantus a cikin kashi na yau da kullun da gajeren insulin. Ana iya yin lissafin daidaitaccen sashi na gajeren hormone ta hanyar amfani da forsham, ƙididdigar ɗaya dangane da gaskiyar cewa 1 rukunin insulin zai rage sukari da kusan 2 mmol / L.
Lokacin Gabatarwa
Idan an yanke shawarar yin allurar Lantus SoloStar bisa ga umarnin, wato, sau ɗaya a rana, zai fi kyau a yi wannan kusan awa ɗaya kafin a kwanta barci. A wannan lokacin, kashi na farko na insulin suna da lokaci don shiga jini. An zaɓi kashi a cikin irin wannan hanyar don tabbatar da glycemia na al'ada da dare da safe.
Lokacin da aka gudanar da shi sau biyu, allurar farko ana yin ta ne bayan farkawa, na biyu - kafin lokacin bacci. Idan sukari yayi daidai da daddare kuma a ɗanɗaɗa shi da safe, zaku iya gwada motsi abincin dare zuwa farkon lokacin, kusan awanni 4 kafin kwanciya.
Haɗuwa tare da allunan hypoglycemic
Yawancin cututtukan type 2, da wahalar bin tsarin abinci mai rauni, da kuma illolin da ke tattare da amfani da magunguna masu rage sukari sun haifar da bullo da sabbin hanyoyin magani.
Yanzu akwai shawarwari don fara allurar insulin idan haemoglobin glycated ya fi 9%. Yawancin karatu sun nuna cewa farkon farawar insulin da kuma saurin canzawa zuwa tsarin kulawa mai zurfi yana ba da sakamako mafi kyau fiye da magani "zuwa tsayawa" tare da wakilai na hypoglycemic. Wannan hanyar na iya rage haɗarin rikice-rikice na ciwon sukari na 2: yawan rage raguwar kashi 40%, ido da ƙananan ƙwayar microangiopathy ya ragu da 37%, yawan mace-mace an rage 21%.
Tabbatar da ingantaccen tsarin magani:
- Bayan ganewar asali - abinci, wasanni, Metformin.
- Lokacin da wannan ilimin bai isa ba, ana ƙara shirye-shiryen sulfonylurea.
- Tare da ci gaba na gaba - canji a rayuwa, metformin da dogon insulin.
- Sannan a ƙara yin insulin gajere zuwa insulin mai tsawo, ana amfani da tsari mai zurfi na ilimin insulin.
A cikin matakan 3 da 4, ana iya amfani da Lantus cikin nasara. Sakamakon dogon aikin tare da nau'in ciwon sukari na 2, allura guda ɗaya a rana ya isa, rashi kololuwa yana taimakawa ci gaba da insulin basal a matakin guda koyaushe. An gano cewa bayan canzawa zuwa Lantus a cikin yawancin masu ciwon sukari tare da GH> 10% bayan watanni 3, matakinsa ya ragu da 2%, bayan watanni shida ya isa ga al'ada.
Analogs
Dogo masu aiki da dorewa sun samar da masana'antun 2 ne kawai - Novo Nordisk (magungunan Levemir da Tresiba) da Sanofi (Lantus da Tujeo).
Kwatanta halaye na kwayoyi a cikin alkalami alkalami:
| Suna | Abu mai aiki | Lokacin aiki, awanni | Farashin kowace fakiti, rub. | Farashi don raka'a 1, rub. |
| Lantus SoloStar | glargine | 24 | 3700 | 2,47 |
| Levemir FlexPen | detemir | 24 | 2900 | 1,93 |
| Tujo SoloStar | glargine | 36 | 3200 | 2,37 |
| Tresiba FlexTouch | degludec | 42 | 7600 | 5,07 |
Lantus ko Levemir - Wanne ya fi kyau?
Ingantaccen insulin tare da kusan bayanan martaba na aiki ana iya kiran su Lantus da Levemir. Lokacin amfani da ɗayan ɗayansu, kuna iya tabbata cewa a yau zai yi aiki daidai kamar jiya. Tare da madaidaicin kashi na tsawon insulin, zaku iya yin bacci cikin kwanciyar hankali duk dare ba tare da tsoron cutar sikila ba.
Bambancin magunguna:
- Aikin Levemir ya yi laushi. A kan zane, wannan bambancin a bayyane yake, a cikin ainihin rayuwa, kusan babu makawa. Dangane da sake dubawa, sakamakon abubuwan insulins iri ɗaya ne, lokacin da sauyawa daga ɗayan zuwa wani mafi yawan lokuta ba lallai ne ku canza sashi ba.
