Tricor magani ne mai rage zafin jiki wanda ake amfani dashi don dyslipidemia, kuma ana amfani dashi don cututtukan sukari, idan maganin abinci da haɓaka ayyukan jiki basu da tasiri.
Magungunan suna rage matakin fibrinogen da abun ciki na ƙananan ƙwayoyin atherogenic na cholesterol a cikin jini (VLDL, LDL), yana ƙara haɓakar uric acid.
Formaddamar da tsari da abun da ke ciki
Ana sayar da Tricor a cikin nau'ikan allunan da aka sanya fim a cikin allunan 30 Allunan. Kowane kwamfutar hannu ta haɗa da ƙwayoyin fnofibrate na micronized na 145, da abubuwa masu zuwa:
- lactose monohydrate,
- sodium lauryl sulfate,
- yi nasara
- sabbinne,
- silicon dioxide
- Sankarinka
- sodium docusate.
Tasirin warkewa
Fenofibrate shine asalin sinadarin fibric acid. Yana da ikon canza matakan nau'ikan ƙananan ƙwayoyin lipids a cikin jini. Magungunan yana da alamun da ke biye:
- Yana kara sharewa
- Yana rage adadin lipoproteins na atherogenic (LDL da VLDL) a cikin marasa lafiya da haɗarin haɗarin kamuwa da cututtukan zuciya,
- Yana haɓaka matakin "mai kyau" cholesterol (HDL),
- Da mahimmanci yana rage abun ciki na adana cholesterol,
- Lowers fibrinogen taro,
- Yana rage matakin uric acid a cikin jini da furotin na C-reactive.
Matsakaicin matakin fenofibrate a cikin jinin mutum yana bayyana awanni kaɗan bayan amfanin guda. A karkashin yanayin tsawan amfani, babu wani sakamako mai tarawa.
Amfani da Maganin Tricor yayin daukar ciki
An ba da labari kaɗan game da amfani da fenofibrate yayin daukar ciki. A cikin gwaje-gwajen dabbobi, ba a bayyana tasirin teratogenic na fenofibrate ba.
Amfrayotoxicity ya faru a matsayin wani ɓangare na gwaji na daidaito dangane da abubuwan da ake sanyawa mai guba ga jikin mace mai ciki. A halin yanzu, ba a gano wani haɗarin ɗan adam ba. Koyaya, ana iya amfani da miyagun ƙwayoyi yayin daukar ciki kawai bisa la'akari da kimantawa sosai game da rabo da fa'ida.
Tunda babu ingantaccen bayanai game da amincin ƙwayar Tricor yayin shayarwa, to a wannan lokacin ba a umurta shi ba.
Wadannan abubuwan contraindications don shan miyagun ƙwayoyi Tricor sune:
- Babban digiri na hankalin mutum a fenofibrate ko wasu abubuwan maganin;
- Wani mummunan rauni na yara, alal misali, cirrhosis na hanta;
- Shekaru zuwa shekaru 18;
- Tarihin daukar hoto ko daukar hoto a cikin maganin ketoprofen ko ketoprofen;
- Cututtuka da yawa na cikin mai saƙar fata;
- Rashin shayarwa;
- Galatosemia mai lalacewa, isasshen matakan lactase, malabsorption na galactose da glucose (maganin ya ƙunshi lactose);
- Ruwan fructosemia mai lalacewa, ƙarancin sucrose-isomaltase (maganin yana ƙunshe da sucrose) - Tricor 145;
- Rashin lafiyar rashin lafiyar ɗanyen gyada, gyada, soya leya, ko kuma tarihin cin abinci irin wannan (tunda akwai haɗarin kamuwa da cuta).
Wajibi ne a yi amfani da samfurin tare da taka tsantsan, idan akwai:
- Rashin raunin da / ko gazawar hanta;
- Almubazzaranci;
- Hypothyroidism;
- Mai haƙuri yana cikin tsufa;
- Mai haƙuri yana da tarihin ɗaukar nauyi dangane da cututtukan tsoka na gado.
Allurai na magani da hanyar amfani
Dole ne a ɗauki samfurin ta hanyar magana da baki, yana haɗiye duka kuma shan ruwa mai yawa. Ana amfani da kwamfutar hannu a kowane lokaci na rana, ba ya dogara da cin abinci ba (don Tricor 145), kuma a lokaci guda tare da abinci (don Tricor 160).
