Rashin insulin ya zama cin zarafin hulɗa da shigowa cikin insulin akan nama. A wannan yanayin, insulin na iya zuwa ta hanyar halitta daga koda, kuma ta hanyar allura ta hanyar hormone.
The hormone, bi da bi, ya shiga cikin metabolism, girma da kuma haifuwar sel Kwayoyin, kwayar halittar DNA da kuma jerin kwayoyin halitta.
A wannan zamani, juriyawar insulin yana da alaƙa ba kawai tare da cuta na rayuwa ba da haɗarin haɗari na nau'in ciwon sukari na 2. Ciki har da juriya na insulin ya cutar da metabolism na fats da sunadarai, bayyanar gene.
Ciki har da juriya na insulin zai rushe aikin aikin ƙwayoyin endothelial, waɗanda sune ƙananan ciki a jikin bangon jijiyoyin jini. A sakamakon haka, cin zarafin yana haifar da vasoconstriction da haɓakar atherosclerosis.
Bayyanar da juriya na insulin
Ana gano cin zarafi idan mai haƙuri yana da alamun cutar mahaifa. Kwayar cutar za ta iya haɗa da adon kitse a cikin kugu, karuwar matsin lamba, ƙarancin jini na triglycerides da cholesterol. Ciki har da wannan sabon abu idan an binciki mai haƙuri ya nuna ƙarin furotin a cikin fitsari.
Bayyanar da juriya ta insulin ana yin ta ne da farko ta hanyar gwaje-gwajen da dole ne a kai a kai. Koyaya, saboda gaskiyar cewa matakan insulin a cikin jini na jini na iya bambanta, yana da matukar wahala a gano irin wannan cutar.
Idan an yi gwaje-gwaje a kan komai a ciki, ƙarancin insulin a cikin jini shine 3-28 mkU / ml. Idan insulin a cikin jini ya haɓaka kuma ya wuce ƙayyadadden tsari, ana gano hyperinsulinism a cikin mai haƙuri.
Dalilin da yasa aka wuce insulin a cikin jini na iya zama saboda gaskiyar cewa kuli-kuli yana fitar da adadinsa saboda ya rama maganin juriya a cikin kyallen.
Irin wannan bincike na iya nuna cewa mai haƙuri na iya haɓaka ciwon sukari na 2 ko cututtukan zuciya.
Don gano daidai ƙeta n6, ana yin babban insulin hyperinsulinemic insulin. Wannan hanyar dakin gwaje-gwaje ta ƙunshi ci gaba da aiki cikin jijiyar insulin da glucose na tsawon sa'o'i huɗu zuwa shida.
Irin wannan cutar tana daukar lokaci sosai, saboda haka ba a amfani da ita. Madadin haka, ana yin gwajin jini a cikin komai a ciki domin sanin matakan plasma.
Yayinda aka gano yayin binciken, wannan cin zarafin zai iya faruwa mafi yawan lokuta:
- A cikin 10 bisa dari na lokuta ba tare da wata damuwa na rayuwa ba;
- A cikin kashi 58 na lokuta, idan akwai alamun cutar hawan jini sama da 160/95 mm Hg. st .;
- A cikin kashi 63 na lokuta tare da hyperuricemia, lokacin da ƙididdigar seric uric acid sun fi 41 μmol / lita a cikin maza da 387 μmol / lita a cikin mata;
- A cikin kashi 84 na lokuta tare da karuwa a matakin ƙwayoyin mai, lokacin da triglycerides ya fi 2.85 mmol / lita;
- A cikin kashi 88 na shari'o'i masu ƙarancin ingancin cholesterol, lokacin da masu nuna alamar ta ƙasa da 0.9 mmol / lita a cikin maza da 1.0 mmol / lita a cikin mata;
- A cikin kashi 84 na lokuta, idan akwai alamun ci gaban nau'in ciwon sukari na 2;
- A cikin kashi 66 na lokuta na rashin haƙuri na glucose.
Likitocin sun ba da shawarar yin gwaje-gwaje ba wai kawai a tantance jimlar cholesterol a cikin jini ba, har ma don gano mummunan da mai kyau. Kuna iya amfani da kayan aiki na musamman don auna cholesterol.
Don gano idan akwai juriya na insulin, ana amfani da jigon insulin juriya na NOMA. Bayan an bincika matakin insulin da glucose akan komai a ciki, an ƙididdige tsarin HOMA.