- Lantus yana aiki fiye da Levemir. A cikin umarnin don amfani, an bada shawarar saka shi sau 1, Levemir - har sau 2. A aikace, magungunan biyu suna aiki sosai idan an yi su sau biyu.
- Levemir an fi son masu ciwon sukari tare da ƙarancin insulin. Ana iya siyan shi a cikin katako kuma saka shi a cikin alkairin sirinji tare da matakan dosing of 0.5 raka'a. Ana sayar da Lantus kawai a cikin alkalam ɗin da aka gama a cikin ƙari na 1 naúra.
- Levemir yana da pH na tsaka tsaki, don haka ana iya dilimin shi, wanda yake da mahimmanci ga yara ƙanana da masu ciwon sukari tare da ƙwayar jijiyoyin jiki. Insulin Lantus yana asarar kaddarorinsa lokacin da aka lalata shi.
- Levemir a cikin bude form an adana shi sau 1.5 ya fi tsayi (makonni 6 da 4 a Lantus).
- Maƙerin ya yi iƙirarin cewa tare da nau'in ciwon sukari na 2, Levemir yana haifar da ƙarancin nauyi. A aikace, bambanci tare da Lantus sakaci ne.
Gaba ɗaya, magungunan biyu suna da alaƙa iri ɗaya, don haka tare da ciwon sukari babu wani dalili don canza ɗaya don ɗayan ba tare da isasshen dalili ba: ƙwayar cuta ko kulawar glycemic mara kyau.
Lantus ko Tujeo - me za a zaɓa?
Kamfanin Tujeo yana fitar da insulin din daga wannan kamfani kamar Lantus. Bambanci kawai tsakanin Tujeo shine haɓaka yawan insulin sau 3 a cikin bayani (U300 maimakon U100). Ragowar abun hade ne iri daya.
Bambanci tsakanin Lantus da Tujeo:
- Tujeo yana aiki har zuwa awanni 36, don haka bayanin ayyukansa ya zama mara nauyi, kuma haɗarin cutar rashin jini a cikin maraice ya ragu;
- a Mililiters, kashi na Tujeo kusan kashi uku bisa uku ne na insulin na Lantus;
- a raka'a - Tujeo yana buƙatar kusan 20%;
- Tujeo wani sabon magani ne, don haka ba a bincika tasirinsa ga jikin yaran ba. An hana yin amfani da umarnin don amfani da shi a cikin masu ciwon suga da ke ƙasa da shekara 18;
- bisa ga sake dubawa, Tujeo ya fi dacewa da yin kuka a cikin allura, don haka dole ne a sauya shi kowane lokaci tare da sabon.
Komawa daga Lantus zuwa Tujeo abu ne mai sauqi: muna yin allurar da yawa kamar yadda muke a baya, kuma muna lura da cutar glycemia tsawon kwanaki 3. Wataƙila, ya kamata a daidaita sauƙin zuwa sama.
Lantus ko Tresiba
Tresiba shine kawai mamba a cikin sabuwar kungiyar insulin na dogon-ins. Yana aiki har zuwa awanni 42. A halin yanzu, an tabbatar da cewa tare da nau'in cuta ta 2, maganin TGX yana rage GH ta 0.5%, hypoglycemia da 20%, sukari yana raguwa da 30% ƙasa da dare.
Tare da nau'in ciwon sukari na 1, sakamakon ba shi da ƙarfafawa: GH an rage shi da 0.2%, yawan maganin bacci a cikin dare yana ƙasa da 15%, amma da rana, sukari yakan faɗi sau da yawa by 10%.Ganin cewa farashin Treshiba yana da girma sosai, har zuwa yanzu ana iya bada shawarar shi ga masu ciwon sukari masu fama da cutar 2 amma da haɓakar hawan jini. Idan ana iya rama cutar sankara da insulin Lantus, canzawar ba shi da ma'ana.
Lantus Reviews
Lantus shine insulin da aka fi so a Rasha. Fiye da 90% na masu ciwon sukari suna farin ciki da shi kuma suna iya ba da shi ga wasu. Marasa lafiya suna danganta alfanun da ba ta shakkar su ba saboda tsawonta, mai santsi, kwanciyar hankali da sakamako mai faɗi, sassauƙa na zaɓin kashi, sauƙi na amfani, da allura mara zafi.
Amsa mai kyau ya cancanci ikon Lantus don cire hawan asuba a cikin sukari, rashin tasiri akan nauyi. Yawancinsa ba shi da ƙasa da NPH-insulin.
Daga cikin gazawar, marasa lafiya masu ciwon sukari suna lura da rashin katuwar katako ba tare da sirinji alkalami a kan siyarwa ba, babban adadin sashi, da warin insulin mara dadi.