Manya suna ɗaukar kwamfutar hannu 1 sau ɗaya a rana. Marasa lafiya waɗanda suka ɗauki 1 capsule na Lipantil 200 M ko kwamfutar hannu 1 na Tricor 160 kowace rana na iya fara shan 1 kwamfutar hannu na Tricor 145 ba tare da ƙarin canjin kashi ba.
Marasa lafiya waɗanda suka ɗauki capsule 1 na Lipantil 200 M kowace rana suna da damar canzawa zuwa kwamfutar hannu 1 na Tricor 160 ba tare da ƙarin canjin kashi ba.
Ya kamata tsofaffi marasa lafiya suyi amfani da daidaitaccen sashi don tsofaffi: 1 kwamfutar hannu na Tricor sau ɗaya a rana.
Marasa lafiya tare da gazawar koda ya kamata ya rage sashi ta hanyar tuntuɓar likita.
Lura cewa ba a yi amfani da maganin Tricor a cikin marasa lafiya da cutar hanta ba. Nazarin ba ya ba da hoto bayyananne.
Dole ne a sha miyagun ƙwayoyi na dogon lokaci, yayin lura da rubutattun magunguna don abincin da mutum ya bi kafin fara amfani da maganin. Ya kamata likitan da ke halartar likitan ya tantance tasirin magungunan.
Ana tantance magani ta hanyar matakan lium. Muna magana ne game da cholesterol LDL, jimlar cholesterol da triglycerides. Idan sakamako na warkewa bai faru ba a cikin 'yan watanni, to za a tattauna batun yin wani magani na daban.
Yawan shaye-shayen kwayoyi
Babu kwatancen adadin abubuwan da suka wuce haddi. Amma idan kuna zargin wannan yanayin, zaku iya aiwatar da maganin alamomi da tallafi. Hemodialysis ba shi da tasiri a nan.
Yadda miyagun ƙwayoyi ke hulɗa tare da wasu kwayoyi
- Tare da maganin anticoagulants na baki: fenofibrate yana haɓaka tasiri na maganin anticoagulants na baki kuma yana kara haɗarin zub da jini. Wannan ya faru ne saboda canzawar maganin anticoagulant daga wuraren da ke rufe furotin na plasma.
A cikin matakan farko na maganin fenofibrate, yana da mahimmanci don rage kashi na maganin anticoagulants ta kashi na uku, kuma sannu a hankali zaɓi zaɓi. Ya kamata a zaɓi sashi ɗin a ƙarƙashin kula da matakin INR.
- Tare da cyclosporine: akwai kwatancen kwatancen shari'o'i masu yawa na raguwar aikin hanta yayin jiyya tare da cyclosporine da fenofibrate. Wajibi ne a kula da aikin hanta a cikin marasa lafiya koyaushe kuma cire fenofibrate idan akwai manyan canje-canje a cikin sigogin dakin gwaje-gwaje.
- Tare da hanawar Hct-CoA reductase inhibitors da sauran fibrates: lokacin ɗaukar fenofibrate tare da Hhib-CoA reductase inhibitors ko wasu fibrates, haɗarin maye a kan ƙwayoyin tsoka yana ƙaruwa.
- Tare da cytochrome P450 enzymes: nazarin microsomes na hanta mutum ya nuna cewa fenofibroic acid da fenofibrate ba su zama masu hana masu irin wannan cytochrome P450 isoenzymes ba:
- CYP2D6,
- CYP3A4,
- CYP2E1 ko CYP1A2.
A magungunan warkewa, waɗannan mahadi suna hana masu hana CYP2C19 da CYP2A6 isoenzymes mai sauƙi ko matsakaici.
Bayan 'yan umarnin musamman lokacin shan magani
Kafin ka fara amfani da miyagun ƙwayoyi, kuna buƙatar yin magani da nufin kawar da abubuwan da ke haifar da hypercholesterolemia, muna magana ne game da:
- nau'in kamuwa da cuta guda 2,
- hawan jini
- nephrotic syndrome
- dysproteinemia,
- cutar hanta
- sakamakon magani,
- barasa
Ana nazarin tasirin magani gwargwadon abubuwan da ke tattare da lipids:
- jimlar cholesterol
- LDL
- magani triglycerides.
Idan tasirin warkewa bai bayyana ba sama da watanni uku, yana da bukatar fara madadin magani ko maganin kwanciyar hankali.