Tare da haɓaka matakin insulin azumi ko glucose, ƙarancin HOMA shima yana ƙaruwa. Misali, idan bincike ya nuna matakin glycemic a kan m komai na ciki na 7.2 mmol / lita, da insulin 18 μU / ml, bayanin HOMA shine 5.76. Ana la'akari da matakan insulin na al'ada idan ƙididdigar HOMA ta ƙasa da 2.7.
Metabolism tare da insulin
Insulin yana ba ku damar kunna matakan metabolism kamar sufurin glucose da kuma glycogen synthesis. Ciki har da wannan maganin yana da alhakin sinadaran DNA.
Insulin yana samar da:
- Garfafawar glucose ta ƙwayoyin tsoka, hanta da ƙwayoyin adipose;
- Maganin glycogen a cikin hanta;
- Kama amino acid ta hanyar sel;
- Kwayar halittar DNA;
- Samuwar sunadarai;
- Halittar acid;
- Kai jigilar kai Ion
Ciki har da insulin yana taimakawa hana alamomin da ba'a so kamar su:
- Rushewar kitse mai shiga jiki da shigowar mai mai kazanta zuwa jini;
- Canza glycogen a cikin hanta da glucose cikin jini;
- Kayan kawar da sel.
Yana da mahimmanci a fahimci cewa sinadarin ba ya barin fashewar kyallen takarda. Saboda wannan dalili, idan an lura da juriya na insulin kuma an inganta matakan insulin, kusan ba zai yiwu a rage kiba mai yawa ba.
Matsayin hankali na hankali ga insulin na kyallen takarda daban-daban na jiki
A cikin lura da wasu cututtuka, hankalin ƙwayar tsoka da ƙashin mai mai zuwa insulin an yi la'akari da farko. A halin yanzu, waɗannan kyallen takarda suna da juriya na insulin daban-daban.
Don haka, don murkushe gushewar kitse a kyallen takarda, ba a wuce 10 mcED / ml na insulin a cikin jini ake bukata. A lokaci guda, ana buƙatar kimanin mcED 30 ml na ml / insulin don rage ƙoshin glucose daga hanta zuwa cikin jini. Don haɓaka tasirin glucose ta ƙwayar tsoka, ana buƙatar 100 mcED / ml ko fiye da hormone a cikin jini.
Tissues suna rasa hankalin insulin saboda haɗarin ƙwayoyin jini da salon rayuwa mara kyau.
A lokacin da ciwon farji ya fara jimre wa nauyin karuwar, mai haƙuri ya kamu da ciwon sukari na 2. Idan an fara magance insulin jurewar ƙwayar insulin da kyau a gaba, za a iya kawar da matsaloli masu yawa
Yana da mahimmanci a fahimci cewa juriyawar insulin na iya faruwa a cikin mutanen da basu da ciwo na rayuwa. Musamman, ana gano juriya a cikin mutane da:
- polycystic ovary a cikin mata;
- rashin cin nasara na koda
- cututtuka;
- glucocorticoid far.
Ciki har da juriya na insulin a wasu yanayi ana gano cikin mata yayin daukar ciki, amma bayan haihuwar yaro wannan yanayin yawanci yakan ɓace.
Hakanan, juriya na iya ƙaruwa tare da shekaru, sabili da haka, akan salon rayuwar mutum yake jagoranci. Ya dogara da ko zai sami ciwon sukari na type 2 a cikin tsufa ko kuma yana da matsaloli a cikin tsarin zuciya.
Me yasa nau'in ciwon sukari na 2 ya haɓaka
Abubuwan da ke haifar da haɓakar ciwon sukari suna kwance kai tsaye a cikin juriya na insulin ƙwayoyin tsoka, ƙwayar tsopose da hanta. Sakamakon cewa jiki ya zama mai hankali ga insulin, ƙasa da glucose ya shiga cikin ƙwayoyin tsoka. A cikin hanta, aiki mai narkewa na glycogen zuwa glucose ya fara da samar da glucose daga amino acid da sauran albarkatun ƙasa.
Tare da juriya na insulin na adipose nama, tasirin antilipolytic na insulin ya raunana. Da farko, ana aiwatar da wannan aikin ta hanyar haɓaka aikin insulin daga ƙwayar cuta.
A ƙarshen ƙarshen cutar, kitse na jikin mutum ya fara karyewa zuwa glycerin da mai mai kyauta.