Marasa lafiya tare da hyperlipidemia waɗanda ke ɗaukar rigakafin hormonal ko estrogens ya kamata su gano yanayin hyperlipidemia, zai iya zama na farko ko na sakandare. A cikin waɗannan halayen, haɓaka yawan adadin lipids na iya haifar da ɗaukar isrogen, wanda aka tabbatar da shi ta hanyar bita da haƙuri.
Lokacin amfani da Tricor ko wasu magunguna waɗanda ke rage yawan ƙwayar lipids, wasu marasa lafiya na iya fuskantar ƙaruwar adadin cututtukan hepatic.
A yawancin halaye, haɓaka ƙanana da ɗan lokaci, yana wucewa ba tare da alamun bayyanar ba. A cikin watanni 12 na farko na magani, ya zama dole a hankali kula da matakin transaminases (AST, ALT), kowane watanni uku.
Marasa lafiya waɗanda, a lokacin jiyya, suna da ƙaruwa mai yawa na transaminases, suna buƙatar kulawa ta musamman idan maida hankali na ALT da AST sun ninka sau 3 ko fiye da hakan a sama. A irin waɗannan halayen, ya kamata a dakatar da miyagun ƙwayoyi da sauri.
Kwayar cutar kansa
Akwai kwatancen lokuta na haɓakar ƙwayar ƙwayar ƙwayar ƙwayar cuta yayin amfani da Traicor. Matsalar da ke haifar da ƙwayar ƙwayar ƙwayar cuta:
- Rashin ingancin maganin a cikin mutanen da ke fama da matsanancin ƙwayar cuta,
- Kai tsaye ga cutar,
- Bayyanar sakandare da ke da alaƙa da duwatsu ko kuma samuwar laushi a cikin ƙwayar cuta, wanda ke haɗuwa tare da toshewar bututu guda biyu.
Muscle
Lokacin amfani da Tricor da wasu kwayoyi waɗanda ke rage yawan ƙwayar lipids, lokuta sun ruwaito sakamako masu guba a kan ƙwayar tsoka. Bugu da ƙari, ba a ɗauka lokuta marasa wuya na rhabdomyolysis.
Irin waɗannan rikice-rikice sun zama mafi yawan lokuta idan akwai lokuta na gazawar koda ko tarihin hypoalbuminemia.
Ana iya zargin abubuwan da ke tattare da guba a kan ƙwayar tsoka idan mai haƙuri ya yi gunaguni na:
- Muscle cramps da katako
- Janar rauni
- Bambancin myalgia,
- Myositis
- Markedara yawan alama a cikin aikin ƙirƙirar phosphokinase (5 ko fiye da haka idan aka kwatanta da babba na yau da kullun).
Yana da mahimmanci a san cewa a duk waɗannan halayen, ya kamata a dakatar da jiyya tare da Tricor.
A cikin marasa lafiya sun yanke shawarar kamuwa da cutar sankara, a cikin mutanen da suka girmi shekaru 70, kuma a cikin marasa lafiya da ke da tarihi mai wahala, rhabdomyolysis na iya bayyana. Bugu da kari, yanayin rikitarwa:
- Cututtukan tsoka na gado
- Paarancin aikin na ƙasa,
- Hypothyroidism,
- Almubazzaranci.
An wajabta magungunan don irin wannan marasa lafiya ne kawai lokacin da amfanin da ake tsammanin magani ya wuce haɗarin haɗarin haɗari na rhabdomyolysis.
Lokacin amfani da Traicor tare da HMG-CoA reductase inhibitors ko wasu fibrates, haɗarin mummunan sakamako mai guba akan ƙwayoyin tsoka yana ƙaruwa. Gaskiya ne gaskiya lokacin da mai haƙuri yana da cututtukan tsoka kafin fara magani.
Haɗin gwiwa tare da Triicor da statin na iya zama idan mai haƙuri ya sami dyslipidemia mai haɗuwa da haɗarin cutar zuciya da jijiyoyin jini. Bai kamata a sami tarihin cututtukan tsoka ba. Tabbataccen alamun alamun tasirin mai guba akan ƙwayar tsoka ya zama dole.
Aikin Renal
Idan an karu da haɓakar maida hankali akan kashi 50% ko fiye, to ya kamata a dakatar da maganin. A cikin watanni 3 na farko na maganin Treicor, ya kamata a ƙaddara maida hankali akan ƙirƙirar halitta.
Nazarin game da miyagun ƙwayoyi ba su da bayani game da kowane canje-canje a kiwon lafiya lokacin tuki mota da sarrafa kayan inji.