Wadannan abubuwa bayan sun shiga hanta an canza su zuwa abinci mai yawa. Wannan abin cutarwa ana sanya shi a bangon jijiyoyin jini, wanda ya haifar da haɓakar atherosclerosis na tasoshin ƙananan ƙarshen.
Hadawa cikin jini daga hanta, haɓaka matakin glucose, wanda aka kafa saboda glycogenolysis da gluconeogenesis, ya shiga.
Tare da juriya na insulin a cikin haƙuri, ana lura da ƙara yawan matakin insulin na hormone a cikin jini shekaru. Idan mutum ya haɓaka insulin a wannan lokacin tare da sukari na al'ada, dalilai na iya haifar da gaskiyar cewa mai haƙuri na iya haɓaka ciwon sukari na 2.
Bayan wani lokaci, ƙwayoyin ƙwayar hanji sun daina jimre wa irin wannan nauyin, matakin wanda ke ƙaruwa sau da yawa. A sakamakon haka, jiki ya fara samar da karancin insulin, wanda ke haifar da ciwon suga. Don hana wannan daga faruwa, kuna buƙatar fara rigakafin cutar da cutar da wuri-wuri.
Cutar Kwayar Zuciya don Jure Maganin Insulin
Kamar yadda kuka sani, a cikin mutane masu ciwon sukari, haɗarin mutuwa farkon yana ƙaruwa sau da yawa. A cewar likitocin, juriya insulin da hyperinsulinemia sune manyan abubuwan haɗari don haɗarin bugun zuciya da bugun zuciya. Babu damuwa idan mara lafiyar ya kamu da ciwon sukari.
Asedara yawan insulin ba daidai ba yana shafar yanayin tashohin jini, yana haifar da gaɓarɗar su da bayyanar filayen atherosclerotic. Ciki har da sinadarin hormone na taimaka wa ci gaban kwayar tsoka mai santsi da ta fibroblasts.
Don haka, hyperinsulinemia ya zama ɗayan manyan abubuwan da ke haifar da ci gaban atherosclerosis. Ana gano alamun wannan cuta tun kafin a fara haɓakar ciwon sukari.
Kuna iya gano babban alaƙa tsakanin insulin wuce haddi da haɓaka cutar zuciya. Gaskiyar ita ce juriyawar insulin yana ba da gudummawa ga:
- ƙurar kiba na ciki;
- lalacewar bayanin martaba cholesterol jini, saboda wanda filayen cholesterol suka bayyana akan bangon jijiyoyin jini;
- ƙara da yiwuwar ƙwanƙwasa jini a cikin hanyoyin jini;
- thickening bango na carotid artery, wanda ke haifar da taƙaitawa daga lumen artery.
Wadannan abubuwan zasu iya faruwa duka a cikin nau'in ciwon sukari na 2 wanda kuma a rashi. A saboda wannan dalili, da sannu majinyaci ya fara neman magani, hakan zai iya yiwuwa. cewa rikitarwa ba zai bayyana ba.
Insulin juriya magani
Idan akwai alamun juriya na insulin, ana gudanar da magani ta amfani da abincin warkewa wanda ke hana cin abinci mai narkewa. Wannan yana taimakawa don sarrafawa da dawo da daidaito a cikin rikicewar metabolism a cikin jiki. An gabatar da irin wannan abincin a cikin ciwon sukari da kuma rashinsa. A lokaci guda, irin wannan menu a cikin abincin yau da kullun ya kamata ya zama babba cikin rayuwa.
Bayan an fara jiyya ta hanyar warkewar abinci, mara lafiya zai fara jin sauki bayan kwana uku zuwa hudu. Bayan sati daya, triglycerides a cikin jinin al'ada.
Makonni shida zuwa takwas bayan haka, tare da ingantaccen abinci mai gina jiki, gwaje-gwaje yawanci suna ba da rahoton karuwa da kyau da raguwa a cikin mummunan cholesterol. A sakamakon haka, an rage haɗarin haɓakar atherosclerosis.
Saboda haka, magungunan insulin juriya ba sa inganta ta magungunan zamani. A saboda wannan dalili, da farko dai yana da mahimmanci a ki cin abincin da aka sake fitarwa. wanda aka samo a cikin sukari, mai dadi da kayan abinci na gari.
Ana bada shawarar yin amfani da maganin rage cin abinci tare da yin amfani da maganin Metformin, wanda aka yi amfani dashi azaman ƙari. Kafin ka fara jinya, tabbas za ka nemi likita.
